Gene 25503 (Tetrahymena)

25503

Species: Tetrahymena
Alias: PreTt25503, 25503, TTHERM_01211820, 275.m00025, 768
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
25503.AA Protein None 1387 None Fasta, JSON
25503.kin_dom Protein Kinase Domain None 218 None Fasta, JSON
25503.kin_dom2 Protein Kinase Domain None 218 None Fasta, JSON
25503.NA RNA None 4164 None Fasta, JSON

Protein domain

Protein domains of 25503.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25503.AA C2 123-361 57 6.1e-141 474.52 In-house 1-245 (245) Show / Hide 
Range on Protein: 123-361
Range on HMM: 1-245/245
Sequence Identity: 57% (143 aa)

GAFAFVLKANNKKINQIVALKVVECDSNNIALMEQVQKEYELLQQLS-SKYIVKVFNSFFLTVEDNSDDDESNDEEEKTAESKIKKEKNERKIFFVIEQE
|||..||||.|||.|..||||..||.||.|..|..|||||....|.. ..||.||.|.|.|||....|.||.||||||..|. |||.|||.|||.|.|||
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQEN-IKKQKNEKKIFVVYEQE

FCQKNLETYIQEYRQKNLELSNQEKEIMVIQMLDSVAYLHRFDIVHRDIKPSNFLLSFDQDGLPIIKIYNYHIQYDQS--DLAFASPLKYNKSKITFSQL
|||.||..|....|..| ....|.|.||.|||.||..||||||||||||||||||..|||.|.|.||...||||| |.  |..||| ||||||.|.||..
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QKKCDFDFASKLKYNKSRIHFSKF

KGTEVY----FAPEIEKRIQKKESDVFS-LGIVFLELDNINTFDICG
|.|..|    ||||....|.||.||.|| .|.|.|||||.....||.
KWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 25503.AA Ciliate-C8 123-348 42 2.3e-98 333.1 In-house 1-238 (238) Show / Hide 
Range on Protein: 123-348
Range on HMM: 1-238/238
Sequence Identity: 42% (106 aa)

GAFAFVLKANNKKINQIVALKVVEC-DSNNIALMEQVQKEYELLQQLS-SKYIVKVFNSFFLTVEDNSDDDESNDEEEKTAESKIKKEKNERKIFFVIEQ
|||..||||.||| |..||||..|| . .... ||...||||...| . ....|.|...|.|. |....||..||....|.|  |||      .|||.|.
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEK-IKK------SFFVMEM

EFCQKN--LETYIQEYRQKNLELSNQEKEIMVIQMLDSVAYLHRFDIVHRDIKPSNFLLSFDQDGLPIIKIYNYHIQYDQSDLAFASPLKYNKSKITFSQ
|.||.|  |..|....|.|....|.|.|||..|||.|||.|||.|.|.||||||.|||..|||.. |.||.... .|    |..||| |..|||......
EKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQ---CDFGFASQLPKNKSHYHSKK

LKGTEVY-----------FAPEIEKRIQKKESDVFS-------LGIVF
 |||. |           ||||.|| .....||.||       .|.|.
FKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 25503.AA C8 114-348 36 6.5e-52 178.44 In-house 1-226 (226) Show / Hide 
Range on Protein: 114-348
Range on HMM: 1-226/226
Sequence Identity: 36% (90 aa)

YADFTYAGNGAFAFVLKANNKKINQIVALKVVECDSN-NIALMEQVQKEYELLQQLSSKYIVKVFNSFFLTVEDNSDDDESNDEEEKTAESKIKKEKNER
  .| |  .||.. ||||.| | |. ..||. .| .. .|  .|...||||..|      ... .. |.  ..|   ..... ||||  . ||    .| 
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQ------VFQQYD-FYVNEYDCFYEMYEVFEEEKCSNEKIV--QTEE

KIFFVIEQEFCQKNLETYIQEYRQKNLELSNQEKEIMVIQMLDSVAYLHRFDIVHRDIKPSNFLLSFDQDGLPIIKIYNYHIQYDQSDLAFASPLKYNKS
| .|| | | |..||. . .| |.|....|...|||. |||.|.| |.| . |.||||||.|||. .||  ...||.          |..||| .. |||
KSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC---------DFGFASQVSKNKS

KITFSQL--KGTEVYFAPEIEKR------IQKKESDVFSLGIVF
.|   .    ||  ||||||||       . ...||.||.|.| 
HIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 25503.AA CMGC 114-274 16 5.6e-22 68.19 In-house 1-214 (513) Show / Hide 
Range on Protein: 114-274
Range on HMM: 1-214/513
Sequence Identity: 16% (38 aa)

YADFTYAGNGAFAFVLKANNKKIN--------------QIVALKVVECDSNNIALME----------QVQKEYELLQQLS-----------------SKY
|    . | |... | |. .|. |              .|||.| .  .  .   .             . | ..|..|.                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKVFNSFFLTVEDNSDDDESNDEEEKTAESKIKKEKNERKIFFVIEQEFCQKNLETYIQEYRQ-----KNLELSNQE------------KEIMV-----
||| ...|    .|..... ..          | .  .......|   |.....|  ||.....     ....||  .            .  ..     
IVKLYDIFYHKNSDGNEYEDKHI---------I-SQ-HFNHLYLV--FEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRY

-IQMLDSVA--YLHRFD--IVHRDIKPSN
  |.| ...  |.|. .  |.|||.||.|
MYQILRGLKLKYCHSHWGNIIHRDLKPEN
Kinase 25503.AA STE 114-289 20 8e-19 63.19 In-house 1-188 (359) Show / Hide 
Range on Protein: 114-289
Range on HMM: 1-188/359
Sequence Identity: 20% (45 aa)

YADFTYAGNGAFAFVLKANNKK---------------INQIVALKVVECDSNN---------------IALMEQVQKEYELLQQLS--SKYIVKVFNSFF
. .    |.|||  | || |.|                ..|.| |... ...|               .  |.|..|| .......  ...||| . ..|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LTVEDNSDDDESNDEEEKTAESKIKKEKNERKIFFVIEQEFCQ-KNLETYIQEYRQKNLELSNQ--------EKEI--MVIQMLDS-VAYLHRFDIVHRD
   ..                     .||. ... .   |..    |.  |...  .. .|...        |..|  .. | |    .|||.  |.|||
KEGHN---------------------HKNDDELWICM--EYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRD

IKPSNFLLSFDQDGLPIIKI
|||.| ||         .|.
IKPANILL---------VKL
Kinase 25503.AA S_TKc 114-413 20 4.4e-15 44.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 114-413
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

YADFTYAGNGAFAFVLKANNKKINQIVALKVVECDSNNIALMEQVQKEYELLQQLSSKYIVKVFNSFFLTVEDNSDDDESNDEEEKTAESKIKKEKNERK
|      | |||. | |. .|| ..|||.|..          |....| ..|..   ..||| . .|                                .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----------------------------DH

IFFVIEQEFCQK---NLETYIQEYRQKNLE--LSNQEKEIMVIQMLDSVAYLHRFDIVHRDIKPSNFLLSFDQDGLPIIKIYNYHIQYDQSDLAFASPLK
...|   |.|     .| .||.... . |   ..  .   .. |... ..|.|.  |.|||.||.| ||.        |||         .|  .|  | 
LYMVM--EYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKI---------CDFGLARQL-

YNKSKITFSQLKGTEVYFAPEIEKRIQKKESDVFSLGIVFLELDN-INTFDICGTTNEDKLKIKDGNIFSNYQINRQSSIYKIAQQCLNYYIDNRKSAIQ
        . . ||  | |||.     |...|. |.|... |.      |.    . .  .|.              ..   . ..||..  ..| .| .
--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-E

LLI--------EFI
.|         ...
ALQDEWDIKCHPWF
Kinase 25503.AA Ciliate-E1 186-342 20 1.9e-13 40.53 In-house 33-202 (202) Show / Hide 
Range on Protein: 186-342
Range on HMM: 33-202/202
Sequence Identity: 20% (36 aa)

DNSDDDESNDEEEKTAESKIKKEKNERKIFFVIE----------QEFCQKNLETYIQ---------EYRQKNLELSNQEKEIMVIQMLDSVAYLHRFDIV
.|....... .|..  .. .|||..  .|. .|.          .|.|...|. |.|         ...|.. ... |.|. ...|..| ...|| . | 
YNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNII

HRDIKPSNFLLSFDQDGLPIIKIYNYHIQYDQSDLAFASPLKYNKSKITFSQLKGTEVYFAPEIEKRIQK----KESDVF
||||||.| | . . . . .        .  .|..   . ... . |   . .. .|.|. ||  . ...    ..||..
HRDIKPQNILINNQ-GNYVYC-------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYKSDIY
Kinase 25503.AA Ciliate-E2 221-351 24 5e-13 41.03 In-house 114-289 (365) Show / Hide 
Range on Protein: 221-351
Range on HMM: 114-289/365
Sequence Identity: 24% (45 aa)

EFCQK-NLETYIQEYRQKNLELSN-----QEKEIMVI--QMLD---------------SVAYLHRFD-IVHRDIKPSNFLLSFDQDGLPIIKIYNYHI--
|.||  .|. ||.. ..| ..  .      ||||  |  | |.                . |||    |.||||||.| |.         |||    .  
EYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSK

QYDQS-------DLAFASPLKYNKSKITFSQLK------------GTEVYFAPEIEKRIQK----------KESDVFSLGIVFLEL
.||..        ..   .   |. ..|.. ..            ||  | |||| .. .           ...|..|||... |.
KYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 25503.AA CAMK 252-289 35 4.7e-12 34.4 In-house 187-237 (425) Show / Hide 
Range on Protein: 252-289
Range on HMM: 187-237/425
Sequence Identity: 35% (18 aa)

QMLDSVAYLHRFDIVHRDIKPSNFLLSFDQDGLP-------------IIKI
|... |.|.|  .|||||.|| | ||. . |. .              |||
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI
Kinase 25503.AA STE20 114-181 25 2.9e-11 37.71 In-house 1-74 (288) Show / Hide 
Range on Protein: 114-181
Range on HMM: 1-74/288
Sequence Identity: 25% (19 aa)

YADFTYAGNGAFAFVLKANNKKINQI----VALKVVECDSNNI--ALMEQVQKEYELLQQLSSKYIVKVFNSFF
| ..   |.|..  | ||..|. ...    || |... .. .     .| .|||.  ..|. ...||| ..|..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYL
Kinase 25503.AA CAMKL 252-278 55 4.2e-10 28.28 In-house 135-161 (297) Show / Hide 
Range on Protein: 252-278
Range on HMM: 135-161/297
Sequence Identity: 55% (15 aa)

QMLDSVAYLHRFDIVHRDIKPSNFLLS
|... |.|.|. .|||||||| | ||.
QIVSAVNYCHSHGIVHRDIKPENILLD
Kinase 25503.AA Pkinase 252-289 35 6.7e-09 32.56 Pfam 116-153 (293) Show / Hide 
Range on Protein: 252-289
Range on HMM: 116-153/293
Sequence Identity: 35% (14 aa)

QMLDSVAYLHRFDIVHRDIKPSNFLLSFDQDGL-PIIKI
|.|  ..|.|.  |.|||.||.|.|.. ... . ...||
QILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKI
Kinase 25503.AA CAMKL 121-177 17 2e-06 16.49 In-house 8-81 (297) Show / Hide 
Range on Protein: 121-177
Range on HMM: 8-81/297
Sequence Identity: 17% (13 aa)

GNGAFAFVLKANNKKI-NQIVALKVVECDSNN-IALMEQ------------VQKEYELLQQLS---SKYIVKVF
| |.|. |  | .... .. || |... .  . .  |..            ...|......|.    . |.| .
GKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLY
Kinase 25503.AA CAMK 121-177 14 4e-06 14.94 In-house 3-104 (425) Show / Hide 
Range on Protein: 121-177
Range on HMM: 3-104/425
Sequence Identity: 14% (15 aa)

GNGAFAFVLKANNKKIN------------QIVALKVVECDSNN--------------------------IALMEQVQKEYELLQQLS-------SKYIVK
| |.|. | .. .|. .            | || |... .                                ...|..|.|....|.        . |.|
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

VF
 .
LY
Kinase 25503.AA Pkinase 121-180 24 5e-06 22.55 Pfam 8-69 (293) Show / Hide 
Range on Protein: 121-180
Range on HMM: 8-69/293
Sequence Identity: 24% (15 aa)

GNGAFAFVLKANNKKINQIVALKVVECDSNNIALMEQVQK--EYELLQQLSSKYIVKVFNSF
| |.|. | |. .|. ..|||.|... ....    ..  .  | .... |....||. . .|
GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWF
Kinase 25503.AA Ciliate-E1 120-182 22 2.4e-05 13.91 In-house 1-66 (202) Show / Hide 
Range on Protein: 120-182
Range on HMM: 1-66/202
Sequence Identity: 22% (15 aa)

AGNGAFAFVLKA-NNKKINQIVALKVVECD--SNNIALMEQVQKEYELLQQLS-SKYIVKVFNSFFL
 ||| |..|.|| ... ... ||.|...|   .| . . .. ...|.... .   .||..... ...
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 25503.AA STE20 258-278 57 0.000162 12.76 In-house 131-151 (288) Show / Hide 
Range on Protein: 258-278
Range on HMM: 131-151/288
Sequence Identity: 57% (12 aa)

AYLHRFDIVHRDIKPSNFLLS
.|||.  |.|||||  | ||.
DYLHSNHIIHRDIKADNILLT
Kinase 25503.AA Ciliate-E2 121-180 20 0.000887 8.83 In-house 8-101 (365) Show / Hide 
Range on Protein: 121-180
Range on HMM: 8-101/365
Sequence Identity: 20% (19 aa)

GNGAFAFVLKANN-----------------------KKINQIVALKVV-----ECDSNNIALMEQVQ------KEYELLQQLSSKYIVKVFNSF
|.|.|. | |...                       |  ..|.|.|..     |  .. | .| ...      .| ..|.||....|.| . .|
GQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECF
Kinase 25503.AA STE 321-351 28 0.044291 3.29 In-house 225-261 (359) Show / Hide 
Range on Protein: 321-351
Range on HMM: 225-261/359
Sequence Identity: 28% (11 aa)

GTEVYFAPEI-EKRIQK------KESDVFSLGIVFLEL
||  . |||. ... |.        .|. |||.. .|.
GTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 25503.AA Pkinase 321-351 30 0.153305 6.53 Pfam 173-205 (293) Show / Hide 
Range on Protein: 321-351
Range on HMM: 173-205/293
Sequence Identity: 30% (10 aa)

GTEVYFAPEI--EKRIQKKESDVFSLGIVFLEL
||  | |||.  . .   ...|..|.|... |.
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 25503.AA STE 392-413 36 0.184839 1.07 In-house 335-359 (359) Show / Hide 
Range on Protein: 392-413
Range on HMM: 335-359/359
Sequence Identity: 36% (9 aa)

QQCLNYYIDNRKSAIQLLI---EFI
..||..  ..| .| |||    .||
NKCLQKDPNKRPTASQLLKSEHPFI
Kinase 25503.AA C2 576-780 39 5.5e-110 371.7 In-house 1-245 (245) Show / Hide 
Range on Protein: 576-780
Range on HMM: 1-245/245
Sequence Identity: 39% (96 aa)

GGKGLVMGAFNKSQGRKVALKIQKLQS-----KHEVVREVGIMRDCQ-MPLVIKFYDFFYMSVNSKDD------------------------FVVFELEK
|..|||..||||.|.|.||||||. ||     .|||..|.||||.|| ||..||.|..||..|| |.|                        |||.|.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CTGNLKQYLERLKEKEILLSESQKMKIAVQIIDVINYLNCIQIVHGDIKLDNILYIDNMQDVPTIKLAD----------FDQSRKLPCGFIGVLDKKQVF
|.||||||..|...... .....||..|.|..|.||||.. .|||.|||..|.||....|..|||||.|          ||...||.. .. . ..|...
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

DYTPAQGIVILFKIENILNNNFKKYGTIGYNSPEFFDKQQYTLEC
.....|.|.......||...|.....|.||...|....||||..|
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 25503.AA Ciliate-C8 576-789 30 4.7e-81 275.6 In-house 1-238 (238) Show / Hide 
Range on Protein: 576-789
Range on HMM: 1-238/238
Sequence Identity: 30% (78 aa)

GGKGLVMG-------AFNKSQGRKVALKIQKLQSKHEVVREVGIMRDCQMPLVIKFYDFFYMS-VNSKDD-----------------FVVFELEKCT--G
|..|.|..       ...... |....|||| |..||......||..||||.|...||.||.. .|.|.|                 |.|.|.|||   .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQYLERLKEKEILLSESQKMKIAVQIIDVINYLNCIQIVHGDIKLDNILYIDNMQDVPTIKLAD------FDQSRKLPCGFIGVLDKKQVFDYTPAQG
|||||..|...|.. .|. .|..||.|.||..|||.| .|.| |||..|.|.....|..|||||.|      |.....||.    ...||..  ......
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

IVILFKIENILNNNFKKYGTIGYNSPEFFDK------QQYTLECEIFSVGVCL
..               .|..||  ||  .|      ..........|||..|
YF---------------CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 25503.AA C8 567-789 28 4.9e-43 147.22 In-house 1-226 (226) Show / Hide 
Range on Protein: 567-789
Range on HMM: 1-226/226
Sequence Identity: 28% (70 aa)

ESELEFISFGGKGLVMGAFNKSQGRKVALKIQKLQSKHEVVREVGIMRDCQMPLVIKFYDFFYMS-VNSKDDFVVFELEKCT------------------
 .. ...|||..|.|. | |  . |...||.|| |.|..   .  ||. ..||.|.. |||...  .  .....|||.|||                   
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

---GNLKQYLERLKEKEILLSESQKMKIAVQIIDVINYLNCIQIVHGDIKLDNILYIDNMQDVPTIKLADFDQSRKLPCGFIGVLDKKQVFDYTPAQGIV
    ||||. . ...|.  .|. .| .||.|.|| .||..| .|.| |||..|.|   . . ...|||.||. . ...      ..|| .          
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT---------

ILFKIENILNNNFKKYGTIGYNSPEFFDK-----QQYTLECEIFSVGVCL
                || .|  ||   |     .||. .  .||||. |
---------------CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 25503.AA CAMK 572-722 19 3.3e-22 67.73 In-house 1-247 (425) Show / Hide 
Range on Protein: 572-722
Range on HMM: 1-247/425
Sequence Identity: 19% (49 aa)

FISFGGKGLVMGAFNK-SQG-----------RKVALKI---QKLQ----------------------------SKHEVVREVGIMRDCQ-------MPLV
 .  |. | |  ...| ..|           .||| ||   .||.                            ....| ||. ||. .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYDFFYM---------------SVNSKDDFVVFEL---EKCTG-NLKQY-LERLKEK--------------EILLSESQKMKIAVQIIDVINYLNCIQ
||.|...                  . .||..... .   | |.|  | .. .....|.              .  ..|..  ..  ||.. ..|.    
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHGDIKLDNILYIDNMQDVP-------------TIKLADFDQSRKLP
||| |.|..|||. ||. | .             .||..||  ..|..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD
Kinase 25503.AA Ciliate-E1 573-718 23 2.2e-17 53.47 In-house 1-161 (202) Show / Hide 
Range on Protein: 573-718
Range on HMM: 1-161/202
Sequence Identity: 23% (38 aa)

ISFGGKGLVMGAFNKSQG-RKVALKIQKLQ---SK---HEVVREVG-IMRDCQMPL-VIKFYDFFYMSVNSKDDFVVFELEKCTGNLKQYLE--------
|. |. ..|  |.....  ..||.||....   ..   ... .|   ||   .    .|...|....  |    . .. .|.|  .||.||.        
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNY---ICIIIFECCCCSLKDYLQNHNRLEYW

-RLKEKEILLSESQKMKIAVQIIDVINYLNCIQIVHGDIKLDNILYIDNMQDVPT-IKLADFDQS
  ...... ... |||.|..|.|| ...|    | |.||| .|||. .. . | . . ...| ..
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKN
Kinase 25503.AA S_TKc 567-856 20 6.5e-15 41.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 567-856
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

ESELEFISFGGKGLVMGAFNKSQGRKVALKIQKLQSKHEVVREVGIMRDCQMPLVIKFYDFFYMSVNSKDDFVVFELEKCTG---NLKQYLERLKE--KE
   |. |  |. | |. . .|. ||.||.|| |      . ||. |..  . | ..|.||.|.       |.. . .| | |   .|..|... .   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

ILLSESQKMKIAVQIIDVINYLNCIQIVHGDIKLDNILYIDNMQDVPTIKLADFDQSRKLPCGFIGVLDKKQVFDYTPAQGIVILFKIENILNNNFKKYG
  ..| .  ... ||.. ..|.   .|.| |.| .|||  .      .||..||  .|.|                                       |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------------------------TTFCG

TIGYNSPEFFDKQQYTL-ECEIFSVGVCLALLDN----FEKLEPVILKKALDHQNGFQIPFEPSINFKDEVINRQVFLLIL-----ISSNNLGSDGAKAI
|  | .|| .   .|.  .| . |.|..|. .      |.  . ...|| .            |  .||  |..   .|       ..   .  |. .. 
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------SPEAKD-FIRK---CLQKDPEKRPTA-EALQDEWDIK

ASEIA
. .  
CHPWF
Kinase 25503.AA CMGC 566-715 15 9.3e-15 44.02 In-house 1-248 (513) Show / Hide 
Range on Protein: 566-715
Range on HMM: 1-248/513
Sequence Identity: 15% (40 aa)

YESELEFISFGGKGLVMGAFN--------------KSQGRKVALKIQKLQSKHEVV---------------REVGIMRDCQ-----------------MP
||  .. |  |  | |  ...              .  ...||.|. |..  .|                 ||. |..  .                  .
YE-IIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

LVIKFYDFFYMSVNSKDD------------FVVFELEKCTGNLKQYLERLKE-----KEILLSESQ------------KMKIA------VQIIDVIN--Y
 ..| ||.|| . . ...             . .  | .  .|.||... .      . . ||| .            . ..        ||.  ..  |
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LNCIQ--IVHGDIKLDNILYIDNMQDV-----------------PTIKLADF
.      |.| |.|  ||| |..  ..                  ..|..||
CHSHWGNIIHRDLKPENIL-INHNCELITRMMWKSEDWNPCQKNGRLKICDF
Kinase 25503.AA Ciliate-E2 587-715 23 2.4e-14 45.61 In-house 44-200 (365) Show / Hide 
Range on Protein: 587-715
Range on HMM: 44-200/365
Sequence Identity: 23% (39 aa)

KSQGRKVALKIQKLQSKHEVVREVGIMR----------------DCQMPLVIKFYDFFYMSVNSKDDFVVFELEKCTG-NLKQYLE--RLKEKEILL---
| .. ..|.||.| . . .. .|  |||                  . | .||.|..|..    .|. . . .| | | .|..|..  ..|.....    
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQE---KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDK

--SESQKMKIAVQIID---------------VINYLNCIQ-IVHGDIKLDNILYIDNMQDVPTIKLADF
  .| .  .|  ||..                ..||     |.| |||..|||.         ||..||
YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDF
Kinase 25503.AA Pkinase 567-721 23 6e-14 50.39 Pfam 1-162 (293) Show / Hide 
Range on Protein: 567-721
Range on HMM: 1-162/293
Sequence Identity: 23% (40 aa)

ESELEFISFGGKGLVMGAFNKSQGRKVALKIQKLQSKHEVVR-------EVGIMRDCQMPLVIKFYDFFYMSVNSKDDFVVFELEKCTG-----NLKQYL
   .. |  |. | |  . .|. |..||.|| |...... ..       |. ||. .. | ....||.|.      .| . . .| | |      |. |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

ERLKEKEILL--SESQKMKIAVQIIDVINYLNCIQIVHGDIKLDNILYIDNMQDVPTIKLADFDQSRKL
..  ...  .  || .  ... ||.  ..|.    |.| |.|..|||. .|..  ...|..||  ....
ST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQF
Kinase 25503.AA STE 570-715 21 3.7e-13 42.93 In-house 1-191 (359) Show / Hide 
Range on Protein: 570-715
Range on HMM: 1-191/359
Sequence Identity: 21% (44 aa)

LEFISFGGK---GLVMGAFNK------SQGRK---------VALKIQKLQS--------------------KHEVVREVGIMRDCQ--MPLVIKFYDFFY
.|.|.. ||   | |  | |.      . |..         .| |. .|..                    . .. .|. ||..|.   | ..|.|. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

MS---VNSKDDFVVFELEKCT-GNLKQYLERLKEKEILLS----------ESQKMKIAVQIIDV-INYLNCIQIVHGDIKLDNILYIDNMQDVPTIKLAD
      ...|.  .. .| .  | | . ... ...   |.          |||  .|..||.    .||   .|.| ||| .|||          .||.|
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD

F
|
F
Kinase 25503.AA CAMKL 584-715 24 2.4e-11 32.3 In-house 18-173 (297) Show / Hide 
Range on Protein: 584-715
Range on HMM: 18-173/297
Sequence Identity: 24% (39 aa)

AFN-KSQGRKVALKIQKLQSKHE------------------VVREVGIMRDCQ---MPLVIKFYDFFYMSVN--SKDDFVVFELEKCTGN---LKQYLER
| . . .|.||| || . . . .                  . ||. ||.  .    | .||.|. .. . .  .  . ..  .| | |    | .|...
ATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVK

LKEKEILLSESQKMKIAVQIIDVINYLNCIQIVHGDIKLDNILYIDNM-QDVPTIKLADF
 ...   ..|..  ..  ||.. .||.    ||| |||..|||  .|. .   .||..||
HGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDF
Kinase 25503.AA TyrKc 573-843 17 2e-06 -119.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 573-843
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)

ISFGGK------GLVMGAFNKSQGRKVALKIQKLQSKHEVVREVGIMRDC--QMPLVIKFYDFFYMS----VNSKDDFVVFELEKCTGNLKQYLERLKEK
|..| |      | |. .  |   ..|| |  |  .. .  ||  ||.    . | ....|     .    . ..  ..|.|. .  |.||.|| . ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPK

EILLSESQKMKIAVQIIDVINYLNCIQIVHGDIKLDNILYIDNMQDVPTIKLADFDQSRKLPCG-FIGVLDKKQVFDYTPA----QGI--VILFKIENIL
   |. ... ....|| .  .||   ...| |.   |.|. .|     |.| .||  ||..  .   |        ||  .    .|   . .       
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIR------

NNNFKKYGTIGYNSPEFFDKQQYTLECEIFSVGVCL------ALLDNFE----KLEPVILKKALDHQNGFQIPFE--------PSINF--------KDEV
             .|| ...  .| .  ..| |||.            .    ....  . . ... .   .| .         .           . . 
-----------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

INRQVFLLILISSNNL
 .|  |  |      .
EDRPTFSEI---HECF
Kinase 25503.AA Ciliate-E2 760-789 33 2e-06 17.84 In-house 248-286 (365) Show / Hide 
Range on Protein: 760-789
Range on HMM: 248-286/365
Sequence Identity: 33% (13 aa)

YGTIGYNSPEFFDKQQ---------YTLECEIFSVGVCL
.|| || .|| . ...         |. .| |.|.||.|
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 25503.AA STE20 576-629 26 3e-06 19.03 In-house 10-74 (288) Show / Hide 
Range on Protein: 576-629
Range on HMM: 10-74/288
Sequence Identity: 26% (17 aa)

GGKGLVMGAFNKSQGRK----VALKIQKLQS-------KHEVVREVGIMRDCQMPLVIKFYDFFY
|. | |  | .|. |..    || |. .| .       ..... |. ||..|. | ..|.|. ..
GSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYL
Kinase 25503.AA CAMK 761-787 23 0.090569 0.67 In-house 281-322 (425) Show / Hide 
Range on Protein: 761-787
Range on HMM: 281-322/425
Sequence Identity: 23% (10 aa)

GTIGYNS-PEFFDKQQ--------------YTLECEIFSVGV
|| .| . || . ...              |. .| . |.||
GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV
Kinase 25503.AA STE20 681-699 57 0.20037 1.33 In-house 131-149 (288) Show / Hide 
Range on Protein: 681-699
Range on HMM: 131-149/288
Sequence Identity: 57% (11 aa)

NYLNCIQIVHGDIKLDNIL
.||   .|.| ||| ||||
DYLHSNHIIHRDIKADNIL