Gene 6414 (Tetrahymena)

6414

Species: Tetrahymena
Alias: 6414, 66.m00213, TTHERM_00526760, 3722.m00071, PreTt06414, 359
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
6414.AA Protein None 369 None Fasta, JSON
6414.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
6414.NA RNA None 1110 None Fasta, JSON

Protein domain

Protein domains of 6414.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6414.AA AGC 47-304 35 3.3e-197 515.77 In-house 1-395 (395) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-395/395
Sequence Identity: 35% (143 aa)

FNLVKVIGKGSYAKVVLVKKK------EDGKVYAIKILKKSY-IEQKK--QVEHIKTE------------RNILVDAD----------HPFIIK-LHYSF
|...|||||||. || ||.||        ||.||.|.|||.. | .||  .|||..||            ||||. ..          ||||.| |||||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QNERK--LFFVLDYCQ---------GG-ELFNLLC---RKRRFSEQDTKFYCTQ-------IVLALEYLHQ-KDIIYRD-LKPENVLIDRQGYLKITDFG
|....  |.||..|..         || |||  |.   ...||.|. ..||. .       |||||||||. ..||.|| |||||.|.|..|..|.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKRNIKD---------------------------------------------------QKNQSICG--TPEYLAPEVLAKVGHGKPVDWWT--LGCLMY
|.|....|                                                   ......||  ||||.|||.|    .||..|||.  ||||||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFLTGFPPFYTE----------DRKSLFELIKN-----NPYPELP--------KEIVISQQCKDIITKLLEKDPNQRLGHL-------GAQEVKQHPFF
|.||| |||| .          ... .|..|.|     |  ...|        ..  .|...||.|.|||.|||..||| .       ||.|.|.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 6414.AA Akt 47-304 59 5e-197 635.48 In-house 1-264 (264) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-264/264
Sequence Identity: 59% (157 aa)

FNLVKVIGKGSYAKVVLVKKKEDGKVY-AIKILKKSYIEQKKQVEHIKTERNILVDADHPFIIKLHYSFQNERKLFFVLDYCQGGELFNLLCRKRRFSEQ
|...||.||||..||.||||| ..|.| |.|.|||.||.||.||||.|||||||.  .||||..||||||.. ||.||.|||.|||||..|.|||||||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DTKFYCTQIVLALEYLHQKDIIYRD-LKPENVLIDRQGYLKITDFGLSKRN-IKD-QKNQSICGTPEYLAPEVLAKVGHGKPVDWWT-LGCLMYEFLTGF
 ..||| .|.||.|.||.|.||||| |||||.|.|..|....|||||.|.| ||| .| ...||||||||||.| ..||.|.||||. |||.|||...|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFYTEDRKSLFELIKNNPYPELPKEIVISQQCKDIITKLLEKDPNQRLG-HLG-AQEVKQHPFF
||||..|.. .|..|||.|.   .| ..||..|||.|..||.|||..||| . . |||.|.||.|
PPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 6414.AA SGK 47-304 46 2.7e-151 470.77 In-house 1-283 (283) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-283/283
Sequence Identity: 46% (134 aa)

FNLVKVIGKGSYAKVVLVKKKED------------------GKVYAIKILKKSYIE-------QKKQVEHIKTER-NILVDADHPFIIKLHYSFQNERKL
| . |||||||. || .||.|.|                  .|.||.|.|.|  |        .||.. ||..|| .||.   ||||..|||.||.. ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVLDYCQGGELFNLLCRKRRFSEQDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDRQGYLKITDFGLSKRNIKDQKN-QSICGTPEYLAPEVLAKV
.||.|| .|||.|. | | ..|.|   .||  .||.|||||| .|||||||||||.| | ||....|||||.| .||...   ..||||||||||||.| 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHGKPVDWWTLGCLMYEFLTGFPPFYTEDRKSLFELIKNNPYPELPKEIVISQQCKDIITKLLEKDPNQRLGHL-GAQEVKQHPFF
.|.. |||| |||..||...| ||||  ... ... | | |   .|.   .| ...|.|. ||.||| .|||.  .. |.|.||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPL-QIPPQ--MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 6414.AA AktR 47-304 51 4.6e-147 494.88 In-house 1-268 (268) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-268/268
Sequence Identity: 51% (139 aa)

FNLVKVIGKGSYAKVVLVKKK-EDGKVYAIKILKKSYIEQKKQVEHIKTERNILV-DADHPFIIKLHYSFQNERKLFFVLDYCQGGELFNLLCRKRRFSE
| . |..||| ..||.||.|| ...|.||.|..||. |....| .|. |||||.   ..||||.||||.||...||||...||.|||||. | .|..|||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QDTKFYCTQIVLALEYLHQK-DIIYRDLKPENVLIDRQGYLKITDFGLSK-RNI--KDQKNQSICGTPEYLAPEVLAK-VGHGKPVDWWTLGCLMYEFLT
....||  ||.||||||||. .|||||||||| |.|  |..|||||||||  ..  .|.|..|.||||||.|||.. | .||.|.||||..|.. || .|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GFPPFYTEDRKSLFELIKNNPYPELPKEIVISQQCKDIIT-KLLEKDPNQRLG--HLGAQEVKQHPFF
| |||| .... .|..||. .  . |. . .|.||||.|. ||| |.||.|||    |..|.| ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 6414.AA PKA 47-304 46 4.2e-129 435.22 In-house 1-263 (263) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-263/263
Sequence Identity: 46% (124 aa)

FNLVKVIGKGSYAKVVLVKKKEDGKVYAIKILKKSYIEQKKQVEHIKTERNILVDADHPFII-KLHYSFQNERKLFFVLDYCQGGELFNLLCRKRRFSEQ
|......|.||...| |...|..|. ||.|.|||..| . |||||...|.|||   .||||. |. ..||..|.|..|..|..|||.|  | ...|||..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DTKFYCT-QIVLALEYLHQKDIIYRDLKPENVLIDRQGYLKITDFGLSKRNIKDQKNQSICGTPEYLAPEVLAKV-GHGKPVDWWTLGCLMYEFLTGFPP
..||| . ||||||||||...|||||||||| |||..|..|||||| .|. ..|   ...||||||||||..    ||||.||||.||.| ||.|.|.||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FYTE--DRKSLFELIKNNPYPELPKEIVISQQC---KDIITKLLEKDPNQRLGHLGA--QEVKQHPFF
|| .  |  ...| | |  . . | .  ....    || | |||..|...|.| . .  . .| |..|
FYDHNRDPMQIYEKICNGKI-KFPRH--FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 6414.AA RSK 50-304 45 4e-123 415.36 In-house 1-278 (278) Show / Hide 
Range on Protein: 50-304
Range on HMM: 1-278/278
Sequence Identity: 45% (126 aa)

VKVIGKGSYAKVVLVKKK---EDGKVYAIKILKKSYIEQKKQ-VEHIKTERNILVDAD-HPFIIKLHYSFQNERKLFFVLDYCQGGELFNLLCRKRR---
.|| |.|.| || |..|.     |..|| |.|||. | |..  ..| .|||||| .   ||||..|||.|| | ||. ...|| |||||  |.....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEQDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDR---QGYLKITDFGLSKR-NIK-DQKNQSICGTPEYLAPEVLA----KVGHGKPVDWWTLGC
||| . .||  .||||.|.|||..||.|||||||.| |    .| .|.||||..|  ...  |. .. |.| ||.|||.|.    ..||.| .|||.||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYEFLTGFPPFYT---EDRKSLFELIKNNP-YPELPKEIVISQQCKDIITKLLEKDPNQRLG--HLGAQEVKQHPFF
|||| |||.|||.    ..|| ... |...   ...|    .|| .||.|.|.|..||..|||  . .|.|.||||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 6414.AA S_TKc 47-304 38 1.2e-112 381.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-231/231
Sequence Identity: 38% (105 aa)

FNLVKVIGKGSYAKVVLVKKKEDGKVYAIKILKKSYIEQKKQVEHIKTERNILVDADHPFIIKLHYSFQNERKLFFVLDYCQG--GELFNLLCRKRR---
. ....||||...|| ....|..|...||||.|          |||. |..||   .||.|.||...||.  .|..|..|| |  |.|| ......|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEQDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDRQGYLKITDFGLSKRNIKDQKNQSICGTPEYLAPEVLAKVGHGK-PVDWWTLGCLMYEF
   |.| ...||. ||..||||.|.. ||.|||||||.|.|.   .||.||||...        ..||||.|.|||||   |.|| ..||| .||..||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTGFPPFYTEDRKSLFELIKNNPYPELPKEIVISQQCKDIITKLLEKDPNQRLGHLGAQE----VKQHPFF
|.| |||.  . . .|..|.             |...||.| |.|.|||..|..   | .    .|.||.|
LCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6414.AA RSK-Unclassified 47-304 39 2.1e-112 354.46 In-house 1-283 (283) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-283/283
Sequence Identity: 39% (112 aa)

FNLVKVIGKGSYAKVVLVKKKEDGKVYAIKILKKSYIEQKKQVEHIKTERNILVDADHPFIIKLHYSFQNERKLFFVLDYCQGGELFNLLC--RKRRFSE
|   . ||.|.  || ||.||.  ..||.|.|.|. . ... .  . ||.||.   .||||..| .||| . .|. ...|| ||..|  |   ....|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

QDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDRQGYLKITDFGLSKRN-------IK---------------DQKNQSICGTPEYLAPEVLAKVGHG
 | .||   ...|||||| .|.|||||||.|.. .  |  . |||.||.         .|                 . .| ||| ||||||..   ||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KPVDWWTLGCLMYEFLTGFPPFYTEDRKSLFELIKNNPYPELPKEIVISQQCKDIITKLLEKDPNQRLG-HLG-AQEVKQHPFF
| ||||||| .||| | |.||.| . .  .|. |  |.   .|..  ||..|.| | |||.. |  |||   | |...|.||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHV-KFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 6414.AA RSK 47-304 40 1.4e-109 370.33 In-house 1-271 (271) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-271/271
Sequence Identity: 40% (109 aa)

FNLVKVIGKGSYAKVVLVKKK---EDGKVYAIKILKKSYIEQKKQVEHIKTERNILVDADHPFIIKLHYSFQNERKLFFVLDYCQGGELFNLLCRKRRFS
..| ..||.||. || ..||.     .. ||.||.||. .  | .    ..||.|| . .||||.||||.|| |.|.. ..| ..||.||  | ... ||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EQDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDRQ----GYLKITDFGLSKRNIKDQK-NQSICGTPEYLAPEVLAKVGHGKPVDWWTLGCLMYEFL
|.. |||   | ||.||||...|..|||||||.|.| .    | .||.|||..|  . . .   . |.| .|.||||| . ||.. .||| .| |||| |
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

TGFPPFYTEDRKSLFELIKNNPYPE----LPKEIVISQQCKDIITKLLEKDPNQRLGH--LGAQEVKQHPFF
||..||.  .|......|.. .        .    ||. .|| ....|. ||..|||    |....||||.|
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 6414.AA p70 47-304 41 6.1e-107 361.58 In-house 1-299 (299) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-299/299
Sequence Identity: 41% (124 aa)

FNLVKVIGKGSYAKVVLVKKKE---DGKVYAIKILKKSYI-EQKKQVEHIK-------------------------TERNILVDADHPFIIKLHYSFQNE
| |.||.||| | || .|.|      ||.|| | |.|  |    |  .| .                          |||||    ||||..|||.|| .
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

RKLFFVLDYCQGGELFNLLCRKRRFSEQDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDRQGYLKITDFGLSKRNIKDQKN-----------QSICG
 ||. .|.|  ||||| .| |.  . |  ..||   |..|||.|||..||||||||||.. . || .. |||||.|  |.| .             ..||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TPEYLAPEVLAKVGHGKPVDWWTLGCLMYEFLTGFPPFYTEDRKSLFELIKNNP-YPELPKEIVISQQCKDIITKLLEKDPNQRLG--HLGAQEVKQHPF
|.|| |||.| ..||.. |||| ||||||  ||| |||  | ||   . |  .   ..||     ..  .|.| ||| ..| ||.|     |.....|||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLP--PYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPF

F
|
F
Kinase 6414.AA Ciliate-E2 47-304 29 9.1e-106 357.69 In-house 1-365 (365) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-365/365
Sequence Identity: 29% (113 aa)

FNLVKVIGKGSYA-----KVVLVKK------------------KEDGKVYAIKILKKSYIEQKKQVEHIK----------TERNILVDADHPFIIKLHYS
....|.||.|...     || .|.|                  | ..| ||.||.||. |||.||..||            |.|||   .||.|||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--NERKLFFVLDYCQGGELFNLLC-------------------RKRRFSEQDTK-------FYCTQIVLALEYLHQKD-IIYRDLKPENVLIDRQGYL
||  .. ....|..|||||.|| ..                      .....| ..       ||...|.|||||||.|  ||.||.||||.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KITDFGLSKRNIKDQKNQS--------------------------------ICGTPEYLAPEVLAKVG---------HGKPVDWWTLGCLMYEFLTGFPP
||.||||||.. .|..|..                                |||||.|.|||.| . .         ... .|.| ||...||.|.| ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYTEDRKSLFELIKNNPYPELPKE---------------IVISQQCKDIITK----LLEKDPNQRLGHLGAQEVKQHPFF
|        .. ||....   ..|                 .||.|||.| |    .|.|||..|..  |......||.|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 6414.AA Pkinase 47-304 33 2.3e-102 351.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 47-304
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

FNLVKVIGKGSYAKVVLVKKKEDGKVYAIKILKKSYIEQKKQVEHIK-TERNILVDADHPFIIKLHYSFQNERKLFFVLDYCQGG----ELFNLLC--RK
. ....||.||...| . ..| .||..|.||.||. .. .|...|.. .|  |.   .||.|..|...|...... .|..||.||    .|| ..   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RRF--SEQDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDRQGYL----KITDFGLSKR--NIKDQKNQSICGTPEYLAPEVLA-KVGHGKPVDWWTL
..|  ||.. |||..||. .|||.|.. ||.|||||||.|||..|..    ||.||||.|   . ... ....||||.|.||||.    ..|..||.| .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCLMYEFLTGFPPFYTE----DRKSLFELIKNNPYPELPKEIVIS---------------------QQCKDIITKLLEKDPNQRLGHLGAQEVKQHPFF
||..||.|.| |||. .    .  .  ..|... .|.|. ..  .                     . |||.|...|.|||..|..   |....|||.|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 6414.AA S_TK_X 305-367 28 3.2e-17 64.46 SMART 1-79 (79) Show / Hide 
Range on Protein: 305-367
Range on HMM: 1-79/79
Sequence Identity: 28% (23 aa)

MDVNWQAIIR--KEVKAPFIPKVK----NEEDTSNIDPEFTQMDISSLQNGGT-LTEPSNIN----------YHGFSYQK
 ...|... .  ||...||.||.|    ...|||| ||||| .... |..  . |.. .. |          . ||.|  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 6414.AA TyrKc 47-293 23 4e-14 5.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-293
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FNLVKVIGKGSYAKVVLVKKKEDGKVYAIKILKKSYIEQKKQVEHIKTERNILVDA--DHPFIIKLHYSFQNE-------RKLFFVLDYCQGGELFNLLC
  | |..| | . .|.. . |      |.| ||..       .| .  | .|.     .|| |..|.     .         |. |. |. .| | . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RKRR-FSEQDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDRQGYLKITDFGLSKRNIKDQ-----KNQSIC-----GTPE-----YLAPEVLAKVGH
..|. .. .|   .|.||    ||||.| .| |||   |.|.....  ||.||||| |.|.|        . .      |.        .|||.. .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GKPVDWWTLGCLMYEFLT-GFPPFYT-----EDRKSLFELIKNNPYPELPKEIV------ISQQCKDIITKLLEKDPNQR------LGHL
    | |  | .|.| .| | .| .       . . ..|..|.  ... |...        ..   .|...  . ||..|         .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 6414.AA Pkinase_Tyr 47-193 26 2.6e-11 38.93 Pfam 1-159 (270) Show / Hide 
Range on Protein: 47-193
Range on HMM: 1-159/270
Sequence Identity: 26% (42 aa)

FNLVKVIGKGSYAKVVLVKKK-----EDGKVYAIKILKKSYIEQK-KQVEHIKTERNILVDA-DHPFIIKLHYSFQ-NERK--LFFVLDYCQGGELFNLL
  . |..|.|.. .|.. . |     .. .| |.|.|| .. ..  .. . .. | .|.    .|| |..|.      ..   .. |. |...| | . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

CR----KRRFSEQDTKFYCTQIVLALEYLHQKDIIYRDLKPENVLIDRQGYLKITDFGLSK
 .    |.... .|   .|.||  ..|||..| .| |||   |.|.....  ||.||||..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 6414.AA Pkinase_C 324-369 31 6.9e-09 34.58 Pfam 1-46 (46) Show / Hide 
Range on Protein: 324-369
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

KVKNEEDTSNIDPEFTQMDIS-SLQNGGTLTEPSNINYHGFSYQKPL
.||...|||| |||||... . .   .  .... . . .||.|  | 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD