Gene Aurora (Slime mold)

Aurora

Species: Slime mold
Alias: DDB0216254, Aurora, DdAurB, aurB, DdisK073
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
Aurora.AA Protein None 384 None Fasta, JSON
Aurora.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of Aurora.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Aurora.AA Aur 110-360 57 3.9e-231 617.64 In-house 1-257 (257) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-257/257
Sequence Identity: 57% (147 aa)

FDIGKLLGMGRFGHVYLAREKKSQFIVALKVLFKNQLQTHNIEHQLRREIEIQSHLRHPNILRLFGYFYDDKRVFLIIEFAKGGECFKELQKV--GSFNE
|.|||.||.|.||.|||||.||..||.||||.||.|......||||||||.|||||.|||||...|||.||.|..||.|.| |||..|||||.  ..|.|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

QTAATYTLQIADALRYCHSKHVIHRDIKPENLLIG-VGGEIKIADFGWSVHAP-NTKRSTFCGTLEYLPPEVIEKKGYDQTADVWSLGILIFEFLVGRSP
|.||.|. ||..||.|||||..|||||||||.|.. . |.|||.|||||||.| | .|.||||||.|.|||..| ...|.. |.|.||.|..|...|..|
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FTS-DEEKNIFHNIQ-ENDVYYPSSISPEAKDLISRLLVSDPHQRITLKDVINHPWI
|.| .. . ....|. ..|...||.||.|||||||..|..||.||.||... |||||
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase Aurora.AA AGC 110-360 25 1.3e-118 307.84 In-house 1-395 (395) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-395/395
Sequence Identity: 25% (103 aa)

FDIGKLLGMGRFGHVYLAREK------KSQFIVALKVLFKNQ--------LQTHNIEHQ-------LRREIEIQSHLR----------HPNILR-LFGYF
|.. |..| | || |||.|.|       .. . |.||| |           . |..  .       ...| .| ....          ||.| . |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

YDDKR--VFLIIEFAK---------GG-ECFKELQ---KVGSFNEQTAATYTLQ-------IADALRYCHS-KHVIHRD-IKPENLLIGVGGEIKIADFG
 |...  .... |...         || | |  ||   | |.|.|..|  |. .       |. || | || ...|||| .||||.|.   | ||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WSVHAPN----------------------------------------------------TKRSTFCG--TLEYLPPEVIEKKGYDQTADVWS--LGILIF
 .   .|                                                     . .||||  | ||..||..    |....| ||  ||.|..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFLVGRSPFTSDE----------EKNIFHNIQ------ENDVYYP----------SSISPEAKDLISRLLVSDPHQRIT----------LKDVINHPWI
|.|.|..||..|.          .. .|..|.      ...| .|          ...||||||||..||. || .|..           ... |||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Aurora.AA S_TKc 110-360 35 4.8e-105 356.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

FDIGKLLGMGRFGHVYLAREKKSQFIVALKVLFKNQLQTHNIEHQLRREIEIQSHLRHPNILRLFGYFYDDKRVFLIIEFAKG--GECFKELQKVGS---
..|....| | || ||..|.||.. |||.|..            ..||||.| .. .|||| .|...|.| ...... |.. |  |. |. ..| |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGGEIKIADFGWSVHAPNTKRSTFCGTLEYLPPEVIEKKGYDQ-TADVWSLGILIFEFL
   |.| .|. |. ||..|| ||||...||||.||||.|.    .|||.||| . .      .|||||..|..|||.   ||.   .|.||.|....|.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

VGRSPFTSDEEKNIFHNIQENDVYYPSSISPEAKDLISRLLVSDPHQRITLKDVIN-------HPWI
.|. ||   ... .|..|           ||||||.|...|. || .|.|  .. .       |||.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Aurora.AA CAMK 115-360 23 2.6e-101 327.26 In-house 1-425 (425) Show / Hide 
Range on Protein: 115-360
Range on HMM: 1-425/425
Sequence Identity: 23% (98 aa)

LLGMGRFGHVYLAREKKSQ------------FIVALKVLFKNQLQ-------------------------THNIEHQLRREIEIQSH-------LRHPNI
 || |.|| |.|...|...              || |.. |..|.                         . . ....|||||| ..       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLFGYFYD-------------------DKRVFLII---EFAKGG----ECFKELQKVGS---------------FNEQTAATYTLQIADALRYCHSKHV
..|. .. |                   ||.....    |.. ||    ..|  ... |.               |.|. |..|  ||..|..||||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENLLI-GVG----------------GEIKIADFGWSVHAP-------------------------NTKRSTFCGTLEYLP-PEVIEK------
.|||.||||.|.   .                . |||.||| . . .                         . | .|||||.|| . |||...      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGYDQTADVWSLGILIFEFLVGRSPFTSD-------------EEKNIFHNIQENDVYYPSS----------------ISPE--------AKD
        ..|.. .|.||.|.. .  |.|..|| .|             .....|..|.. . ..|..                || |        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISRLLVSDPHQRITLKDVINHPWI
||...|. || .|.|.... ||||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Aurora.AA CAMKL 110-360 32 7.1e-92 293.47 In-house 1-297 (297) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-297/297
Sequence Identity: 32% (96 aa)

FDIGKLLGMGRFGHVYLARE-KKSQFIVALKVLFKNQLQ-THNIEHQ-----------LRREIEIQSHLR---HPNILRLFGYFYDDKR------VFLII
..||| || | || | ||.  .  .  || |.. |. ..   ...             .||||.|...|.   |||| .|.  .....       ..|. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFAKGGE--CFKELQKV----GSFNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGG--EIKIADFGWS-----V-HAPNTKRSTFCGTLEYL
| . |||   |  ..|     |.. |  |  |  || .|. ||||....||||||||.|.   |   |||.||| |     .   |. | .||||...| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEVIEK--KGYD-QTADVWSLGILIFEFLVGRSPFTSD--------EEKNIFHNIQENDVYYP--SSISPEAKDLISRLLVSDPHQRITLKDVINHPWI
.||....  | || . .|.||.|.. .  ..|. ||  |           . .. | .   |.|  ...| ...|||...|. .| .|.|.... |||| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase Aurora.AA Pkinase 110-360 32 5.4e-91 313.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-293/293
Sequence Identity: 32% (95 aa)

FDIGKLLGMGRFGHVYLAREKKSQFIVALKVLFKNQLQTHNIEHQLRR--EIEIQSHLRHPNILRLFGYFYDDKRVFLIIEFAKGG----ECFKELQ--K
. ||. .| | || ||....|... |||.|.. |   . .. . ..||  ||.|  .|.||||.||...|.|.... .. |.. ||    . |  ..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VGSF--NEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGGEI----KIADFGWSV---HAPNTKRSTFCGTLEYLPPEVIE-KKGYDQTADVWS
 |.|   |...  | .||. .| ||||. .||||.||||.||   |.|    ||.||| .    . .|.  .|||||..|..||||   ..|.. .|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILIFEFLVGRSPFTSD------EEKNIFHNIQENDVYYPSSIS---------------------PEAKDLISRLLVSDPHQRITLKDVINHPWI
.|....|.| || || ..      ... .. .| . .. .... .                     .|.||.|...|  ||..|.| ... .|||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Aurora.AA MARK 110-360 37 5.6e-91 297.61 In-house 1-262 (262) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-262/262
Sequence Identity: 37% (99 aa)

FDIGKLLGMGRFGHVYLAREKKSQFIVALKVLFKNQLQT-HNIEHQLRREIEIQSHLRHPNILRLFGYFY--DDKR-VFLIIEFAKGGECFKELQKV--G
. ..| .| | .. |.||. |...  ||.|.. |..|.  ....  ..||||| ..| |||| .|| ..   . .. ..|| | | ||| .  ....  |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMK-NVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

SFNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGG--EIKIADFGWSVHA-PNTKRSTFCGTLEYLPPEVIEKKGYD-QTADVWSLGILIFEF
   |  | ..  ||  |. |||||...||||||||.||   |   |||.|||.|..  |..| .|||||..| .||...|| || . .|.||||.. .  
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LVGRSPFTSDE--EKNIFHNIQENDVYYPSSISPEAKDLISRLLVSDPHQRITLKDVINHPWI
..|. ||  |   .|... .|.  .  .|. .|.|...||.|||. .|..|.|.... .|||.
VCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase Aurora.AA Ciliate-E2 110-360 26 1.8e-86 293.6 In-house 1-365 (365) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-365/365
Sequence Identity: 26% (99 aa)

FDIGKLLGMGRFGHVYLAREKKSQ-----------------------FIVALKVLFKNQLQTHNIEHQLRREIE----------IQSHLRHPNILRLFGY
... |..| | || ||... .| |                       .|.|.|.. |||..  . | .. |||.          |...| ||||.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY--DDKRVFLIIEFAKGGE-----------CFKELQ-KVGSFNEQTAATYTLQIAD---------------ALRYCHSKH-VIHRDIKPENLLIGVGGE
|.  ||. ..|. |...||.           ...|.. . ..|.|. ..... ||..               ||.|.|||. .|||||||||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKIADFGW--SVHAPNTKRS-------------------------------TFCGTLEYLPPEVIEKKG---------YDQTADVWSLGILIFEFLVGRS
|||.|||    .. .| .|.                               |.|||..|..||....|.         ||  .|.||||....|.| |. 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFTSDEEKNIFHNIQENDVYYP------------------SSISPEAKDLISR----LLVSDPHQRIT-LKDVINHPWI
||        . .|..... .|                   ..|.|.||||..    .|. || .|||  ....||||.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Aurora.AA RSK 113-360 34 1.2e-83 284.24 In-house 1-278 (278) Show / Hide 
Range on Protein: 113-360
Range on HMM: 1-278/278
Sequence Identity: 34% (96 aa)

GKLLGMGRFGHVYLAREK---KSQFIVALKVLFKNQLQTHN--IEHQLRREIEIQSHLR-HPNILRLFGYFYDDKRVFLIIEFAKGGECFKELQKVGS--
 |.|| | .| |.| |..   ... | | ||| |. . ...  ..|  ..|..| .. . ||.| .|.  | ... ..|| |. .||| |. ||| ..  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRH-TMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-FNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGV---GGEIKIADFGWSVHA---PNTKRSTFCGTLEYLPPEVIE----KKGYDQTADVWSLG
 | | .|. |  .|. |... |....||||.|||| |       |.||. ||| .  .    | .  |||.|.||..||..     ..|.|. .|.||||
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

ILIFEFLVGRSPFTS---DEEKNIFHNIQEND--VYYP--SSISPEAKDLISRLLVSDPHQRIT-----LKDVINHPWI
.|..| |.|..||..   .  | |. .||...  .  |  ...|.||||||...|  |||.|..     .... .|||.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Aurora.AA Ciliate-E2-Unclassified 110-360 27 5.5e-77 262.08 In-house 1-352 (352) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-352/352
Sequence Identity: 27% (96 aa)

FDIGKLLGMGRFGHVYLAREKKSQFIVALKVLFKNQLQT-HNIEHQ---LRREIEIQSH------------------LRHPNILRLFGYFYDDKRVFLII
. |.| .| | || ||....|| ... |.| . |.| .  ..|...   .. ..|....                  . ||.|...| .| |.. .... 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFAKGGECFKELQKVGS-----------------FNEQTAA-----TYTLQIADALRYCHSKH-VIHRDIKPENLLIGVGG---EIKIADFGWSVHA---
|...||. .. ..| ..                 | || |.     .|. || ..| |.|.|. .|||||||||.|.  .|   .|||.||| | .    
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------PNTKRSTFCGTLEYL----PPEVIEKKGYDQT----ADVWSLGILIFEFLVGRSPFTS-DEEK---------------NIFHNIQE
              .. . .|||||..|.    .|||.....||..    .|.||||....|.| |. || . ..|.               ... ||..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

NDVYYPS--------SISPEAKDLIS----RLLVSDPHQRITLKDVINHPWI
.....|.         .||||||.|.    ..|. .| .|||.....||||.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Aurora.AA PKA 110-360 37 9e-77 261.37 In-house 1-263 (263) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-263/263
Sequence Identity: 37% (99 aa)

FDIGKLLGMGRFGHVYLAREKKSQFIVALKVLFKNQLQTHNIEHQLRREIEIQSHLRHPNILR-LFGYFYDDKRVFLIIEFAKGGECFKELQKVGSFNEQ
|.| ..||.|.|| |.|.|.|.|  ..|.|.| |..    . ..    |. | . ..||.| . . . | ||.  ... |.. ||| |. |.|.|.|...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TAATYTL-QIADALRYCHSKHVIHRDIKPENLLIGVGGEIKIADFGWSVHAPNTKRSTFCGTLEYLPPEVIEKK-GYDQTADVWSLGILIFEFLVGRSPF
.|  |   ||  || | ||.. |.|| ||||.||   | |||.||| .    .   .| ||| |||.||.|  | |.    | |.|||||.|.|.| .||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPF

TSD--EEKNIFHNIQENDVYYPSSISPEA---KDLISRLLVSDPHQRI-TLK----DVINHPWI
. .  .   |.  |.. .. .|..... |   ||||..||. |. .|. ..|    |. ||.| 
YDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase Aurora.AA AktR 110-360 36 1.4e-73 250.73 In-house 1-268 (268) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-268/268
Sequence Identity: 36% (97 aa)

FDIGKLLGMGRFGHVYLAREK-KSQFIVALKVLFKNQLQTHNIEHQLRREIEIQS-HLRHPNILRLFGYFYDDKRVFLIIEFAKGGECFKELQKVGSFNE
|.. |.||.| || |||...| ..| ..|.|.. |  ..  | .|....|  |   . .|| | .|.  | ...  |.|.|. .||| |  |.| . |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QTAATYTLQIADALRYCHSK-HVIHRDIKPENLLIGVGGEIKIADFGWSV----HAPNTKRSTFCGTLEYLPPEVIEK-KGYDQTADVWSLGILIFEFLV
..|  |  ||  || | |.. ..| ||.||||.|..  | .||.||| |      . . |  .|||| ||..||.| | ||.. ..| |..||.|.| ..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRSPFTSDEEKNIFHNIQEND---VYYPSSISPEAKDLIS-RLLVSDPHQRIT-----LKDVINHPWI
|  ||...  . .|..|.. .   . ||| .|...||||  .||  .| .|..      ... .||| 
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase Aurora.AA Pkinase_Tyr 110-253 29 1.3e-22 77.17 Pfam 1-156 (270) Show / Hide 
Range on Protein: 110-253
Range on HMM: 1-156/270
Sequence Identity: 29% (47 aa)

FDIGKLLGMGRFGHVYLAREK----KSQFIVALKVLFKNQLQTHN-IEHQLRREIEIQSHL-RHPNILRLFGYFY-DDKR--VFLIIEFAKGGECFKE-L
  .|| || | ||.||... |    . .  || |.| |..   .. .   . ||..| ..| .||||.|| |  . ...   .... |....| . .. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-DLLDYL

QK----VGSFNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGGEIKIADFG
.|     .... ..   . .|||... | .||. ||||.   | |.. .. .||.|||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase Aurora.AA TyrKc 110-360 23 1.7e-20 75.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 110-360
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FDIGKLLGMGRFGHVYLAREKKSQFIVALKVLFKNQLQTHNIEHQLRREIEIQSHL--RHPNILRLFGYFYDD-------KRVFLIIEFAKGGECFKELQ
   || || | || ||... |     || |.| ..       .  ..||..| ..|  .||||.||.|.  ..       . .... |....| . . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KVGS-FNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGGEIKIADFGWSVHAPNT---------KRSTF--CGT----LEYLPPEVIEKKGYD
| .  .. ..   . .|||.  .| |||..||||.   | |.| .. .||.||| |    .          .|..   .|     .  ..||.| .. . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

QTADVWSLGILIFEFL-VGRSPFTS-----DEEKNIFHNIQENDVYYPSSI---------SPEAKDLISRLLVSDPHQRITLKDVINHPWI
   |||| |....| .  | .|         . . ....... .   .            ..|  .....    ||..| | ...  |  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Aurora.AA Pkinase_Tyr 273-306 33 0.001281 12.88 Pfam 181-216 (270) Show / Hide 
Range on Protein: 273-306
Range on HMM: 181-216/270
Sequence Identity: 33% (12 aa)

LPPEVIEKKGYDQTADVWSLGILIFEFLV-GRSP-F
..||.|  . .    |||| |.|..| .  |..| .
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY