Gene CK1a (Human)

CK1a

Species: Human
Alias: CK1a, PRO2975, CSNK1A1, HLCDGP1, CK1, CKI-Alpha
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q33-q35,

Classification

Group: CK1
Family: CK1
Subfamily: CK1-A

Sequence

Name Sequence Type Origin Length Description Download
CK1a.NA RNA Sugen Kinome 3149 None Fasta, JSON
CK1a.AA Protein Sugen Kinome 365 None Fasta, JSON
CK1a.kin_dom Protein Kinase Domain Sugen Kinome 289 None Fasta, JSON

Protein domain

Protein domains of CK1a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CK1a.AA CK1 17-303 69 8.70000000001e-217 726.48 In-house 1-271 (271) Show / Hide 
Range on Protein: 17-303
Range on HMM: 1-271/271
Sequence Identity: 69% (209 aa)

YKLVRKIGSGSFGDIYLAINITNGEE--VAVKLESQKARHPQLLYESKLYKILQG------GVGIPHIRWYGQE--KDYNVLVMDLLGPSLEDLFNFCSR
|...||||.||||||||.||.|||||  ||.|||..|..||||.||.|.||||||      ..||||..|.|||  .|||..||||||||||||||||.|
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

RFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI-GRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYRE
.|..|||||.|||||.||||||.||||||||||||||||. |.||.                            |...|||||||.||| .|.|||||||
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCH----------------------------QVYIIDFGLAKRYRDDKTHQHIPYRE

DKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKG-FPAEFAMYLNYCRGLRFEEAPDYM
.|||||||||||||.||||||||||||||||||||||.| |||||||||.|||||||||.|||||||||.|||| ||.||||||||||.|.|||.||||
NKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase CK1a.AA CK1-A 17-305 79 5.9e-210 703.79 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-305
Range on HMM: 1-261/261
Sequence Identity: 79% (231 aa)

YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLML
|.|||||||||||||||.||||||||||.|.||.|||||||.||.|.|.||||.|||||.||||.||||||.||||||||||||||||.|||||||||||
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

ADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYA
|||||.||||||.||||||||||||||||||||||                            .||||||||||||||.|||||||||||||||||||||
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCN----------------------------KLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYA

SINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYL
||||||||||||||||||.|||.|||||..|||||.||.|||||||||||||||||.|.|||||||||.||.||||.|||||.||||||
SINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase CK1a.AA CK1-Unclassified 17-277 59 1.6e-196 585.5 In-house 1-244 (244) Show / Hide 
Range on Protein: 17-277
Range on HMM: 1-244/244
Sequence Identity: 59% (161 aa)

YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGV-------GIPHIRWYGQE--KDYNVLVMDLLGPSLEDLFNFCSRR
|....|||.||||.||..||. ..||||.|||. ...||||.|| |....||.|        |||.. |.|||   |||..||||||||||||||.| |.
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDN-RTRQHIPYRED
|..|||||.|||||.||||.| ||||||||||||||||                            .    .|...|||||.|.|.|  .| .||||||.
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGK---------------------------LGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYREN

KNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC
|||||||||||||||||||||||||.|||||||.|| . |||||..|| .||.||||| |.||||||| ||
KNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase CK1a.AA CK1-G 17-305 52 2.5e-150 505.73 In-house 1-266 (266) Show / Hide 
Range on Protein: 17-305
Range on HMM: 1-266/266
Sequence Identity: 52% (152 aa)

YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGV-GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLM
|.  .||| |.|| ...  |. |.| ||.|.|  | | |||  | . |||| | . |||.. ..||.  ||..|||||||||||||..| |.|..|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

LADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARY
.| |||.|.||||... | ||.|||||| |                           ||    . ...||||.||.|.| .|.||||||| | |||||||
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGR--------------------------PSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARY

ASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKG--FPAEFAMYLNYCRGLRFEEAPDYMYL
 ||| ||| |||||||||.|| . ||| | ||||||||| . |..|.|| ..| .|..|.||..  || .|| || | | | |.| ||| ||
MSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase CK1a.AA CK1 17-305 38 2.7e-144 485.66 In-house 1-339 (339) Show / Hide 
Range on Protein: 17-305
Range on HMM: 1-339/339
Sequence Identity: 38% (140 aa)

YKLVRKIGSGSFG-DIYLA-----INITNG-----EEVAVKLESQKAR--HPQLLYESKLYKILQGG-------------------VGIPHIRWYGQEKD
.|.|.|||.|.|| .||..     ....|.     ||.|.|.|. |..  ||||..|...||.||||                   ...|...||..|.|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--YNVLVMDLLGPSLEDLFN---FCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI------GRHCNKCLESPVGKRKRSMTVSTSQDP
  ||..||.||||.||||..   .| |.|.|||.||.|.||....||.| ..|||||||||||.||.      |.| .                    ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-H--------------------HE

SFSGLNQLFLIDFGLAK-KYRDN-----------RTRQHIPYRE---DKNLTG-TARYASINAHLGIEQSRRDDMESLGYVLMYFNRTS--LPWQGLKAA
. . ..|...||||.|. ||||.           .| ||.|.||    |...| ||||.|||.|||.||.||||..|..|.|..... .  ||||..|. 
WNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDE

TK-------KQKYEKISEKKMSTPVEVLCKG-----FPAEFAMYLNYCRGLRFEEAPDYMYL
.|       |.|||.|.|||||||.. ||..     .| || ....|.|.|.....|||...
MKPKDHQVEKMKYEFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase CK1a.AA CK1-D 17-151 72 6.1e-92 311.75 In-house 1-135 (261) Show / Hide 
Range on Protein: 17-151
Range on HMM: 1-135/261
Sequence Identity: 72% (98 aa)

YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLML
|.. ||||||||||||.  ||...||||.|||. |..|||| .|||.||..|||.|||.|||.||| ||||.||||||||||||||.|.|.| .||||||
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

ADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCN
|||||.||||.|..|||||||||||||||.|.. |
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGN
Kinase CK1a.AA CK1-D 179-305 76 7.4e-87 294.87 In-house 135-261 (261) Show / Hide 
Range on Protein: 179-305
Range on HMM: 135-261/261
Sequence Identity: 76% (97 aa)

NQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCK
|  ..|||||||.||| ||.|||||||.||||||||||||| |.|||||||||.|||||||||||| ||||||||||||.||||.|.||||||....|||
NMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCK

GFPAEFAMYLNYCRGLRFEEAPDYMYL
|.| ||. |.|||| |.|.. |||.||
GYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase CK1a.AA Pkinase 17-264 21 1.5e-36 130.27 Pfam 1-230 (293) Show / Hide 
Range on Protein: 17-264
Range on HMM: 1-230/293
Sequence Identity: 21% (58 aa)

YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLY------ESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFC------
|...|||||||||  |..... .|..||||  . . .... ..      | .. | |.    .  ..|.   ||.  .||....  |. ..  .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTW

-SRRF--TMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHI
 ...|  ..... . . |... .|| | ...||||.||.|.|.    |..                             . ..||||||...      . 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---------------------------CVKICDFGLAKQFD------Y-

PYREDKNLTGTARYASINAHL-GIEQSRRDDMESLGYVLMYFNRTSLPWQGL----KAATKKQKYEKI
...  . ..|| .|..   .. | . ... || |.| .| ..    .|..|     . ....|....|
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI
Kinase CK1a.AA Worm6 17-142 31 1.4e-29 103.35 In-house 1-135 (279) Show / Hide 
Range on Protein: 17-142
Range on HMM: 1-135/279
Sequence Identity: 31% (43 aa)

YKLVRKIGSGSFGDIYLAINITNGE--EVAVKLES--QKARHPQLLYESKLYKIL--QGGVGIPHIRWYGQEKD--YNVLVMDLLGPSLEDLFNFC-SRR
.|...|||.|.||..|.. . ....  ..|.|.|.   .. ...|  |    | .  ... . . |  .|. .   .| .|| |.|..|.||  ..  |.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNF
|.| | | .| |.. .|| .|   |||||.|| ||
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNF
Kinase CK1a.AA TTBKL 17-153 31 1.2e-28 93.93 In-house 1-145 (288) Show / Hide 
Range on Protein: 17-153
Range on HMM: 1-145/288
Sequence Identity: 31% (45 aa)

YKLVRKIGSGSFGDIYLAINITN-GEEVAVKLESQK-ARHPQLL-YESKLYKILQ--GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLF--NFCSRRFT
.. |..||.| || .|....... ... |.| |... .. .. .  | .. . ||  |   .|.. ..|..|||| .|| |.||.| ||   . . .||.
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

MKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRH-CNKC
  |.. .. | .  . ..| . |||||.|| |. .|.  | | .|
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERC
Kinase CK1a.AA TTBKL 181-309 27 4.4e-27 88.53 In-house 148-288 (288) Show / Hide 
Range on Protein: 181-309
Range on HMM: 148-288/288
Sequence Identity: 27% (40 aa)

LFLIDFGLAKKYRDNRTRQ----------HIPYRE---DKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEK
..|||||.|..|...   .          . . |.      . || ||.|.|.|.. ||.| ||. |. |......   |||.... .      ..| ..
VYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDK------MEIEHM

KMSTPVEVLCKG------FPAEFAMYLNYCRGLRFEEAPDYMYLRQLF
|...  |.|.|.      .| ||..   . | ||. . |||......|
KKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase CK1a.AA TTBK 17-145 40 1.3e-26 91.04 In-house 1-131 (257) Show / Hide 
Range on Protein: 17-145
Range on HMM: 1-131/257
Sequence Identity: 40% (53 aa)

YKLVRKIGSGSFGDIYLAINITNG-EEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR-RFTMKTVL
 | |.||| | || || | .. |  |.||.|.|| ..    |  |    | |||   .      | . ..| .||.|.| .| ||    .|  |.. | |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

MLADQMISRIEYVHTKNFIHRDIKPDNFLMG
 |  |..  || .|   | |||||| || ||
RLGVQILQSIESIHSVGFLHRDIKPSNFAMG
Kinase CK1a.AA Worm6 178-305 24 5.9e-25 86.63 In-house 148-279 (279) Show / Hide 
Range on Protein: 178-305
Range on HMM: 148-279/279
Sequence Identity: 24% (32 aa)

LNQLFLIDFGLAK-KYRDNRTRQHIPYR-EDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQ-KYEKISEKKMSTPVE
. .....|||... |. .|.  . .. | ..    || |||....| |.||.|.||.||  |..  . .  |||...|.   ..  ....  .. ..  .
HHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMR

VLCKGFPA-EFAMYLNYCRGLRFEEAPDYMYL
 . ...|. ||   . |  .......||| ..
MFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase CK1a.AA TTBK 179-305 35 3.1e-20 68.24 In-house 138-257 (257) Show / Hide 
Range on Protein: 179-305
Range on HMM: 138-257/257
Sequence Identity: 35% (45 aa)

NQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCK
.. ...||||| .|  | . .  | ||     ||.||||||||.  |  |.||. || |.|  |    |||  .|        ... | |      .| |
RKCYMLDFGLARQYT-NACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKIKDK------DQVGEMKEKYDHRMLLK

GFPAEFAMYLNYCRGLRFEEAPDYMYL
  | || ....  . | .|. |||  .
HCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase CK1a.AA S_TKc 17-311 18 1.3e-13 22.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-311
Range on HMM: 1-231/231
Sequence Identity: 18% (58 aa)

YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRR--------F
|...||||.|.||  |.....  |..||.|  .      ... | .. |   .   | ..  . |. |.  .||.... .| ||| .  .|        |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKN
.  ..  .. |... .|| | ...||||.||.| |.                                   .. ..|||||...              . 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------------------HIKICDFGLARQL--------------TT

LTGTARYASINAHLGIEQSR-RDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEA--PDYMYL
. ||  | .         .. . |. |.| .|  .     |..     . .. ..||                . |.   .. |  |... .  |    .
FCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKC--LQKDPEKRPTA-EA

RQ-------LFRI
 |          .
LQDEWDIKCHPWF
Kinase CK1a.AA VRK 174-258 35 1e-12 37.5 In-house 164-251 (284) Show / Hide 
Range on Protein: 174-258
Range on HMM: 164-251/284
Sequence Identity: 35% (32 aa)

SF-SGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLT--GTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKA--ATKK
.|  . .| .|.|.||| .| .|    | .| ||.     ||  . |. ||.|   ||| | |.||| .|.    .|||  ..    ..|
GFEKNPDQVYLVDYGLAYRYCPN--GKHRQYKEDPRRCHNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEK
Kinase CK1a.AA VRK 88-145 40 6e-11 31.74 In-house 106-164 (284) Show / Hide 
Range on Protein: 88-145
Range on HMM: 106-164/284
Sequence Identity: 40% (24 aa)

LVMDLLGPSLEDLFN-FCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMG
.||. .| .|. .    .  ||.||||| || .|.   || | ..  | |||  | | |
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLG
Kinase CK1a.AA TyrKc 17-303 17 3.2e-05 -138.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-303
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)

YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKIL---------QGGVGIPHIRWYGQEKDYNVLVMDLLGP-SLEDLFNFCSR
 .| .|.|.| || .|... .   ..||||     | .  .. | .. . |           || . . |    . .   .|| .    .| |    . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHRP

RFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDN---RTRQHIPY
...||. |  . |  .  || | ||.||||.   | | | ..                               .    ||||...  |        .  |
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------------------------TVKISDFGLSRDIYDDDQQG-ESKDYY

REDK--NLT--GTARYASINAHLGIEQSRRDDMESL-GY------------VLMY--FNRTSLPWQGLKA--ATKKQKYEKISEKKMSTPVEVLCKG---
|  .  .       |  ..              |..  .            |.|.  | .   |. |      . .. .|.. . ..  . .  .     
RKKEHKGGKTMLPIRWMAP--------------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSF

--FPAEFAMYLNYC------RGLRFEEAPDYM
   |.|  .    |         .|.|  ...
VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CK1a.AA Pkinase_Tyr 17-46 29 4.7e-05 17.74 Pfam 1-34 (270) Show / Hide 
Range on Protein: 17-46
Range on HMM: 1-34/270
Sequence Identity: 29% (10 aa)

YKLVRKIGSGSFGDIYLAINI----TNGEEVAVK
 .. .|.|.|.||..|...       .. .||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase CK1a.AA VRK 17-34 55 0.000341 9.82 In-house 1-18 (284) Show / Hide 
Range on Protein: 17-34
Range on HMM: 1-18/284
Sequence Identity: 55% (10 aa)

YKLVRKIGSGSFGDIYLA
..| ..||.| || ||||
WRLGKPIGQGGFGCIYLA
Kinase CK1a.AA Pkinase_Tyr 125-137 61 3.47862 1.25 Pfam 125-137 (270) Show / Hide 
Range on Protein: 125-137
Range on HMM: 125-137/270
Sequence Identity: 61% (8 aa)

EYVHTKNFIHRDI
|| . ||.||||.
EYLESKNCIHRDL