Gene Erk5 (Human)

Erk5

Species: Human
Alias: ERK4, Erk5, BMK1, PRKM7, MAPK7, ERK5
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 17p11.2,

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK5

Sequence

Name Sequence Type Origin Length Description Download
Erk5.NA RNA Sugen Kinome 3183 None Fasta, JSON
Erk5.AA Protein Sugen Kinome 816 None Fasta, JSON
Erk5.kin_dom Protein Kinase Domain Sugen Kinome 293 None Fasta, JSON

Protein domain

Protein domains of Erk5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk5.AA ERK5 55-347 81 1.4e-240 805.57 In-house 1-295 (295) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-295/295
Sequence Identity: 81% (239 aa)

YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPL
|.|||.|||||||||.|||||..||||||||||||||||||||||.||||||.||.|||||||.|||.|.|||.|.|.||||.|||||||||||||.||.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCT-SPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFG
||||.||||||.||||||||||||||||||||||||||||||||||||||||||| ||..||.|||||||||||||||||.|.|.||||||.||||||||
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS-LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
||.||||.||||||.|||||||||||.|.|..||||.|..|..|.|. .|.|||..||.|||.||||||.||.||||||||.||....||.||||
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase Erk5.AA MAPK 55-347 51 8.49999999999e-195 653.43 In-house 1-328 (328) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-328/328
Sequence Identity: 51% (169 aa)

YEIIETIGNGAYGVVSSARRRL------TGQQVAIKKIPNAFDVVTNAKRTLRELKILKHF-KHDNIIAIKDILRPT-----VPYGEFKSVYVVLDLMES
|.|.. || |||||| ||. ..      .|..||||||...|. .| .|||.||.|.|.|| .|.||| ..||..|.      . .||. .|.| .|||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQIIHSSQPLTLEHVRYFLYQLLRG--LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQ----------YFMTEYVATRWYRAP
||||||.| |||. .|..||.||.|||  |||.|||.||||||||||.||||||.|||.|||.||.....  .|.          ..|||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELMLS--LHEYTQAIDLWSVGCIFGEMLA-RRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG-AERVRAYIQSL---PPRQPVPWETVYPG----ADRQ
|.||.  ...||.|.| |||||||.|||  |..|||||.|..|..||| ||||||. .|| ..  |..| |||||   |.....|||...|.    |..|
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALSLLGRMLRFEPSARISAAAALRHPFL
|. || .|| | |. ||... ||.||..
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk5.AA ERK 55-347 55 1.1e-174 586.58 In-house 1-307 (307) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-307/307
Sequence Identity: 55% (170 aa)

YEIIETIGNGAYGVVSSARRRL-----TGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK-HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQII
|.||. || |||||| ||.  .     ||| ||||||.||||    .||||||.|.|.||| |.||| ..||..|. |  ... .|.| .|||.||||||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

HSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAE----HQYFMTEYVATRWYRAPELMLSLHEYTQAID
.|.|.|. .|. ||.||.|.||||.|||.||||||||||.|||.|| ||| ||| ||.. .|..|     | |||||||||||||||.|||. .||.|.|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

LWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTP-SPAVIQAVGAERVRAYIQSLPP--RQPVPWETVYPGAD--RQALSLLGRMLRFEPSARISAA
 ||.|||| |||.|. |||||.||||...|  ..||| |   .|  . |... || .||   |.|.|||...| |.   ||. || .|| | |. ||...
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

AALRHPFL
 .|.||..
ECLEHPYF
Kinase Erk5.AA CMGC 55-347 28 2.7e-141 467.58 In-house 1-513 (513) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-513/513
Sequence Identity: 28% (148 aa)

YEIIETIGNGAYGVVSSARRRLTG--------------QQVAIKKIPNAFDVVTNAK----------RTLRELKILKHFK-----------------HDN
||||. || |.|||| ..| ..|.              ..|||||| |.|   . ||          |.|||.|||||..                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIAIKDILRPTVPYGE-----------FKSVYVVLDLMESDLHQIIHSSQ---------PLTLEH------------VRYFL------YQLLRGLK--YM
|. ..||...  . |.           |...| | ..|. ||.|.|.. |         ||.  |            ..||.      ||.|||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAQ--VIHRDLKPSNLLVNENCEL--------------------KIGDFGMARGLCTSPAEH-----------------QYFMTEYVATRWYRAPELML
||.   .|||||||.|.|.|.||||                    ||.|||.|| . . . .|                 . ..|.||.||||||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SL---------HEYTQAIDLWSVGCIFGEMLAR--------RQLFP-----------GKNYVHQLQLIMMVLGTPS---------------PAVIQAVGA
.          ..||..|| |||||||.||. .        . |||           ||....||..|. |||||.               .  .  .  
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

---------------------ERVRAYIQS---LPPRQPVPWETVYPG-----------------------------------ADRQALSLLGRMLRFEP
                     | .| ||||   .|...| ||. ..|.                                   .| ||. || .||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SARISAAAALRHPFL
. ||.|. ||.||..
DKRITAEQALQHPYF
Kinase Erk5.AA p38 55-347 46 3.2e-135 455.54 In-house 1-289 (289) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-289/289
Sequence Identity: 46% (139 aa)

YEIIETIGNGAYGVVSSARRRLTGQQ---VAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRP-TVPYGEFKSVYVVLDLMESDLHQIIHS
|. .. .| |||| |..|. | |||.   |||||.   |  .  |||| |||. ||| .|.|.| . |.  |      .|. ||.|  .|..||..|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

SQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGC
 . |. .|... .||.|||||| ||| .|||||||||. |||.|||.| ||| ||       .    ||.||||||||||| ||.  .|||..| |||||
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGC

IFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
|  |.. .| ||||.....||| || |.|||.. ..| .  |. |.||||.|...    ..|..||..||. || .||   |  ||.|. |..||..
IMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Erk5.AA ERK1 55-347 52 5.9e-128 431.38 In-house 1-289 (289) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-289/289
Sequence Identity: 52% (155 aa)

YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPL
|  .. ||.||||.|.||  ....|.||||||   |.  |  .|||||.|||. |||.||| |.||.|      ... ||.| .||| || ...  .|.|
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADT-IEQMRDVYIVQCLMETDLYKLLK-TQHL

TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGE
  .|. |||||.||||||.||| |.||||||||||.|  |.||| |||.|| .     .|  |.|||||||||||||.||    ||..||.||||||  |
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE

MLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
||. | .|||| |. || .|. ||| || . .. .  |. |.|.|||| .. |||. ..|.|| .|| ||..|| | |  ||    || ||.|
MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Erk5.AA ERK7 55-347 41 5.4e-112 378.38 In-house 1-292 (292) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-292/292
Sequence Identity: 41% (122 aa)

YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK-HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQP
|||.. .| ||||.|  |  . |.| ||.|||  ||   | | || ||  .|. |. |.||| . ...|        . .|.| . ||.||| .|   . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRAD----NDRDIYLVFEFMETDLHAVIRKGNI

LTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSP--AEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCI
|   |..| .||||| .|||||..||||||||||.|.. .| .|. |||.|| .   .  .|..  .||||||||||||| .|. |.||...|.||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

FGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
 ||||  . .|||   ..|. .|. ... |. . |.|.| .     ..... ... . . ..|..  .|..|| |.| | |  |..|  ||.||. 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase Erk5.AA nmo 56-347 46 8.9e-111 342.0 In-house 2-292 (292) Show / Hide 
Range on Protein: 56-347
Range on HMM: 2-292/292
Sequence Identity: 46% (138 aa)

EIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVP-YGEFKSVYVVLDLMESDLHQIIHSSQPL
.    || ||.||| |      |. ||.||.|| |  .  .||  ||||.|  |||||... .|||.|  . .  |. .||| .|| ||||.|| | |.|
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDF--FQEIYVVTELMQSDLHKIIVSPQHL

TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGE
. .||. ||||.||||||.|||...|||.|| ||||| || ||| |||.||   .   ...  ||. | | .|||||...  . ||.|.|.|||||||.|
SSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLAR---VWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAE

MLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----RQALSLLGRMLRFEPSARISAAAALRHPFL
.| || ||  .. ..|||.|. .|||||   ..    |  .| .   |...|   . .|  .        |  || ||| |.|. |||.  || ||.|
LLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYA-CEGAKAHMLRMPHKPPC-LQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase Erk5.AA S_TKc 55-347 28 1.4e-98 334.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-231/231
Sequence Identity: 28% (88 aa)

YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES---DLHQIIHSS
|||...|| ||.|.|  .| . ||..||||.|.         ....||..|||. .|.||. ..|. .        ...|.|.....    ||...|.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

QP------LTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQ-AID
..      ..  |.|...||....|.|.|| ..|||||||.|.|..|  ..||.|||.|| |           | .. |.||.|||..     |.  ..|
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCKCD

LWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALR-
 ||.|||. |||... .||      |.|... ..|                                     ...|.... ..|...|. |..|  ||. 
WWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------HPFL
      ||..
EWDIKCHPWF
Kinase Erk5.AA CDK 55-347 34 1.2e-97 313.02 In-house 1-284 (284) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-284/284
Sequence Identity: 34% (111 aa)

YEIIETIGNGAYGVVSSARRRLTG-----QQVAIKKIPNAFD----VVTNAKR-TLRELKILKHFKHDNIIAIKDILRPTVPYGEF-----KSVYVVLDL
||..| || |.||||  || ..||     | ||.|||    .      .     ..|| ..||.  |.||. ..|.     .  ..     ...| | . 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCE-----LKIGDFGMARGLCT---SPAEHQYFMTEYVATRWYRAPE
|. || ....         .. ...|||||| |.||  ..||||||.|.|.|.| |     |||.||| ||        . | .  .|  | |.||||||
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPE

LMLSLHEYT--QAIDLWSVGCIFGEMLA---RRQLFPGKNYVHQLQLIMMVLGTPS----PAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALS
| |   .|.   .||.|||||||.||.    |. ||||..  .|| .|  ..|||.    | | .  .                                
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------------D

LLGRMLRFEPSARISAAAALRHPFL
|| .|| ..|. |||| .|| ||..
LLNKMLCYDPKKRISAEQALQHPYF
Kinase Erk5.AA Pkinase 55-347 28 2.4e-89 307.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-293/293
Sequence Identity: 28% (88 aa)

YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLR--ELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-----DLHQI
|.|...|| |..|.|  .... ||..||.|.|.   .     .. .|  |..|.|...|.||. ..|. .        ...|.|....|      ||. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IH--SSQPL--TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCEL----KIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEY
|.  .. ..  . .... ..||.||||.|.||  .|||||||.|.|...|...    ||.||| |. .      ..  || .. |.||.|||. ..  .|
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

TQAIDLWSVGCIFGEMLARRQLFPGK----NYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSAR
....| ||.|||. ||| .| .|||.    | . |.|.| ...|.| .  ..    .. .  ..  . .     .|. . ... ..... ..|.. |. |
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKR

ISAAAALRHPFL
..|. .| ||..
PTAEQILQHPWF
Kinase Erk5.AA MAPK-Unclassified 55-205 50 3.7e-80 272.61 In-house 1-157 (575) Show / Hide 
Range on Protein: 55-205
Range on HMM: 1-157/575
Sequence Identity: 50% (80 aa)

YEIIETIGNGAYGVVSSARRRLT-GQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYG-EFKSVYVVLDLMES---DLHQIIH
|| .. || ||||.|  |    . .|||||||.. .|  .| .||.|||. || .  | |||.|.||...  . . ||. .|.| |.|..   ||||||.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SSQ-PLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR
| | ..  .|..||.||.||||||.||| .|||||||||||.|..| ..| ||||.|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase Erk5.AA MAPK-Unclassified 212-347 32 1.8e-56 193.93 In-house 399-575 (575) Show / Hide 
Range on Protein: 212-347
Range on HMM: 399-575/575
Sequence Identity: 32% (57 aa)

AEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLAR-----------RQLFPGKN--------------------YVHQLQLIMMVLGT
..| | ||.||.||||||||.|||.|||. ..|.||.||||.||. .           |.||||..                    .. |...|  .||.
CHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGM

PSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADR----------QALSLLGRMLRFEPSARISAAAALRHPFL
|   ... ..  ..| ||||. .  ||..   .. . .          ... ..  || | |. ||.| .|| ||. 
PPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk5.AA Pkinase_Tyr 55-205 29 6e-21 71.58 Pfam 1-159 (270) Show / Hide 
Range on Protein: 55-205
Range on HMM: 1-159/270
Sequence Identity: 29% (48 aa)

YEIIETIGNGAYGVVSSARRR----LTGQQVAIKKIPNAFDVVTN--AKRTLRELKILKHF-KHDNIIAIKDILR-PTVPYGEFKSVYVVLDLMES-DLH
 ......| ||.|.|  .. .     |...||.|.. .      .   .  .||.||.|.. .|.||.    .      |     ..|.|. .|.  ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDLL

QIIHS----SQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR
   ..     ||||...   . .|  .|. | .| . |||||   | ||.||   ||.|||.||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase Erk5.AA TyrKc 55-347 20 2.8e-15 24.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-347
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP-NAFDVVTNAKRTLRELKILKHF--KHDNIIAIKDILRPT--VPYGEF---KSVYVVLDLMES-DLH
 . ....|.||.|.|  .. .   .|||.|..  .|       .  .||..|....  .|.||...  . .         |   . ...|. .|.  ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLK

QIIHSSQP-LTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS---PAEHQYFMT-----EY--VATRWYRAPELML
. .....| |....  .| .|  .|  | || ..|||||   | ||.||   ||.|||..| .       ....| ..     .   .  ||. ||| . 
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-

SLHEYTQAIDLWSVGCIFGEMLAR-RQLFPG-----KNYVHQLQLIMMVLGTPSPAV---IQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLG
  ...| . | || |    |.. .  |  ||     ..  . .....     | |.    .                          ....     ..  
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMK

RMLRFEPSARISAAAALRHPFL
.  ...|. | . ..   | ..
QCWHEDPEDRPTFSEI--HECF