Gene 6778 (Tetrahymena)

6778

Species: Tetrahymena
Alias: PreTt06778, 6778, 885, 16.m00434, TTHERM_00195930
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: NAK,

Classification

Group: TKL
Family: TKL-ciliate1

Sequence

Name Sequence Type Origin Length Description Download
6778.AA Protein None 1583 None Fasta, JSON
6778.kin_dom Protein Kinase Domain None 268 None Fasta, JSON
6778.kin_dom2 Protein Kinase Domain None 259 None Fasta, JSON
6778.NA RNA None 4752 None Fasta, JSON

Protein domain

Protein domains of 6778.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6778.AA TKL-ciliate1 19-277 43 1.7e-178 599.31 In-house 1-279 (279) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-279/279
Sequence Identity: 43% (121 aa)

ITLKQEIGSGSFSNVYLTSNSSYVAKVMNLNYVPSQRSFINERKYYQELGQHSNIVQYLGSQELQGGSLG----VLVIENCPKGSLVDIMSMTPK--NQL
||..|.||||.|.|||.....||....||.||..||.||||......|..||..|.|....|.|||.|..    ....|.|.||...||......  ...
ITMGQKIGSGHFCNVYKGRCNSYDVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMI

SEQQILRVIYEVAQGLSHIHKRK--LIHRDIKIENILYSEENRFKICDFGSVTNNLVPKISKCNIQDIKEEMDRNTTPMYRAPEILDPHIFPDYPINEKI
..|...|.....|||....|.|.  |||||.|..||||.|....|||.|..|.......|..|..||...||.||||....|||..||||||.|||||||
KWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKI

DIFALGVLAYILCFKKPPFDSILGAISGSCLWPEFP------------ITSDEFHNFIMRMLSINPADRPSANEIIQII
||.|.|...|||||.|.||......|...|.|.|||            .....|||..||....||..||..||||||.
DIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase 6778.AA NAK 19-277 29 1.4e-66 221.25 In-house 1-299 (299) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-299/299
Sequence Identity: 29% (90 aa)

ITLKQEIGSGSFSNVYLTSN-------------SSYVAKVMNLNY-VPSQRSFINERKYYQELGQHSNIVQYLG---SQEL--QGGSLGVLVIENCPKGS
.| .. ...| || |||  .              .|  | |  .   ....  ..| .... | .| |||||..   ...   .|..  .|. | |..||
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS

LVDIM-SMT--PKNQLSEQQILRVIYEVAQGLSHIHKRK----LIHRDIKIENILYSE---ENRFKICDFGSVTNNLVPKISKCNIQD---IKEEMDRNT
|.|.| ...  ... ..|..||. ...|..|....| ..    .|||||||||||.||   ....|.|||||.|.  ..   .  .|.   ..... ..|
LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT

TPMYRAPEILDPHIFPDYPINEKIDIFALGVLAYILCFKKPPFD--------SILGAISG--SCLWPEFPITSDEFHNFIMRMLSINPADRPSANEIIQI
||||||||..|  .. . ||.||.|| |||.. | .|| . ||.        | |. ..|  .   |. .  |...|..|  || ..|  ||. ......
TPMYRAPEMCD--LYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQ

I
.
L
Kinase 6778.AA S_TKc 19-282 22 1.1e-54 188.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-282
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

ITLKQEIGSGSFSNVYLTSNSS----YVAKVMNLNYVPSQRSFINERKYYQELGQHSNIVQYLGSQELQGGSLGVLVIENCPK--GSLVDIMSMTPK---
 .. ..||.|.|. ||.  . .    .  |...       .....|..  ..  .| |||..... .    .   .| | |.   |.| |..   ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-NQLSEQQILRVIYEVAQGLSHIHKRKLIHRDIKIENILYSEENRFKICDFGSVTNNLVPKISKCNIQDIKEEMDRNTTPMYRAPEILDPHIFPDYPINE
  ...| .. ...|.....| ..|... ||||.| |||| .|  . ||||||. .                  .    || |.|||.|        . . 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL--------GYGK

-KIDIFALGVLAYILCFKKPPFDSILGAISGSCLWPEFPITSDEFHNFIMRMLSINPADRPSANEIIQ----IITKDLK
 |.|. ..|.. |...  .|||.  . ..   ..       |.|. .||...|  .|..||.| |. |    |      
CKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6778.AA TKL 25-277 17 1e-46 161.52 In-house 1-364 (364) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-364/364
Sequence Identity: 17% (65 aa)

IGSGSFSNVYLTSNSS------------YVAKVMNLNYVPS----------------------QRSFINERKYYQELG----QHSNIVQYLG-SQELQGG
||||.|. ||                   . |... ... .                        |...... .. .     .| ||||..| ... ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

S----------LGVLVIENCPKGSLVDIMSMTPKNQLSEQQILRVIYEVAQGLSHIHKRK--------LIHRDIKIENILYSEENR--------------
              .| | ||.||| ...          .|..| ....|.|... | ..        .||||.| .|||  | ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

FKICDFGSVTNNLVPKISKCNIQDIKE----------EMDRNTTPMYRAPEIL------------DPHIFPDYPINEKIDIFALGVLAYILCFKKPPFDS
 ||||||  ...   . ....  ...|           | .  || . |||.|            |. ... .. .||.|... |.. . ..  ..|.. 
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

I---------------LGAISGSCLWPEF------------PITSDEFHNFIMRMLSINPADRPSANEIIQII
.                .... ..  |              | . ... . ...  . .| .|||..||....
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 6778.AA Pkinase 19-277 22 3.7e-42 150.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-293/293
Sequence Identity: 22% (70 aa)

ITLKQEIGSGSFSNVYLTSNSSY----VAKVMNLNYVPS--QRSFIN--ERKYYQELGQHSNIVQYLGSQELQGGSLGVLVIENCPKG----SLVDIMSM
..... ||||||. ||.  . ..    . |....    |  ... ..  | .. ..| .| |||..... |   ..   .| | |..|    .| |..| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

TPKNQL--SEQQILRVIYEVAQGLSHIHKRKLIHRDIKIENILYSEENRF----KICDFGSVTN-NLVPKISKCNIQDIKEEMDRNTTPMYRAPEILDPH
  .. .  ||... ...|....|| ..|... ||||.| ||||.....      ||||||.    .         .      ...  || |.|||.    
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------Y-NNS-MTTFCGTPWYMAPEV----

IFPDYPINEKIDIFALGVLAYILCFKKPPFDSI------------LGAISGSCLWPEFPITS-------------------DEFHNFIMRMLSINPADRP
|  . ..  |.|....|.. |......|||..                 ..   ....   |                   .|.  || ..|  .|..||
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

SANEIIQI--I
.| .| |   .
TAEQILQHPWF
Kinase 6778.AA Ciliate-E2 19-275 18 6e-42 141.78 In-house 1-361 (365) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-361/365
Sequence Identity: 18% (70 aa)

ITLKQEIGSGSFS-----NVYLT----------------------SNSSYVAKVMNLNYVPSQRSFINERK-----YYQELGQ---------HSNIVQYL
. . . ||.|.|.     .|...                       .. |  |.|. | . .. . |.. .     |   . .         | ||... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFY-KKI-NEKNILEQLNHPNIIKMY

GSQELQGGSLGVLVIENCPKGSLVDIMSMTPKN---------QLSEQQILRVIYEVAQ---------------GLSHIHKRK-LIHRDIKIENILYSEEN
 . . .  .   || | |  |.| |..   .|.         ...|..|........|               .| ..|...  |||||| ||||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

RFKICDFGSVTNNLVP---KISKCNIQDIKEEMDRNT---------------------TPMYRAPEILD-PHIF---PDYPINEKIDIFALGVLAYILCF
  ||.|||  ...  .   ..  .... .. .   .|                     ||.| |||||    .       . ..|.||..|||. |...|
-IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

KKPPFDSILGAISGSCLWPEFPITSDEFH-----------------------NFIMR----MLSINPADRPS-ANEIIQ
.||||              . .|  ....                       ..| .    ||  .|  |.. ...|..
GKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 6778.AA STE 19-276 20 1.6e-32 112.15 In-house 1-359 (359) Show / Hide 
Range on Protein: 19-276
Range on HMM: 1-359/359
Sequence Identity: 20% (76 aa)

ITLKQEIGSGSFSNVYLTSNSS-------------------YVAKVMNLNYV-----------------PSQRSFINERKYYQELGQ-HSNIVQYLGSQE
 .. ..||.|.|  ||.  |                     .  |.|||.                     . ....| |  ... . | |||.|.|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LQG-----GSLGVLVIENCPKGSLVDIMS---MTPKNQ---------LSEQQILRVIYEVAQG-LSHIHKRKLIHRDIKIENILYSEENRFKICDFGSVT
  |     ..   .. | .. ||| ||.    ...|..         ..|.|| ...... .| |...|. . ||||||  |||       |.||||  .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

--NNLVPKISKCNIQDIKE-----EMDRNT-----TPMYRAPEILDPHIFPDY--PINEKIDIFALGVLAYILCFKKPPF---DSI--LGAIS--GSCLW
  .. ...|   .  ..        |. ..     || . |||....   . .  . ..| ||  || ..  ..  |||.        . .|   . . .
QLTDSMANI-Q-S--NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ

------------PEFP--------------------ITSDEFHNFIMRMLSINPADRPSANEIIQ-----I
            | .|                      |.||..|| . | ..| .||.|.. ..     |
QFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 6778.AA TK 19-160 15 1.8e-23 74.92 In-house 1-296 (486) Show / Hide 
Range on Protein: 19-160
Range on HMM: 1-296/486
Sequence Identity: 15% (47 aa)

ITLKQEIGSGSFS---NVYLT-----------------------------SNSSYVAKVMNLNYVPSQRSFIN-----------------ERKYYQE-LG
||| ...|.| |     ||.                               .     |.. .    ||. |.                  |.|  .. ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHSNIVQYLG-SQELQG---------GSLGVLVIENCPKGS----LVDIMSMTP----------------------------------------------
.| |||. .| . . ..         .    .| | .|.|.    | |     .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------KNQLSEQQILRVIYEVAQGLSHIHKR------KLIHRDIKIENILYSEENR-----------FKICDFG
                            |.||. .| |   . .|.|....|..      ...|||.   |.| .|.|.            ||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Kinase 6778.AA TKL-Unique 21-217 23 3.8e-15 50.03 In-house 1-216 (290) Show / Hide 
Range on Protein: 21-217
Range on HMM: 1-216/290
Sequence Identity: 23% (56 aa)

LKQEIGSGSFSNVYLTSN--SSYVAKVMN-LNYVPSQ--RSFINERKYYQELGQHSNIVQYLGSQELQGGSL------G--VLVIENCPKGSLVDIMSM-
    ||.|....|| .    ...  |. . .. . ..  . |.|| .    |  | |||.|       |..       .   .| | || ||| |  .  
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYM------GYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQN

-------TPKNQLSEQQILRVIYEVAQGLSHIHKRK--LIHRDIKIENILYSEE-----NRFKICDFGSVTNNLVPKISKCNIQDIKEEMDRN-------
        ... |. ||... .  .|||. ..| ..   ||||.|  |.| ...     .. ||||||         .|| | ...|.   ..       
NNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFG---------LSKFNSKINKMTNNEHKGTRNQT

--TTPMYRAPEILDPHIFPDYPINEKIDIFALGV
  ... ..|||.|       . ..||.|... |.
RCGSFRWMAPEVLRMNF---CQYSEKSDVYSFGI
Kinase 6778.AA TyrKc 19-277 22 5.1e-14 4.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

ITLKQEIGSGSFSNVYLTSNSSYVA---KVMNLNYVPSQRSFINERKYYQELG-QHSNIVQYLGSQELQGG-----SLGVLVIENCPKGSLVDIMSMTPK
|||....|.| |  ||.   .  .    |... .    .. |..| .   .|| .| |||. .|    ||.         .| | .|.|.| |    . .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NQLSEQQILRVIYEVAQGLSHIHKRKLIHRDIKIENILYSEENRFKICDFGSVTNNLVPKISKCNIQDI------KEEMDRNTTPMYR--------APEI
. |. .. |   . .|.| ...|....||||.   |.|..|... ||.|||          |. .| |       |.  .  ..   .        ||| 
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG---------LSR-DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LDPHIFPDYPINEKIDIFALGVLAY-ILCFKKPPFDS-----------ILGAISGSCLWPEFP-------ITSDEFHNFIMRMLSINPADRPSANEIIQI
.. ..|     ..| |... ||. . |. . ..|              |    .|  . .          . .|| .. . .    .|.|||. .||...
INYGKF-----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase 6778.AA Pkinase_Tyr 44-160 31 7.8e-13 44.09 Pfam 34-156 (270) Show / Hide 
Range on Protein: 44-160
Range on HMM: 34-156/270
Sequence Identity: 31% (39 aa)

KVMNLNYVPSQ---RSFINERKYYQELGQHSNIVQYLGSQELQGGS-LGVLVIENCPKGSLVDIMSMT--PKNQLSEQQILRVIYEVAQGLSHIHKRKLI
|... .. ..|   ..|..| |   .||.| |||...|    ||..    .| | .|.|.| |       .|..|. ...|   ...|.|... . ...|
KMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI

HRDIKIENILYSEENRFKICDFG
|||.   |.| .|.|  ||||||
HRDLAARNCLVTENNVVKICDFG
Kinase 6778.AA Dicty4-Unclassified 91-160 37 1.2e-12 39.61 In-house 80-154 (263) Show / Hide 
Range on Protein: 91-160
Range on HMM: 80-154/263
Sequence Identity: 37% (28 aa)

VIENCPKGSLVDIMSMTP--KNQ-LSEQQ--ILRVIYEVAQGLSHIHKRKLIHRDIKIENILYSEENRFKICDFG
| |  .|| |  .    |  ..| ..     |...  ..|||. | | | .||||||  |||    .  || |||
VMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFG
Kinase 6778.AA Dicty4 95-160 30 2e-09 27.79 In-house 84-159 (277) Show / Hide 
Range on Protein: 95-160
Range on HMM: 84-159/277
Sequence Identity: 30% (23 aa)

CPKGSLVDIMSM-----TPKNQLSEQQILR---VIYEVAQGLSHIHKRK--LIHRDIKIENILYSEENRFKICDFG
.|||.|  .         .. .|.   |.|       .|.|. . | .    ||||.|  |.| .. .| |.||||
MPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFG
Kinase 6778.AA MLK 89-160 26 4.5e-09 27.74 In-house 86-178 (291) Show / Hide 
Range on Protein: 89-160
Range on HMM: 86-178/291
Sequence Identity: 26% (25 aa)

VLVIENCPKGSLVDIMSM-TPKNQ-----------LSEQQILRVIYEVAQGLSHIHKRK---LIHRDIKIENILYSE------ENRFKICDFG
..| | |..||| ..    ..|              . .....  . .|.|..  |. .   .||||.|  ||| .|      .   ||||||
CIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG
Kinase 6778.AA MLK 249-277 20 0.000184 11.54 In-house 263-291 (291) Show / Hide 
Range on Protein: 249-277
Range on HMM: 263-291/291
Sequence Identity: 20% (6 aa)

SDEFHNFIMRMLSINPADRPSANEIIQII
.. . ...... . .|..|||  .|.|. 
PEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 6778.AA Dicty4 19-35 52 0.000751 8.92 In-house 1-17 (277) Show / Hide 
Range on Protein: 19-35
Range on HMM: 1-17/277
Sequence Identity: 52% (9 aa)

ITLKQEIGSGSFSNVYL
|.  |.||.|||. ||.
INIEQRIGKGSFGEVYK
Kinase 6778.AA TK 244-277 12 0.001836 6.62 In-house 450-486 (486) Show / Hide 
Range on Protein: 244-277
Range on HMM: 450-486/486
Sequence Identity: 12% (5 aa)

EFPITS-----DEFHNFIMRMLSINPADRPSANEIIQII
..         .|.. ....  . .|.|||.  .. . .
RM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 6778.AA MLK 19-36 44 0.007647 5.85 In-house 1-18 (291) Show / Hide 
Range on Protein: 19-36
Range on HMM: 1-18/291
Sequence Identity: 44% (8 aa)

ITLKQEIGSGSFSNVYLT
|.... ||||||  |...
IQFHEWIGSGSFGKVWKG
Kinase 6778.AA Pkinase_Tyr 19-35 41 0.018658 8.94 Pfam 1-17 (270) Show / Hide 
Range on Protein: 19-35
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

ITLKQEIGSGSFSNVYL
||. ...|.|.| .||.
ITFGKKLGEGAFGEVYK
Kinase 6778.AA Dicty4-Unclassified 260-277 38 0.028335 3.55 In-house 246-263 (263) Show / Hide 
Range on Protein: 260-277
Range on HMM: 246-263/263
Sequence Identity: 38% (7 aa)

LSINPADRPSANEIIQII
..  |  ||. |.|||  
WHNDPNKRPTMNQIIQYL
Kinase 6778.AA Dicty4-Unclassified 19-34 50 0.072112 2.14 In-house 1-16 (263) Show / Hide 
Range on Protein: 19-34
Range on HMM: 1-16/263
Sequence Identity: 50% (8 aa)

ITLKQEIGSGSFSNVY
|   |.|| | || |.
IQIDQFIGKGHFSKVH
Kinase 6778.AA Dicty4 263-279 42 0.089912 1.89 In-house 259-277 (277) Show / Hide 
Range on Protein: 263-279
Range on HMM: 259-277/277
Sequence Identity: 42% (8 aa)

NPADRPSANEIIQI--ITK
.|  ||| .||||.     
DPQHRPSFEEIIQRRILEH
Kinase 6778.AA TKL-Unique 263-277 46 0.105738 2.0 In-house 276-290 (290) Show / Hide 
Range on Protein: 263-277
Range on HMM: 276-290/290
Sequence Identity: 46% (7 aa)

NPADRPSANEIIQII
.| .||| .|||  .
DPSQRPSFDEIIHRL
Kinase 6778.AA Pkinase_Tyr 263-277 40 0.344791 4.65 Pfam 256-270 (270) Show / Hide 
Range on Protein: 263-277
Range on HMM: 256-270/270
Sequence Identity: 40% (6 aa)

NPADRPSANEIIQII
.|.|||.  ||....
DPEDRPTFSEIHEQL
Kinase 6778.AA TKL-ciliate1 1305-1572 52 3.4e-192 644.8 In-house 1-279 (279) Show / Hide 
Range on Protein: 1305-1572
Range on HMM: 1-279/279
Sequence Identity: 52% (147 aa)

IKMGNKIGSGNSCEVYKGRCKNKDVAIKVIKLDNSDE--LHLKEFQREIQALIKLKNHENLLQLVAISSYDNNFYIITEFCEGGTLFELLHKKKQQIKMI
|.||.|||||..|.||||||...||||......||.|  ...||||||||..||.|.|.||.||..||.||||||||.|.|..||.|...|.|..||.||
ITMGQKIGSGHFCNVYKGRCNSYDVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMI

KWDHRIRWLKDLAKGMLYLHQNN--LIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTRVGSSQAVPFQSGALGTFHWMAPETMR-----NQPVSTQA
||.||.||.||.|.||.|||...  |||||||..|.|.|.||.....|.|..|||||...|..|.|..........||||||||.|.     |.|.....
KWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKI

DVYSFAIVMYELASRETPFKEKGNVAAIIKYVSEEKGRPNL--QKLHFDTPQFIIKLMIKCWDENPKKRPKFDQIIQVL
|.|...||||.|..|.|||..|..|..|..|..|..|||||  |..|||.||....||..||..||.|||.|..|||.|
DIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase 6778.AA TKL 1311-1572 26 7.7e-98 331.34 In-house 1-364 (364) Show / Hide 
Range on Protein: 1311-1572
Range on HMM: 1-364/364
Sequence Identity: 26% (100 aa)

IGSGNSCEVYKGRCKN----------KDVAIKVIKLDN-----------------------SDELHLKEFQREIQALIKLK-NHENLLQLVAISSYDNN-
|||| ..|||||....          ||||.|..| .|                       ..|..  .|..| ....... .|.|..|..... . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FYIITEFCEGGTLFELLHKKKQQIKMIKWDHRIRWLKDLAKGMLYLHQNN--------LIHRDLKSLNLLFDKPYDPNSDNIPT----
            ..|..|.|.||.|...||          |..|.|| .| |.|| |||..|        .||||||| |.| |. . ..| |..     
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNA

---MKIADFGLTRVGSSQAVPFQSG------------------ALGTFHWMAPETMRNQ----------------PVSTQADVYSFAIVMYELASRETPF
    ||.|||| |. |       ..                    ||. ||||| .|.|                . |...|||||.||..|...|..|.
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

KEKGNV--------AAIIKYVSEEKGRPNLQ---------KLHFDTPQFIIKLMIKCWDENPKKRPKFDQIIQVL
.. ..          .....|.... || .              |.|. ..||| .|||..|.||| |..|.. |
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 6778.AA MLK 1305-1572 31 8.8e-76 258.07 In-house 1-291 (291) Show / Hide 
Range on Protein: 1305-1572
Range on HMM: 1-291/291
Sequence Identity: 31% (96 aa)

IKMGNKIGSGNSCEVYKGRCKNKD-----VAIKVIKLDN----SDELHLKEFQREIQALIKLKNHEN----LLQLVAISSYD-NNFYIITEFCEGGTLFE
|.   .|||| ...|.|||..|||     ||.| .. .     . .   ..|..|.  | .|. |.|      |...... . ..|.|..|.|||| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILS-HPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHKKKQQIK----------MIKWDHRIRWLKDLAKGMLYLHQNN---LIHRDLKSLNLLFDK-----PYDPNSDNIPTMKIADFGLTRVGSSQAVPFQS
.|| .. ..            .. || ..| .. |.|| |||..    .||||||| |.| |       ..       |.||.|||. |  ..       
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG-------TLKICDFGTSRDWHQMC-TNMM

GALGTFHWMAPETM---RNQPVSTQADVYSFAIVMYELASRETPFKEKGNVAAIIKYVSEEKGRPNLQKLHFDTPQFIIKLMIKCWDENPKKRPKFDQII
.. ||. |||||     |....|  .||.|...|..|. .||.|.|.  . .||. .| ... || . .     |  . ||| .||...|.|||.|.||.
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIV

QVL
| |
QHL
Kinase 6778.AA TKL-Unique 1307-1572 32 7e-69 235.16 In-house 1-290 (290) Show / Hide 
Range on Protein: 1307-1572
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)

MGNKIGSGNSCEVYKGRCKNKDVAIKVIKLDNSDELHL--KEFQREIQALIKLKNHENLLQLVAISS----YDNNFYIITEFCEGGTLFELLH------K
 .||||.| ...||||  . ..||||.... |.|      .|| .|.  . ||. |.|........     | .|..|..|.|.||.| ..||       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

KKQQIKMIKWDHRIRWLKDLAKGMLYLHQNN--LIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTRVGSSQAVPFQS--------GALGTFHWMAPE
   . . . .  |..  .| |.|| ||| ..   |||||||.|.| |     .  ||   ||.|||| .. |.    . .        . .|.| |||||
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNI---KICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

TMRN--QPVSTQADVYSFAIVMYELASRET------PFKEKGNV--AAIIKYVSEEKGRPNL-QKLHFDTPQFIIKLMIKCWDENPKKRPKFDQIIQVL
 .|.     |...|||||.||..|.|.|.       |...      .....|. ||. || . . .    |. . .|. .||. .| .|| ||.||  |
VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHC----PKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 6778.AA Dicty4 1305-1574 34 2.5e-68 227.05 In-house 1-277 (277) Show / Hide 
Range on Protein: 1305-1574
Range on HMM: 1-277/277
Sequence Identity: 34% (100 aa)

IKMGNKIGSGNSCEVYKGRCKNKDVAIKVIKLDNSD--ELHLKEFQREIQALIKLKNHENLLQLVAISS----YDNNFYIITEFCEGGTLFELLHK-KKQ
|. ...||.|.  |||||... |.||.|. ...| .  |  |.|| .|.  . |.  | |....   .         . | ||..  |.|..|||.    
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIR-HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

QIKMIKWD--HRIR---WLKDLAKGMLYLHQ-N-NLIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTR---VGSSQAVPF-QSGALGTFHWMAPETM
| ..|| |   ..|     .| |.|| .||  | . ||||||| ||| || .        . |..|||| .    ....   . |..| ||  ||||| |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNW--------RVKVCDFGLSQYMKKHEDHK--DNQMTACGTPCWMAPEVM

RNQPVSTQADVYSFAIVMYELASRETPFK-EKGNVAAIIKYVSEEKGRPNLQKLHFDTPQFIIKLMIKCWDENPKKRPKFDQIIQV--LEN
..||    ||||||.|| .|.. |. |.  .  .   ..  | ..| || . .   ..| ....|. .|||..|..|| | .|||   || 
MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPD---WCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 6778.AA S_TKc 1305-1577 25 8.2e-63 215.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 1305-1577
Range on HMM: 1-231/231
Sequence Identity: 25% (73 aa)

IKMGNKIGSGNSCEVYKGRCKN--KDVAIKVIKLDNSDELHLKEFQREIQALIKLKNHENLLQLVAISSYDNNFYIITEFCEG--GTLFELLHKKKQQIK
 ....|||.|   .|||.| |.  . ||||.||         . ..|||| | |  .|.|. .|  .    ...|...|.|.|  |.||....|.. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

M--IKWDHRIRWLKDLAKGMLYLHQNNLIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTRVGSSQAVPFQSGALGTFHWMAPETMRNQPVST-QADV
   .   |  .... ..... |.|... ||||||  |.|.|.          . ||.|||| |.         .   || ..|||| .   . ..  .|.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDW

YSFAIVMYELASRETPFKEKGNVAAIIKYVSEEKGRPNLQKLHFDTPQFIIKLMIKCWDENPKKRPKFDQIIQ----VLENPTL
.|. ...||......||    ......| .               .|...  .. ||.. .|.|||   .. |    .   | .
WSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6778.AA Pkinase_Tyr 1305-1572 28 2.8e-62 211.57 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1305-1572
Range on HMM: 1-270/270
Sequence Identity: 28% (82 aa)

IKMGNKIGSGNSCEVYKGRCK------NKDVAIKVIKLDNSDELH--LKEFQREIQALIKLKNHENLLQLVAISS-YDNN--FYIITEFCEGGTLFELLH
|..| |.|.|.  |||||..|      . .||.|..  ..... .  ...| ||.. . .| .|.|...|... .  .     ||..|....| | . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KK---KQQIKMIKWDHRIRWLKDLAKGMLYLHQNNLIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTRVG---SSQAVPFQSGALGTFHWMAPETMR
|.   ||...|    . . .  . |||| ||...|.|||||   | | ..       |  ..||.||||.|     .   .  ..|.     ||||| ..
KHREDKQPLTMK---DLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------NN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECIN

NQPVSTQADVYSFAIVMYELASRE-TP-FKEKGNVAAIIKYVSEEKGRPNLQKLHFDTPQFIIKLMIKCWDENPKKRPKFDQIIQVL
.   .|. ||.|| ..|.|. ..  .| ...    . ...|. |. .|  . .   ..|. | .|| .||...|..|| | .|.. |
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR--MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 6778.AA Pkinase 1305-1572 24 4.1e-60 210.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1305-1572
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

IKMGNKIGSGNSCEVYKGRCKNKD--VAIKVIKLDNSDELHLKEFQR--EIQALIKLKNHENLLQLVAISSYDNNFYIITEFCEGG----TLFELLH-KK
.. | |||||.. .|||.. |.    ||.|.||... ..  ...  |  ||| . .| ||.| ..|  .  .... |...|.||||     ||.... ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KQQIKMIKWDHRIRWLKDLAKGMLYLHQNNLIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTRVGSSQAVPFQSGALGTFHWMAPETMR-NQPVSTQ
.  .    ... ..... ...|. |.|... ||||||. |.|.|. .....    . ||.|||| .. .    .  ..  || ..||||  | .|. .. 
HGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

ADVYSFAIVMYELASRETPFKEK----GNVAAIIKYVSEEKGRPNLQKLHFDT------------------PQFIIKLMIKCWDENPKKRPKFDQIIQV-
.|..|. ...||......||...    . .  . ...   ....  .    ..                  ..  .... .|.. .||||| ..|| |  
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
Kinase 6778.AA TyrKc 1305-1572 26 3.3e-58 200.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 1305-1572
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

IKMGNKIGSGNSCEVYKGRCKNKDVAIKVIKLDNSDELHLKEFQREIQALIKL-KNHENLLQLVAISSYD-------NNFYIITEFCEGGTLFELLHKKK
|..| |.|.|. .|||||. |  .||.|..| |      ...| ||.. . || ..|.|...|... . .          .|..|....| | . |.|..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

QQIKMIKWDHRIRWLKDLAKGMLYLHQNNLIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTRVGSSQ--------AVPFQS--GAL--GTFHWMAPE
 .   ..... . .  . |.|| |||..|.|||||   | | ....        |.||.||||.| . .             ..  |.       |||||
PK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

TMRNQPVSTQADVYSFAIVMYELASRETPFKEK-----GNVAAIIKYVSEEKGRPNLQKLHFD-----TPQFIIKLMIKCWDENPKKRPKFDQIIQVL
...    .|. ||.|| ..|.|. ..  .  .       . . .|.|| . . .|  .           |. . ..| .||.|.|..|| | .|.. .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 6778.AA TK 1305-1572 16 6.3e-58 192.44 In-house 1-486 (486) Show / Hide 
Range on Protein: 1305-1572
Range on HMM: 1-486/486
Sequence Identity: 16% (78 aa)

IKMGNKIGSGNSC---EVYKGRCKNK---------------------------DVAIKVIKLD--NSDELHLKEFQR----------EIQALIKLKN---
|..|.|.|.|. .   |||||. ...                           .||.|..|..  .|.| .. |. .          | ... ....   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HENLLQLVAISSYDNN------------FYIITEFCEGGT----LFELLHKKKQQIKM-----------------------------------------
 |.|...|..... . .            ..|..|....|     | . |.|..   .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IKWDHRIRWLKDLAKGMLYLHQN------NLIHRDLKSLNLLFDKPYD---PNSDNIPTMKIADFG---
                               .   ... .  ..|.|| |||..      |..||||   | | .. .    ..... |. ||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTRVGSSQAVPFQSGALGTFH-------------------------WMAPETMRNQP---------VSTQADVYSFAIVMYELAS--RETPFKEK
     |.|   |      ..  ||                           |||||... .           .|. ||.|| ..|.|. .  .|..  . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

GN--------VAAIIKYVSEE-----------KGRPNLQKLHFDTP-------------QFIIKLMIKCWDENPKKRPKFDQIIQVL
 |        .. ...|. ..            .|  . .    ..             ...  || .||...|..|| |.|. . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 6778.AA Dicty4-Unclassified 1305-1572 34 2.2e-57 195.05 In-house 1-263 (263) Show / Hide 
Range on Protein: 1305-1572
Range on HMM: 1-263/263
Sequence Identity: 34% (96 aa)

IKMGNKIGSGNSCEVYKGRCKNKDVAIKVIKLDNSDELH---LKEFQREIQALIKLKNHENLLQLVAIS----SYDNNFYIITEFCEGGTLFELLH-KKK
|.    || |   .|.||  | ||||.| .  .|..      ...| .|. ..  .  | ||...   .    |    . |..||   |.|||. | |  
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFN-ENKFKFREEMIQDFKKEV-EILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

QQIKMIKWDH--RIRWLKDLAKGMLYLHQNNLIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTRVGSSQAVPFQSGALG-TFHWMAPETMRNQPVST
 | . || |    |.   | |.|| .||  |.||||.|| |.| || .     ||   ||||||. || .     |   . . |  | .|| ..      
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHF-----NI---KIADFGISRVIDFN---FNMTTIAGTPKWESPECLMHESYNQ

QADVYSFAIVMYELASRETPFKEKGNVAAIIKYVSEEKGRPNLQKLHFDTPQFIIKLMIKCWDENPKKRPKFDQIIQVL
 .||||.|...||||  . |. |   .  .   | . | ||   |.    . |. ||   || . |.||| ..|||| |
KSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRP---KIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 6778.AA STE 1305-1567 17 2.5e-44 153.56 In-house 1-350 (359) Show / Hide 
Range on Protein: 1305-1567
Range on HMM: 1-350/359
Sequence Identity: 17% (63 aa)

IKMGNKIGSGNSCEVYKGRCKNKD-----------------VAIKVIKLDNSD---------------ELHLKEFQREIQALIKLKN-HENLLQLVAISS
 .   |||.|.. .|||.......                 .|||...|.|..               .  ......||. . |... |.|  .      
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YD-------NNFYIITEFCEGGTLFELLH---KKKQQIK-------MIKWDHRIRWLKDLAKG-MLYLHQNNLIHRDLKSLNLLFDKPYDPNSDNIPTMK
..       .. .|. |...||.| ....   ..... .        .. .  .. .... || . |||... ||||.|. | |.              |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------------VK

IADFGLTRVGSSQAVP-------------------FQSGALGTFHWMAPETMRN------QPVSTQADVYSFAIVMYELASRETPFKEKGNV----AAII
..|||.    ..| ..                         ||  ||||| ...      .. .|..|..|. ... |.|  . |. .  .     ....
LCDFGV----CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPF

KYVSEE---------KGRPNLQ-KLH---------------FDTPQFIIKLMIKCWDENPKKRPKFDQ
.|....         .. | |. .|.                   .  .  . || . .|.|||. .|
NYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase 6778.AA Ciliate-E2 1305-1570 18 6.1e-43 145.22 In-house 1-361 (365) Show / Hide 
Range on Protein: 1305-1570
Range on HMM: 1-361/365
Sequence Identity: 18% (72 aa)

IKMGNKIGSGNSCEVYKGRCKNK--------------------DVAIKVIKLDNSDELHLKEFQREIQALIKLK---------------NHENLLQLVAI
.|  .|||.||   |||.. ...                     |.|| . . .  .  .... .||. . ...               || |.....  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

SS--YDNNFYIITEFCEGGTLFELLHKKKQQI-------KMIKWDHRIRWLKDLAK---------------GMLYLHQNN-LIHRDLKSLNLLFDKPYDP
     |||.|...|.|.||.||... ..|..        | ... ....  | ...               .. |||..|  ||||.|  |.||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

NSDNIPTMKIADFGL----------TRVGSSQAVPFQSGA----------------------LGTFHWMAPETMRNQP---------VSTQADVYSFAIV
        ||.||||          ..   .|.  ..                         .|| . ||||  ....          ....|..|. ..
-------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

MYELASRETPFKEKGNVAAIIKYVSEEKGRPNLQKLH-------FDTPQFIIKLMIK----CWDENPKKRPK-FDQIIQ
.||. . ..|| .. .    |.. ..|.. . .| .        .. .|  . |. |    . . .|.||.  ..||..
LYEMLFGKPPF-QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 6778.AA NAK 1340-1458 27 1.8e-11 34.45 In-house 46-171 (299) Show / Hide 
Range on Protein: 1340-1458
Range on HMM: 46-171/299
Sequence Identity: 27% (36 aa)

DELHLKEFQREIQALIKLKNHENLLQLVA--IS-SYDNN----FYIITEFCEGGTLFELLHKKKQ-QIKMIKWDHRIRWLKDLAKGMLYLHQNN----LI
||  |.. .|||... ||..|.|. |..   |. . |.|     ... |.|..|.|..|. |... . . .. |  .. . | ..|  ..|| .    .|
DEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPII

HRDLKSLNLLFD-KPYDPNSDNIPTMKIADFG
|||.|  |.|..        ..  . |. |||
HRDIKIENILLSES------HHDGNYKLCDFG
Kinase 6778.AA NAK 1547-1572 23 0.008699 5.04 In-house 274-299 (299) Show / Hide 
Range on Protein: 1547-1572
Range on HMM: 274-299/299
Sequence Identity: 23% (6 aa)

IIKLMIKCWDENPKKRPKFDQIIQVL
...| ... ...|..||. .|....|
MHDLIRYMLTPDPEQRPNIYQVLNQL