Gene DDB0229871 (Slime mold)
DDB0229871
Group:
TKL
Family:
TKL-Unique
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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DDB0229871.AA | Protein | None | 1024 | None | Fasta, JSON |
DDB0229871.kin_dom | Protein Kinase Domain | None | 249 | None | Fasta, JSON |
DDB0229871.kin_dom2 | Protein Kinase Domain | None | 282 | None | Fasta, JSON |
Protein domains of DDB0229871.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | DDB0229871.AA | TKL-Unique | 362-606 | 40 | 2.8e-138 | 465.71 | In-house | 86-375 (290) | Show / Hide |
Range on Protein: 362-606 Range on HMM: 86-375/290 Sequence Identity: 40% (116 aa) FIKKIGSGACGEVCQYEWKGTPVAVKTIFK-SLLRKDKKEEFEKEVSILKCLR-HPNVVLFMGTCL----LNGNLAIITEYLNRGSLRDVLTT------- |..|||.|..|.|....|.|.|||.|.... .........|||.||...|.|. |||.|..||.| ..|. |..||...|||.|||.. FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN -MNKSELSLSVKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNN-----FNVKVSDFGLSRFISGGIGSSAK--------TFCGTLSWIAPEVFNG .|...|.....||| ||.||||.|||...||||||||||.|.||||| .|.|..|||||.| | . .... |.||.. |.||||... NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM --SGYTTKVDVYSFGIVLWEILTHKQ------PSGNISATSLG----------HPELPSNCPQSFSDLIKECCNRNPDQRPNFSQILLKL . |..|.||||||||||||.|.|. | ... ... .|..|..||....|||..|....|.|||.|..|. .| NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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Kinase | DDB0229871.AA | TKL | 366-606 | 28 | 2.2e-102 | 346.46 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 366-606 Range on HMM: 1-364/364 Sequence Identity: 28% (106 aa) IGSGACGEVCQYEWKG----------TPVAVKTIFK--SLLRKDKKEE---------------------FEKEVSILKCLR--HPNVVLFMGTCLLNGN- ||||. |||.. .|.| ..||||.. . . .. .. .| |..|. |. ..| |||.|.||| |. ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------LAIITEYLNRGSLRDVLTTMNKSELSLSVKVKMLIDVAQGMNYLHTYS------PPIIHRDLKSLNLLVDNNFN-------------- |.|..|| .|||...|. ....... .|.|.||||||. |||||||||| |.|||.|.. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC VKVSDFGLSRFISGGIGSSAKT------------------FCGTLSWIAPEVFNGS----------------GYTTKVDVYSFGIVLWEILTHKQPSG-- .|..|||||||.|. .... |||. | ||||..|. |..|.|||||||||||||| ..| CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY ---------------NISATSLGHPELP------------SNCPQSFSDLIKECCNRNPDQRPNFSQILLKL . . .|..| ..||.|...|...|.. .|..||.|..|| .| PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | DDB0229871.AA | MLK | 360-606 | 32 | 7.5e-84 | 284.88 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 360-606 Range on HMM: 1-291/291 Sequence Identity: 32% (95 aa) LLFIKKIGSGACGEVCQYEWKGTP-----VAVKTIFKSL----LRKDKKEEFEKEVSILKCLRHPN----VVLFMGTCLLNGN-LAIITEYLNRGSLRDV ..| ..||||. |.|. .|... |||| .. . ...||.|. .|. |.||| .. |.|.|| ... ..|..||. ||| .| IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV LTT-MNKSE-----------LSLSVKVKMLIDVAQGMNYLHTYSP-PIIHRDLKSLNLLVDN------NFNVKVSDFGLSRFISGGIGSSAKTFCGTLSW | . .|.. ....... ..|.||.||| | ||||||||| |.|.|. . ..|..|||.||... . ..||. | LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW IAPEVF---NGSGYTTKVDVYSFGIVLWEILTHKQPSG-NIS--------ATSLGHPELPSNCPQSFSDLIKECCNRNPDQRPNFSQILLKL ||||. .. |. |.||.|.|.||||.|| . | .. | .| .||.|| ... |.|.| | .| .||.|.||. .| MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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Kinase | DDB0229871.AA | DRK | 363-608 | 42 | 4.5e-82 | 277.74 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 363-608 Range on HMM: 1-258/258 Sequence Identity: 42% (110 aa) IK---KIGSGACGEVCQYEWKGTPVAVKTIFKSLLR-KDKKEEFEKEVSILKCLRHPNVVLFMGTCLLNGNLAIITEYLNRGSLRDVLTTMNKS-ELSLS || || | .||| | || |||| | . || .|. ... |||||...|||||. |..||. |||| .| . | |.. . IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNIL--HDESIEMDWP VKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNVKVSDFGLS-RFISGGIGSSAKTFCGTLSWIAPEVFNGSGYTTKVDVYSFGIVLWEILTH .| .|.| ||.||| | |||||||| ||||| .. |||.||||| || |.| ||| |.|||| .|| | |||||.|||||..| LMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTR KQPSGNISA----TSLGH----PELPSNCPQSFSDLIKECCNRNPDQRPNFSQILLKLKL . | . | | | | .|| . |...| | .| .|| . ..| | QDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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Kinase | DDB0229871.AA | Dicty4 | 360-559 | 43 | 3.3e-80 | 267.22 | In-house | 1-216 (277) | Show / Hide |
Range on Protein: 360-559 Range on HMM: 1-216/277 Sequence Identity: 43% (94 aa) LLFIKKIGSGACGEVCQYEWKGTPVAVKTI--FKSLLRKDKKEEFEKEVSILKCLRHPNVVLFMGTCL----LNGNLAIITEYLNRGSLRDVLTT----- . . ..||.|..||| |.|. |||| . .. . .|| |||.|.. .||||..||||.|. | . | |||. .|.| .| INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ --MNKSELSLSVK-VKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNVKVSDFGLSRFISGGIGSSA--KTFCGTLSWIAPEVFNGSGYTTKVDV . |....| . .| .|.|.|||.||. | |||||||| ||||| |..|||.|||||. . .. .. .| ||| | |||| . .|. |.|| QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV YSFGIVLWEILTHKQP |||||||||||| . | YSFGIVLWEILTRQEP |
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Kinase | DDB0229871.AA | CZAK | 360-606 | 38 | 9.2e-72 | 244.72 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 360-606 Range on HMM: 1-279/279 Sequence Identity: 38% (108 aa) LLFIKKIGSGACGEVCQYEWKGTPVAVKTIFKSLLRKDKK----EEFEKEVSILKCLRHPNVVLFMGTCLLNG--NLAIITEYLNRGSLRDVLTTMNKSE | | . || | ||| |.|. ||.| |.. | . |.|||||. |.|||.| |.| | . | |..|. |||| || .. LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLT--DHYF LSLS---VKVKMLIDVAQGMNYLHT-YSP-PIIHRDLKSLNLLVDNNFN-------------VKVSDFGLSRFISGGIGSSAKTFCGTLSWIAPEVFNGS . . .. .| ||.|.||||||. . | ||.|||| | | | | . |..|||||| . .. | | | |||.| | YHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQ-PFEMTQTMGCLCWMAPECFKGE GYTTKVDVYSFGIVLWEILTHKQPSGNISATSLGH--------PELPSNCPQSFS---DLIKECCNRNPDQRPNFSQILLKL || ||||||||..||.|.| || |. . | | .| . || | | ||| || |.||| | NYTEKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL |
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Kinase | DDB0229871.AA | Pkinase | 360-606 | 28 | 2.6e-70 | 244.7 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 360-606 Range on HMM: 1-293/293 Sequence Identity: 28% (86 aa) LLFIKKIGSGACGEVCQYEWKGTP--VAVKTIFKSLLRKDKKEEFEK--EVSILKCLRHPNVVLFMGTCLLNGNLAIITEYLNRG----SLRDVLTTMNK . ...|||||. |.|.. .|||. ||||.| |. ...|... . |..|.| |.|||.| . ... .... ...||.. | .| |...|... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH SEL--SLSVKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNV----KVSDFGLSRFISGGIGSSAKTFCGTLSWIAPEVFN-GSGYTTKVDVY . | . ... ...|..|.| |||||||. |.|.||| .. |..||||..... .| ..|||||. ..|||| . |..|..|||.. GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW SFGIVLWEILTHKQPSGNI----------SATSLGHPELPSNCP-----------------------QSFSDLIKECCNRNPDQRPNFSQILLK--L |.|..|.| |. . | . ..|.|....| ... |.|| |....| .||.. ||| . SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | DDB0229871.AA | TyrKc | 360-606 | 31 | 2.2e-64 | 221.14 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 360-606 Range on HMM: 1-280/280 Sequence Identity: 31% (91 aa) LLFIKKIGSGACGEVCQYEWKGTPVAVKTIFKSLLRKDKKEEFEKEVSILKCL--RHPNVVLFMGTCLLN-------GNLAIITEYLNRGSLRDVLTTMN . ..||.|.|| |||.. .|| ..||||.. .. .|.| .| .|.. | .|||.| . | |. . | |..|| |.|.| | ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR KSELSLSVKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNVKVSDFGLSRFISGG--------IGSS----AKTFCGTLSWIAPEVFNGSGYT . |... .... ...|.||.||| ..||||| | ||..|. ||.|||||||.| . .. . . . | |||..| . .| PK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT TKVDVYSFGIVLWEILTH-KQPSGN-----ISATSL-------GHPELPSN--------CPQSFSDLIKECCNRNPDQRPNFSQILLKL || ||.|||...|||.| .|| . .|.. . . .. | | ||. ...|.|....|..||.||.| .. TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | DDB0229871.AA | LRRK | 360-608 | 26 | 2e-63 | 217.03 | In-house | 66-416 (351) | Show / Hide |
Range on Protein: 360-608 Range on HMM: 66-416/351 Sequence Identity: 26% (95 aa) LLFIKKIGSGACG-EVCQYEWKGTPVAVKTIFKSLLRK------------D--------KKE-------------------------------------- | . ..||.|. | .| . .|.| ||.|.... . | . . ... LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA --EFEKEVSILKCLRHPNVVLFMGTCLLNGNLAIITEYLNRGSLRDVLTTMNKSE-------LSLSVKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLL || .||.|. |.|||.| .| |. |....||. |.| ..| ... .| ..| | ...| ||.||| .|||||||||| | | FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL V---D---------NNFNVKVSDFGLSR--FISGGIGSS-AKTFCGTLSWIAPEVFNG---SGYTTKVDVYSFGIVLWEILTHK-QPSGNIS-------A . . .. ..|..|||.|| .. .... ||.. |. | |||. .. . ||.|||.||||..|||.|| . .| .... LWSSPQNHSPNYPNAHVCAKIADFGISRMFQC---FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWM TSLGH-------PELPSN-CPQ-----SFSDLIKECCNRNPDQRPNFSQILLKLKL . . | .|.. ||. ...|||..| . .|..|| ||||. .|. EQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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Kinase | DDB0229871.AA | S_TKc | 360-609 | 26 | 2.2e-62 | 214.51 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 360-609 Range on HMM: 1-231/231 Sequence Identity: 26% (71 aa) LLFIKKIGSGACGEVCQYEWKG--TPVAVKTIFKSLLRKDKKEEFEKEVSILKCLRHPNVVLFMGTCLLNGNLAIITEYLNR--GSLRDVLTTMNK---- ...|||.|| |.|.. .|. ||.| | | ...|..||| .|||.| . ... ..| ...||.. |.|.|.. ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR SELSLSVKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNVKVSDFGLSRFISGGIGSSAKTFCGTLSWIAPEVFNGSGYTT-KVDVYSFGIVL . .. . ... ......|.| ||||||| |.|.|. ..|..||||.|.. .|||||. ..||||. ||.. |.|..|.|..| FPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL WEILTHKQPSGNISATSLGHPELPSNCPQSFSDLIKECCNRNPDQRPNFSQILL------KLKLM .| |. . | . . . .... |.|. |....|..|| ..| . . YEMLCGYPPFP--QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | DDB0229871.AA | Dicty4-Unclassified | 360-606 | 33 | 1.5e-61 | 209.58 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 360-606 Range on HMM: 1-263/263 Sequence Identity: 33% (89 aa) LLFIKKIGSGACGEVCQYEWKGTPVAVKTIFKSLLRKDK---KEEFEKEVSILKCLRHPNVVLFMGTCLLN----GNLAIITEYLNRGSLRDVLT----T . . || |. .| ||| |||| .| . | ..| ||| || . ||| | | |. . |..| . .| | | IQIDQFIGKGHFSKVHKGNWKGKDVAVK-KFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE MNKSELSLSV--KVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNVKVSDFGLSRFISGGIGSSAKTFCGTLSWIAPEVFNGSGYTTKVDVYSF ... ..| .|. .|.|||| .||| .||||.|| |.|.| .||.|. |||.|| |. | || | .||. . |. | ||||. QQQP-IKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVID--FNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY GIVLWEILTHKQPSGNIS-ATSLG--------HPELPSNCPQSFSDLIKECCNRNPDQRPNFSQILLKL ...|.| .| | | .. |..|.||. .. ||| | | || . || .| AMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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Kinase | DDB0229871.AA | Pkinase_Tyr | 360-555 | 36 | 8.7e-60 | 203.1 | Pfam | 1-209 (270) | Show / Hide |
Range on Protein: 360-555 Range on HMM: 1-209/270 Sequence Identity: 36% (78 aa) LLFIKKIGSGACGEVCQYEWK------GTPVAVKTIFKSLLRKDK--KEEFEKEVSILKCL-RHPNVVLFMGTCL-LNGN--LAIITEYLNRGSLRDVLT . |.||.|.|| |||.. .|| ..|||||.. | .. .|.| .|..|.| | .|||.| ..| |. . . |..|| |.|.| | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR TM--NKSELSLSVKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNVKVSDFGLSRFI-SGGIG--SSAKTFCGTLSWIAPEVFNGSGYTTKVD . .| |... ...| ...|.||.||. .||||| | ||..|. ||..||||.| | . . .. .. | |||..| . .||| | KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSD VYSFGIVLWEILT |.|||...|||.| VWSFGVLMWEIFT |
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Kinase | DDB0229871.AA | TKL-ciliate2 | 360-607 | 35 | 5.2e-54 | 178.44 | In-house | 1-273 (273) | Show / Hide |
Range on Protein: 360-607 Range on HMM: 1-273/273 Sequence Identity: 35% (98 aa) LLFIKKIGSGACGEVCQYEWKGTPVAVKTIFKSLLRKD-KKEEFEKEVSILKCLRHPNVVLFMGTCLLNGNLAIITEYLNRGSLRDVLTTMNKSELSLSV | || | | . . |. . |||| || .. . .| | . |||||.|.|.| | | .|| || |||| .| |. LEIQNKITEGGYGIIYKAKWREIVVAVKK-FKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQ-DVRLTWED KVKMLIDVAQGMNYLHTYSPPIIHRDLK--------------------SLNLLVDNNFNVKVSDFGLSRFISGGIGSSAKTFCGTLSWIAPEVFNGSGYT . .. .|.|.|. ||| ||||||||| |||.||| || |..||| | .| || |.|||| || RRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNK--IGTYQWMAPEVIKAFYYT TKVDVYSFGIVLWEILTHKQPSGNISATSLGH--------PELPSNCPQSFSDLIKECCNRNPDQRPNFSQILLKLK | ||.|..|.|||| | |.. . | .| ||| |.||.. | . | . || | .|. .|. EKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE |
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Kinase | DDB0229871.AA | ARK | 360-555 | 38 | 4.2e-50 | 172.78 | In-house | 1-210 (280) | Show / Hide |
Range on Protein: 360-555 Range on HMM: 1-210/280 Sequence Identity: 38% (82 aa) LLFIKKIGSGACGEVCQYEWKGTPVAVKTIFKS-LLRKDKKEEFEKEVSILKCLRHPNVVLFMGTCLLNG----NLAIITEYLNRGSLRDVLTTMNKSEL | ...|||||. . | ..| .||.|. .|| . . ||| || |. .| |.|| | | |. | ...|| |||| .... || . LEYTCKIGSGSSCKVYKGKYRGKEVAIKV-LKSIMTDSMQIEEFKKEFQIMSSIRSPHVVYFYGACIEPEPQKQKLCMVMEYCSRGSLYHIMNN-NKMDF SLSVKVKMLIDVAQGMNYLHTYSPPIIHRDLKSLNLLVDNNFNVKVSDFGLSRFISGGIGSSAKTFCGTLSWIAPEVFN-----------GSGYTTKVDV . | . . | |.||. |.|.||||||||||| |. .||.||||||| . ... . || ||||.. |. |||| || GWDRFFKWMMQMVRGINCLHNWTPQIVHRDLKSLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDV YSFGIVLWEILT ||.||..||. . YSMGIIMWEMVY |
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Kinase | DDB0229871.AA | Dicty4 | 571-608 | 35 | 4.9e-10 | 29.84 | In-house | 238-277 (277) | Show / Hide |
Range on Protein: 571-608 Range on HMM: 238-277/277 Sequence Identity: 35% (14 aa) PELPSNCPQSFSDLIKECCNRNPDQRPNFSQILLK--LKL |..|..|| |...||..| . .| .|| |..|. . | PPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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Kinase | DDB0229871.AA | Pkinase_Tyr | 574-606 | 45 | 8.9e-10 | 33.73 | Pfam | 238-270 (270) | Show / Hide |
Range on Protein: 574-606 Range on HMM: 238-270/270 Sequence Identity: 45% (15 aa) PSNCPQSFSDLIKECCNRNPDQRPNFSQILLKL | |||. ||.|.| . .|..|| ||.|. .| PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | DDB0229871.AA | ARK | 571-605 | 37 | 9e-10 | 31.95 | In-house | 246-280 (280) | Show / Hide |
Range on Protein: 571-605 Range on HMM: 246-280/280 Sequence Identity: 37% (13 aa) PELPSNCPQSFSDLIKECCNRNPDQRPNFSQILLK | .| |||.....||. | . .|| ||. .|. PTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE |
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Kinase | DDB0229871.AA | TKL-Unique | 735-1016 | 30 | 3.5e-117 | 395.62 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 735-1016 Range on HMM: 1-290/290 Sequence Identity: 30% (90 aa) VLASIKSPLAVRFIGVVFNTDEYAIISEHVGNNGSLLTLMQNHSNQLNWSNTIDLAIQITQSIQYLHKHQPPILHRNITSDCFLLSSLNNNSNQNNNNNN ....|... ..............||...|. |..| ...||...|..||.........|.....| ..||... ...|..... ..||.....||||||| FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN NNNNNNNNNNNNNNNNNKKNDGGDDNGENTNTTTTTTTTTTTATNITNELNINEIKIKVHDFGLSRFNTQENEESLKEI--------KGNFLYSPPELLS |||||...|.............|........................|..||.|..||..|||||.||...|.....|. .|.|....||.|. NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR L--NTYSNKSDIYSLSIVLYELFETCLTKTYKKPYHEVTLDFDFQIIHKTSKLNLRPTISNNMPNEISKILQQGWFSDSVLRPSLDTIIKEL ..||.|||.|| .|||.|......||||||||.... .......|.. . |.||.|.|..|.|.....||.|..|.. |||.|.||..| MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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Kinase | DDB0229871.AA | TKL | 709-1016 | 17 | 8.3e-52 | 178.44 | In-house | 12-364 (364) | Show / Hide |
Range on Protein: 709-1016 Range on HMM: 12-364/364 Sequence Identity: 17% (73 aa) GQYKG----------KLVSIKQINGS------------------------------INDFEMKQLGVLASIKSPLAVRFIGVVFNTDE------------ |...| | | .|... ...|| ... .. ... | |.|.|.... . GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG -YAIISEHVGNNGSLLTLMQNHSNQLNWSNTIDLAIQITQSIQYLHKHQ------PPILHRNITSDCFLLSSLNNNSNQNNNNNNNNNNNNNNNNNNNNN ..|. | . .|||| ... |. ....|..| . ..||| .. |||.||...|. |. . ..| . | QLCIVMEYC-PGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMY----------------- NNKKNDGGDDNGENTNTTTTTTTTTTTATNITNELNINEIKIKVHDFGLSRFNTQENEESLKE------------------IKGNFLYSPPELLSLN--- ......|. |||||||..|... . . . |.. . .||.| . ----------------------------------NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNY -------------TYSNKSDIYSLSIVLYELFETCLTKTYKKPYHEVTLDFDF------QIIHKTSKLNLRPTIS------------NNMPNEISKILQQ .|| |.|.|| |||.|.. |. ||.. . ... . .. .|||.| ...| ...|..|. TEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQD GWFSDSVLRPSLDTIIKEL | .| ||| ..|.|.| CWDHDPEKRPSFQEILKRL |
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Kinase | DDB0229871.AA | ARK | 890-1015 | 40 | 4.5e-38 | 132.82 | In-house | 141-280 (280) | Show / Hide |
Range on Protein: 890-1015 Range on HMM: 141-280/280 Sequence Identity: 40% (56 aa) KIKVHDFGLSRFNTQENEESLKEIKGNFLYSPPELLS-----------LNTYSNKSDIYSLSIVLYELFETCLTKTYKKPYHEV-TLD--FDFQIIHKTS ..|| ||||||||| |.|.| ..| | | ||. |. |||.||. |...|. | . .| .||.| . |||||. || TCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDVYSMGIIMWEMVYRCINGCYMRPYSEYKHIKNAFDFQILIQTS KLNLRPTISNNMPNEISKILQQGWFSDSVLRPSLDTIIKE | ||||||..| | .. |. | .|. .||| . |. | KNNLRPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE |
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Kinase | DDB0229871.AA | MLK | 709-1016 | 19 | 2.7e-19 | 63.71 | In-house | 18-291 (291) | Show / Hide |
Range on Protein: 709-1016 Range on HMM: 18-291/291 Sequence Identity: 19% (66 aa) GQYKGKL-----VSIKQINGSI------------NDFEMKQLGVLASIK-SPLAVRFIGVVFNTDE-YAIISEHVGNNGSLLTLM---QNHSN------- |....|. | .|... .| . | ..| .| .| ..| || .. ..|..| . .||| .. ..... GRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYC-EGGSLYNVLHGARSKWMDANHNQK ---QLNWSNTIDLAIQITQSIQYLHKHQP-PILHRNITSDCFLLSSLNNNSNQNNNNNNNNNNNNNNNNNNNNNNNKKNDGGDDNGENTNTTTTTTTTTT . .. | |. . ..|||...| || || . | |.. NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEIC---------------------------------------------------- TATNITNELNINEIKIKVHDFGLSRFNTQENEESLKEIKGNFLYSPPELL---SLNTYSNKSDIYSLSIVLYELFETCLTKTYKKPYHEVTLDFD-FQII . .... . |. |||.||. .| . .|.. . || . ..|| |.|..| .||.|.. | . ||. . | ..|. -------H-DMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML------TREVPYK---QHYDPMAIA HKTSKLNLRPTISNNMPNEISKILQQGWFSDSVLRPSLDTIIKEL . .|||.| .. | ..| ..| | .|. ||| . |...| WWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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Kinase | DDB0229871.AA | TKL-ciliate2 | 889-1017 | 33 | 2.5e-14 | 43.65 | In-house | 156-273 (273) | Show / Hide |
Range on Protein: 889-1017 Range on HMM: 156-273/273 Sequence Identity: 33% (43 aa) IKIKVHDFGLSRFNTQENEESLKEIKGNFLYSPPELLSLNTYSNKSDIYSLSIVLYELFETCLTKTYKKPYHEVTLDFDFQIIHKTSKLNLRPTISNNMP .. |. ||| | |.| | | | . . || .. . | | |..| ||.|.|. || .. | . | . |||||| | | FRCKLTDFGWTRVKPQDNYMTNK-I-GTYQWMAPEVIKAFYYTEKADVFSYSIILWEIA------SREPPYRNKKGDV---VAEKVMCNNLRPTIPKNCP NEISKILQQGWFSDSVLRPSLDTIIKELL ... ..|. | . ||||.. ||||| PQFADLMQRCWDNNQNLRPSFNEIIKELE |
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TyrKc | DDB0229871.AA | TyrKc | 699-1016 | 16 | 4.4e-14 | 5.06 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 699-1016 Range on HMM: 1-280/280 Sequence Identity: 16% (57 aa) IVKDSY-------SILEGQYKGKLVSIKQIN-GSINDFEMKQLGVLASI--KSPLAVRFIGVVFNT-------DEYAIISEHVGNNGSLLTLMQNHSNQL |... . .|..| | .| .. ... || |. . .. .. . | ||..||. . . |. |.. . |.|. ..| ..| ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPKL NWSNTIDLAIQITQSIQYLHKHQPPILHRNITSDCFLLSSLNNNSNQNNNNNNNNNNNNNNNNNNNNNNNKKNDGGDDNGENTNTTTTTTTTTTTATNIT ... .. ..|| . .|||.. .. || . |... . CMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH---------------------------------------------------------- NELNINEIKIKVHDFGLSRFNTQE-----NEESLKE-----IK--GNFLYSPPELLSLNTYSNKSDIYSLSIVLYELFETCLTKTYKKPYHEVTL--DFD .|. ||||||. . . ... . | .|| . .... |||..| ....|.| . ..|| .... . --------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYG-----QQPYPGMIQQMMSN FQIIHKTSKLNLRPTISNN-------MPNEISKILQQGWFSDSVLRPSLDTIIKEL ...|.. . . .| |. .| |. .| .| | | ||. .|.... QEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | DDB0229871.AA | Dicty4-Unclassified | 891-1016 | 32 | 6.1e-14 | 44.1 | In-house | 148-263 (263) | Show / Hide |
Range on Protein: 891-1016 Range on HMM: 148-263/263 Sequence Identity: 32% (41 aa) IKVHDFGLSRFNTQENEESLKEIKGNFLYSPPELLSLNTYSNKSDIYSLSIVLYELFETCLTKTYKKPYHEVT--LDFDFQIIHKTSKLNLRPTISNNMP ||. |||.|| .. . | | || | | |||.|| ..|||| | || |. .. . | ||| |. | . IKIADFGISR--VIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELA------TGDEPYQEIQSIMNAARSVCDK----KLRPKIPDNCD NEISKILQQGWFSDSVLRPSLDTIIKEL | ..| | | ||... ||. | NFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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Kinase | DDB0229871.AA | ARK | 709-814 | 28 | 3.2e-11 | 37.29 | In-house | 18-131 (280) | Show / Hide |
Range on Protein: 709-814 Range on HMM: 18-131/280 Sequence Identity: 28% (33 aa) GQYKGKLVSIKQING-S-----INDFEMKQLGVLASIKSPLAVRFIGVVFNTD----EYAIISEHVGNNGSLLTLMQNHSNQLNWSNTIDLAIQITQSIQ | |.|| | || . | .| | .....|| ||. | | |.. . .. | .||| .| | . . | .. ...|.. .|. GKYRGKEVAIKVLKSIMTDSMQIEEF-KKEFQIMSSIRSPHVVYFYGACIEPEPQKQKLCMVMEY-CSRGSLYHIMNNNKMDFGWDRFFKWMMQMVRGIN YLHKHQPPILHRNITS .||. |.|.|| ..| CLHNWTPQIVHRDLKS |
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Kinase | DDB0229871.AA | LRRK | 767-829 | 26 | 4.8e-10 | 31.7 | In-house | 139-216 (351) | Show / Hide |
Range on Protein: 767-829 Range on HMM: 139-216/351 Sequence Identity: 26% (21 aa) NGSLLTLMQNHS-NQ-------LNWSNTIDLAIQITQSIQYLHKHQPPILHRNITSDCFLLSSLNNN-------SNQN .|.| ....|.. .. ..|. .. .|.|| ..|||.| |||.||. .|. || |...| ... HGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVC |
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Kinase | DDB0229871.AA | Pkinase | 733-947 | 14 | 9e-10 | 35.64 | Pfam | 51-206 (293) | Show / Hide |
Range on Protein: 733-947 Range on HMM: 51-206/293 Sequence Identity: 14% (33 aa) LGVLASIKSPLAVRFIGVVFNTDEYAIISEHVGNNG----SLLTLMQ-NHSNQL--NWSNTIDLAIQITQSIQYLHKHQPPILHRNITSDCFLLS-SLNN . .......| ||..... . |.. .. |.. ..| .| .... .. . . .. . || . ..|.|.. |.|| . .. .|.. .. IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYC-EGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHI NSNQNNNNNNNNNNNNNNNNNNNNNNNKKNDGGDDNGENTNTTTTTTTTTTTATNITNELNINEIKIKVHDFGLSR-FNTQENEESLKEIKGNFLYSPPE .. ..|. ||||.. |. | . .. . | | .|| DA---------------------------------------------------------------CVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPE LLS-LNTYSNKSDIYSLSIVLYELF .. . |. |.|..|. ..|||.. VIRGGQYYGPKVDMWSCGCILYEML |
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Kinase | DDB0229871.AA | TKL-ciliate2 | 742-812 | 35 | 1e-09 | 28.01 | In-house | 56-125 (273) | Show / Hide |
Range on Protein: 742-812 Range on HMM: 56-125/273 Sequence Identity: 35% (25 aa) PLAVRFIGVVFNTDEYAIISEHVGNNGSLLTLMQNHSNQLNWSNTIDLAIQITQSIQYLHKHQPPILHRNI | | |.| . ..|| | ||| |.|| . .| | .|. | . . ||| .|||.|| . PNIVMFLGACTKIPNFCIIMEYC-QRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLHSSNPPIIHRDL |
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Kinase | DDB0229871.AA | LRRK | 887-946 | 33 | 3.5e-09 | 28.6 | In-house | 213-275 (351) | Show / Hide |
Range on Protein: 887-946 Range on HMM: 213-275/351 Sequence Identity: 33% (22 aa) NEIKIKVHDFGLSR-FNTQENEES-LKEIKGNFLYSPPELLSLN---TYSNKSDIYSLSIVLYEL .....|. |||.|| | | .. .| ||... || . | .|. |.|.|| ..|.|| AHVCAKIADFGISRMF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWEL |
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Kinase | DDB0229871.AA | Dicty4 | 890-947 | 33 | 8.2e-09 | 25.7 | In-house | 152-211 (277) | Show / Hide |
Range on Protein: 890-947 Range on HMM: 152-211/277 Sequence Identity: 33% (20 aa) KIKVHDFGLSR-FNTQENEES-LKEIKGNFLYSPPELLSLNTYSNKSDIYSLSIVLYELF ..|| |||||. . . |. .. .| .. || . . | |.| || .|||.|.. RVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEIL |
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Kinase | DDB0229871.AA | DRK | 768-815 | 27 | 1e-05 | 15.43 | In-house | 82-129 (258) | Show / Hide |
Range on Protein: 768-815 Range on HMM: 82-129/258 Sequence Identity: 27% (13 aa) GSLLTLMQNHSNQLNWSNTIDLAIQITQSIQYLHKHQPPILHRNITSD ||| . | .. |. . ... . . ||| | |.|| |. GSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSH |
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Kinase | DDB0229871.AA | CZAK | 742-821 | 31 | 8.9e-05 | 13.45 | In-house | 60-144 (279) | Show / Hide |
Range on Protein: 742-821 Range on HMM: 60-144/279 Sequence Identity: 31% (27 aa) PLAVRFIGVVFNTD--EYAIISEHVGNNGSLLTLMQNHSNQLNW--SNTIDLAIQITQSIQYLHK-HQP-PILHRNITSDCFLLSS | | |.|. . |. | | ||| | |.. . . .|| | . ||| | ||||| .| || . PNCVQFLGACSEDGPNHHCIVMEWMG-GGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDH |
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Kinase | DDB0229871.AA | CZAK | 888-946 | 30 | 0.00011 | 13.11 | In-house | 158-215 (279) | Show / Hide |
Range on Protein: 888-946 Range on HMM: 158-215/279 Sequence Identity: 30% (18 aa) EIKIKVHDFGLSRFNTQENEESLKEIKGNFLYSPPELLSLNTYSNKSDIYSLSIVLYEL .|. |. |||||| | . | . || |. |.|.|| ..|... DIICKINDFGLSREMMEQPFEMTQTM-GCLCWMAPECFKGENYTEKVDVYSFGMILWCI |
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Kinase | DDB0229871.AA | LRRK | 979-1018 | 30 | 0.000156 | 11.94 | In-house | 306-351 (351) | Show / Hide |
Range on Protein: 979-1018 Range on HMM: 306-351/351 Sequence Identity: 30% (14 aa) LRPTISNN-MPN-----EISKILQQGWFSDSVLRPSLDTIIKELLI |||||... .| . .. .|. | | ||. .|.| | LRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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Kinase | DDB0229871.AA | Pkinase_Tyr | 745-812 | 21 | 0.000372 | 14.7 | Pfam | 67-137 (270) | Show / Hide |
Range on Protein: 745-812 Range on HMM: 67-137/270 Sequence Identity: 21% (16 aa) VRFIGVVF-NTDE--YAIISEHVGNNGSLLTLMQNH---SNQLNWSNTIDLAIQITQSIQYLHKHQPPILHRNI ||..||. . . |. |.. . .||. ..| ..|. . .. ..|| . .||. .. . || . VRLYGVCTDQGEPNQIYIVMEYMPHG-DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDL |
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Kinase | DDB0229871.AA | Pkinase_Tyr | 921-947 | 29 | 0.001141 | 13.05 | Pfam | 182-208 (270) | Show / Hide |
Range on Protein: 921-947 Range on HMM: 182-208/270 Sequence Identity: 29% (8 aa) PPELLSLNTYSNKSDIYSLSIVLYELF .|| .. . .. |||..| ....|.| APECINYGKFTTKSDVWSFGVLMWEIF |
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Kinase | DDB0229871.AA | DRK | 890-946 | 37 | 0.001198 | 8.27 | In-house | 138-195 (258) | Show / Hide |
Range on Protein: 890-946 Range on HMM: 138-195/258 Sequence Identity: 37% (22 aa) KIKVHDFGLS-RFNTQENEESLKEIKGNFLYSPPELLSLNTYSNKSDIYSLSIVLYEL ..|| ||||| || . . | || | | | |.|| ||| |. QVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWEC |
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Kinase | DDB0229871.AA | Dicty4 | 768-810 | 25 | 0.005518 | 5.99 | In-house | 87-138 (277) | Show / Hide |
Range on Protein: 768-810 Range on HMM: 87-138/277 Sequence Identity: 25% (13 aa) GSLLTLMQN------HSNQLNWSNTID---LAIQITQSIQYLHKHQPPILHR |.|..| . | .| |. . .|. . . ...|| | |.|| GNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHR |
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Kinase | DDB0229871.AA | Pkinase_Tyr | 986-1016 | 35 | 2.426245 | 1.78 | Pfam | 240-270 (270) | Show / Hide |
Range on Protein: 986-1016 Range on HMM: 240-270/270 Sequence Identity: 35% (11 aa) NMPNEISKILQQGWFSDSVLRPSLDTIIKEL | | || ....| | | ||. |. .| NCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |