Gene 21155 (Tetrahymena)

21155

Species: Tetrahymena
Alias: 907, 21155, 129.m00126, TTHERM_00778430, PreTt21155
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
21155.AA Protein None 684 None Fasta, JSON
21155.kin_dom Protein Kinase Domain None 202 None Fasta, JSON
21155.kin_dom2 Protein Kinase Domain None 194 None Fasta, JSON
21155.NA RNA None 2052 None Fasta, JSON

Protein domain

Protein domains of 21155.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21155.AA C8 42-256 61 8.9e-121 407.55 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 61% (138 aa)

FQNFEYLSSGAYALVLRANNTKANRTVALKFLISTNKEDKNGIESLKKEYEMLQKFSQSDFLVNVYDCFYLMEEDVEDDENGFEKVVITQEKSFFVMEME
|.||.|||.|||..||.|.|.| ||...|||....||.|...|||..|||||.|.|.|.||.||.|||||.|.|..| .... ||.|.|.|||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCKQNLKQLFDFFRNTQPP-PNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCDLGFASTVTKSKSHYLSKK----GTDAYFAP
||.||||||.|..||.| . ..|.|| |||||..|.|..|.||||||||||||.|| ..|.|||.|||||.||||.|.|.|||..|||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEKG------QSRIQSDIFSLGLVL
|.||.      |.|||||.||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 21155.AA Ciliate-C8 51-256 55 5.1e-118 398.38 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 55% (133 aa)

GAYALVLRANNTKANRTVALKFLISTNKEDKNGIESLKKEYEMLQKFSQSDFLVNVYDCFYLMEEDVEDDENGFEKVVITQEK---SFFVMEMELCKQN-
||...||.|.|.| ||.|||||. ..||..||..|...|||||...|.|..|.|.||||||||||....|..| .|.| ||||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFFRNTQ-PPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCD------LGFASTVTKSKSHYLSKK--GTDAY---
 |||.||..|..| .| ...||.|||||....|.||..|||||||||||.||...|.|..||||||      .|||| ..|.||||.|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEKGQSRIQSDIFS-------LGLVL
        |||||||.||||||||||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 21155.AA C2 51-269 37 9.8e-63 213.11 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 37% (92 aa)

GAYALVLRANNTKANRTVALKFLISTNKEDKNGIESLKKEYEMLQKFSQSDFLVNVYDCFYLMEEDVEDDENGFEKVVITQEK---------SFFVMEME
|| .||| |.| | ||.||||     .  | || ... |||....... . ....||..||| ... ||..   .    .||.         .|.|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCKQNLKQLFDFFRNTQ-PPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCD----------LGFASTVTKSKS-HYLSK-K
 |. |||| |.  |. .  | ...|...||||. . | || ..| |||||| | |.. .|    ||||||          . ||| . ..||  . || |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEKGQSRIQSDIFS-LGLVLLELDNLNVLNDNW
.| .|    |||||...  . .||.|| .|.||||||| .  . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 21155.AA Pkinase 42-259 23 9.5e-28 99.19 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 23% (53 aa)

FQNFEYLSSGAYALVLRANNTKANRTVALKFLISTNKEDKNGIESLK-KEYEMLQKFSQSDFLVNVYDCFYLMEEDVEDDENGFEKVVITQEKSFFVMEM
..  . . ||... | .. . . ...||.| .   .....  .. ..  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCKQNLKQLFDFF------RNTQP--PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCDLGFASTV-TKSKSHYLSKKGTD
|.|   |. ..| |      |..    ...|.| ..  |.|.||. .| ..|.|||.|| | |..   . . ..|.|| |.|  . . ..| . .  || 
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

AYFAPEV--EKGQSRIQSDIFSLGLVLLEL
 | ||||  .       .|..|.|..| |.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 21155.AA STE 42-259 19 1.8e-25 87.01 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 19% (56 aa)

FQNFEYLSSGAYALVLRANNT------KANRT---------VALKFLISTNKE----------DKNG----IESLKKEYEMLQKFSQ-SDFLVNVYDCFY
... | . .||.  | .| |       | ...         .| | .   |..          ..|     .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEDVEDDENGFEKVVITQEKSFFVMEMELCK-QNLKQLFDFFRNTQPPP-----------NEIKEVIAIQMLEG-LNNLHVKNIMHRDIKPHNYLVSP
   ..             .....   . ||..    | .. .    .. |             ..  .|. | |.| |. || ..|.|||||| | |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SQTYGFTIKLCDLGFASTVTKS----------------KSHYLSKKGTDAYFAPEVEKG-QSR------IQSDIFSLGLVLLEL
       .|||| |... .|.|                ...  .  ||  . |||| .. ..       ...|| |||....|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 21155.AA Ciliate-E2 42-259 17 2.6e-24 80.33 In-house 1-289 (365) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-289/365
Sequence Identity: 17% (55 aa)

FQNFEYLSSGAYALVLRANNTKANRTVALK-----------------FLISTNKEDKNGIESLKKEYEMLQ---------------KFSQSDFLVNVYDC
.   . . .|... | .... | .. .|.|                 ...  .   ||.||..|.|  ...               .. ....... |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY-------------LMEEDVED-----DENGFEK----VVITQEKSFFVMEMELC----KQNLKQLFDFFRNTQPPPNEIKEVIAIQMLEGLNNLHVKN
|.             .   | .|     . . ...      .| ..  ..|.  |     |.                    | .. .....|. || ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA--------------------EFYIACIILALEYLHSKN

-IMHRDIKPHNYLVSPSQTYGFTIKLCDLGFASTVTKS---------KSHYLSKK-----------------------GTDAYFAPEVEKGQSR------
 |.|||||| | |.         ||..|.|..  ....            |.  |                       ||  | |||. .|..       
NIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQ

----IQSDIFSLGLVLLEL
     ..||.||| .| |.
KGYDYKCDIWSLGVILYEM
Kinase 21155.AA CMGC 42-214 16 2.6e-24 75.99 In-house 1-251 (513) Show / Hide 
Range on Protein: 42-214
Range on HMM: 1-251/513
Sequence Identity: 16% (42 aa)

FQNFEYLSSGAYALVLRANN--------------TKANRTVALKFLIST-NKED------KNGIE-SLKKEYEMLQKFS---------------QSDF-L
... ... .|.|. | .. .              .. |. ||.| . .  ..|.      |.|.  .   | ..|....               . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVYDCFYLMEEDVEDDE-----NGFEKVVITQEKSFFVMEMELCKQNLKQLFDFFR-------NTQPPPNE------------IKEVI-----AIQMLE
|. ||.||  ..| ...|               .   . . .|.. ..|.|. .  .       .   .. .            ||  .     . |.|.
VKLYDIFYHKNSDGNEYEDKHIIS-------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILR

GLN--NLHVKN--IMHRDIKPHNYLVSPSQTY----------------GFTIKLCDLGFA
||.   .| ..  |.|||.|| | |...  ..                 ...|.|| |.|
GLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 21155.AA TKL 168-259 21 7.7e-20 68.13 In-house 137-282 (364) Show / Hide 
Range on Protein: 168-259
Range on HMM: 137-282/364
Sequence Identity: 21% (31 aa)

IAIQMLEGLNNLHV--------KNIMHRDIKPHNYLVSPSQT----------YGFTIKLCDLGFASTVTKSKS-------------------HYLSKKGT
.|...  |.| ||         ..| |||.|..| ||    |          .  ..|.||.|.. ....|..                   .  .. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EKGQSRIQSDIFSLGLVLLEL
 .. ||||                 ....   ..|..| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 21155.AA CAMK 47-256 14 2.8e-18 54.81 In-house 1-324 (425) Show / Hide 
Range on Protein: 47-256
Range on HMM: 1-324/425
Sequence Identity: 14% (50 aa)

YLSSGAYALVLRANNTKAN------------RTVALKFLISTNKEDKN-------------------------GIESLKKEYEMLQKFS------QSDFL
 | .|... | .. ... .            . || |..  .   ||.                           .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MEEDVEDDENGFEKVVITQEKSFFVMEM---ELCKQN--LKQLFDFFRNTQP----------------PPNEIKEVIAIQ
.. |. .               ...          |.   .....| |   |.|     .  |||. .   .                .  | . ..  |
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-Q

MLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYG-------------FTIKLCDLGFASTVTKSKSHYLS-----------------------KKGTDAYFA
...... .| .||.|||.|| | |.. . .               ..||..| |||  ...... .                           || .| |
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PEVEKG-------------QSRI--QSDIFSLGLVL
 ||| .|             .  .  ..|. |.| .|
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 21155.AA S_TKc 42-322 20 5.1e-17 63.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-322
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

FQNFEYLSSGAYALVLRANNTKANRTVALKFLISTNKEDKNGIESLKKEYEMLQKFSQSDFLVNVYDCFYLMEEDVEDDENGFEKVVITQEKSFFVMEME
..  . . .||.. | .. ..| .| ||.| .           |....| ..|.|  . ...|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCKQNLKQLFDFFRNTQP-------PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCDLGFASTVTKSKSHYLSKKGTDAYF
.| ..|  |||. .. ..       |. ... ... |....|. .| ..|.|||.|| | |..       .||.|| |.|  .        .  ||  | 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYM

APEVEKGQSRIQSDIFSLGLVLLELDNLNVLNDNWIDLDTKAEIHKGKAIASKYQIDRKSNIYKIAEICLKPNYLERKSSGDLLY--------ELI
||||  | ..  .|. |.| .| |.     . .     . .. ..| .           .    . . ||. .  .| .  ..|         . .
APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21155.AA Ciliate-E1 128-250 22 1.8e-16 50.47 In-house 63-202 (202) Show / Hide 
Range on Protein: 128-250
Range on HMM: 63-202/202
Sequence Identity: 22% (33 aa)

VITQEKS-FFVMEMELCKQNLKQLFD---------FFRNTQPPPNEI-KEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCDLGFAST
.| .... ...  .|.|...||. ..          ....|   ..  |. |..|...||. || .||.||||||.| |.. .  | ..    |.| ...
YIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKF

VTKSKSHYLSKKGTDAYFAPEVEKG----------QSRIQSDIF
  ... ..  .||   |..|. ..           .  ..|||.
LKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 21155.AA Ciliate-E2-Unclassified 42-259 19 2.3e-16 53.28 In-house 1-263 (352) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-263/352
Sequence Identity: 19% (55 aa)

FQNFEYLSSGAYALVLRANNTKANRTV-----ALKFLISTNKEDKNG---------IESLKKEYEMLQKFSQSDFLVNVYDCFYLMEEDVE---------
.   . . .|... | .. . | .  .     . |. |   |  .|          ....|| | .  |                     .         
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-K--------------------YNKIMQQILLN

-DDENGFEKVVITQEKSFFVMEMELCKQ-NLKQLFDFFRN---------------TQPPPNEIK----EVIAIQMLEGLNNLHVKN-IMHRDIKPHNYLV
 ....   .. . | |  . . ||.|.. .|.|    . .                . . ...|    . .. | |.||. || || | |||||| | |.
HPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF

SPSQTYGFTIKLCDLGFASTVTKS---------------KSHYLSKKGTDAYF----APEVEKG-QSR----IQSDIFSLGLVLLEL
. ..   . ||..|.|...   ..               . .. .. ||  |     |||| .| .      ...||.||| .| |.
DNNGK-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase 21155.AA Ciliate-E1 48-112 19 3.2e-07 20.07 In-house 1-66 (202) Show / Hide 
Range on Protein: 48-112
Range on HMM: 1-66/202
Sequence Identity: 19% (13 aa)

LSSGAYALVLRANNTKAN-RTVALKFLISTNKEDKNGIESLKKEYE-MLQKFSQSDFLVNVYDCFYL
...| ...|..| . . | . ||.|.     ....| .....|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 21155.AA TKL 48-107 12 0.199869 0.91 In-house 1-91 (364) Show / Hide 
Range on Protein: 48-107
Range on HMM: 1-91/364
Sequence Identity: 12% (11 aa)

LSSGAYALVLRANNTKAN--------RTVALKFLISTNKEDKNGIES----------------------LKKEYEMLQKFSQ-SDFLVNVY
. ||... | ...    .        ..|| | . |.|   .. ..                        ..|.|.... .   . .|  .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM
Kinase 21155.AA C8 390-591 48 2.8e-103 349.43 In-house 1-226 (226) Show / Hide 
Range on Protein: 390-591
Range on HMM: 1-226/226
Sequence Identity: 48% (110 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCS-----------CSLQD-
.||||.|.||..||||..|.|. .|.||.||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.||||           |.... 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCDFGLSVQLGKDCEQIEVQCM--VGNMTYSA
          |.||..|...||.|.|..||.|.||.||||||.||.||||||.|||||||.|.. ||||||||.. |..|....|. . |  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEIIAKEDDQNKIYSKKSDSYSVGLLL
|||..|.|.|.|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 21155.AA Ciliate-C8 399-591 40 1e-98 334.25 In-house 1-238 (238) Show / Hide 
Range on Protein: 399-591
Range on HMM: 1-238/238
Sequence Identity: 40% (97 aa)

GSFGMVLST------KKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEK-----------------YVVFELEKCS--C
|.|||||..      .||.|...|...||||.....||.....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQDYLER-QTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLD-GNQLEIKLCD------FGLSVQLGKDCE---------QIEVQCM
.|..|..| . |....|...|..|| |.||||||.|||||.||||||.|||||.| ..|..|||||      ||.. || |...         ......|
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNMTYSAPEIIAK-EDDQNKIYSKKSDSYSVGLLL
  .||..|.|||...| ...|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 21155.AA C2 399-591 30 1.5e-48 163.94 In-house 1-232 (245) Show / Hide 
Range on Protein: 399-591
Range on HMM: 1-232/245
Sequence Identity: 30% (73 aa)

GSFGMVLSTKKVNLN-NKEIALKIQKIVN-----DQEIQNEIRIMQQLK-TPLVVQLYD-HYVIEKATAP------------EK----------YVVFEL
|.||.||  |  | . |...|||||..        .|.|.|..||.|..  |.....|.  |. ..                |.           ||.|.
GAFGLVL--KAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQ

EKCSCSLQDYLERQTKEG-EFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCD----------FGLSVQLGKDCEQIEVQCM
|.|.. |. |..|..|.  ......|  .| |..||.||.|.|.|.||||||.|||. .| ...  |||||          |  .  | .. ..| .. .
EFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKF

VGNMTY----SAPEIIAKEDDQNKIYSKKSDSYS-VGLLL
..  .|    .|||..       .|| |.|| .| ||. |
KWTQQYYQHIFAPEVYQ------NIYKKNSDLFSTVGYVL
Kinase 21155.AA CAMK 395-591 19 4.7e-38 119.7 In-house 1-324 (425) Show / Hide 
Range on Protein: 395-591
Range on HMM: 1-324/425
Sequence Identity: 19% (63 aa)

ILNFGSFGMVLSTKKVNLNN-----------KEIALKI---QKIV----------------------------NDQEIQNEIRIMQQ-------LKTPLV
.|  |||| |   .  | ..           .. | ||   .|.                             . .....||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDHYVIEKA--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQTK------------EGEFSDEQKLNIALQIIDSVNYIHCFN
..||..|  ..         |        .|.... .   | ||       | ||. ....            .| |. ..   .  ||.. |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVCLDG--------------NQLEIKLCDFGLSVQLGKDCEQI---------------------EVQCMVGNMTYSA-PEIIAKE----
|.|||.|||| |.. ..              |.  ||..|||.. .. .. ..                        . ..|   | | ||.. ..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DDQNKIYSKKSDSYSVGLLL
     |.... |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 21155.AA S_TKc 393-661 24 1e-32 115.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 393-661
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FQILNF---GSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC---SLQDYLERQTKEG
..||.    |.|| |   ....  ... |.|| |    . |..||.|... . | .|.|||...        ... . .| |.    .| ||.... ..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDDQNKIYSK-KS
    |.  .   .. ||.. ..|.|  .|||||.|||| |..      .||.|||||. ||           ..|   | |||..         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVG-LLLSLLDNYLILNEIVGITFPSMAFEQYNEPFQNINIKRNTEIFEFIKLLVVWERVNRASLSTIVE----QNTNQFK
| .|.| .|  .|  |                 |... |..|      |  .||. . ...  .| .   . .     .  .. 
DWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21155.AA Ciliate-E1 396-585 28 1.1e-31 100.46 In-house 1-202 (202) Show / Hide 
Range on Protein: 396-585
Range on HMM: 1-202/202
Sequence Identity: 28% (60 aa)

LNFGSFGMVLSTKKVNLNNKEIALKIQKIV---N----DQEIQNEIRIMQQLKTPL-VVQLYDHYVIEKATAPEKYVVFELEKCSCSLQDYLE-------
.  |||..|.  |. | |....|.||...    |    ..||.... ||. .|.   ..|..| . |...    .  .. .|.|.|||.|||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---RQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEII---AKEDDQ
    |.....|...||..|. |.|| ....| .|||||||||.| |.. . ... .   |||.| .| .  .|  ..    .. |. ...      | ..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNK

NKIYSKKSDSY
|.....||| |
NQKINYKSDIY
Kinase 21155.AA Pkinase 390-591 27 9.2e-30 106.32 Pfam 1-202 (293) Show / Hide 
Range on Protein: 390-591
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQN-------EIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC-----SLQD
    ...  |||| |   .... ..|. |.|| | ... . ..       ||.||. |. | .|.||| .        .... . .| | .     .| |
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERQTKEGEF--SDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL--EIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDD
|...  ..| |  |...  ....||.  ..|.|  .|||||.||||.|.  . ...   .|.|||||. |.     .   .  .|   | |||.|     
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----

QNKIYSKKSDSYSVGLLL
 .. |..|.| .|.|..|
GGQYYGPKVDMWSCGCIL
Kinase 21155.AA CMGC 390-541 17 1.5e-29 93.53 In-house 1-251 (513) Show / Hide 
Range on Protein: 390-541
Range on HMM: 1-251/513
Sequence Identity: 17% (44 aa)

VNNFQILNFGSFGMVLSTKKVNLN-------------NKEIALKIQKIVNDQEIQ---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.| . .  . |             |...|.|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDHYVIEKATAPEK-----------YVVFELEKCSCSLQDYLERQT--KEG----EFSDEQ------------KLNIA------LQIIDSVN--YI
.|.|||... .. . .|.           .. .  | . ..| .|....   . |    ..|. .            . ..        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPENFLVCLDGNQ-----------------LEIKLCDFGLS
|  .  |||||.|||| |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 21155.AA Ciliate-E2 390-591 22 1.3e-27 91.79 In-house 1-286 (365) Show / Hide 
Range on Protein: 390-591
Range on HMM: 1-286/365
Sequence Identity: 22% (67 aa)

VNNFQILNFGSFG-----MVLSTKKVN-----------------LNNKEIALKIQKIVNDQEIQNEIRIMQ----------------QLKTPLVVQLYDH
 .  ... .|.||      | ...|                    ..|..|.||.|  . ..| .||.||.                ||. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YVIEKATAPEKYVVFELEKCSC-SLQDYLERQ-TKE-------GEFSDEQKLNIALQIID---------------SVNYIHCFN-IIHRDIKPENFLVCL
.  ..    .... . .| |.  .|.||.. . .|.       . |.... ..|  ||..                ..|.|  | |||||||||| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLEIKLCDFGLSVQLGKD---CEQIEVQCM---------------------------VGNMTYSAPEIIAKEDDQN----KIYSKKSDSYSVGLLL
      ||..||||| .. .|   . .  .||                            .|.  | ||||. .....|    | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 21155.AA STE 391-591 22 4.8e-25 85.44 In-house 1-258 (359) Show / Hide 
Range on Protein: 391-591
Range on HMM: 1-258/359
Sequence Identity: 22% (60 aa)

NNF-QILNFGSFG-MVLSTKKVNL-------------NNKEIALKIQKIVN--------------------DQEIQNEIRIMQQLK--TPLVVQLYDHYV
  . ...  |.||  ..  .. |              ... .| |. .. |                     |.|..||.||....   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KATAPEKYVVFELEKCSC-SLQDYLER--QTKE---------GEFSDEQKLNIALQIIDS-VNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCD
 |   .    | ... |.  ..  || | ...   ...         . |. .|   |. ||.    .|.|  .|||||||| | |.        .||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSVQLGKDCE------------QIEVQC--MVGNMTYSAPEIIAKEDDQ-NKIYSKKSDSYSVGLLL
||.. || ...              .  ..  .||   . |||.| ...   .| |. |.| .|.|...
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 21155.AA TKL 491-591 24 1.5e-24 85.37 In-house 132-279 (364) Show / Hide 
Range on Protein: 491-591
Range on HMM: 132-279/364
Sequence Identity: 24% (36 aa)

EQKLNIALQIIDSVNYIHCFN--------IIHRDIKPENFLVCLDGN-----------QLEIKLCDFGLSVQLGKDCEQIEVQCM---------------
.|....||.|   .|| |  |        |||||.|..| ||  ...           .  .|.||||||  . .. ..   . .               
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

--VGNMTYSAPEIIAKEDDQNK-----------IYSKKSDSYSVGLLL
  .|.  . |||.. .... ..            ||.|.| || |..|
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 21155.AA Ciliate-E2-Unclassified 407-591 23 1.3e-18 61.2 In-house 45-260 (352) Show / Hide 
Range on Protein: 407-591
Range on HMM: 45-260/352
Sequence Identity: 23% (54 aa)

TKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQ--LKTPLVVQLYDHYVIEKATAPEKYVVFELEKC-SCSLQDYLERQTK--------------EGEFS
.|. ...|........|  ..|.  .  .||||  |  |  . ....|. ..    .... . .|.|   .|..|.. . |                .|.
NKD-EIMNEMKEMNNKKK-YHQR-KY-NKIMQQILLNHPHPFIVKMFYCFQD----KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFT

DEQKL-----NIALQIIDSVNYIHCFN-IIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCE-------------QIEVQCMVGNMTYS----APE
..| .     ... ||..  .|.|  | |||||||||| |.  .|. ..||..|||.| ..... .             | . . ..|.  |     |||
EQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE

IIAK-EDDQNKIYSKKSDSYSVGLLL
.. . . |. |   .|.| .|.| .|
VLQGQNYDHSKA--YKCDIWSLGVIL
Kinase 21155.AA TyrKc 390-656 20 2.5e-11 -39.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 390-656
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQK-IVNDQEIQNEIRIMQQL--KTPLVVQLYDHYVIEK----ATAPEKYVVFELEKCSCSLQDYLERQ
.   ..|  | || |   .       . | |  |     ... .|.||| .|  . | .|.||  .....      ..  ..|.|. .   .|.||| . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

TKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKD------CEQIEV----QCM-VGNMTYSAPEIIAKE
 ..  .. ...|....|| .  .|.|  |.||||.   | ||  ..    .| .|||||  .. |       . . .    ..  .      ||| |   
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

DDQNKIYSKKSDSYSVGLLL-----------SL-----LDNYLILNEIVGITFPSMAFEQYNEP--FQNINIKRNTEIFEFIKLLVVWERVNRASLSTIV
  . .... ||| .| | ..           .      ..|. ... .     .    . |  |  |        .|... .|     .  .| . |.|.
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEIH

EQN
|. 
ECF