Gene PDGFRb (Human)

PDGFRb

Species: Human
Alias: PDGFR, PDGFRb, PDGFRB, CD140B, PDGFR1, PDGF-R-beta, JTK12
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 5q33.1-q35 ,

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
PDGFRb.NA RNA Sugen Kinome 5718 None Fasta, JSON
PDGFRb.AA Protein Sugen Kinome 1106 None Fasta, JSON
PDGFRb.kin_dom Protein Kinase Domain Sugen Kinome 354 None Fasta, JSON

Protein domain

Protein domains of PDGFRb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG PDGFRb.AA IG 39-121 17 2.8e-05 24.8 SMART 1-58 (58) Show / Hide 
Range on Protein: 39-121
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

GPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDT---GEYFCTHNDSRGLETDER-KRLYIFVP
 | .. .. .| .|||  |  . |                      ||. |..  |.   |.|.|. .      ...  .  .. | 
PP-VTVKEGETVTLTC-VS-QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
IGc2 PDGFRb.AA IGc2 45-107 22 0.000308 15.51 SMART 1-56 (56) Show / Hide 
Range on Protein: 45-107
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

NVSSTFVLTCS----GSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRG
.   ...|||       . . | . .|. |           .. ||..| |  | |.| |.   . |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set PDGFRb.AA V-set 32-100 18 0.001368 14.21 Pfam 1-110 (128) Show / Hide 
Range on Protein: 32-100
Range on HMM: 1-110/128
Sequence Identity: 18% (20 aa)

GLVVTP-PGP----ELVLNVSSTFVLTCSGS-------AP--VVWER-MSQ-EPPQEMA------KAQ----------DGTFS-----S----VLTLTNL
 ..||. | .    ... ..  .  |.|. |       ..  . | |  .. ..||...      ...           |...     |     ||..||
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TGLDTGEYFC
.  |.| |.|
QPSDSGTYYC
IGc2 PDGFRb.AA IGc2 226-298 24 9.2e-14 52.97 SMART 1-56 (56) Show / Hide 
Range on Protein: 226-298
Range on HMM: 1-56/56
Sequence Identity: 24% (18 aa)

RQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVN
..|...|| |.. ||.. |. |..    . .|               .. |.| ....||||.||| .. ...
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG PDGFRb.AA IG 220-311 21 8.3e-13 49.8 SMART 1-58 (58) Show / Hide 
Range on Protein: 220-311
Range on HMM: 1-58/58
Sequence Identity: 21% (21 aa)

AVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDS---GTYTCNVTESVNDHQDEK--AINITVV
   ..|. ||..|| | |      .. |.                           |.| ....|||   |||.| .|     .|...   ...|| 
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
V-set PDGFRb.AA V-set 276-310 34 2.5e-05 20.23 Pfam 95-128 (128) Show / Hide 
Range on Protein: 276-310
Range on HMM: 95-128/128
Sequence Identity: 34% (12 aa)

LHIPSAELEDSGTYTCNVTESVNDHQDEKAINITV
|.| .....|||||.| |. . | .. .. .. ||
LTISNLQPSDSGTYYCAVWNC-NEDYFGHGTRLTV
I-set PDGFRb.AA I-set 276-294 42 0.005019 12.78 Pfam 60-78 (92) Show / Hide 
Range on Protein: 276-294
Range on HMM: 60-78/92
Sequence Identity: 42% (8 aa)

LHIPSAELEDSGTYTCNVT
| |  .. .|.|.||| .|
LTISNVQPDDEGKYTCVAT
IGc2 PDGFRb.AA IGc2 331-403 17 0.002227 7.29 SMART 1-56 (56) Show / Hide 
Range on Protein: 331-403
Range on HMM: 1-56/56
Sequence Identity: 17% (13 aa)

HRSRTLQVVFE--AYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDA
|  ....   .  ..| |.. |.| .  |                   . ..||. .|... .|.|| .| ..  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG PDGFRb.AA IG 325-416 10 0.011654 14.04 SMART 1-58 (58) Show / Hide 
Range on Protein: 325-416
Range on HMM: 1-58/58
Sequence Identity: 10% (10 aa)

LQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEA---GHYTMRAFHEDAEVQLSF--QLQINVP
 .  .  .  |..    .    .. |.                             ||. .|... .   | |. .|       | .     .. | 
PP-VTVKEGETVTLTC-VS---QIWWY-----------------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
I-set PDGFRb.AA I-set 335-398 26 0.018219 10.88 Pfam 19-77 (92) Show / Hide 
Range on Protein: 335-398
Range on HMM: 19-77/92
Sequence Identity: 26% (17 aa)

TLQVVFEAYPPPTVLWFKDNRTLGD-SSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRA
....  . .|||.| ||||.. |   |.   .  .       .. . ||  .|. . .| || .|
RFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDG------DGTYTLTISNVQPDDEGKYTCVA
Kinase PDGFRb.AA PDGFR 600-958 65 1.7e-292 950.26 In-house 1-358 (358) Show / Hide 
Range on Protein: 600-958
Range on HMM: 1-358/358
Sequence Identity: 65% (238 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHT
|..|.||||||||.||||||.|||.|||.|||||||||.||.||||.|||||||||||||.|.|.||||||||.|||||||||||.||||..||||..|.
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

FLQHHSDKRRPPSAELYSNAL-PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINE-SPV
|.|||..|   |..|..||.. |.. .....|....|.||.|||||..|...|||||..||..||.|....|||.|..||..|..|......|... |.|
FHQHHPEK---PKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNV

LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIF
|.|.||..||||||.|||||||||||||||||||||.|.||.|||||||||||||.||||..||...||.|||||||||...|||.|||||.||||||||
LTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIF

TLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL
.|||.|||..|....||..||.|||||||.||..||||||||||....| ||.|.||...|
SLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase PDGFRb.AA Pkinase_Tyr 600-958 36 2.7e-155 526.59 Pfam 1-270 (270) Show / Hide 
Range on Protein: 600-958
Range on HMM: 1-270/270
Sequence Identity: 36% (133 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSE--KQALMSELKIMSHLGPHLNVVNLLGACT-KGGP--IYIITEYCRYGDLVDYLH
...|..||.||||.|...|..| .... ...||||||| .| ...  ....|.|.|||..|| | |.|.|.|.|| .|.|  |||..||. .||| |||.
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINE
...                                                                                               ..
KHR-----------------------------------------------------------------------------------------------ED

SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY-ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILL
 . |.  ||.....|.|.|||.|.||||.||||||||.|. |.. ||||||||||||. |..|  ..|.. || ||||||.|... .|| |||||||.|.
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLM

WEIFTLGGTP-YPELPMNEQFYNAI-KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL
|||||.|..| ||..  ||..|..| ..||||..| ...||||..|..||... | || ||...  |
WEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase PDGFRb.AA TyrKc 600-958 32 1.7e-137 464.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 600-958
Range on HMM: 1-280/280
Sequence Identity: 32% (126 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG-PHLNVVNLLGACTKG-------GPIYIITEYCRYGDLVD
..||..||.||||.|...|.         ..|||||||. |    ....|.|..||..||  | |.|.|.|.||..       .|..|..||. .||| |
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATL
||......                                                                                            
YLRKHRPK--------------------------------------------------------------------------------------------

INESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRD------SNYISK----GSTF-LPLKWMAPESIFNSLY
      |.  ||. |..|.|.|||.|.||||.||||||||.|. |.. |||.||||.|||  |      . |..|    |. . ||..|||||.|. . .
------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTLSDVWSFGILLWEIFTLGGTPYPEL----PMNEQFYNAIKRGYRMAQPAH--------ASDEIYEIMQKCWEEKFEIRPPFSQLVLLL
|| |||||||...|||||.|..|||.       |.. .. .|.|||| ||..        ..||.|.||..||.|. | || ||... ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PDGFRb.AA TK 600-958 25 7.89999999999e-128 430.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 600-958
Range on HMM: 1-486/486
Sequence Identity: 25% (137 aa)

LVLGRTLGSGAFG---QVVEATAHGLS--------------------HSQATMKVAVKMLKSTARSSEKQALM----------------SELKIMSH-LG
..||..||.|.||   .| .....|..                    .......|||||||... .|... ..                .|.|.|.| ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHLNVVNLLGACTKG------------GPIYIITEYCRYGD----LVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDM
 | |.|.|.|.||.|            .|..|..||. .||    | |||......| .. . . . .. ...|. |   . ..                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-L---H-HC----------------

SKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINE-SPVLSYMDLVG-------------------FSYQVANGMEFLASK---
          |   |||     |   .|  ...|..  ..|..   .|| . .| |.  ||.                    ...|.|.|||.|.||   
----------M---KGD-----I---TY-SHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCE

---NCVHRDLAARNVLICEGKL-----------VKICDFG--------LARDIMRDSNYISKG------------------------STFLPLKWMAPES
   |.|||||||||.|..|..            .||.|||        ||||| .|..| .|.                        .. ||..|||||.
FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPEC

IF---------NSLYTTLSDVWSFGILLWEIFTLG-GTPYPELPM--------NEQFYNAIKRG--------------YRMAQPAHAS------------
..         .  .|| |||||||.|.|||||.| ...|....         |..... ..||              .||.||.|..            
LNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHC

--DEIYEIMQKCWEEKFEIRPPFSQLVLLL
  .|.|..||.||... | || ||||.  |
PPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase PDGFRb.AA TK-Unique 600-958 34 1.8e-112 379.95 In-house 1-294 (294) Show / Hide 
Range on Protein: 600-958
Range on HMM: 1-294/294
Sequence Identity: 34% (129 aa)

LVLGRTLGSGAFGQVVEATAHGLS-HSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGG-PIYIITEYCRYGDLVDYLHRNK
|..|...|.||||||  ... |.. |. .. .|||||||  |.  .||....|...|..||.| |.|..||.||| . | .|| |||..|.| .||....
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

HT--------FLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRA
 .         |.                                                                                 . . ..
PAMRQHQTYGNLK---------------------------------------------------------------------------------FDFHHM

TLINESPVLSYMDLVGFSYQVANGMEFLAS--KNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGS-TFLPLKWMAPESIF--NSLY-TTL
. ...   .|. ||. | .|.|.|||.|||  |..|||||.|||||. |.| .||||||.|||.. .  |....|   .|..||||||.      | || 
PDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTK

SDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHA-SDEIYEIMQKCWEEKFEIRPPFSQLVLLL
|||||||.|.|||||||..|||..|  . . ..|..|||| ||.|  |.|.|..|. || .. | || |.|..  |
SDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase PDGFRb.AA VEGFR 802-958 59 2.3e-95 323.14 In-house 174-332 (332) Show / Hide 
Range on Protein: 802-958
Range on HMM: 174-332/332
Sequence Identity: 59% (95 aa)

DLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARD-IMRDSNYISKGS-TFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL
||. .|.|||.|||||||..|.||||||||.|.|| . ||||||||||. | .| .|  ||. . ||.|||||||||   ||| |||||.|..|||||.|
DLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSL

GGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL
|| |||   ..| |.| .| ||||  |  .  |||.||. || .  | || || ||  |
GGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase PDGFRb.AA FGFR 775-958 52 1.7e-84 286.98 In-house 113-293 (293) Show / Hide 
Range on Protein: 775-958
Range on HMM: 113-293/293
Sequence Identity: 52% (96 aa)

YDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPES
| .| |. || .    ||   | |.  ||| . |||| |||.|||. |.||||||||||. ..   |||||||||||     |  ..   || ||||||.
YTDYKPRKPEQQDDIELI---PNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEA

IFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL
 |   ||. |||||.|.|||||.|.||.|||  |  |. |   | |.||  |.. | ||| .|  || .| . ||.| |||  |
LFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase PDGFRb.AA Src 798-958 46 1.8e-69 235.18 In-house 94-255 (255) Show / Hide 
Range on Protein: 798-958
Range on HMM: 94-255/255
Sequence Identity: 46% (76 aa)

LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR--DSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWE
|.  .|. .. |||.||..| |.| .||||||||||. |. ..|..|||||| ..   | .| ..    .| ||.||| |    .|. ||||||||||.|
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

IFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYE-IMQKCWEEKFEIRPPFSQLVLLL
|.| | .|||   .|..   ...||||| .|..  ||.|| ||..||... | || |  |   |
IVTYGRVPYPGM-TNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase PDGFRb.AA UTK 785-958 33 3.3e-67 228.94 In-house 102-296 (296) Show / Hide 
Range on Protein: 785-958
Range on HMM: 102-296/296
Sequence Identity: 33% (66 aa)

RTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEG-------KLVKICDFG---LARDIMR--------DS-NYISKGSTFL
|..| |.  .   |.  .........|.||..|.|...|||||||||.|...         ..||.|||   ..|.. .        .|  | . . . .
RRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRW

PLKWMAPESIFNS-LYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRG--YRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL
|..|||||.. .   .||.|||||||...|||.| | .|||..  |.|   .. .|  |||..|.. ....|..|..||.   . || | .||  .
PIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase PDGFRb.AA Tie 792-958 47 1.8e-66 201.05 In-house 105-267 (267) Show / Hide 
Range on Protein: 792-958
Range on HMM: 105-267/267
Sequence Identity: 47% (80 aa)

INESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGI
.| .  ||   ...|   ||.||..|. |.|.||||||||.|.||  . || ||||.|    |  |. |    || .||| ||.  | ||| |||||.|.
VNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGV

LLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL
||||| .||||||  .   | .|. . .|||| ||    ||.|..|..|| ..   ||||.|... |
LLWEIVSLGGTPYCGMTCAE-LYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase PDGFRb.AA RTKB 785-958 44 1.9e-62 209.3 In-house 94-264 (264) Show / Hide 
Range on Protein: 785-958
Range on HMM: 94-264/264
Sequence Identity: 44% (79 aa)

RTCRATLINESPV-LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTL
| |||.   . |  |.   || |. |.|.|| || ..| .||||.|||||.  .   ||||||.|| |  |     .. | || |||||||.  . ||| 
RMCRAS--QHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTK

S-DVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL
| ||||||.  ||||.||||||.... | .  .    |.|. .|  .. ....|||.|| .  . || |. || ..
SGDVWSFGVTMWEIFSLGGTPYQQYR-NGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase PDGFRb.AA Ret 802-960 45 2.8e-62 211.5 In-house 136-293 (293) Show / Hide 
Range on Protein: 802-960
Range on HMM: 136-293/293
Sequence Identity: 45% (73 aa)

DLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGG
... |  |.  || .|..   |||||||||||. ||.. || |||| ||.  |  |. .    .| ||||.|| .   ||| |||||||.|.||| |.|.
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

TPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER
 |||  |  |  ..  | ||||  |   | |.| || .|| .  . || |  .   .|.
NPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase PDGFRb.AA VEGFR 600-700 53 7.1e-53 181.97 In-house 1-104 (332) Show / Hide 
Range on Protein: 600-700
Range on HMM: 1-104/332
Sequence Identity: 53% (56 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTK---GGPIYIITEYCRYGDLVDYLHRN
| ||. || ||||||.||.| |.  .. .  |||||||..| .||. |||||||.. |.| ||||||.||.|||   .||  .| |||..| | .||   
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

KHTF
  .|
RMYF
Kinase PDGFRb.AA Pkinase 600-958 20 5.9e-40 142.36 Pfam 1-293 (293) Show / Hide 
Range on Protein: 600-958
Range on HMM: 1-293/293
Sequence Identity: 20% (82 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQ--ALM-SELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYG----DLVDY
...||..|||.||.| ... .| ..     .|||| .|   ..|.|.  ..  ||..|| .|  | |.| |..... .. ||...|||. |    || ||
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLI
...                                                                                                 
IST-------------------------------------------------------------------------------------------------

NESPVL--SYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLIC-EGKL---VKICDFGLARD--IMRDSNYISKGSTFLPLKWMAPESIF-NSLYTTL
 .. ..  |. ..  . ||.. |.|.. |....||||   |.||  .| .   |||||||||.   . ..| . .   |   . .|||| |  .. |.. 
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT---PWYMAPEVIRGGQYYGPK

SDVWSFGILLWEIFTLGGTPYPEL------PMNEQFYNAIKRGYRMAQPAHAS-------------------DEIYEIMQKCWEEKFEIRPPFSQLVLL-
.|.||.|..|.| .. | .|.|.        ... ...  .. ..   |   |                   .|  ... .|.. . . || . |..   
VDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
Kinase PDGFRb.AA FGFR 600-696 44 1.1e-37 125.99 In-house 1-99 (293) Show / Hide 
Range on Protein: 600-696
Range on HMM: 1-99/293
Sequence Identity: 44% (44 aa)

LVLGRTLGSGAFGQVVEATAHGLSHS--QATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRN
|.|| .|| |.||||. |.| |.  .  .....|||||||. .   .   | ||. .|   | | |..||||.|| .|| |.| |||  | | |.|  .
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRAR
Kinase PDGFRb.AA Tie 609-693 40 5.1e-27 78.72 In-house 2-83 (267) Show / Hide 
Range on Protein: 609-693
Range on HMM: 2-83/267
Sequence Identity: 40% (34 aa)

GAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYL
| ||||. |.   .      |.||.||.|  |   ...  | || .|  .| | |..||.||| . | .|. .|| .|| |.|.|
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFL
Kinase PDGFRb.AA Ret 600-693 43 7.6e-27 88.68 In-house 1-96 (293) Show / Hide 
Range on Protein: 600-693
Range on HMM: 1-96/293
Sequence Identity: 43% (42 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKST-ARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGG--PIYIITEYCRYGDLVDYL
|.|. ||| | ||||| |.|  .        |||||||   | |||  .| ||. .   .  | .|. |.|||.  .  |  .| |||.|| |  .|
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVN-HPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFL
Kinase PDGFRb.AA UTK 600-703 36 1.2e-23 77.77 In-house 1-111 (296) Show / Hide 
Range on Protein: 600-703
Range on HMM: 1-111/296
Sequence Identity: 36% (40 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQA----LMSELK---IMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDY
. |||.||.||||.| .|..   |    .|.|||| ....| .  ...    .| | .   .|...  | ||..|.| ||...|..|.|||.. |||..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LHRNKHTFLQH
| |...|. ..
LRRHRPTPPAC
Kinase PDGFRb.AA S_TKc 600-962 18 2e-21 78.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 600-962
Range on HMM: 1-231/231
Sequence Identity: 18% (69 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRY--GDLVDYLHRNK
  ..|..|.||||.|  .. ..        .||.|..|        . ...|..|...   | |.|.|....   . .|...|||    ||| ||.....
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

HTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPV
.  |..                                                                                             .
RHGLRF---------------------------------------------------------------------------------------------P

LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTT-LSDVWSFGILLWEI
..  .   . ||.....|.. |.. .||||   |.|..|   .||||||||| .          .    . .|||| .    |..  .|.||.|..|.| 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

FTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL-----LLERLL
.. | .|.|     .. .. |.           |.|  ....||..   | ||   ..        .   .
LC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PDGFRb.AA Src 600-697 37 1.2e-20 66.84 In-house 1-90 (255) Show / Hide 
Range on Protein: 600-697
Range on HMM: 1-90/255
Sequence Identity: 37% (37 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLH-RNK
. | | ||.| || | ...  |      ..||||| ||.     . .|.  | .||  |  | ..|.|.  |... ||||.||| . | | |||. . .
IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGE
Kinase PDGFRb.AA RTKB 600-694 37 1.8e-20 65.76 In-house 1-94 (264) Show / Hide 
Range on Protein: 600-694
Range on HMM: 1-94/264
Sequence Identity: 37% (36 aa)

LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLH
. ||. ||.||||.|  |    ..|.  .  .|.| ||  | . |.|.  ||. .|  ||.| ||. ..| | .  |  .  |.| .| | |||.
VWLGEKLGNGAFGEVFQAWVR-NRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLR