Gene 5665 (Tetrahymena)

5665

Species: Tetrahymena
Alias: 656, 50.m00234, PreTt05665, 3681.m00093, 5665, TTHERM_00442650
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
5665.AA Protein None 399 None Fasta, JSON
5665.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
5665.NA RNA None 1200 None Fasta, JSON

Protein domain

Protein domains of 5665.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5665.AA Akt 44-300 53 7.70000000001e-191 615.38 In-house 1-264 (264) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-264/264
Sequence Identity: 53% (141 aa)

FYLLSIIGKGSYAKVSLVRKKDDNQVY-ALKAIKKSLIEAKNQKEHIITERNILQTVNNQYIVKMKYAFQDKQKLFFVLEYCGGGELYSLLSSKKYLNEQ
|..| ..||||..|| ||.|||....| |.|..||. |..|||.||..|||||||..|...||...|.||...||.||..||.||||...|. |.. .|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

QTKFYAAQLVKAIEYLHSHNIIYRD-LKPENILIDKDGYIKLTDFGLSKMD-IKHNTEATSLCGTPEYLAPEILEQSGHGKPVDWWT-LGNIIWEMMTGL
...||.|... |||.|||.|||||| |||||||.||||.|.||||||.|.. ||.. .....||||||||||||.. ||.|.||||. || ...|||.|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFYNENRKEMFHHIKELPLKNH--PRIQGDLKNLLHSLLEKDPNKRLG-TIDGAKEIIDHPWF
|||||.....||..||. |.| .  ..|. . |.|...||.|||.|||| ....|.|| .||||
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 5665.AA AGC 44-300 34 1.5e-179 469.07 In-house 1-395 (395) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-395/395
Sequence Identity: 34% (136 aa)

FYLLSIIGKGSYAKVSLVRKK------DDNQVYALKAIKKSL-IEAKN--QKEHIITE------------RNILQTVN----------NQYIVK-MKYAF
| .| .|||||. || |||||      | ...||.| .||.  |  |.  . ||..||            ||||...|          ...||| ..|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKQK--LFFVLEY---------CGGG-ELYSLLS---SKKYLNEQQTKFYAAQ-------LVKAIEYLHS-HNIIYRD-LKPENILIDKDGYIKLTDFG
|||..  |.||.||         |||| ||.. |     .....|....||||.       .| |.||||| ..||.|| |||||||.|.||.|||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKMDIKHN--------------------------------------------------TEATSLCG--TPEYLAPEILEQSGHGKPVDWWT--LGNIIW
|.|. .. .                                                    ....||  ||||.|||||    .||..|||.  || .. 
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMTGLPPFYNEN----------RKEMFHHIK--------ELPLKNH--------PRIQGDLKNLLHSLLEKDPNKRLGTID------GAKEIIDHPWF
||.||.||||..|          ..|||. |.        .... ..        . .  ..|.|.  ||.|||.||||. .      ||.|| .||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 5665.AA SGK 44-300 45 2.2e-136 423.88 In-house 1-283 (283) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-283/283
Sequence Identity: 45% (128 aa)

FYLLSIIGKGSYAKVSLVRKKDD------------------NQVYALKAIKKSLIE-------AKNQKEHIITER-NILQTVNNQYIVKMKYAFQDKQKL
| .|..|||||. || .|..|||                   ..||.| ..|  |        .|..  || .|| .||. ..   ||. .|||| |.||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVLEYCGGGELYSLLSSKKYLNEQQTKFYAAQLVKAIEYLHSHNIIYRDLKPENILIDKDGYIKLTDFGLSKMDIKHNTEATSLCGTPEYLAPEILEQS
.||..|  |||. . |   |.. | . .||||..| |.||||| .|||||||||||| | .|...||||||.| .||.|.. .. ||||||||||.|   
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHGKPVDWWTLGNIIWEMMTGLPPFYNENRKEMFHHIKELPLKNHPRIQGDLKNLLHSLLEKDPNKRLGTIDGAKEIIDHPWF
.|.. |||| || .  |||.||||||. |...|.  |   ||.  | .. | . |.  ||.||| ||||| ... || .||.|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 5665.AA AktR 44-300 51 4.3e-134 451.78 In-house 1-268 (268) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-268/268
Sequence Identity: 51% (137 aa)

FYLLSIIGKGSYAKVSLVRKK-DDNQVYALKAIKKSLIEAKNQKEHIITERNILQ-TVNNQYIVKMKYAFQDKQKLFFVLEYCGGGELYSLLSSKKYLNE
| .. ..||| ..|| ||.|| |....||.| |||. |. .||..|.||||||..  .|.  |||..|.||.| ||||..||| ||||.. |..|| ..|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QQTKFYAAQLVKAIEYLHSH-NIIYRDLKPENILIDKDGYIKLTDFGLSK--MDIKHNTEATSLCGTPEYLAPEILEQ-SGHGKPVDWWTLGNIIWEMMT
.|..||.|| . |.||||.| |||||||||||||.|.||..|.|||||||   ..  . .|.|.||||||.|||.. .  ||.|.||||..|  | ||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GLPPFYNENRKEMFHHIKELP-LKNHPRIQG--DLKNLLH-SLLEKDPNKRLG-TIDGAKEIIDHPWF
|.||||..|...||. ||. . .|. . ..    .|.|.   || |.||||||    |..|| .||||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 5665.AA PKA 44-300 45 8.20000000001e-119 401.02 In-house 1-263 (263) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-263/263
Sequence Identity: 45% (121 aa)

FYLLSIIGKGSYAKVSLVRKKDDNQVYALKAIKKSLIEAKNQKEHIITERNILQTVNNQYIV-KMKYAFQDKQKLFFVLEYCGGGELYSLLSSKKYLNEQ
| ..  .|.||...| |.|.|.. . ||.| .||. |   .|.||...|.|||| ... .|| ||.. ||| ..|..|.||..|||. | |  .. ....
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

QTKFYAA-QLVKAIEYLHSHNIIYRDLKPENILIDKDGYIKLTDFGLSKMDIKHNTEATSLCGTPEYLAPEILEQS-GHGKPVDWWTLGNIIWEMMTGLP
..||||| | | |.|||||.||||||||||||||||.|.||.|||| .|  ..   .  .||||||||||||.  . ||||.||||.|| .| ||..| |
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYNE--NRKEMFHHIKELPLKNHPRIQGDL---KNLLHSLLEKDPNKRLGTID-GAKEIIDHPWF
|||..  .  ...  | .  .|  . .  |.   | |. .||..|..||.|. . |.  | .|.||
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 5665.AA RSK 47-300 42 8.4e-108 364.44 In-house 1-278 (278) Show / Hide 
Range on Protein: 47-300
Range on HMM: 1-278/278
Sequence Identity: 42% (119 aa)

LSIIGKGSYAKVSLVRKK---DDNQVYALKAIKKSLIEAKNQ-KEHIITERNILQTVN-NQYIVKMKYAFQDKQKLFFVLEYCGGGELYSLLSSKKY---
|.  |.|.| ||.|.||.   | .|.|| | .||. | ...   .|  ||||||....  . ||. .||||...||. ..||| ||||.  |. .|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LNEQQTKFYAAQLVKAIEYLHSHNIIYRDLKPENILIDK---DGYIKLTDFGLSKM-DIKHNTEATSLCGTPEYLAPEILE----QSGHGKPVDWWTLGN
. |   .||.|..|.|.|.||.. ||.||||||||| |    .| |||||||..|  ...||  . . |.| ||.|||.|     |.||.| .|||.|| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

IIWEMMTGLPPFYN---ENRKEMFHHIKELP--LKNH--PRIQGDLKNLLHSLLEKDPNKRLG-TIDGAKEIIDHPWF
.. || || |||..   .|||| .  |..    |.    . .  . |.|.  .|..||.||||   ..|.|| .||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 5665.AA S_TKc 44-300 37 8.4e-105 355.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-231/231
Sequence Identity: 37% (100 aa)

FYLLSIIGKGSYAKVSLVRKKDDNQVYALKAIKKSLIEAKNQKEHIITERNILQTVNNQYIVKMKYAFQDKQKLFFVLEYCGG--GELYSLLSSKKY---
. .| .||||...|| ..|.|......|.| ||          |||. |..||.  .  .|||....||| ..|..|.|||.|  |.|.... ....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNEQQTKFYAAQLVKAIEYLHSHNIIYRDLKPENILIDKDGYIKLTDFGLSKMDIKHNTEATSLCGTPEYLAPEILEQSGHGK-PVDWWTLGNIIWE
   ..| ...||..|...|.||.|||.||.|||||||||.|.   ||..||||..         |..||||.|.|||.|   |.|| ..||| .| |..|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MMTGLPPFYNENRKEMFHHIKELPLKNHPRIQGDLKNLLHSLLEKDPNKRLGTIDGAK---EIIDHPWF
|..| |||.  . ..||..|.            ..|...  .|.|||.||..  .  .   .|  ||||
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5665.AA RSK-Unclassified 44-300 38 6.9e-103 324.06 In-house 1-283 (283) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-283/283
Sequence Identity: 38% (109 aa)

FYLLSIIGKGSYAKVSLVRKKDDNQVYALKAIKKSLIEAKNQKEHIITERNILQTVNNQYIVKMKYAFQDKQKLFFVLEYCGGGELYSLLS--SKKYLNE
|     ||.|.  || |||||| .|.||.|  .|. .  .|    ..||.||. | |  .||.. ..|| . .|. ..||| ||...  |    .| . |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

QQTKFYAAQLVKAIEYLHSHNIIYRDLKPENILIDKDGYIKLTDFGLSKMD-------IK--------------HNTEATSLCGTPEYLAPEILEQSGHG
 . .|||.  . | ||||   .|||||||.||. ...| ..||||.||.         .|              | . . | ||| ||||||..   ||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KPVDWWTLGNIIWEMMTGLPPFYNENRKEMFHHIKELPLK--NHPRIQGDLKNLLHSLLEKDPNKRLGTIDG-AKEIIDHPWF
| ||||||| ...||. |.||.| .|. |.|  |   ..|  .   |  . . |.  ||.. | ||||   | | .|  || |
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 5665.AA Pkinase 44-300 32 2.9e-99 340.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

FYLLSIIGKGSYAKVSLVRKKDDNQVYALKAIKKSLIEAKNQKEHII-TERNILQTVNNQYIVKMKYAFQDKQKLFFVLEYCGGG----ELYSLLS--SK
. ....||.||...| . ..|......|.| |||. .. . ...|.  .|  |.. .|  .||.....|.||... .|.|||.||    .|....|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KYL--NEQQTKFYAAQLVKAIEYLHSHNIIYRDLKPENILIDKDGYI----KLTDFGLSKMD-IKHNTEATSLCGTPEYLAPEILE-QSGHGKPVDWWTL
. .   |.. |||. |.....||.||..||.|||||||||||..|.|    |..||||.|   . .|. .|..||||.|.|||..  ....|..||.| .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GNIIWEMMTGLPPFYNE------NRKEMFHHIKELPLKNHPRIQ---------------------GDLKNLLHSLLEKDPNKRLGTIDGAKEIIDHPWF
| |..||..| |||...      . ..|.  |.. ||. .                          ..| .. ..|.|||.||..    |..|  ||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase 5665.AA Ciliate-E2-Unclassified 44-300 29 9.1e-96 324.47 In-house 1-352 (352) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-352/352
Sequence Identity: 29% (105 aa)

FYLLSIIGKGSYAKVSLVRKKDDNQVYALKAIKKSLIEAKNQKEH---------IITERN-------------ILQTVNNQYIVKMKYAFQDKQKLFFVL
. .. .||.|...|| ....|...|.||.| .||. | ...|...         .. ...             ||.  .. .|||| |.|||||....|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCGGGELYSLLSSK-----------------KYLNEQQTK-----FYAAQLVKAIEYLHSHN-IIYRDLKPENILIDKDG---YIKLTDFGLSK-----
||| ||.|   ....                 | . |||.|     ||.||.....||||. | ||.||.||||||.|..|   |||..|||.||     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------MDIKHNTEATSLCGTPEYL----APEILEQSGHG----KPVDWWTLGNIIWEMMTGLPPFYNENRKE----------------MFHHIKE
          |.|  . .... ||||.|.    |||.|.. ...    . .|.|.|| |. ||..| .||| .|...                ..  ||.
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

--LPLKNHP------RIQGDLKNLLH----SLLEKDPNKRLGTIDGAKEIIDHPWF
  .  ...|      ...   |...     ..|.|.||||.    ....|. ||||
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI----TFEQILNHPWF
Kinase 5665.AA RSK 44-300 38 8e-95 321.33 In-house 1-271 (271) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-271/271
Sequence Identity: 38% (104 aa)

FYLLSIIGKGSYAKVSLVRKK---DDNQVYALKAIKKSLIEAKNQKEHIITERNILQTVNNQYIVKMKYAFQDKQKLFFVLEYCGGGELYSLLSSKKYLN
. |.. ||.||. || ...|.   | || || | |||. . .| .     .||.||  .. ..||| .|.||| .|.. ... . ||.|   |. .|.. 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EQQTKFYAAQLVKAIEYLHSHNIIYRDLKPENILIDKD----GYIKLTDFGLSKMDIKHNTEATSLCGTPEYLAPEILEQSGHGKPVDWWTLGNIIWEMM
|.  |||.| . .| |||||. |..|||||||||.| .    | ||..|||..|  . .|  . . |.| .|.|||.| . ||.. .||| .| .  || 
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

TGLPPFYNENRKEMFHHIKELPLKN-------HPRIQGDLKNLLHSLLEKDPNKRLGT-IDGAKEIIDHPWF
|| .||.| .|....  |.  .|            |    | ||  .|. ||..|||.  .|...|  ||||
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 5665.AA Ciliate-E2 44-300 28 1.2e-94 320.79 In-house 1-365 (365) Show / Hide 
Range on Protein: 44-300
Range on HMM: 1-365/365
Sequence Identity: 28% (110 aa)

FYLLSIIGKGSYA-----KVSLVRK------------------KDDNQVYALKAIKKSLIEAKNQKEHII----------TERNILQTVNNQYIVKMKYA
. .. .||.|...     || .|.|                  |.... ||.| .||. ||...|..||.           |.|||...|. .|.||...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DKQKLFFVLEYCGGGELYSLLSSK-------------------KYLNEQQTK-------FYAAQLVKAIEYLHSHN-IIYRDLKPENILIDKDGYI
||  |......|.||| ||.|.... ..                   ||. .|...       ||.|....|.||||| | ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLSK------------------MDIKHNTEATSL--------------CGTPEYLAPEILE---------QSGHGKPVDWWTLGNIIWEMMTGLP
|..||||||                  |. | .|. |.               ||||.|.|||||.         | |... .|.| || |. ||..| |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFYNENRKEMFHHIKELPLK------------------NHPRIQGDLKNLLHS----LLEKDPNKRLGTIDGAKEIIDHPWF
||        .  ||. ...                  ..  .  . |.|.      .|.|||.||..   |...|..||||
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase 5665.AA TyrKc 44-294 20 8.8e-14 0.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 44-294
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

FYLLSIIGKGSYAKVSLVRKKDDNQVYALKAIKKSLIEAKNQKEHIITERNILQTV--NNQYIVKMKYAFQDK-------QKLFFVLEYCGGGELYSLLS
  |. ..| | . .| . . |         |.|.   .|   .| .. | .|.  .  ... ||..  .  ..       . |. |.||. .| | . | 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SKKY-LNEQQTKFYAAQLVKAIEYLHSHNIIYRDLKPENILIDKDGYIKLTDFGLSKMDIKHN------TEATSL----CGTP----EYLAPEILEQSGH
...  |. ..   .. |  .  |||||.|.| |||   |.|..... .| .|||||. ||..       ..  .     .|        .||| .  .  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSR-DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GKPVDWWTLGNIIWEMMT-GLPPFYN-----ENRKEMFHHIKELPLKNHPRI---------QGDLKNLLHSLLEKDPNKRLGTIDGAKEI
    | |  |  .||..| | .| ..      . .|.....|.      |             .. ..  .  . ||..|    .  ...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 5665.AA Pkinase_Tyr 44-190 24 5.7e-13 44.56 Pfam 1-159 (270) Show / Hide 
Range on Protein: 44-190
Range on HMM: 1-159/270
Sequence Identity: 24% (39 aa)

FYLLSIIGKGSYAKVSLVRKK-DDNQVYALKAIKKSLIEAKNQ---KEHIITERNILQTV-NNQYIVKMKYAFQ-DKQK--LFFVLEYCGGGELYSLLSS
  ..  .|.|.. .| . . | |. .     |.|.    |  .   .|  . | .|. .  ... ||..  .   ...   .. |.||. .| |.. | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----KKYLNEQQTKFYAAQLVKAIEYLHSHNIIYRDLKPENILIDKDGYIKLTDFGLSK
    |. |. ..   ...|  |. |||.|.|.| |||   |.|..... .| .||||..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 5665.AA S_TK_X 301-364 20 6.6e-10 40.16 SMART 1-79 (79) Show / Hide 
Range on Protein: 301-364
Range on HMM: 1-79/79
Sequence Identity: 20% (17 aa)

KDLRWDQLEQ--RKINPPFVPNLE----TDIDLKYIDYEFKEMPIYSVDNNNSSMHSGNFNQ-----------YDNFTVQS
... ||.|..  ..| |||.|..      ..|... | || |...   . . ... |.. .|           . .||   
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF