Gene GSK3A (Human)

GSK3A

Species: Human
Alias: DKFZp686D0638, Hs.118890, GSK3A
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19q13.13-q13.2,

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
GSK3A.NA RNA Sugen Kinome 2200 None Fasta, JSON
GSK3A.AA Protein Sugen Kinome 483 None Fasta, JSON
GSK3A.kin_dom Protein Kinase Domain Sugen Kinome 285 None Fasta, JSON

Protein domain

Protein domains of GSK3A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GSK3A.AA GSK 119-403 61 5.8e-233 719.83 In-house 1-328 (328) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-328/328
Sequence Identity: 61% (203 aa)

YTDIKVIGNGSFGVVYQARLA----ETREL----VAIKKVLQDKRFK-NRELQIMRKL---DHCNIVRLRYFFYSSGEKKDE--LYLN-LVLEYVPETVY
|...||||.||||||||| .     || |     ||||||.||||.| |||||||..|   ||.|||||.||||...|||||  .|.| ||.||.|.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVR--GEPNVSYICSRYYRAPELIFGATDYTSSI
.|.||. |.| ..||...|.||||.||.|||.|| |.|||||||||.||||||.|||.|||||||||..  .|||.||||||||||||||||.|.||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP-----QIKAHPWTK-------------------VFKS-RTPPE-
||||.|||.||.|.|||.|||||.|||||||||.|||||.|||..|||.|.|||||     |||.|||.|                   .||. .|... 
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

AIALCSSLLEYTPSSRLSPLEACAHSFF
.| |.|..|.|.|..|||||||||| ||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GSK3A.AA CMGC 119-403 22 3.6e-128 423.63 In-house 1-513 (513) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-513/513
Sequence Identity: 22% (116 aa)

YTDIKVIGNGSFGVVYQARL--------------AETRELVAIKKVLQDKRFKN----------------RELQIMRKL-----------------DHCN
|. ||.|| |..||||..|                || |.|||||. ... ...                ||..|...|                 .| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLRYFFYSSGEKKDEL-----------YLNLVLEYVPETVYRVARHFTK------------------------AKLTIPILYVKVYMYQLFRSLA--Y
||.|...||.......|            .|.|| ||.. . |.. ..  .                         .  ..| ... ||||..|.|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHSQG--VCHRDIKPQNLLVDPDTAV-------------------LKLCDFGSAKQLVRG----------------------EPNVSYICSRYYRAPELI
.||..  ..|||.||.|.|..... .                   ||.||||.|...                         .|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGA---------TDYTSSIDVWSAGCVLAELLLG--------QPIFPGDSG-----------VDQLVEIIKVLGTPT---------------REQIREMN
.|.         ..||..||.||.||..||...|        .|.|||.|.           .||| .|.|||||||                |.. .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PNYTEFK---------------------------FPQIKAHPWTKVFKS----------------------------------RTPPEAIALCSSLLEYT
.... .|                           ||... .||...|.                                   . .|.|| | . .|.| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PSSRLSPLEACAHSFF
|. |... .|..| .|
PDKRITAEQALQHPYF
Kinase GSK3A.AA Pkinase 119-403 31 8.9e-107 365.83 Pfam 1-293 (293) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR--------ELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHF-
|. ...|| ||||.||...   |...||.|..  ... ..         |.|||..|.|.|||||...|..    ||..|  .|.||.. ..| |.  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIY--MVMEYCEGGLY-VMDLFD

---TKAKLTI--PILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAV---LKLCDFGSAKQ--LVRGEPNVSYICSRYYRAPELIFGATDYTS
   |... ..  .   .| ||||..| |.|.||.|..|||.||.|.|.| .  .   .|.||||.|||  . ... . .. ....|.|||.| |...|..
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDVWSAGCVLAELLLGQPIFPGD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPL
..|.||.||.|.|.|.|.|.|||.    . .||.. | ...|.|..... . ......| |.. . |. ...|  ....|.. .....|.. |..|... 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

EACAHSFF
... | .|
QILQHPWF
Kinase GSK3A.AA S_TKc 119-403 28 7.1e-88 299.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-231/231
Sequence Identity: 28% (86 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPE---TVYRVARHFTKAKLT
|. ...|| |.||.||..|  .| ..||||..    .   ||.||..| .| |||.| ..|..        .| .|.||..    ..... ..  . .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS-SIDVWSAGCVLAE
  .|   .. ||||... |.|.||.|..|||.||.|.|.|    ..|.||||.|.||       ... ...|.|||..     |.  ..|.|| ||.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACA-------HSFF
.| |.| ||      |. ...|..|                                   .|||. . . .|.. |. |..  || .       | .|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GSK3A.AA RCK 119-403 31 3.1e-78 247.8 In-house 1-298 (298) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-298/298
Sequence Identity: 31% (97 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN-------RELQIMRKLD-HCNIVRLRYFFYSSGEKKD--ELYLNLVLEYVPETVYRVARH
|. || .| |..|.|  |.  || |.|||||    ..|..       ||.. .|||  | ||. |.  ..     .|  .||  .|.||. . .|   ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR----DNDTYQLY--FVFEYMDMNLYQMMKD

FTKAKLT-IPILY--VKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPD--------TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY
| . . . .|     .| .|||.. .||..|..|  |||.|| |... ..        . ..|..|||...      |.  |. .|.|||||..  .| |
FKE-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYY

TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPL
.| .|.|. ||. .||   .| ||| | .||. .|.||.|||. .   .     . ..|.||| |. |  ... .  ....| |.  .| . |. | .. 
NSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQ

EACAHSFF
.|. | .|
QALQHPYF
Kinase GSK3A.AA CDK 119-403 29 1.1e-76 244.84 In-house 1-284 (284) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-284/284
Sequence Identity: 29% (95 aa)

YTDIKVIGNGSFGVVYQARLAETR-----ELVAIKKVL--------QDKRFKN---RELQIMRKLDHCNIVRLRYFFYSS-----GEKKD-ELYLNLVLE
|  .. || |..|||| ||  .|      ..||.||.          .  |     ||  ....| | |||.|.  ....     . |   |  | .| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTA----VLKLCDFGSAKQLV-------RGEPNVSYICSRYY
|..   . . .             .| ||.|| | |.|.||... |||.||||.|.. .      .||. ||| |.             .  . .  . |
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELIFGATDYT--SSIDVWSAGCVLAELLL---GQPIFPGDSGVDQLVEIIKVLGTPTREQ---IREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAI
||||| .|...|.   .||.||.||..||...   ..|.|||||  |||  |....|||| ..   . .. |.|                          
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKL-PDY--------------------------

ALCSSLLEYTPSSRLSPLEACAHSFF
 | ...| | |. |.|  .|  | .|
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GSK3A.AA CDC2 119-403 31 1.5e-72 222.11 In-house 1-301 (301) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-301/301
Sequence Identity: 31% (97 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN--------RELQIMRKLD-HCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHF
|. |. || |..||||...  .| ..||.||.  .             ||. .. .|. | |||.|.  ...       ||  .| ||.     .  .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLY--MVFEYLDMDLKKYMDMS

TKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICS-----RYYRAPELIFGATDYTSSIDVW
 . .  .|  .|| ||||. . ... |.... |||.||||.|.| .....|. ||| |.    | |   |        . |||||. .|. .|. ..|.|
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

SAGCVLAEL---LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK--FPQIKAHPWTKVFKS--------RTPPEAIALCSSLLEYTPSSR
| ||..||.       |.|.|||  |||  | ..||||. .   ..  .....|  ||. |.   .|....         ..||.| | ...| | |. |
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVT-QLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

LSPLEACAHSFF
.|  || .| .|
ISAKEALQHPYF
Kinase GSK3A.AA CDKL 119-403 35 2e-64 219.14 In-house 1-286 (286) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-286/286
Sequence Identity: 35% (105 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQ---DKRFK---NRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKA
|  . ..| || |||.  |  || ..||||| .    |.  |    ||. . . | | ||| |.  |     .| .|.  || ||.  ||  .  .. . 
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVF----RRKRKLH--LVFEYCDHTVLHELEEYPNG

KLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLA
   ..   |. ||.|. ..... |.. . |||||| |.|. |   ..|||||| |..|   ||    |   | ||||||  | |.| ...|.|..|||.|
---VDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMA

ELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPNYTEFKFPQIK-AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
|.. |||..||.| .|||  |.|.||  .|  ..|  .|| .   |||.|.   |  | .     ..|. .  ..|.  |. |..  ..  |..|
EMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GSK3A.AA CDK7 221-403 37 6.5e-63 166.2 In-house 104-288 (288) Show / Hide 
Range on Protein: 221-403
Range on HMM: 104-288/288
Sequence Identity: 37% (71 aa)

VKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ
.| || .. . | | |   . |||.|| |||....  .||. ||| |..   | ||  |   .  |.|||||| |||  |....|.|| ||..|||.|  
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNEN-GQLKIADFGLARFY--GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFK-FPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
|..|||| .|||. | . ||||| |.  .|   ..| .|| ||     |  ..| .  . ... | . ..   |. |..  ..  . .|
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIF-TAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase GSK3A.AA CDK5 119-403 34 3e-62 195.31 In-house 1-287 (287) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-287/287
Sequence Identity: 34% (104 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR------FKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKA
|  .  ||.| .|.|| ||  ||.|.||.|.|  |           ||  ... | | |||||     |  |||    | || |.. .   .    ..  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHS--EKK----LTLVFEFCDQDLKKYMDSCNG-

KLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCV
   .    .| .|||| . ||. |.. | ||| ||||||.      ||| ||| |     | |   |   .    ||.|   .|.  |. |||.||.||.
--EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN-KNGELKLADFGLARAF--GIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

LAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQ---IREMNPNYT--EFKFPQIKAHP-WTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSF
.||.   |.| ||| .  |||  | |..|||. ..   | .. |.|     ..|   ||. | .. ..    .   | . .|.. |  |.|  .|  | .
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKL-PDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPY

F
|
F
Kinase GSK3A.AA MAPK 225-403 34 1.7e-54 186.82 In-house 121-328 (328) Show / Hide 
Range on Protein: 225-403
Range on HMM: 121-328/328
Sequence Identity: 34% (74 aa)

MYQLFRS--LAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNV-------------------SYICSRYYRAPELIFG--ATDYTSSI
|||. |   | |||| .| |||.|| |.||. .  . |.||||    | |.. .                     |.  |.|||||....  ...|| ..
MYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFG----LARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAV

DVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-P----NYTE-FK-FPQIKAHPWTKVFKS---RTPPEAIALCSSLLEYTPSS
|.||.|| .||.|  ..|.|||.. .||.  |..|||||..| |. .  .    || . .. .|. ...||.|.|.    .. |.|| | . .|.  |. 
DMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDK

RLSPLEACAHSFF
|..  || .| .|
RITVEEALQHPYF
Kinase GSK3A.AA ERK 225-403 34 4.6e-52 179.29 In-house 114-307 (307) Show / Hide 
Range on Protein: 225-403
Range on HMM: 114-307/307
Sequence Identity: 34% (68 aa)

MYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAK-QLVRGEPNV--------SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL
|||. . | ||||..| |||.|| |.||  .  .|| |||| |  . .  ..|.         |. .|.|||||..  ...||...|.||.|| .||.| 
MYQILCGLKYIHSANVIHRDLKPSNILVNSN-CDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLG

GQPIFPGDSGVDQLVEIIKVLGTP-TREQIREM-NPNYTEF--KFPQ--IKAHPWTKVFKSRTP--PEAIALCSSLLEYTPSSRLSPLEACAHSFF
..|.||| . |.|. .|....||| . |....  ..|. ..  ..|   ... || ..|. ...  |.|| | ...|.  |. |..  |. .| .|
RKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFP-NANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase GSK3A.AA TyrKc 119-403 23 9.9e-14 -0.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 119-403
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN---RELQIMRKL--DHCNIVRLRYFFYSSGEKKDE---LYLNLVLEYVPETVYRVARHFT
 | .|..|.| ||.||....    . ||.|..  |.  .    ||..||.||  .| |||||     ..|..        | .|.||.|    .   . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKH

KAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRG----EPNVSYI-----CSR-----YYRAPELIFGATD
. |  ..      ...|  .  .|.||... |||.   | ||. .  . | .||| .. .  .    |    |      ...        ||| |   . 
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYG

-YTSSIDVWSAGCVLAELL-LGQPIFPG---DSGVDQLVEIIKVLGTPTREQIREM----NPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYT
 .|.  |||| | .. |.. .||.  ||      .    |.|. . .  |  . .                         |  . |.|   . ..  .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F-VCCPDEMYQIMKQCWHED

PSSRLSPLEACAHSFF
|..| .  |   |..|
PEDRPTFSEI--HECF
Kinase GSK3A.AA CDK7 119-150 50 1.3e-12 29.46 In-house 1-32 (288) Show / Hide 
Range on Protein: 119-150
Range on HMM: 1-32/288
Sequence Identity: 50% (16 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKV
|. || || | |..|| |.  .| . |||||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase GSK3A.AA Pkinase_Tyr 119-199 31 3.6e-12 41.83 Pfam 1-90 (270) Show / Hide 
Range on Protein: 119-199
Range on HMM: 1-90/270
Sequence Identity: 31% (29 aa)

YTDIKVIGNGSFGVVYQARLA----ETRELVAIKKVLQDKRFKN-------RELQIMRKL-DHCNIVRLRYFFYSSGEKKDELYLNLVLEYVP
 | .|..| |.||.||....     .|.  ||.|.. ..   ..       ||..||..| .| |||||    .. || .   .. .|.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMP
Kinase GSK3A.AA MAPK 119-176 32 1.4e-10 32.53 In-house 1-71 (328) Show / Hide 
Range on Protein: 119-176
Range on HMM: 1-71/328
Sequence Identity: 32% (23 aa)

YTDIKVIGNGSFGVVYQARLAETREL------VAIKKV---LQDKRFKN---RELQIMRKL-DHCNIVRLR
|...| || |..|||  |.  .|..       |||||.    |.. .     ||. ..| . .| ||..|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLL
Kinase GSK3A.AA ERK 119-176 34 1.1e-08 28.66 In-house 1-70 (307) Show / Hide 
Range on Protein: 119-176
Range on HMM: 1-70/307
Sequence Identity: 34% (24 aa)

YTDIKVIGNGSFGVVYQARLAE-----TRELVAIKKV---LQDKRFKN---RELQIMRKLD-HCNIVRLR
| .|| || |..|||  |.  |     |.. |||||.     .... .   ||. ..| .. | ||. |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLF