Gene 1560 (Tetrahymena)

1560

Species: Tetrahymena
Alias: 1560, 314.m00021, TTHERM_01298470, 745, PreTt01560
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
1560.AA Protein None 355 None Fasta, JSON
1560.kin_dom Protein Kinase Domain None 262 None Fasta, JSON
1560.NA RNA None 1068 None Fasta, JSON

Protein domain

Protein domains of 1560.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1560.AA Akt 23-284 52 8.49999999999e-182 586.01 In-house 1-264 (264) Show / Hide 
Range on Protein: 23-284
Range on HMM: 1-264/264
Sequence Identity: 52% (140 aa)

FFMKAVLGKGSFAKVILVKKKDNGKFY-AIKVLKKSKLEKQRHIDNVIAERNILVGVNHPFVIQLHYSFQNSEKLYFVLEFCPGGELFNLLHKAQKFTED
| .. |||||||.||.||||||..|.| |.|||||......... ....|||||. .||||...||||||...|||||...|.|||||..|.....|.||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

YLDCACNRTSSLIEHHIQRSIEMCGQRVTTYLKPENVMIDFDGYIRITDFGLSKNN-ISNHEKTYSVCGTPEYLAPEILTMQGHEKSADWWS-LGALIYE
.  . |.. .. |||. ...| ..      ||||||...| ||.|..|||||.|.| |..|.||...|||||||||||| ..|| |..|||. ||...||
RARFYCAEIILAIEHLHSKNIIYRD-----YLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYE

LLTGLPPFYNQNREVMYELIKNQNVNIP--DYISPICKDLIYRLLQKNPENRLG--KNGAFEIKNHPWL
...|.||||||....|...||||.|..|  |.||| |||||..||.|.|..|||  .|.| |||.|||.
MMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 1560.AA AGC 152-284 33 3.6e-95 245.85 In-house 180-395 (395) Show / Hide 
Range on Protein: 152-284
Range on HMM: 180-395/395
Sequence Identity: 33% (74 aa)

YLKPENVMIDFDGYIRITDFGLSKNNISNH--------------------------------------------------EKTYSVCG--TPEYLAPEIL
||||||...| ||.|..|||||.| .....                                                  ..|.. ||  ||||.|||||
YLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL

TMQGHEKSADWWS--LGALIYELLTGLPPFYNQN----------REVMYELIK------NQNVNIP----------DYISPICKDLIYRLLQKNPENRLG
    . |..||||  ||.|.||.|||.||||..|          .. |...|.      |..| .|          ...|| .|||| .||.|.||.|||
----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLG

KN-------GAFEIKNHPWL
 .       || ||||||| 
CGGNDFGDKGAEEIKNHPWF
Kinase 1560.AA SGK 153-284 50 1.1e-78 242.56 In-house 151-283 (283) Show / Hide 
Range on Protein: 153-284
Range on HMM: 151-283/283
Sequence Identity: 50% (67 aa)

LKPENVMIDFDGYIRITDFGLSKNNISNHEKTYSVCGTPEYLAPEILTMQGHEKSADWWSLGALIYELLTGLPPFYNQNREVMYELIKNQNVNIPDYISP
|||||.. | .|....|||||.| .|   ..| . ||||||||||.|  |.| .. |||.||.. ||...||||||..|.. ||. | ||  .|| ..|.
LKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSN

ICKDLIYRLLQKNPENRLGKN-GAFEIKNHPWL
 ..|||  ||||.|..||| . .. ||||||. 
DAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 1560.AA AktR 153-284 53 7.1e-77 261.71 In-house 128-268 (268) Show / Hide 
Range on Protein: 153-284
Range on HMM: 128-268/268
Sequence Identity: 53% (75 aa)

LKPENVMIDFDGYIRITDFGLSK--NNISNHEKTYSVCGTPEYLAPEILTM-QGHEKSADWWSLGALIYELLTGLPPFYNQNREVMYELIKNQN---VNI
||||| ..| ||...||||||||  . ... ||.||.||||||.|||..|  .|| ||.|||..|..|||..||.||||..|.. |...||...   ...
LKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPY

PDYISPICKDLIY-RLLQKNPENRLG--KNGAFEIKNHPWL
| |.|. |||||. .||.|||..|||  .||. |||.||| 
PSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 1560.AA S_TKc 23-284 32 1.5e-75 258.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-284
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

FFMKAVLGKGSFAKVILVKKKDNGKFYAIKVLKKSKLEKQRHIDNVIAERNILVGVNHPFVIQLHYSFQNSEKLYFVLEFCPG--GELFNLLHKAQK---
. .  ..|||.|.|| ....|. |. .|||..|          .... |..||   .||....|...||. ..||.|.|.|.|  |.|| ...| ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTEDYLDCACNRTSSLIEHHIQRSIEMCGQRVTTY--LKPENVMIDFDGYIRITDFGLSKNNISNHEKTYSVCGTPEYLAPEILTMQGHEK-SADWW
   |.|             . . | . .| | ..   .  |||||...|    | |.||||..         ...||||.|.|||.|   |. | ..|||
RFPFPE-HA--------RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGALIYELLTGLPPFYNQNREVMYELIKNQNVNIPDYISPICKDLIYRLLQKNPENRLGKNGAFE----IKNHPWL
|.| ..||.|.| |||.  . ..|...|.          || .||.| ..|||.||.|..   |..    ||.|||.
SCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1560.AA AGC 23-121 36 2.2e-62 159.1 In-house 1-146 (395) Show / Hide 
Range on Protein: 23-121
Range on HMM: 1-146/395
Sequence Identity: 36% (54 aa)

FFMKAVLGKGSFAKVILVKKK------DNGKFYAIKVLKKSK---LEKQRHIDNVIAE------------RNILVGVN----------HPFVIQ-LHYSF
| .. |.||||| ||.||.||      |.||.||.|||||..   . |.. ......|            ||||. .|          |||... |||||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QNSEK--LYFVLEFCP---------GG-ELFNLLH---KAQKFTED
|. ..  ||||.|..|         || |||  |.   | ..|.|.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEE
Kinase 1560.AA RSK 153-284 42 4.9e-61 209.09 In-house 130-278 (278) Show / Hide 
Range on Protein: 153-284
Range on HMM: 130-278/278
Sequence Identity: 42% (63 aa)

LKPENVMIDF---DGYIRITDFGLSKN-NISNHEKTYSVCGTPEYLAPEILT---MQG-HEKSADWWSLGALIYELLTGLPPFYN---QNREVMYELIKN
|||||.. |    .| |..||||..|  .... ..|.. |.| ||.|||.|.    || | |..||||||.|.||.||| |||..   .||..  . |..
LKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQK

QN--VNIP--DYISPICKDLIYRLLQKNPENRLG--KNGAFEIKNHPWL
 .  ...|  .|.|. .|||| ..|...|..|||  ...| |||.|||.
GKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 1560.AA RSK 153-284 40 4.5e-57 195.92 In-house 127-271 (271) Show / Hide 
Range on Protein: 153-284
Range on HMM: 127-271/271
Sequence Identity: 40% (58 aa)

LKPENVMIDFD----GYIRITDFGLSKNNISNHEKTYSVCGTPEYLAPEILTMQGHEKSADWWSLGALIYELLTGLPPFYNQNREVMYELIKNQNVNI--
|||||. .| .    | |.|.|||..|  ..  ..... |.| .|.|||.|  ||| ...||||.|.| || ||| .||.|..|. . ..|... . .  
LKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFS

-----PDYISPICKDLIYRLLQKNPENRLGK--NGAFEIKNHPWL
     .|.||. .|||. ..|  .|.||||   ||. .||.|||.
MTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 1560.AA PKA 153-284 48 6.9e-57 195.31 In-house 127-263 (263) Show / Hide 
Range on Protein: 153-284
Range on HMM: 127-263/263
Sequence Identity: 48% (68 aa)

LKPENVMIDFDGYIRITDFGLSKNNISNHEKTYSVCGTPEYLAPEILTMQ-GHEKSADWWSLGALIYELLTGLPPFYNQ--NREVMYELIKNQNVNIPDY
||||| .|| .|.| ||||| .|.  .    |...|||||||||||..   || || |||.|| ||||.|.| ||||.   .   .|| | |  .. | .
LKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRH

ISPIC---KDLIYRLLQKNPENRLG--KNGAFEIKNHPWL
...     |||| .|||.... |.|  |||.  ||||.| 
FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 1560.AA Ciliate-E2 153-284 28 6.7e-51 172.96 In-house 187-365 (365) Show / Hide 
Range on Protein: 153-284
Range on HMM: 187-365/365
Sequence Identity: 28% (55 aa)

LKPENVMIDFDGYIRITDFGLSKNNISNHE-------------------------------KTYSVCGTPEYLAPEILTMQG---------HEKSADWWS
.||||...     | |.||||||..  ...                                ....||||.|.||||| ...         . ...|.||
IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

LGALIYELLTGLPPFYNQNREVMYELIKNQNVNIP------------------DYISPICKDLIYR----LLQKNPENRLGKNGAFEIKNHPWL
|| ..||.|.| |||        .. ||......|                  ...|. ||||| .    .|||.||.|..  |. .|.||||.
LGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 1560.AA RSK-Unclassified 153-284 39 1.3e-50 156.94 In-house 127-283 (283) Show / Hide 
Range on Protein: 153-284
Range on HMM: 127-283/283
Sequence Identity: 39% (62 aa)

LKPENVMIDFDGYIRITDFGLSKNN---------------------ISNHEKTYSVCGTPEYLAPEILTMQGHEKSADWWSLGALIYELLTGLPPFYNQN
|||.|.. . .| .. |||.||.                       ..   .| | ||| ||||||..   || |  ||| || ..||.| |.||.|  |
LKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNN

REVMYELIKNQNVNIP--DYISPICKDLIYRLLQKNPENRLG-KNG-AFEIKNHPWL
.. ... |  ..| .|   |||  |.||| .|||.||  ||| | | | .|| ||  
KNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 1560.AA p70 153-284 39 3.1e-50 173.19 In-house 154-299 (299) Show / Hide 
Range on Protein: 153-284
Range on HMM: 154-299/299
Sequence Identity: 39% (58 aa)

LKPENVMIDFDGYIRITDFGLSKNNISNHEK----------TYSVCGTPEYLAPEILTMQGHEKSADWWSLGALIYELLTGLPPFYNQNREVMYELIKNQ
|||||.| .  | .  |||||.|  |   ..          |.. |||.|| |||||.  ||..  ||||||.|.|  ||| |||   || .  . |   
LKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKG

N--VNIPDYISPICKDLIYRLLQKNPENRLG--KNGAFEIKNHPWL
   ...| | ..  .||| .|| ..|  |.|   . | .|. ||. 
KQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 1560.AA SGK 23-121 38 2.5e-45 137.66 In-house 1-125 (283) Show / Hide 
Range on Protein: 23-121
Range on HMM: 1-125/283
Sequence Identity: 38% (48 aa)

FFMKAVLGKGSFAKVILVKKKDN------------------GKFYAIKVLKKSKLE-------KQRHIDNVIAER-NILVGVNHPFVIQLHYSFQNSEKL
|  . |.||||| || .||.||                   .||||.|||.|           |  .  .. ||| .||. ..||| ..|||.||. .||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFVLEFCPGGELFNLLHKAQKFTED
|||...  |||.|. | ....| ||
YFVMDYVNGGEMFYHLQREKHFPED
Kinase 1560.AA AktR 23-121 51 7.5e-45 155.32 In-house 1-101 (268) Show / Hide 
Range on Protein: 23-121
Range on HMM: 1-101/268
Sequence Identity: 51% (52 aa)

FFMKAVLGKGSFAKVILVKKK-DNGKFYAIKVLKKSKLEKQRHIDNVIAERNILV-GVNHPFVIQLHYSFQNSEKLYFVLEFCPGGELFNLLHKAQKFTE
|   ..|||| |.||.||.|| ||.|.||.|..||.|..... .. .| ||||.   .|||| ..|||.||. |||.|..|.|||||||. | | .||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

D
.
E
Kinase 1560.AA Pkinase 153-284 30 2.7e-44 157.72 Pfam 134-293 (293) Show / Hide 
Range on Protein: 153-284
Range on HMM: 134-293/293
Sequence Identity: 30% (51 aa)

LKPENVMIDFDGYI----RITDFGLSKNN-ISNHEKTYSVCGTPEYLAPEILT-MQGHEKSADWWSLGALIYELLTGLPPFYNQ------NREVMYELIK
|||||..|| .|.|    .|.||||.|   . | . ....||||.|.|||..   |.. ...|.||.| ..||.|.| |||...      .  .|...|.
LKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIM

NQNVNIPDYIS---------------------PICKDLIYRLLQKNPENRLGKNGAFEIKNHPWL
   .  . . .                     . |||.|...|.|.|. |..   | .|..|||.
GPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 1560.AA PKA 23-121 38 5e-40 139.3 In-house 1-100 (263) Show / Hide 
Range on Protein: 23-121
Range on HMM: 1-100/263
Sequence Identity: 38% (38 aa)

FFMKAVLGKGSFAKVILVKKKDNGKFYAIKVLKKSKLEKQRHIDNVIAERNILVGVNHPFVI-QLHYSFQNSEKLYFVLEFCPGGELFNLLHKAQKFTED
|  ...||.|||..| |...|..|..||.|.|||..  . .... |. |.|||  ..|||.. .. ..||.. .||.|.|..||||.|  | | ..|...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP
Kinase 1560.AA RSK-Unclassified 23-121 42 1.9e-39 121.21 In-house 1-101 (283) Show / Hide 
Range on Protein: 23-121
Range on HMM: 1-101/283
Sequence Identity: 42% (43 aa)

FFMKAVLGKGSFAKVILVKKKDNGKFYAIKVLKKSKLEKQRHIDNVIAERNILVGVNHPFVIQLHYSFQNSEKLYFVLEFCPGGELFNLLH--KAQKFTE
|     .|.|.| || ||.|||  . ||.|||.|.|. ... |  |. |.||.   ||||...| .||| . .|| ..|.|.||..|  |   |  .|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

D
|
D
Kinase 1560.AA RSK 23-121 36 1.6e-34 120.69 In-house 1-101 (271) Show / Hide 
Range on Protein: 23-121
Range on HMM: 1-101/271
Sequence Identity: 36% (38 aa)

FFMKAVLGKGSFAKVILVKKK---DNGKFYAIKVLKKSKLEKQ-RHIDNVIAERNILVGVNHPFVIQLHYSFQNSEKLYFVLEFCPGGELFNLLHKAQKF
.  . ..|.||| || ..||.   |... ||.|..||...    |  .   .||.||  ..|||...|||.||  .|.| ...|. ||.||  | |   |
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMF

TED
.|.
SER
Kinase 1560.AA RSK 26-121 45 5.9e-33 115.8 In-house 1-104 (278) Show / Hide 
Range on Protein: 26-121
Range on HMM: 1-104/278
Sequence Identity: 45% (47 aa)

KAVLGKGSFAKVILVKKK---DNGKFYAIKVLKKSKLEK-QRHIDNVIAERNILVGVN-HPFVIQLHYSFQNSEKLYFVLEFCPGGELFNLLHKAQK---
  |||.|.. || |..|.   |.|. || |||||.|. . |. .  . .|||||  .. |||...|||.||  .||| ..|.|.|||||  | | .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTED
|.||
FSED
Kinase 1560.AA p70 23-122 37 8.4e-30 105.12 In-house 1-129 (299) Show / Hide 
Range on Protein: 23-122
Range on HMM: 1-129/299
Sequence Identity: 37% (48 aa)

FFMKAVLGKGSFAKVILVKKKD---NGKFYAIKVLKKSK-LEKQRHIDNVI-------------------------AERNILVGVNHPFVIQLHYSFQNS
|  . ||||| . || .|.|     .|| || |||.| | .  |.  .                            ||||||  |.|||.. |||.||  
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

EKLYFVLEFCPGGELFNLLHKAQKFTEDY
.||| .||. .||||| .| .   . ||.
GKLYLILEYLHGGELFMHLERHGIWMEDT
Kinase 1560.AA Ciliate-E2 23-120 24 2.7e-26 87.25 In-house 1-144 (365) Show / Hide 
Range on Protein: 23-120
Range on HMM: 1-144/365
Sequence Identity: 24% (36 aa)

FFMKAVLGKGSFA-----KVILVKK------------------KDNGKFYAIKVLKKSKLEKQRHIDNVI----------AERNILVGVNHPFVIQLHYS
.    ..|.|.|.     ||..|.|                  |...|.||.|..||...| .  .....           |.|||  .|||..|.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--NSEKLYFVLEFCPGGELFNLLH------------KAQKFTE
||  . ...|.|.|.| ||.|| ..             . ..|||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTE
Kinase 1560.AA Pkinase 23-121 26 4e-25 89.91 Pfam 1-108 (293) Show / Hide 
Range on Protein: 23-121
Range on HMM: 1-108/293
Sequence Identity: 26% (29 aa)

FFMKAVLGKGSFAKVILVKKKDNGKFYAIKVLKKSKLEKQRHIDNVI-AERNILVGVNHPFVIQLHYSFQNSEKLYFVLEFCPGG----ELFNLLH--KA
.  . ..|.|||..| . ..|..|| .|.|..||.. ... .. ..  .|  |.  .|||....|...|... ..|.|.|.|.||    .|| ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QKF--TED
 .|  .|.
GCFYFSEW
Kinase 1560.AA TyrKc 23-284 17 1.1e-11 -33.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-284
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)

FFMKAVLGKGSFAKVILVKKKDNGKFYAIKVLKKSKLEKQRHIDNVIAERNILVGV--NHPFVIQLHYSFQNS-------EKLYFVLEFCPGGELFNLLH
  .. .|| | | .| . . |      |.|.||...      .   . | .|.  .  .|| ...|.     .       | |. |.|..|.| | . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KAQKFTEDYLDCACNRTSSLIEHHIQRSIEMCGQRVTTY--------------------LKPENVMIDFDGYIRITDFGLSKNNISN-----HEKTYSV-
| ..                           | .    .                    |   |.... .. ..|.|||||..  .       ...|.. 
KHRPK-------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKK

---CGTP----EYLAPEILTMQGH--EKSADWWSLGALIYELLT-GLPPFYN------QNREVMYELIKNQNVNIPDY--------ISPICKDLIYRLLQ
   .|        .||| . . |   .|| | || | ...|..| | .| ..       |.||.  . .     .|..         ..   ... .  .
EHKGGKTMLPIRWMAPECI-NYGKFTTKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

KNPENRLGKNGAFEIKNHPWL
 .||.|   .       |  .
EDPEDRPTFSEI-----HECF
Kinase 1560.AA S_TK_X 285-346 23 3e-08 34.67 SMART 1-79 (79) Show / Hide 
Range on Protein: 285-346
Range on HMM: 1-79/79
Sequence Identity: 23% (19 aa)

QDVDWEILLR--KEYRPPFIPILD----N--IVANFPVDFTQQPIDSVDPFQSVKQLNQNNN----------IGGFTYNQ
 ..||. |..  ||. |||.| .     .   . ||. .|| ....  .|....   ....|           .||||. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF