Gene JNK1 (Human)

JNK1

Species: Human
Alias: PRKM8, JNK1, SAPK, JNK21B1_2, JNK21B1/2, JNK1A2, JNK, MAPK8, SAPK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 10q11.1-11.2,

Classification

Group: CMGC
Family: MAPK
Subfamily: JNK

Sequence

Name Sequence Type Origin Length Description Download
JNK1.NA RNA Sugen Kinome 1412 None Fasta, JSON
JNK1.AA Protein Sugen Kinome 427 None Fasta, JSON
JNK1.kin_dom Protein Kinase Domain Sugen Kinome 296 None Fasta, JSON

Protein domain

Protein domains of JNK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase JNK1.AA JNK 26-321 69 3.3e-244 817.57 In-house 1-309 (309) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-309/309
Sequence Identity: 69% (214 aa)

YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP--FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ---
|||||.||.|||||||.|.|......|||||..||  |||..|.||||||...|||.||||||...|.||||..||||||||||||.||.||||||.   
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG--YKENVDLWSVGCIMGEM
|||||||||||.|||.||||||||.||||||||||||||..||||||.|||.|||....||||||||||||||||||.||.  |||||| |||||||.||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

VCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENR---PKYAGYSFEKLFPDVLFP--ADSEHN-KLKASQARDLLSKMLVIDASKRISV
..|..||||.|.||||||.||.||||.|.||...||.||.|||||   |.|..|.|...||| |||  ..||.. .|....|||||..||||.  .||||
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRISV

DEALQHPYI
|.|||||||
DDALQHPYI
Kinase JNK1.AA MAPK 26-321 48 3.2e-190 638.23 In-house 1-328 (328) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-328/328
Sequence Identity: 48% (164 aa)

YQNLKPIGSGAQGIVCAAYDAILERN------VAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIIGLLNVFTP-----QKSLEEFQDVYIVMELMDA
||.|||||.||.|.||.|.|  ....      |||||.||||||.||.||.|||. |...  .|.|||.||..|||     |.|||||.|.|||||||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLCQVIQ-ME-LDHERMSYLLYQMLCG--IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS---------------FMMTPYVVTRYYRAP
.|.|.|. .  |......|..||.|.|  .|..|||..||||||||||.| ..|.|||.||||||.. ..               ..||.||.||.||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILG---MGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ-P-TVRTYVENR---PKYAGYSFEKLFPDVLFPADSE
|..|.   |.|...|| ||||||..||.  .|.||||.|||||||...|.|||| .||..... .  .|.|....   ||| ....||.||. .|     
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF-----

HNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
   .. .||.|||.||||.| .|||.|.|||||||.
---NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase JNK1.AA p38 26-321 49 3.2e-139 468.83 In-house 1-289 (289) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-289/289
Sequence Identity: 49% (149 aa)

YQNLKPIGSGAQGIVCAAYDAILERN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTP-QKSLEEFQDVYIVMELMDANLCQVIQM
||||.|.|||| | ||.|.|.  .     ||||||.||||   ||||.|||| | |. .| |.|.||.||||  .|...|||||.|...|.| | ... .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

E-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMV
. |  ..  .|.||.| | |  ||||||||||||||| |  || |.|||||||| . ..  || ||.|| |||||..|  | | . || ||||||| |..
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE--MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI

CHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV-RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQH
  ..|||| |.||| ..... .||| .||..|.|    |.|....|..    |...|.                || ||| |||..|. |||.. ||.||
TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGA------------NPQAIDLLEKMLELDPDKRITAEEAMQH

PYI
||.
PYF
Kinase JNK1.AA CMGC 26-321 25 7.1e-133 439.38 In-house 1-513 (513) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-513/513
Sequence Identity: 25% (132 aa)

YQNLKPIGSGAQGIVCAAYDAILERN--------------VAIKKLSRPFQNQTHAK----------RAYRELVLMKCVN-----------------HKN
|...|.||.|. |.|. ..|   ...              |||||...|| ....||          ||.||. ..|..|                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIGLLNVFTPQKS------------LEEFQDVYIVMELMDANLCQVIQM-----------ELDHER------------MSYLL------YQMLCGIK--H
|..|...|.. .|            . .|...|.|.|.|| .|.|.|..           .|..                |..      ||.|.|.|  .
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSAG--IIHRDLKPSNIVVKSDCTL--------------------KILDFGLARTAGT----------------------SFMMTPYVVTRYYRAPEVI
.||..  ||||||||.|| . ..|.|                    || ||||||  ..                      . ..|.|||||.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LG----------MGYKENVDLWSVGCIMGEMVC--------HKILFP-----------GRDYIDQWNKVIEQLGTP----------------CPEFMKKL
||          |.| . .| ||||||..||.         .|.|||           |...|||..| .. ||||                  |.....
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

Q---------------------PTVRTYVEN---RPKYAGYSFEKLFPDVLFPADSEHNK-------------------------LKASQARDLLSKMLV
.                     . .|.|...    |.. . ....|||.  ...| . ||                         .  .||.|||.|||.
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

IDASKRISVDEALQHPYI
.| .|||....||||||.
YDPDKRITAEQALQHPYF
Kinase JNK1.AA ERK 26-321 41 1.7e-109 370.1 In-house 1-307 (307) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-307/307
Sequence Identity: 41% (132 aa)

YQNLKPIGSGAQGIVCAAYDAI-----LERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI
|| .|.|| || |.||.| |        .  ||||| ...| .   .||..||. |..  . |.|||.|.... | .| |.. |.|.| |||.  | |.|
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMP-NSPEQYNDIYCVEELMETDLHQII

QME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVVTRYYRAPEVILGM-GYKENVD
. .  |  .   |..||.|||.|..|||..|||||||||| | |.|.||| ||||||         . ... .|| ||.||.|||||..|    | . .|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

LWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTP-CPEFMKKL-QPTVRTYVENRPK--YAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV
 ||.|||. ||.  | ||||.||..| | ... .|||   | ...   . .. |. | |.  ... ..|..||.              .|| |||.||||
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNAN----------CNPQAIDLLEKMLV

IDASKRISVDEALQHPYI
.| .|||.|.|.|.||| 
FDPDKRITVEECLEHPYF
Kinase JNK1.AA ERK5 26-321 40 2.1e-90 306.66 In-house 1-295 (295) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-295/295
Sequence Identity: 40% (124 aa)

YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--L
|. .  || || |.||.|      . |||||.   |   | ||| .||| ...   | ||| . ..  |.. . |..|||.|..||.. | |.|  .  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT------SFMMTPYVVTRYYRAPEVILGM-GYKENVDLWSVGCIMG
  | . | |||.| |.| .||| .|||||||||..|   | ||| |||.||   |       . || || ||.|||||... .  |   .|.||||||.|
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYVEN-RPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDE
||.  . .|||. ||.| . ... ||.| |  ..      |. |.    |      .||..|     ||         || |||..||. . |.||.| .
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPK----AD--------RQALDLLARMLRFEPSERITVNK

ALQHPYI
|||||..
ALQHPFL
Kinase JNK1.AA S_TKc 26-321 27 6.5e-89 302.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-231/231
Sequence Identity: 27% (88 aa)

YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA---NLCQVIQME
|. |..||.|| | |. ...    | ||||...         ....||. ..|  .|.||. |. ||         ...|.|||..|    .| ..|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

--------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE-NVDLWSVGC
        ..  .  ...||..|.....|| |||||||||.|| . .  ..|| ||||||        | ...|..|.||||.   ||    .| ||.||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

IMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVD
|. ||.| . .||      | .......|                                                 ..|.|...|.|. | .||... 
ILYEMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

EALQ-------HPYI
||||       ||..
EALQDEWDIKCHPWF
Kinase JNK1.AA nmo 27-321 39 4.5e-86 264.6 In-house 2-292 (292) Show / Hide 
Range on Protein: 27-321
Range on HMM: 2-292/292
Sequence Identity: 39% (118 aa)

QNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELD
|  .||| || |.| .  |    . ||.||.   |||   .|| .||| ..   .| |.. .|..  | . .. ||..|.| ||| . | ..|    .| 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQHLS

HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGM-GYKENVDLWSVGCIMGEMVCH
 . .   |||.| |.| ||||.|.|||.|| |..| |.| ||| ||||||.    .|  ||  ||| ||||||...|   | . ||.|||||| .|..  
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

KILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
.|||  .  |.| . ... ||||  | ||      .. .  .|. .  ....|.  .  | .  |       | .||..||. | .||||. .||.|||.
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPP-CLQVLY-TLSSPDHATH------EAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase JNK1.AA ERK1 26-321 41 1.1e-82 281.04 In-house 1-289 (289) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-289/289
Sequence Identity: 41% (127 aa)

YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQM-ELD
| ||. || || |.||.||| . .. |||||.| ||  ||. .|  ||. ...  .| |||.. ..    ...|...||||| .||.  | ....  .| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMV
 . . | |||.| |.| .||| ..||||||||...   | ||| |||||| |         .| || ||.|||||..|   ||   .|.||||||. ||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

CHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK-LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQH
  . .|||. |.|| |...  || |  . ..  .    | |..  |  .  ....|||.    ||        |.| ||| |||     ||| |.||| |
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPK----AD--------SKALDLLDKMLTFNPHKRITVEEALAH

PYI
||.
PYL
Kinase JNK1.AA ERK7 26-321 37 8.9e-79 268.03 In-house 1-292 (292) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-292/292
Sequence Identity: 37% (115 aa)

YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ--ME
|. .| .| || |||  |||      ||.||    |.||| | | .|| ....  . | ||| |.||.      .  .|.|.| | |.. |  ||.    
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR----ADNDRDIYLVFEFMETDLHAVIRKGNI

LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-------MMTPYVVTRYYRAPEVILG-MGYKENVDLWSVGCI
|      | .||.|  ||..||. .|||||||||| . |.|..|. ||||||. .          |.| || || |||||. ||   |   ||.||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYV-ENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVD
.|||.  | .|||   ..| .|..| .. |  | .. ... ..  . |. ..   .......|.               .| ||| ..||    ||....
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQC------------CDDAIDLLKRLLVFNPKKRLTAE

EALQHPYI
.||||||.
QALQHPYV
Kinase JNK1.AA Pkinase 26-321 27 2e-74 258.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-321
Range on HMM: 1-293/293
Sequence Identity: 27% (87 aa)

YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYR--ELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-----NLCQV
|. ...||||. | |. ...   .. ||.|..... ..    ... |  |. .|| .||.||. |. .|.        ...|.|||...       |. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IQ-------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL----KILDFGLART--AGTSFMMTPYVVTRYYRAPEVIL-GMGYKE
|.       . .. .     .||.|.|....|| |||||||||.|| .......    || |||||.      .  || ...|..|.|||||. | .|  
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

NVDLWSVGCIMGEMVCHKILFPGR----DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
 || ||.|||. ||.| . .|||.    . .||  .. . .|.| ..   .. .  . .  .. . .             .  ..  ..  . ..|....
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKW

MLVIDASKRISVDEALQHPYI
.|  | .||.. ...||||..
CLCKDPKKRPTAEQILQHPWF
Kinase JNK1.AA MAPK-Unclassified 26-174 43 1.1e-56 194.7 In-house 1-157 (575) Show / Hide 
Range on Protein: 26-174
Range on HMM: 1-157/575
Sequence Identity: 43% (69 aa)

YQNLKPIGSGAQGIVCAAYDAIL-ERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLE-EFQDVYIVMELMDA---NLCQVIQ
|   | ||||| |.|| | |  .  . |||||. . |.|.| .||. ||. .    || ||| . ..|..   .  ||.|.||||..|     .| |.|.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

MEL---DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR
  .    |.   |..|| | |.| ||||.||||||||||. .  ||...| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase JNK1.AA MAPK-Unclassified 182-321 30 4.5e-37 129.49 In-house 405-575 (575) Show / Hide 
Range on Protein: 182-321
Range on HMM: 405-575/575
Sequence Identity: 30% (55 aa)

MTPYVVTRYYRAPEVILGMG-YKENVDLWSVGCIMGEMVC-----------HKILFPGRD--------------------YIDQWNKVIEQLGTPCPEFM
|| |||||.||||| .| |. |   ||.||.||| .||.            |..||||.|                    ..|| .  .. ||.|  | .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

KKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKAS----------QARDLLSKMLVIDASKRISVDEALQHPYI
   . . .| |..   . . . |  |..             ||.          ...|...|||.....|||. |.||.|||.
NFITCDSARKYIQSFKCKTPVHFTDLMF------------CKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase JNK1.AA TyrKc 26-279 23 3.1e-12 -24.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-279
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCV--NHKNIIGLLNVFTPQKSLEEF---QDVYIVMELMDA-NLCQVI
 . .| .|.|| |.|. .      ..||.|.|          .  .||. .|. .  .|.||. |. | | |.    |   . ..||||.|.  .| . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

-QME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS---------FMM-----TPYVVTRYYRAPEVILGMGY
   .  | .. . .  .|  ||  .||| ..|||||   |. |... | || ||||.|  .            ..     . ...     |||.|    .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

KENVDLWSVGCIMGEMVCHKILFPGRDYID------QWNKVIEQLGTP----------------CPEFMKKLQPTVRTY-VENRPKYAGYSFEKLFPDVL
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TTKSDVWSFGVCMWEIFT----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI-HECF
Kinase JNK1.AA Pkinase_Tyr 26-175 29 2e-06 22.27 Pfam 1-160 (270) Show / Hide 
Range on Protein: 26-175
Range on HMM: 1-160/270
Sequence Identity: 29% (48 aa)

YQNLKPIGSGAQGIVCAAYDAI-----LERNVAIKKLSRPFQNQTH--AKRAYRELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLC
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ITFGKKLGEGAFGEVYKGT-WKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLL

QVIQME------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART
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DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD