Gene PKD3 (Human)

PKD3

Species: Human
Alias: PRKCN, PKD3, nPKC-NU, PKC-NU, EPK2, PKCnu, PRKD3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2p22.2,

Classification

Group: CAMK
Family: PKD

Sequence

Name Sequence Type Origin Length Description Download
PKD3.NA RNA Sugen Kinome 5907 None Fasta, JSON
PKD3.AA Protein Sugen Kinome 890 None Fasta, JSON
PKD3.kin_dom Protein Kinase Domain Sugen Kinome 257 None Fasta, JSON

Protein domain

Protein domains of PKD3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PKD_Nterm_DUF PKD3.AA PKD_Nterm_DUF 60-145 52 2.6e-58 192.39 In-house 1-87 (87) Show / Hide 
Range on Protein: 60-145
Range on HMM: 1-87/87
Sequence Identity: 52% (46 aa)

VSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFG-MYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALA
..|..|.|..||.|..|..||.|.|.|.|.|....||.|.||... .||||.|||||.||.||||.||||....||.|.|.|||| .
CHFHFQCGFHREMVCVEGHELTLTALKELACQFIEQKYPDCGCCNRLYDKIYLFRHDYNSPNILQMITSASDVTEGCLIEIVLSACP
C1_1 PKD3.AA C1_1 155-207 45 8.5e-17 65.32 Pfam 1-55 (55) Show / Hide 
Range on Protein: 155-207
Range on HMM: 1-55/55
Sequence Identity: 45% (25 aa)

HTLYVH-SYKAPTFCDYCGEMLWG-LVRQGLKCEGCGLNYHKRCAFKIPNNCSGV
|   .| ..| ||||..|||..|| | .||.||. |..|.|.||. | |..| . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKD3.AA C1 155-204 29 7.3e-16 59.95 SMART 1-61 (61) Show / Hide 
Range on Protein: 155-204
Range on HMM: 1-61/61
Sequence Identity: 29% (18 aa)

HTLYVHSYKAPTFCDYCGEMLWGLVRQ-----GLKCEGCGLNYHKRCAFKIPN-------NC
|. . ...  ||.|..|..|.||. .|     |..|. |....||.|. |.|.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKD3.AA C1_3 166-197 25 6.2e-05 14.05 Pfam 1-30 (30) Show / Hide 
Range on Protein: 166-197
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCA
 .|. ||. . .  . . .|  |  . |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1 PKD3.AA C1 272-321 32 1e-18 69.39 SMART 1-61 (61) Show / Hide 
Range on Protein: 272-321
Range on HMM: 1-61/61
Sequence Identity: 32% (20 aa)

HTFAVHSYTRPTICQYCKRLLKGLFRQ-----GMQCKDCKFNCHKRCASKVPR-------DC
|..  ... .|| |..|. ...|.|.|     |..| .||..|||.|..|||        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PKD3.AA C1_1 272-324 38 2e-17 67.61 Pfam 1-55 (55) Show / Hide 
Range on Protein: 272-324
Range on HMM: 1-55/55
Sequence Identity: 38% (21 aa)

HTFAVH-SYTRPTICQYCKRLLKG-LFRQGMQCKDCKFNCHKRCASKVPRDCLGE
| . .| .. .|| | .|. .. | |..||..| .|..|||.||..|||  | . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1_3 PKD3.AA C1_3 283-314 25 0.003481 9.6 Pfam 1-30 (30) Show / Hide 
Range on Protein: 283-314
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TICQYCKRLLKGLFRQGMQCKDCKFNCHKRCA
  |. |.. ...  . .  |  | |. |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
PH PKD3.AA PH 417-534 18 2e-12 48.5 SMART 1-82 (82) Show / Hide 
Range on Protein: 417-534
Range on HMM: 1-82/82
Sequence Identity: 18% (22 aa)

MVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVG
..||||. ...     .|... .|...||......   |. ..||||.. ...               ||||.. .                ....    
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P------------CFEIHH-DR-------------TYYFQCE--S

LDVAQSWEKAIRQALMPV
 . .|.| .||..|. . 
EEEMQEWMQAIQKAIHNN
PH PKD3.AA PH 417-532 20 1.2e-11 44.67 Pfam 1-92 (92) Show / Hide 
Range on Protein: 417-532
Range on HMM: 1-92/92
Sequence Identity: 20% (24 aa)

MVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVG
 .||||.  .. .   .|...  | ..|| ...... ... . ||||.. ..  . |        .||||.|.| .             .  ...|    
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN------KRPHCFQIRT-DR------------RTYYFQAESE-

LDVAQSWEKAIRQALM
 . ...| .||..|. 
-EEMNDWMQAIQSACR
Kinase PKD3.AA PKD 576-832 84 4.1e-232 777.39 In-house 1-260 (260) Show / Hide 
Range on Protein: 576-832
Range on HMM: 1-260/260
Sequence Identity: 84% (220 aa)

IFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQ--ESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPE
||.|||||||||||||||.||.|||.||.|||||.||||||  |.|.||||||||...|||.|.||||.|||.|.||||||.|||||||||||||.||.|
IFPDEVLGSGQFGIVYGGIHRHTGRHVAVKVIDKLRFPTKQSGEEQMRNEVAILQQVCHPGVVCLECMCETPDRIFVVMEKMHGDMLEMILSSEKGRLNE

RITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASA-EPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSG
|.|||..||||.||..||..||||||||||||||.|. ..|||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||
RVTKFLITQILCALKYLHHQNIVHCDLKPENVLLSSMGSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG

TFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWL
||||||||||||||||||||||||||.||| .|||||||||||||||||.|||.||||||
TFPFNEDEDINDQIQNAAFMYPPNPWKEISENAIDLINNLLQVKMRKRYTVDKCLSHPWL
Kinase PKD3.AA CAMK 581-832 23 2.2e-104 337.3 In-house 1-425 (425) Show / Hide 
Range on Protein: 581-832
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

VLGSGQFGIVYGGKHRKTG------------RDVAIKVIDKMRFP--------------------------TKQESQLRNEVAILQN-------LHHPGI
.||.|.||.|. ..|..|.            . ||||.||| . .                           | . ..|.|..|...       |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLECMFE------------TPER--------VFVVM---EKLHG-----DMLEMILSSEK-------------SRLPERITKFMVTQILVALRNLHFKN
..|  ..|            | ..        .. ||   |   |     |....| . ..              |..|| ..... ||. |.. .| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHCDLKPENVLLASAEPFP--------------QVKLCDFGFARIIGE------------------------KSFRRSVVGTPAYLA-PEVLRS-----
|||.||||||.|| . ..                ..|..|||||... .                            . ..|||.| | ||||..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KGYNRSLDMWSVGVIIYVSLSGTFPFNED---------------EDINDQIQNAAFMYPPNP------------WREISGE--------AI
         ..|... ||||.||| |. |.|..||..|               ...  .|... . .|| .            | .|| |        ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLINNLLQVKMRKRYSVDKSLSHPWL
|||...|||   ||....  |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PKD3.AA RAD53 579-832 34 1.5e-98 294.13 In-house 4-305 (305) Show / Hide 
Range on Protein: 579-832
Range on HMM: 4-305/305
Sequence Identity: 34% (105 aa)

DEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFP------TKQESQLRNEVAILQNLHHPGIVNLECMFETP-ERVFVVMEKLHG-DMLEMILSSEKS-
...|||| ||.|. .. .||.. |||| ||| .|       .| ..|..||| ||..|.|| |....  |.|| . .. |.|.  | . .. | |...  
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKRCQ

-RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-SAEPF--------------PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSK--
  . | . |.   |.. |.. || ..|.| ||||||.|..  .|.                ..|. ||| ....||.|| .   |||.|.||||..||  
MGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGH

-------------GYNRSLDMWSVGVIIYVSLSGTFPFNED-------EDINDQIQN-AAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHP
             ||... |.|| |.| |..|.|. || .|        ....|| | . . .|.  |..|| || |||...|.|   |||..|. |.||
NCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHP

WL
|.
WM
Kinase PKD3.AA S_TKc 576-832 33 1.2e-91 311.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 576-832
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

IFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHG---DMLEMILSSEK----
    ...|.| || || ..|.|||| ||||.|.          ..|.|..||.. ||| ||.|  .|.. .....||| . |   |....| .  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

SRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNR-SLDMWSVGVIIY
...||  ..|.. ||. ||  .| ..|.|.||||||.|| .     ..|.||||.||..      ....||| |.|||||   ||.. . |.||.|.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

VSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLS-------HPWL
  |.|  ||    ...  ...             | ||.|.|...||.  .||... . |        |||.
EMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKD3.AA AGC 577-832 22 2.3e-82 211.97 In-house 1-395 (395) Show / Hide 
Range on Protein: 577-832
Range on HMM: 1-395/395
Sequence Identity: 22% (91 aa)

FADE-VLGSGQFGIVYGGKHR------KTGRDVAIKVID---K-------MRFPTKQESQ------LRNEVAILQNLH----------HPGIVN-LECMF
|    |.| | || ||  ...       ||.  |.||..   |       |   |. |.       ...|  ||....          || ||. | . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETPER--VFVVME----KLH-----GD-MLEMILSS--EKSRLPERITKFMVTQ-------ILVALRNLHF-KNIVHCD-LKPENVLLASAEPFPQVKLC
.....  .. |||     .      |. .| ..|     . |..|  ..|.  .       |. ||  ||  ..|.| | |||||.|| .      .||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT

DFGFARIIG---------------------------------------------------EKSFRRSVVG--TPAYLAPEVLRSKGYNRSLDMWS--VGV
|||.. ..                                                    ..    . .|  || |.|||.|    |... | ||  .|.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

IIYVSLSGTFPFNEDE------------DINDQIQ------NAAFMYPPN------PWREISGEAIDLINNLLQVKMRKRYS----------VDKSLSHP
..|  |.|  ||. |.            .. ..|.      |    .|..      ..|..| || |||. ||..  .||            ..   .||
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

WL
| 
WF
Pkinase PKD3.AA Pkinase 574-832 31 1.2e-73 255.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 574-832
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRN--EVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGD----MLEMILS-S
|.|   ...||| || || ..|..||. ||.|.|.| .   ... ..|.  |..|...|.|| || | ..||.. .. .||| . |.     |  ..| .
YHI--GRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

EKSRL--PERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFP--QVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLR-SKGYNRSLDM
.. ..  .|.  ||...||| .|  .| ..|.|.||||||.|.   .. .   ||.||||.|.   .  .|   ...||| |.||||.| ...| .. ||
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGVIIYVSLSGTFPFNED--------EDINDQIQNAAFMYPPNPWREIS-----------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL
||.|.|.|  |.| .|| ..          . ..|  . ....   |..||                  |..|.|...|.... ||.. .  | |||.
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PKD3.AA CAMKL 574-832 30 6.2e-70 222.33 In-house 1-297 (297) Show / Hide 
Range on Protein: 574-832
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

YQIFADEVLGSGQFGIVYGGKH-RKTGRDVAIKVID--KMRFPTKQESQ-----------LRNEVAILQNLH---HPGIVNLECMFETPER------VFV
|.|   ..|| | || |  ..| | ||. ||||.||  |..  .. ..            .| |..|.. |.   || |. |  ..||||       .. 
YRI--GKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VMEKLHGD---MLEMILSSEK--SRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAE-PFPQVKLCDFGFARIIGE-----KSFRRSVVGT
|||   |    ....| . ..   |.||. .... .||. |.  .| ..||| |.||||.|| .      ..|..||||. .. .       . .   |.
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PAYLAPEVLRS--KGYN-RSLDMWSVGVIIYVSLSGTFPFNEDEDI-------NDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSH
|.| |||.. .  | |. .  |.|| ||| |. . |..||..| .        .   ..    | |..| ..| ...|||  .|||.  ||....  ..|
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWL
||.
PWM
Kinase PKD3.AA Ciliate-E2 576-832 22 7.9e-67 228.34 In-house 1-365 (365) Show / Hide 
Range on Protein: 576-832
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

IFADEVLGSGQFGIVYGGKHRKTGR------------------DVAIKVIDKMRFPTKQESQLRNEVAILQNLH----------------HPGIVNLECM
.   ...|.|.||.|| .|..|...                   |.|| . . ..  .|  |. .|  |.. ..                || |...   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--TPERVFVVMEKLHG-DMLEMILSS-----------------EKSRLPERITK-------FMVTQILVALRNLHFKN-IVHCDLKPENVLLASAEPF
|.  . . .. ||| . | |... | ..                 | ... . |..       |....|..||. || || |.| |.||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PQVKLCDFGFARIIGEKSFRRS--------------------------------VVGTPAYLAPEVLRSKG---------YNRSLDMWSVGVIIYVSLSG
  .|..|||..... ... .|.                                ..||| |.|||.|..|.         |. . |.||.|||.|  |.|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

TFPFNEDEDINDQIQNAAFMYPPN--------------PWREISGEAIDLINN----LLQVKMRKRYS-VDKSLSHPWL
 .||       .||..  . .|..               | ..| |..|||..    .||..  ||..  .. | |||.
KPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PKD3.AA ULK 576-832 28 9.2e-62 211.5 In-house 1-324 (324) Show / Hide 
Range on Protein: 576-832
Range on HMM: 1-324/324
Sequence Identity: 28% (94 aa)

IFADEVLGSGQFG-IVYGGKHRKT---GRDVAIKVID---KMRFPTKQE-----SQLRNEVAILQNLH---HPG--IVNLECMFETPER--VFVVMEKLH
.  ...||.|.||  || |.. ||   . .||.|.||      .. .||      .|.||. |.. |.   ||   || |  .|||.    .. .||   
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GDMLEMILSSEKS--------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPF---------PQVKLCDFGFARIIGE----KSFRRS
|  || ..   |         ||.| ...    ||. ... || .||.|.|.||.| |.    |          ...|..|||||... .    .  . .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VV------GTPAYLAPEVLRSKG----YNRS-LDMWSVGVIIYVSLSGTFPFNEDEDINDQ----------------IQNAAFMYPPN-PWREISGEAID
 |      ||| | ||..| ..|    |. .  |.||.|.|.|  | |  ||...   ...                |.|  . .|.. .   || | .|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LINNLLQVKMRKRYSVDKSLSHPWL
||  .||.. ..| | .  ..|||.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase PKD3.AA Ciliate-E2-Unclassified 579-832 25 1.5e-61 210.82 In-house 4-352 (352) Show / Hide 
Range on Protein: 579-832
Range on HMM: 4-352/352
Sequence Identity: 25% (88 aa)

DEVLGSGQFGIVYGGKHRKTGRDV-----AIKVIDKM----RFPTKQESQLRNEVA----------------ILQNLHHPGIVNLECMFETPERVFVVME
 ...|.|.||.||  .|.|..  .     ..|.....    ..   ....  .|.                 ||.|. || ||... .|.. . .. |||
IKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

KL-HGDMLEMILSSEK---------------SRLPERITK-----FMVTQILVALRNLHFKN-IVHCDLKPENVLLASAE-PFPQVKLCDFGFARIIGE-
.. .||....| ...|                ...|. .|     |.  |||..|  || || |.| |.||||.|. .    . ..|..|||... ... 
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNY-YIKIIDFGISKKYQQN

---------------KSFRRSVVGTPAYL----APEVLRSKGYNRS----LDMWSVGVIIYVSLSGTFPFN--EDED----------------INDQIQN
               .    ...||| |.    |||||....|. |     |.||.|||.|  | |..||.   .|.                . ..|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

AAFMYPPNPW----REISGEAIDLIN----NLLQVKMRKRYSVDKSLSHPWL
  . .|. ||      .| ||.|.||     .|.... ||.. .. | |||.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase PKD3.AA ULK 576-832 29 2.3e-61 210.18 In-house 1-329 (329) Show / Hide 
Range on Protein: 576-832
Range on HMM: 1-329/329
Sequence Identity: 29% (96 aa)

IFADEVLGSGQFGIVYGGKHRKT----GRDVAIKVID--KMRFPTKQES------QLRNEVAILQNLH--------HPGIVNLECMFETPER--VFVVME
.  ...||.|.|| || |.. ||    . .||.|.||  ||.   ..        .|.||. |.. |.        || || |  .|||.    .. .||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

KLHGDMLEMILSSEKS---------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPF---------PQVKLCDFGFARIIG----EKS
   |  || ...  |          ||.| ...    ||| ... || .||.|.|.||.|.|.    |          ...|..|||||. .     |. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FRRSVV------GTPAYLAPEVLRSKG----YNRS-LDMWSVGVIIYVSLSGTFP----FNEDE-----DINDQ-------IQNAAFMYPPN-PWREISG
   . |      ||| | ||..| ..|    |. .  |.||.|.|.|  | |  |    ||..      .  ..       |..  . .|.. .   || 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

EAIDLINNLLQVKMRKRYSVDKSLSHPWL
| .|||  .||.. ..| | .  ..|||.
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase PKD3.AA CAMK1 680-832 38 1.1e-58 169.24 In-house 114-276 (276) Show / Hide 
Range on Protein: 680-832
Range on HMM: 114-276/276
Sequence Identity: 38% (62 aa)

VTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVK--LCDFGFARIIGEKS-FRRSVVGTPAYLAPEVLRS---KGYNRSLDMWSVGVIIYVSLSGT
. ||| |.  .| |.|||.|||||| |... ..  ..|  ..||| ..|..... .   ..||| | |||||     |.|  . ||||.||| |. | | 
MKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGY

FPFNEDE-D--INDQIQNAAFMYPPNPWREISGE-AIDLINNLLQVKMRKRYSVDKSLSHPWL
 ||...  |  . ..| .. . .| . | .|| . | |.|...| |   |||.....| |||.
PPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase PKD3.AA CAMK1 574-653 30 9.4e-28 77.7 In-house 1-88 (276) Show / Hide 
Range on Protein: 574-653
Range on HMM: 1-88/276
Sequence Identity: 30% (27 aa)

YQIFADEVLGSGQFGIVYGGKHRKT---GRDVAIKVID-KMRFPTKQE---SQLRNEVAILQN---LHHPGIVNLECMFETPERVFVVME
|...  ...|.| |..|| ..|..|   |...|||.|| |    .| .    .|.||..|...   ..|| |..... .|... .  |||
YEFG--KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVME
Kinase PKD3.AA TyrKc 576-832 21 8.3e-15 16.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 576-832
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

IFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNL--HHPGIVNLECMFETP-------ERVFVVMEKL-HGDMLEMILS
|  ...||.|.||.|| |. .   ..||.|.. .       .  ...|  |. .|  ||| ||.|     ..       | ...|||   ||| .. . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEK--------SFRRSV-VGTP-----AYLAPEVLRSK
...  |. .    . .||    . || ||..| ||   |.|...     .|| .||| .| |...          | .   |.        .|||... .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYNRSLDMWSVGVIIY--VSLSGTFPFN------EDEDINDQIQNAAFMYPPNP-WRE-----ISGEAIDLINNLLQVKMRKRYSVDKSLSHPWL
 ..   | || || ..   .. .. . .      .....  ....   | .|     .      . |  ...    . .  .| .      |  .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase PKD3.AA Pkinase_Tyr 576-638 34 6.2e-12 41.04 Pfam 1-69 (270) Show / Hide 
Range on Protein: 576-638
Range on HMM: 1-69/270
Sequence Identity: 34% (24 aa)

IFADEVLGSGQFGIVYGGKHR----KTGRDVAIKVIDKMRFPTKQ--ESQLRNEVAILQNL-HHPGIVNL
|  ...||.|.|| || |. .    .|. .||.|.. |     .|     . .|..|. .| ||| ||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase PKD3.AA Pkinase_Tyr 690-727 44 0.111536 6.31 Pfam 127-161 (270) Show / Hide 
Range on Protein: 690-727
Range on HMM: 127-161/270
Sequence Identity: 44% (17 aa)

LHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARII
|. ||..| ||   |.|...     .|| |||| || |
LESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDI