Gene DDB0216407 (Slime mold)

DDB0216407

Species: Slime mold
Alias: DdisK118, DDB0216407
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
DDB0216407.AA Protein None 1700 None Fasta, JSON
DDB0216407.kin_dom Protein Kinase Domain None 534 None Fasta, JSON

Protein domain

Protein domains of DDB0216407.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD DDB0216407.AA RWD 67-194 21 9.5e-25 93.33 Pfam 1-119 (119) Show / Hide 
Range on Protein: 67-194
Range on HMM: 1-119/119
Sequence Identity: 21% (29 aa)

QLKDQQDMELEALQAIFNDEFITMDPIIINRNMDTIIEGIKPIRESARFRITIKPYVGDDEKCFVSIYLVVGFPEKYP-VVLPSIQ-VLVNKGLP---QK
  ...|..|||||..|. |.|..           . .. . .  .. .|.|.|     . ........| . .||.||  ..| |. . . ..|.   . 
MCQEEQEDELEALESIYPDDFED-----------LRGTICWTEISPWHFTIKI---DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDY

KAIELEEKLIRESQGKI-GNIMIFDLCEIAKDFL
   .|..||... .  . |  |||...| ....|
QIQQLCKKLQEYWEENCHGMVMIFEWIEWLQENL
RWD DDB0216407.AA RWD 74-197 23 9.1e-09 36.37 SMART 1-128 (128) Show / Hide 
Range on Protein: 74-197
Range on HMM: 1-128/128
Sequence Identity: 23% (34 aa)

MELEALQAIFND--EFITMDP--------IIINRNMDTI---IEGIKPIRESARFRITIKPYVGDDEKCFVSIYLVVGFPEKYPVVLPSIQVLVNK-GLP
||||||..|. |  | |  |.        | |......    | .            .    .   |. ...| |.. .||.|| ..| |...  . .| 
MELEALESIYPDDFECIDEDRHHWVINCCIQIHIHPHEDEMQI-T---------NY-D-NF-YE-GEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLS

QKKA--IELEEKLIRESQGK--IGNIMIFDLCEIAKDFLNEN
  .    || ..|   ..    .|  |||.... ...||.|.
DEQKYYQELQKHLQEIWEENWCRGMCMIFEWVQWVQEFLSEH
Kinase DDB0216407.AA GCN2 494-1027 46 4.6e-277 926.71 In-house 1-511 (511) Show / Hide 
Range on Protein: 494-1027
Range on HMM: 1-511/511
Sequence Identity: 46% (256 aa)

FEEIQLLGRGGFGQVVK-VRNKLDGRYYAIKKIKLD-SNQSLNRR--ILREVITLSRLHHQHVVRYYQAWIESAESLSLTNDNSDDDDDDDDEFESGSES
||||..||.|||||||| |||..|||||||||.... ....|...  |.|||..|.||||||||||||||||.......|..|.|||..........||.
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

EESQSESESESSESEESSESEESSESSESEESEESEYSDDSEFESEENNDFDQSFSEVFLFQNGNKRSLEFDLTDDSYSFLHSDCGFLLEVFDLNNKIGG
...|.|.......|||....|||.|.|.|.|...|...|...|.||..|.|||.|.....|..|. .. .||||||.||..||||.|...|||....|..
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQ-KR-TFDLTDDHYSYCHSDCEFDDDVFDIDWDIES

NNTRSMGSSNQHLQQQQQQNQSQQQKKQPQQNQSQQQKKLKNSNSKSKSKSKSKSKSKSKSNSKKSISSSKLKNIKKSTSIPYLYIQMEYCQ-KILRN-L
||.|.|.|.... .|.||.|||.|.|....|||...|..|.|..|....|.||....|...|..|.....|..|.||.....|||||||||. |.||. .
NNVRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYI

TETGMNLEDDDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGDIKIGDFGLAINNKTTSTLSPTTNINSSTSSAGSLTTSSNSVQSVINTKQQQQ
...|.....|..|..||||.||..|.| ||.|||||||||||.|.||..||||||||.|||..|.                           ||.|||.|
DNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQ---------------------------INRKQQKQ

QQQPQNYWEDEVEGQQQQQQQQQQQQQQQQQQQQQQQQHTARVGTLFYTSPEQEAGTNGDSAYDDKVDMYSL-GIVFFEMWYV-FSTGHERVIVLRNLRE
|||....|....|..|..|..|||.|..|..||..|..||..||| ||..|||.     .|.|..||||||| ||.||||||  |.|..|||..|..|| 
QQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-----KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-

KFEFPSDFE---RNHSR-QATLIRMLIDKDPAKRPSAQQLLQSELM
..|||.||.   .||.. |...||.... ||.||||||||||.|..
SCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase DDB0216407.AA PEK 494-1027 30 4.2e-213 714.24 In-house 1-655 (655) Show / Hide 
Range on Protein: 494-1027
Range on HMM: 1-655/655
Sequence Identity: 30% (212 aa)

FEEIQLLGRGGF-GQVVKVRNKLDGRYYAIKKIKLDSNQ----------------SLNRRILREVITLSRLHHQHVVRYYQAWIESAESLSLTNDNSDDD
|||||.||.||| |||.||.|||||.|||||.|||...|                ......|||| ||.||.|...|||..||||. |  ..........
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

DDDDDEFESGS-------------------------------ESEESQSESESESSESEESSESEESSESSESEESEESE--------------------
.|.......|.                               ..........|||...... ..|||.|.|.||.|..|.                    
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

----YSDDSEFESEENNDFDQSFSEVFLFQNGNKRSLEFDLTDDSYSFLHSDCGFLLEVFDLNNKIGGNNTRSMGSSNQHLQQQQQQNQSQQQKKQPQQ-
    .|......|...|.||.|||... ..|.||..........|||. ..|| .. .....|...|..|......|.|. ...|...||.|.....|. 
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

------NQSQQQKKLKNSNSKSKSKSKSKSKSKSKSNSKKSISSSKLKNIKKSTSIPYLYIQMEYCQ-KILRNLTETG----------------------
      ...|.|...|| |......|.|.|......|....  . | .. .|.... |||||||||. | ||.... .                      
KKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYI

----------------------MNLEDDDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGD-----IKIGDFGLAINNKTTSTLSPTTNINSSTS
                      |... | .|..||||.||..|.|.||.|||||||||||.|..|.     .||||||||.|....|. |... .|    
MNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQ-SQKN-YN----

SAGSLTTSSNSVQSVINTKQQQQQQQPQNYWEDEVEGQQQQQQQQQQQQQQQQQQQQ---------------QQQQHTARVGTLFYTSPEQEAG-TNGDS
                      | |. |.||........|.....||.....|....               ....||..|||..| ||||. | ....|
----------------------Q-QD-QSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKS

AYDDKVDMYSLGIVFFEMWYVFSTGH-ERVIVLRNLR-EKFEFPSDFE----RNHSR-QATLIRMLIDKDPAKRPSAQQLLQSELM
.|. |||||||||.|||||| |.| . |||..|..|| |...||.||.    .|. . ||..|......||..||||||.||.|..
HYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase DDB0216407.AA S_TKc 494-1027 13 1.7e-49 171.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 494-1027
Range on HMM: 1-231/231
Sequence Identity: 13% (77 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRYYAIKKIKLDSNQSLNRRILREVITLSRLHHQHVVRYYQAWIESAESLSLTNDNSDDDDDDDDEFESGSESEESQ
.| ....|.|.||.| |.|.| .||..|||.||                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

SESESESSESEESSESEESSESSESEESEESEYSDDSEFESEENNDFDQSFSEVFLFQNGNKRSLEFDLTDDSYSFLHSDCGFLLEVFDLNNKIGGNNTR
                                                                                                    
----------------------------------------------------------------------------------------------------

SMGSSNQHLQQQQQQNQSQQQKKQPQQNQSQQQKKLKNSNSKSKSKSKSKSKSKSKSNSKKSISSSKLKNIKKSTSIPYLYIQMEYCQK----ILRNLTE
                                                 ..  .  .  ||       | .    .  .||. ||||       .. . .
-------------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

TGMN-----LEDDDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGDIKIGDFGLAINNKTTSTLSPTTNINSSTSSAGSLTTSSNSVQSVINTKQ
 | .     .   .......||.....| | .|||||||||.||..|.   |||.|||||                                        
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------

QQQQQQPQNYWEDEVEGQQQQQQQQQQQQQQQQQQQQQQQQHTARVGTLFYTSPEQEAGTNGDSAYDD-KVDMYSLGIVFFEMWY---VFSTGHERVIVL
                                          |  .||..| .||          |.  |.|..|.|....|| .    |.   .   ..
------------------------------------------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMF

RNLREKFEFPSDFERNHSRQAT-LIRMLIDKDPAKRPSAQQLLQ-------SELM
....             |..|  .|| . .|||.|||.| ..||        . .
KKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0216407.AA STE 494-966 12 3.4e-47 163.11 In-house 1-261 (359) Show / Hide 
Range on Protein: 494-966
Range on HMM: 1-261/359
Sequence Identity: 12% (65 aa)

FEEIQLLGRGGFGQVVKVRNKL---------------DGRYYAIKKIKLDSNQ----------------SLNRRILREVITLSRLH--HQHVVRYYQAWI
.| |. .|.|.||.|.| .|.                 |...|||...|....                .   .||.|. ......  |...|.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ESAESLSLTNDNSDDDDDDDDEFESGSESEESQSESESESSESEESSESEESSESSESEESEESEYSDDSEFESEENNDFDQSFSEVFLFQNGNKRSLEF
   .                                                                                                
KEGHN-----------------------------------------------------------------------------------------------

DLTDDSYSFLHSDCGFLLEVFDLNNKIGGNNTRSMGSSNQHLQQQQQQNQSQQQKKQPQQNQSQQQKKLKNSNSKSKSKSKSKSKSKSKSNSKKSISSSK
                                                                                                    
----------------------------------------------------------------------------------------------------

LKNIKKSTSI-PYLYIQMEYCQ-KILRNLTE----TGMNLE----------DDDIWKLFRQIVEG-MAYVHGQGIIHRDLKPSNIFFDSCGDIKIGDFGL
       ..   .|.| |||.    |. . .    .|..|            . | .  |||..| ..| | ..|||||.||.||..     .|. |||.
-------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGV

AI---------------NNKTTSTLSPTTNINSSTSSAGSLTTSSNSVQSVINTKQQQQQQQPQNYWEDEVEGQQQQQQQQQQQQQQQQQQQQQQQQHTA
.                ..                                                                        . .||. . 
CGQLTDSMANIQSNNIIDC-----------------------------------------------------------------------IETMQQKRNT

RVGTLFYTSPEQEAGTNGD--SAYDDKVDMYSLGIVFFEM
 |||  . .||   . ...  . || |.|..|||..  ||
FVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase DDB0216407.AA PEK 760-925 39 4.2e-39 127.44 In-house 401-583 (758) Show / Hide 
Range on Protein: 760-925
Range on HMM: 401-583/758
Sequence Identity: 39% (77 aa)

KLKNIKKSTSIPYLYIQMEYC-QKILRNLTETG---MNLEDDDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGD--------------------
|. . ... .  |.||||..| .. |. . ..     . .   .  .| ||.||  |.|. |.|||||||||||| . ..                    
KNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDG

----IKIGDFGLAI-NNKTTSTLSPTTNINSSTSSAGSLTTSSNSVQSVINTKQQQQQQQPQNYWEDEVEGQQQQQQQQQQQQQQQQQQQQQQQQ
    ||||||||.     .|.| .||.|   .| |     |   ..  .||  || |||| |         ||||||||||||||||||||||||
GHQIIKIGDFGLVTDHTIVTPTPTPTPN---NTPSTTPINTHITPIDQIININQQPQQQQQQ---------QQQQQQQQQQQQQQQQQQQQQQQQ
Kinase DDB0216407.AA Ciliate-E2 681-1027 17 9.6e-36 120.17 In-house 1-365 (365) Show / Hide 
Range on Protein: 681-1027
Range on HMM: 1-365/365
Sequence Identity: 17% (79 aa)

FDLNNKIGGNNTRSMGSSN-----QH-LQQQQQQNQSQQQKKQPQQNQSQ--QQKKLKNSNSKSKSKSKSKSKSKSKS----------NSKKSISSSKLK
.....|||       |.       .. ..|.|.... .. .|| |..| |  ...|... ....|.. ..... ..            | |.  .. . .
YKFIKKIGQ------GNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHP

NIKKSTSIPY------LYIQMEYCQKI-LRNLTE------------TGMNLEDDDIWKLFRQIVE---------------GMAYVHGQG-IIHRDLKPSN
|| |     .      .|. |||||   |. . .               .. .  | ....||..               .. | | .. |||||.||.|
NIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN

IFFDSCGDIKIGDFGLAI-----------------------NNKTTSTLSPTTNINSSTSSAGSLTTSSNSVQSVINTKQQQQQQQPQNYWEDEVEGQQQ
|.|     ||| ||||.                        ...|.. ..    .                                             
ILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMD----Q---------------------------------------------

QQQQQQQQQQQQQQQQQQQQQHTARVGTLFYTSPEQEAGTN-----GDSAYDDKVDMYSLGIVFFEMWYV---FSTGHERVIVLRNLRE-KFEFPSDFER
                 ||...   .||. | .||   | .     .   || |.|..|||....|| .    |         ...  . |..||. . .
---------------IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQ

NHSRQ----------------ATLIRM----LIDKDPAKRPS-AQQLLQSELM
..  |                  ||.     ...||| ||.. ..|.|. . .
KD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase DDB0216407.AA PEK 926-1027 31 1.7e-30 98.15 In-house 645-758 (758) Show / Hide 
Range on Protein: 926-1027
Range on HMM: 645-758/758
Sequence Identity: 31% (36 aa)

HTARVGTLFYTSPEQEAGT------------NGDSAYDDKVDMYSLGIVFFEMWYV-FSTGHERVIVLRNLREKFEFPSDFERNHSRQATLIRMLIDKDP
||..|||. | ||||  ..                 |. ||| ||||..|||. .  |||  ||. ....|| .  .|..|  ..  .. .|  ... .|
HTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLR-NGQWPKWFTQKYPQEYEFIQQMMSMNP

AKRPSAQQLLQSELM
  ||.| |.. . . 
DERPTADQISMHDFF
Kinase DDB0216407.AA PEK 494-561 44 2.2e-28 90.96 In-house 547-622 (758) Show / Hide 
Range on Protein: 494-561
Range on HMM: 547-622/758
Sequence Identity: 44% (34 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRYYAIKKIKLDS-------NQSLNR-RILREVITLSRLHHQHVVRYYQAWIE
||.|| ||.|||| | .. ||.|. .||||.| ...       | .. | . .||| ||  | |   |||. || |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase DDB0216407.AA HRI 494-561 49 8.9e-27 91.08 In-house 1-69 (613) Show / Hide 
Range on Protein: 494-561
Range on HMM: 1-69/613
Sequence Identity: 49% (34 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRYYAIKKIKLDSNQSLN-RRILREVITLSRLHHQHVVRYYQAWIE
||.   .|.||.|.| |||.|||. .|||||||  . ..    ...||| .|  | |  .||| |||||
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase DDB0216407.AA WEE 494-561 43 1.6e-25 82.6 In-house 1-76 (297) Show / Hide 
Range on Protein: 494-561
Range on HMM: 1-76/297
Sequence Identity: 43% (33 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRYYAIKKI-KLDSNQSLNRRILREVITLSRLH-------HQHVVRYYQAWIE
|.|.| .|.| ||.|.|.|...||. |||||. .  . .|   |.||||  .. |        | |.||||.||.|
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEE
Kinase DDB0216407.AA HRI 924-1027 44 1.1e-24 83.52 In-house 515-613 (613) Show / Hide 
Range on Protein: 924-1027
Range on HMM: 515-613/613
Sequence Identity: 44% (46 aa)

QQHTARVGTLFYTSPEQEAGTNGDSAYDDKVDMYSLGIVFFEMWYVFSTGHERVIVLRNLREKFEFPSDFERNHSRQATLIRMLIDKDPAKRPSAQQLLQ
| || ||||  | ||||  |..    || | ||||.|.. ||..  | |  ||  ||  .|     |    .    ||  | .|  .  ..|||| ||||
QTHTSRVGTCTYASPEQLDGSQ----YDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTG-QIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQ

SELM
||| 
SELF
Kinase DDB0216407.AA WEE 773-846 26 1.2e-22 72.89 In-house 80-181 (297) Show / Hide 
Range on Protein: 773-846
Range on HMM: 80-181/297
Sequence Identity: 26% (27 aa)

LYIQMEYCQK-------ILRNLTETGMNLEDDDIWKLFRQIVEGMAYVHGQ-GIIHRDLKPSNIFFDSCG--------------------DIKIGDFGLA
.||||||| .       ..   .  .  |... ||.....|..| ...| . |..| |.||.|||. . .                     .||||||..
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV

IN
..
TD
Kinase DDB0216407.AA Pkinase 771-844 37 3.4e-22 79.55 Pfam 73-159 (293) Show / Hide 
Range on Protein: 771-844
Range on HMM: 73-159/293
Sequence Identity: 37% (33 aa)

PYLYIQMEYCQKIL---RNL----TETGMNL--EDDDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGDI----KIGDFGLA
...|. ||||.. |          |. . ..  ..... . ..||..|..| | .|||||||||.||..|. |.|    ||.|||||
DHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase DDB0216407.AA STE-Unique 751-877 30 3.5e-22 75.18 In-house 350-492 (616) Show / Hide 
Range on Protein: 751-877
Range on HMM: 350-492/616
Sequence Identity: 30% (45 aa)

NSKKSISSSKLKNIKKSTSIPYLYIQMEYC-QKILRNLTETGMN---------LEDDDIWKLFRQIVEGMAYVHGQG--IIHRDLKPSNIFFDSCG----
||| | |||. |  |     . ..|.||||  . |. ...             .. . . .. .||.||  | | |.  ||||||||.|||... |    
NSKLSTSSSRKKPPKE---QNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRV

-DIKIGDFGLAINNKTT--STLSPTTNINSSTSSAGSLTTSSNSVQ
  .||.|||.|.       . .    | |.  ..  .  | |   |
CKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQ
Kinase DDB0216407.AA STE-Unique 495-561 36 2.5e-21 72.1 In-house 1-72 (616) Show / Hide 
Range on Protein: 495-561
Range on HMM: 1-72/616
Sequence Identity: 36% (26 aa)

EEIQLLGRGGFGQVVKVRNKLDGRYYAIKKIKLDSNQ-----SLNRRILREVITLSRLHHQHVVRYYQAWIE
...| .|||.|| |.. .|| |....|||.|.|.         |   |..|. ....|||| .|.||..|..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase DDB0216407.AA NEK 494-561 36 6.2e-20 67.19 In-house 1-75 (286) Show / Hide 
Range on Protein: 494-561
Range on HMM: 1-75/286
Sequence Identity: 36% (27 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRY-----YAIKKIKLDSNQSLNRRI-L-REVITLSRLHHQHVVRYYQAWIE
.|.|. .|.| ||.| ||| | ||.      |..|||.... .. ...  .  ||. |..|.|...|.|| ..||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE
Kinase DDB0216407.AA NEK 772-844 31 9.5e-20 66.54 In-house 80-170 (286) Show / Hide 
Range on Protein: 772-844
Range on HMM: 80-170/286
Sequence Identity: 31% (29 aa)

YLYIQMEYCQ------KI---LRNLTETGMNLEDDDIWKLFRQIVEGMAYVHGQ-----GIIHRDLKPSNIFFDSCGD----IKIGDFGLA
.|.| ||||       .    . . .. | ..| . ||. | |.. .. |.| .      |.|||.||.||| .. .     .||||||..
CLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase DDB0216407.AA HRI 799-844 56 4.9e-19 63.17 In-house 435-484 (613) Show / Hide 
Range on Protein: 799-844
Range on HMM: 435-484/613
Sequence Identity: 56% (28 aa)

IWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGD----IKIGDFGLA
| |.| |||||| |.|. .|.|||.|| |||     .    .||||||||
IQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLA
Kinase DDB0216407.AA PEK-Unclassified 494-564 29 3.5e-18 59.46 In-house 688-764 (835) Show / Hide 
Range on Protein: 494-564
Range on HMM: 688-764/835
Sequence Identity: 29% (23 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRYYAIKKIKLD------SNQSLNRRILREVITLSRLHHQHVVRYYQAWIESAE
| ..| .|.|||. | .. .|.|   ||.|.|..         |    . ..||  . .. |  ..|||  |||  .
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEI
Kinase DDB0216407.AA PEK-Unclassified 927-1025 34 1.9e-16 53.25 In-house 731-835 (835) Show / Hide 
Range on Protein: 927-1025
Range on HMM: 731-835/835
Sequence Identity: 34% (37 aa)

TARVGTLFYTSPEQE--------AGTNGDSAYDDKVDMYSLGIVFFEMWYVFSTGHERVIVLRNLREKFEFPSDFERNHSRQATLIRMLIDKDPAKRPSA
|. .||  | |.|||        |   .|  |. . |.||.||.||.|   . |  |||  . |.. | | |  |     | | .|.  .  || |||  
TSTCGTYTYSSNEQESQKKVRIKAHFQAD-FYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCK-KGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLL

QQLLQSE
 .. |  
SKIEQTL
Kinase DDB0216407.AA Pkinase 923-1027 24 9.7e-16 56.74 Pfam 166-293 (293) Show / Hide 
Range on Protein: 923-1027
Range on HMM: 166-293/293
Sequence Identity: 24% (32 aa)

QQQHTARVGTLFYTSPEQEAGTNGDSAYDDKVDMYSLGIVFFEMWY---VFSTGH-------ERVIVLRNLREKFEFPSDFERN----------------
..  | ..||..| .||     .|.. |. ||||.|.|....||      |. ||       ..... |... ...|... ...                
NS-MTTFCGTPWYMAPEV---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFH

--HSRQATLIRMLIDKDPAKRPSAQQLLQSELM
  ..    .|. ...|||.|||.|.|.||.. .
NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDB0216407.AA STE-Unique 930-1027 25 1.3e-15 51.42 In-house 509-616 (616) Show / Hide 
Range on Protein: 930-1027
Range on HMM: 509-616/616
Sequence Identity: 25% (27 aa)

VGTLFYTSPEQEAGT-NGDSAYDDKVDMYSLGIVFFEMWYVFSTGHERVIVLR--NLREKFEFPSD-------FERNHSRQATLIRMLIDKDPAKRPSAQ
.|| .|..||   .   . . || |||..|||...|.|   . . |.|   ..   .. .  ..         ..     |. .|. .....| .|||| 
CGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAH

QLLQSELM
|||.... 
QLLHHFWL
Kinase DDB0216407.AA Pkinase 494-562 29 4.1e-15 54.52 Pfam 1-72 (293) Show / Hide 
Range on Protein: 494-562
Range on HMM: 1-72/293
Sequence Identity: 29% (21 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRYYAIKKIKLDSNQSLNRRILR---EVITLSRLHHQHVVRYYQAWIES
.. .. .|.|.||.| | ..| .|. .|.|.||.... |  ....|   |.  . ||.| ..||.| .. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDK
Kinase DDB0216407.AA PEK-Unclassified 804-844 48 3e-13 41.74 In-house 620-662 (835) Show / Hide 
Range on Protein: 804-844
Range on HMM: 620-662/835
Sequence Identity: 48% (21 aa)

RQIVEGMAYVHGQG-IIHRDLKPSNIFF-DSCGDIKIGDFGLA
|||. .. ..| |. ..|||.|| |||  ..   ||||||||.
RQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLV
Kinase DDB0216407.AA Ciliate-E2 494-556 18 5.9e-12 37.3 In-house 1-98 (365) Show / Hide 
Range on Protein: 494-556
Range on HMM: 1-98/365
Sequence Identity: 18% (18 aa)

FEEIQLLGRGGFGQVVKVRNKLDGR-----------------------YYAIKKIKLDSNQSLNR--RILREVI----------TLSRLHHQHVVRYY
.. |...|.|.||.| |........                       .||.| .| .  .....  .|.||.            |..| | .....|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY
Kinase DDB0216407.AA TyrKc 494-1026 9 9.2e-10 -64.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 494-1026
Range on HMM: 1-280/280
Sequence Identity: 9% (56 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRYYAIKKIKLDSNQSLNRRILREVITLSRL--HHQHVVRYYQAWIES----------------AESLSLTNDNSDD
 . .. ||.| ||.|.| . |   .  |.|..| |.     . ..||   ...|  ||...|| | . ...                ..  .| .   . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

DDDDDDEFESGSESEESQSESESESSESEESSESEESSESSESEESEESEYSDDSEFESEENNDFDQSFSEVFLFQNGNKRSLEFDLTDDSYSFLHSDCG
 ..                                                                                                 
RPK-------------------------------------------------------------------------------------------------

FLLEVFDLNNKIGGNNTRSMGSSNQHLQQQQQQNQSQQQKKQPQQNQSQQQKKLKNSNSKSKSKSKSKSKSKSKSNSKKSISSSKLKNIKKSTSIPYLYI
                                                                                                    
----------------------------------------------------------------------------------------------------

QMEYCQKILRNLTETGMNLEDDDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGDIKIGDFGLAINNKTT-------STLSP----TTN------
                  |  .|  .   || .||.| | ...|||||   |.  .. . .||.||||. . .         .. ..     ..      
------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

------INSS------------------TSSAGSLTTSS----NSVQSVINTKQQQ-QQQQPQN----YWEDEVEGQQQQQQQQQQQQQQQQQQQQQQQQ
      || .                   .  ..          | | ||.  .|     ||.|                                    
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------

HTARVGTLFYTSPEQEAGTNGDSAYDDKVDMYSLGIVFFEMWYVFSTGHERVIVLRNLREKFEFPSDFERNHSRQATLIRMLIDKDPAKRPSAQQLLQSE
                                                                   | . ..   .....  . ||..||. ...  ..
-------------------------------------------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HEC

L
.
F
Kinase DDB0216407.AA WEE 1003-1027 44 3.2e-09 27.15 In-house 273-297 (297) Show / Hide 
Range on Protein: 1003-1027
Range on HMM: 273-297/297
Sequence Identity: 44% (11 aa)

LIRMLIDKDPAKRPSAQQLLQSELM
||.. ...|| .||..|||||....
LIKWMMHPDPEQRPTCQQLLQHPVL
Kinase DDB0216407.AA NEK 1003-1027 40 2.2e-07 22.52 In-house 262-286 (286) Show / Hide 
Range on Protein: 1003-1027
Range on HMM: 262-286/286
Sequence Identity: 40% (10 aa)

LIRMLIDKDPAKRPSAQQLLQSELM
||.... ||| .|||..|.|.  ..
LISQMLQKDPEQRPSCNQILEMPFI
Kinase DDB0216407.AA Pkinase_Tyr 494-556 25 5.1e-07 24.4 Pfam 1-70 (270) Show / Hide 
Range on Protein: 494-556
Range on HMM: 1-70/270
Sequence Identity: 25% (19 aa)

FEEIQLLGRGGFGQVVKVRNKLDGRYY----------AIKKIKLDSNQSL--NRRILREVITLSRL-HHQHVVRYY
 . .. ||.| ||.|.|      |...          |.|..| .. ..    .  .||. ... | ||...||.|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase DDB0216407.AA STE 1009-1027 47 9e-05 12.92 In-house 339-359 (359) Show / Hide 
Range on Protein: 1009-1027
Range on HMM: 339-359/359
Sequence Identity: 47% (10 aa)

DKDPAKRPSAQQLLQ--SELM
.||| |||.|.|||.   .  
QKDPNKRPTASQLLKSEHPFI
Kinase DDB0216407.AA NEK 917-966 34 0.032281 4.08 In-house 172-217 (286) Show / Hide 
Range on Protein: 917-966
Range on HMM: 172-217/286
Sequence Identity: 34% (17 aa)

QQQQQQQQQHTARVGTLFYTSPEQEAGTNGDSAYDDKVDMYSLGIVFFEM
.... .. ..|  |||  | |||.  .      |. |.|. ||| | .||
VLNHTTDMAYTTQVGTPYYMSPEVCQNK----PYNNKSDIWSLGCVLYEM
Kinase DDB0216407.AA Pkinase_Tyr 571-823 5 6.63519 0.3 Pfam 100-137 (270) Show / Hide 
Range on Protein: 571-823
Range on HMM: 100-137/270
Sequence Identity: 5% (13 aa)

DNSDDDDDDDDEFESGSESEESQSESESESSESEESSESEESSESSESEESEESEYSDDSEFESEENNDFDQSFSEVFLFQNGNKRSLEFDLTDDSYSFL
...                                                                                                 
KHR-------------------------------------------------------------------------------------------------

HSDCGFLLEVFDLNNKIGGNNTRSMGSSNQHLQQQQQQNQSQQQKKQPQQNQSQQQKKLKNSNSKSKSKSKSKSKSKSKSNSKKSISSSKLKNIKKSTSI
                                                                                                    
----------------------------------------------------------------------------------------------------

PYLYIQMEYCQKILRNLTETGMNLEDDDIWKLFRQIVEGMAYVHGQGIIHRDL
                  | . .|   |. .  .|| .||.| . ...|||||
------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase DDB0216407.AA Pkinase_Tyr 836-844 77 6.726003 0.28 Pfam 150-158 (270) Show / Hide 
Range on Protein: 836-844
Range on HMM: 150-158/270
Sequence Identity: 77% (7 aa)

IKIGDFGLA
.||.|||||
VKICDFGLA
Kinase DDB0216407.AA Pkinase_Tyr 1009-1026 27 6.771875 0.27 Pfam 254-270 (270) Show / Hide 
Range on Protein: 1009-1026
Range on HMM: 254-270/270
Sequence Identity: 27% (5 aa)

DKDPAKRPSAQQLLQSEL
..||..||. ... ...|
HYDPEDRPTFSEI-HEQL
HGTP_anticodon DDB0216407.AA HGTP_anticodon 1600-1687 17 8e-06 24.95 Pfam 1-92 (95) Show / Hide 
Range on Protein: 1600-1687
Range on HMM: 1-92/95
Sequence Identity: 17% (16 aa)

DIFVISLGP---NLFLERIGIVGDLCNAGFNAETMYIENPTPEEQQDASITSGALYIITIKEKGA-KKTIKVKNIEKRREDDVSRDEIVKFF
...|| ...   ... ... .. .| .||. .|  . .| ..  .     . |. |.|.. .. . ..|..|.. ....  ..|.||.|...
QVVVIPVNEKAEKHMDYAQKLYQELRDAGIRVEVDDRRNERIGKKFRDWDLIGIPYMIVVGDRELENGTVTVRDRDTGEQYTMSIDEFVEWI