Gene MAST3 (Human)

MAST3

Species: Human
Alias: KIAA0561, Hs.173864, MAST3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.1,

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
MAST3.NA RNA Sugen Kinome 5993 None Fasta, JSON
MAST3.AA Protein Sugen Kinome 1331 None Fasta, JSON
MAST3.kin_dom Protein Kinase Domain Sugen Kinome 274 None Fasta, JSON

Protein domain

Protein domains of MAST3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 MAST3.AA DUF1908 160-354 70 3e-143 486.97 Pfam 168-369 (369) Show / Hide 
Range on Protein: 160-354
Range on HMM: 168-369/369
Sequence Identity: 70% (142 aa)

VLDEE----GGRSPRLRPRSRSL-SPGRATGTFDNEIVMMNHVYRERFPKATAQMEGRLQEFLTAYA--PGARLALADGVLGFIHHQIVELARDCLAKSG
. ||.    |.|||..||||||| ||.|. .|||||||||||||.|||||||.|||.|||.|.....  |  .|.|||.|..|||||.||.|||||.|| 
CQDEDNNFCGCRSPHHRPRSRSLSSPSRSCITFDNEIVMMNHVYKERFPKATQQMEERLQHFIHHFKNIPCDSLRLADPVVRFIHHQVVEMARDCLHKSH

ENLVTSRYFLEMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGHAREGQGIKTDLPQYIIGQLGLAKDPLE
. |.|||||.||||||||||..|||||.|||| ||.....||||||||||||||||||||||||||||||||.|...||||||.|.||| ||||..||.|
AKLITSRYFYEMQEKLERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAKVMQGIKTDIPRYIIHQLGLNRDPIE

EM
||
EM
DUF1908 MAST3.AA DUF1908 80-159 65 7.2e-48 170.15 Pfam 1-94 (369) Show / Hide 
Range on Protein: 80-159
Range on HMM: 1-94/369
Sequence Identity: 65% (62 aa)

PLDSPRNFSAASALNFPF--AR-------RADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERL----HQLPFQPTPDELHFLSKHFRSSE-N
|.|||||||..|..||||  .|       ||||||||.|||||||||||.|||..||..||.|||    |||||||| |.||||||||...| |
PIDSPRNFSTSSMMNFPFVPIRRITNCRDRADGRRWSVASLPSSGYGTNPPSSNVSSQCSSQERLNQLPHQLPFQPTQDDLHFLSKHFCCTESN
Kinase MAST3.AA MAST 389-662 53 1.4e-230 712.68 In-house 1-337 (337) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-337/337
Sequence Identity: 53% (180 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFET--RRHLCMVMEYVEGGDCATLLKNMG-PLP
||.||.||.|||||||||.|..|..|||.|.||.|..|..||..||||||.|||...|||||.||.||.|  ...|||||||.||||||.||...| ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEG---------------HIEKDAREFI------------
..||..|.|||||.|||||.||||||||||||.||.|.||||||||||||.|.|...||.|||               ||.|....|             
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DKQVCGTPEYIAPEVIFRQG-YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEE-LFGQVVS--DEIMWPEG-----D
                        .||.||||.|||||||..|| ||||||||.||...|||||||.||.|||||| .|.....  .||.|||.     |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

EALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFF
......||||| .||.. |..|||..| .|.||||||
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase MAST3.AA MAST 389-662 50 3.5e-211 687.5 In-house 1-334 (334) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-334/334
Sequence Identity: 50% (170 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDM
||.||.||.||||.||||.|..|..|||.|.|.|...|..|...||.|||.||....|||||.||.||.|...|||||||.||||||.||...|.....|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEG---------------HIEKDAREFI---------------
|..|.|||||.|||||..|||||||||||.||.|.||||||||||||.|.|......|||               ....|...|                
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DKQVCGTPEYIAPEVIFRQG-YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDE---IMWPEG-----DEALP
                    .||.||||.||||||| .|| .|||||||.||...|||||||.||..|||||.|.......   |.||||     |||..
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

ADAQDLITRLLRQSPLDRLGTG-GTHEVKQHPFF
 .||||| .|| . |..|||.. | .||||||||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MAST3.AA AGC 389-662 29 2.2e-171 447.49 In-house 1-395 (395) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-395/395
Sequence Identity: 29% (117 aa)

FETIKLISNGAYGAVYLVRHR------DTRQRFAIKKINKQN-LILRN--QIQQVFVE------------RDILTFAE----------NPFVVS-MFCSF
|| .|.|. |..| |||||..      || . .|.|...|.   ....  ..... .|            |.||. .           .||.|. ...||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETRRH--LCMVMEYVE--------GGDCATLLKNMG-----PLPVDMARLYFAE-------TVLALEYLHN-YGIVHRD-LKPDNLLITSLGHIKLTDFG
.. .|  |..||||..        ||.| ..| ..|      .. ..|| |.||       .||||||||.  ||.||| |||.|.|... |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKIGLMSM-----------ATNLYEG---------------HIEKDA----------REFIDKQVCG--TPEYIAPEVIFRQGYGKPVDWWA--MGVVL
|.|.| ...            .. ...               .. ...           ..  .  ||  ||||.|||..    |||..|||.  .|...
LCKEGMNDGEKGQQSQSNMKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEFLVGCVPFFGDTPE----------ELFGQVV------SDEIMWP-------EGDEALPADAQDLITRLLRQSPLDRLGTG-------GTHEVKQHPFF
||.|.|. ||.||.|.          |.| ..       .... .|       ..|. .  .|.|||..||   | .|||.|       |. |.|.||.|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAST3.AA S_TKc 389-662 32 2.1e-101 344.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-231/231
Sequence Identity: 32% (93 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEG--GDCATLLKNMGP---
.| ...|  ||.| ||..||..| ...|||.|.          ...  |..||     |..| .. .|..  ||.|||||..|  ||  ...|..|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYG
   .|  .|| |......||||.|. ||.||||||.|.|...  |||..||||...                       . .||||.|.||||.   |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

K-PVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHE----VKQHPFF
| ..|||. |..|||.|.|. ||   .....| ...             . .| |.| ..|.  | .|..     .    .|.||.|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAST3.AA RSK-Unclassified 389-662 37 2.5e-92 290.28 In-house 1-283 (283) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-283/283
Sequence Identity: 37% (108 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLK--NMGPLPV
|. ..||  |  | ||||| .|| | .|.|  .|. .| .| |. |  |..|.   . ||.| .. || |.  | ..|||  |||    |       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIG------LMS--MATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQG
| .| | .|...||||||  ... ||||||| .    ||..||||.||. .       |       . .  |  .   |  .  ||| ||.|||.| | |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHG--FRTNSFCGTEEYLAPEMIRRCG

YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG-G-THEVKQHPFF
 .| |||| .|.|.|| |.|| |. |.  .|.|  .   ..  |. |. .  ...||| .|| . |  ||| . |   ..|.||||
HTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPH-DSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase MAST3.AA AktR 389-662 36 3.7e-89 302.52 In-house 1-268 (268) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-268/268
Sequence Identity: 36% (103 aa)

FETIKLISNGAYGAVYLVRHR-DTRQRFAIKKINKQNLILRNQIQQVFVERDILT-FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPV
|. .|.. .||.| ||||... |. . .|.| | |...| |||....  ||.|.   . .|| | .. .|.|...|  .|||..||.  . ||. . .  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DMARLYFAETVLALEYLHNY-GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDA-REFIDKQVCGTPEYIAPEVIFR-QGYGKPV
..|| |||. .|||||||.   |. |||||.|.|. . ||.|.|||||||              ....  .. . . .||||||.|||.|.. .|..|.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSV

DWWAMGVVLYEFLVGCVPFFG-DTPEELFGQVVSDEIMWPEGDEALPADAQDLIT-RLLRQSPLDRLG--TGGTHEVKQHPFF
|||| |...|| ..|| ||.  .. .... .  .. .  ..  . .   ..|||. .|| . |  |||  . |. |.| ||.|
DWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MAST3.AA Pkinase 389-662 28 8.8e-82 282.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 389-662
Range on HMM: 1-293/293
Sequence Identity: 28% (88 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFV--ERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGG----DCATLLK--N
..... |  |..| ||. .|..|....|.|.|.|.  .  .. |. .   |  |.     |..| ....||...|..|||||.|||    | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

MGPL--PVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHI----KLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVI
 |..  . . .. |. ... .|||.|. ||.||||||.|.|| . |||    |..||||.|               .   . .  . .||||.|.|||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-M--TTFCGTPWYMAPEVI

F-RQGYGKPVDWWAMGVVLYEFLVGCVPFFGD------TPEELFGQVVSDEIMWPEGDE------------------ALPADAQDLITRLLRQSPLDRLG
  .|.||..||.|..|..|||.| |  || |.      .. ... .. . ......  .                  ... ...|.|...|.. | .|..
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

TGGTHEVKQHPFF
    ....|||.|
---AEQILQHPWF
Kinase MAST3.AA RSK 392-662 34 1.1e-81 277.68 In-house 1-278 (278) Show / Hide 
Range on Protein: 392-662
Range on HMM: 1-278/278
Sequence Identity: 34% (101 aa)

IKLISNGAYGAVYLVRHR---DTRQRFAIKKINKQNLILRNQ-IQQVFVERDILTFAE-NPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP---
.|.   |.||.|.|.|     ||.| .| | ..|  .. |.  .  .. ||.||   .  ||.|. . .|.|  .| ..|||..||.  | |.. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITS---LGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIF----R
.  | |. |.|| |||.|.||  ||.||||||.| | ..    |||||||||..|..  ..   ..                |.| ||.|||..     .
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT--------------FCYTIEYMAPEMLKRANQQ

QGYGKPVDWWAMGVVLYEFLVGCVPFFG---DTPEELFGQVVSDEIMWPEGD--EALPADAQDLITRLLRQSPLDRLG--TGGTHEVKQHPFF
 |..| .|||  ||..|| |.||.|| |   ....|.. .. . .   ....  . | ..|.|||...|   | .|||   ... |.||||.|
GGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK-FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAST3.AA NDR 389-535 48 2.1e-80 247.59 In-house 1-152 (350) Show / Hide 
Range on Protein: 389-535
Range on HMM: 1-152/350
Sequence Identity: 48% (73 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAE--NPFVVSMFCSFETRRHLCMVMEYVEGGDCAT---LLKNMGP
|| ||.|. ||.| |.|||..||.. .|.|...|.  . .||. .|  ||||.. |   ||.||....||    .|. ||||. |||  |   ||..|. 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSK
.. |.|| | ||.|.|.|..|..|..|||.||||.|| . ||||||||||..
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCT
Kinase MAST3.AA PKA 389-535 42 2.3e-54 186.95 In-house 1-149 (263) Show / Hide 
Range on Protein: 389-535
Range on HMM: 1-149/263
Sequence Identity: 42% (64 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVV-SMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVD
||.|... .| .| |.|.||... . .|.| ..||  . ..|.. |  |. ||.  ..||.| .|  .| ..|.| ||||||.||.  . | . | .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MARLYFA-ETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSK
.|..| | . ||||||||.  |..||||| |.|| . ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase MAST3.AA Akt 389-540 39 1.4e-52 166.34 In-house 1-154 (264) Show / Hide 
Range on Protein: 389-540
Range on HMM: 1-154/264
Sequence Identity: 39% (61 aa)

FETIKLISNGAYGAVYLVRHRDTRQRF-AIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVD
|. .|..  |..| |.||.  || . . |.| . |. .| .||..... || ||    .||.|..  || |  .|..||.|. ||.  ..|.  .  . |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MARLYFAETVLALEYLHNYGIVHRD-LKPDNLLITSLGHIKLTDFGLSKIGLMS
 || | || .||.|.||. .|. || ||| |.|. . |||.||||||.| ....
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIK
Kinase MAST3.AA SGK 389-535 36 1.3e-51 157.43 In-house 1-173 (283) Show / Hide 
Range on Protein: 389-535
Range on HMM: 1-173/283
Sequence Identity: 36% (63 aa)

FETIKLISNGAYGAVYLVRHRDT------------------RQRFAIKKINKQNLI-------LRNQIQQVFVER-DILTFAENPFVVSMFCSFETRRHL
|. .|.|  | .| ||.|.| |.                   . .|.| ..||  |        ...   .  || .||     || |.   .| |   |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSK
 .||.||.||.    |.  . .| | || | || |.||||||   |..|||||.|.|  . ||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase MAST3.AA NDR 564-662 43 3.2e-43 130.75 In-house 243-350 (350) Show / Hide 
Range on Protein: 564-662
Range on HMM: 243-350/350
Sequence Identity: 43% (47 aa)

GTPEYIAPEVIFR-QGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMW-----PEGDEA-LPADAQDLITRLLRQSPLDRLG-TG-GTH
|||.|.||||. . .||.. .|||  |...||.|||  ||..|||.| .  . . ...|       . || |  .|.|||.||.   |  |||  | | .
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EVKQHPFF
|.|.||||
EIKSHPFF
Kinase MAST3.AA Akt 562-662 36 2e-39 123.6 In-house 162-264 (264) Show / Hide 
Range on Protein: 562-662
Range on HMM: 162-264/264
Sequence Identity: 36% (38 aa)

VCGTPEYIAPEVIFRQGYGKPVDWWA-MGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLG--TGGTHEVKQ
.||||||.|||..  .|..|.||||.  |.|.||.. |  ||. .  ...| .  . ..  |.  ...  ...|||..||   |  |||   ....|.|.
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKR

HPFF
||.|
HPWF
Kinase MAST3.AA SGK 563-662 41 5.3e-39 117.76 In-house 186-283 (283) Show / Hide 
Range on Protein: 563-662
Range on HMM: 186-283/283
Sequence Identity: 41% (42 aa)

CGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTG-GTHEVKQHPF
|||||| ||||.  |.... |||| .| ||||...|  ||.    .... .  . ..  | .     .|| |||. ||   | .||||  .  |.|.|||
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase MAST3.AA PKA 562-662 37 4.1e-32 113.0 In-house 158-263 (263) Show / Hide 
Range on Protein: 562-662
Range on HMM: 158-263/263
Sequence Identity: 37% (41 aa)

VCGTPEYIAPEVIFRQ-GYGKPVDWWAMGVVLYEFLVGCVPFFGD--TPEELFGQVVSDEIMWPEGDEALPADA---QDLITRLLRQSPLDRLGT--GGT
.||||||.|||.| .  |.||.||||| |.. ||.|.|  ||. .  .| ...   .. .| .|. .     ||    ||| .||   .  |.|.  .|.
LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFD---SDANYFKDLIKKLLQVDLTKRYGNMKNGV

HEVKQHPFF
  .| |..|
NDIKNHKWF
Kinase MAST3.AA TyrKc 389-648 18 2e-13 -5.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 389-648
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFA--ENPFVVSMFCSFETR-------RHLCMVMEYVEGGDCATLLK
 . .| . .||.| ||. . .   .  |.|....        ..    |  |..    ..| .| ..    .          |..||||...||.   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NMGP-LPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMS----MATNLYEGHIEKDARE-FIDKQVCGTPEYIAPEV
. .| |...    .        ||||  ...||||   | |... ...| .|||||. .        ..  |    .|...  .  .         |||.
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR-------WMAPEC

IFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGD------TPEELFGQVVSDEIMWPEGD-------EALPADAQDLITRLLRQSPLDR---------L
|.   .    | |. ||...| .  . .   .      ...|.. .| . . | .  .       .. ..  | ....  .  | ||         .
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase MAST3.AA Pkinase_Tyr 461-535 30 9.1e-08 26.93 Pfam 81-159 (270) Show / Hide 
Range on Protein: 461-535
Range on HMM: 81-159/270
Sequence Identity: 30% (24 aa)

HLCMVMEYVEGGDCATLLKNM----GPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSK
....||||...||  . |..     .||.. .   . ..   ..|||.. ...||||   | |.|. ...| .||||..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase MAST3.AA S_TK_X 663-726 17 0.00087 8.22 SMART 1-79 (79) Show / Hide 
Range on Protein: 663-726
Range on HMM: 1-79/79
Sequence Identity: 17% (15 aa)

LALDWAGLLR----HKAEFVPQLE----AEDDTSYFD--TRSERYRHLGSEDDETNDEESSTEIPQ------------FSSCSHRF
  .|| .|..     .. |.|..      . |||.||    .|  .       .|.|.. .... .            |   . .|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
PDZ MAST3.AA PDZ 980-1060 25 3.7e-17 64.25 SMART 1-80 (80) Show / Hide 
Range on Protein: 980-1060
Range on HMM: 1-80/80
Sequence Identity: 25% (24 aa)

KKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAG------LRAGDLITHING-ESVLGLVHMDVVELLLKSGN-----KISLRTTALE
. .|||..              .... ||..|.||  ||      ||.|| |. .|| ..| .. | ..|..| ..|.     |..|     .
GGLGFSIVG-------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ MAST3.AA PDZ 1007-1057 25 1e-08 32.45 Pfam 33-86 (86) Show / Hide 
Range on Protein: 1007-1057
Range on HMM: 33-86/86
Sequence Identity: 25% (14 aa)

SVEDG-SPAQEAG-LRAGDLITHINGESVLGLVHMDVVELLLKSGN-KISLRTT
.|  | ..|. .| ...|| |. |||... .. |...|... .|.. ...|   
EVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ