Gene CDK5 (Human)

CDK5

Species: Human
Alias: PSSALRE, NCLK, CDK5
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7q36.1,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK5

Sequence

Name Sequence Type Origin Length Description Download
CDK5.NA RNA Sugen Kinome 1211 None Fasta, JSON
CDK5.AA Protein Sugen Kinome 292 None Fasta, JSON
CDK5.kin_dom Protein Kinase Domain Sugen Kinome 283 None Fasta, JSON

Protein domain

Protein domains of CDK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK5.AA CDK5 4-286 79 5.5e-248 792.54 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 79% (228 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIV
|||.|||||||||||.||.|.||||||||||||||..||||||.|.||||||||||||||||||||.||.|||||||||||||||||.|||||..|..|.
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLF
|||..||||||.|||...||||||||||||||.|||||||||||||||||||||||.|||||||||||||.|.|.|||||||||.||||||.||||||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK----PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
|||||.|||||||...|||.|..|||.|||||||    .||||||..|....||||...|.||||..|.||| |||||..||.||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK5.AA CDK 4-286 50 7.89999999999e-192 619.21 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-284/284
Sequence Identity: 50% (162 aa)

YEKLEKIGEGTYGTVFKAKNRETH-----EIVALKRVRLDD-----DDEGVPSSALREICLLKELKHKNIVRLHDVLHSD-----------KKLTLVFEF
|||||||||||||.|.||....|.     .|||||..|..      ..||.|..|.|||.||||| |.|||.|||| |..           .||..|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGE-----LKLADFGLARAFGI------PVRCYSAEVVTLWYRPPD
.|.||||| |          .|....|||.|| .|||....||||||||.|||.|||     ||.|||||||||||      |.|.|. ||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLFGAKLYS--TSIDMWSAGCIFAELAN--AGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLL
.|.|.| ||  |.|||||.||||||...  ...|||||.   |||..|||..|||||..||..||||||                        |||...|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKML

KCNPVQRISAEEALQHPYF
 ..| .|||||.|||||||
CYDPKKRISAEQALQHPYF
Kinase CDK5.AA CDC2 4-286 54 9.69999999999e-180 557.6 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-301/301
Sequence Identity: 54% (166 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEG--VPSSALREICLLKELK-HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFD---SCNGD
|.|.||||||||| |.|.|...|..|||||..||. .|||  |||.|.|||..||||| |.|||.||||.|. .|| .|||..|.||||| |   . |  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS--AEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL
..|..|||...|.|.|. |||.| ..||||||||.||...|..|.||||||||||||.| |    ||||||||.| .|.|.| |||..|||| ||||||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

-AN-AGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP-YPMYPATTSLVNVVPK---------LNATGRDLLQNLLKCNPVQRISAEEALQH
  .   .|||.|    ||| .||| ||||.|. ||..|.|||||. .|.....  | ...|.         |. .|.|||...|  .| .||||.|||||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQ-DLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PYF
|||
PYF
Kinase CDK5.AA CMGC 4-286 28 1.8e-153 508.28 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 28% (145 aa)

YEKLEKIGEGTYGTVFKAKN--------------RETHEIVALKRVRLDDDDE----------GVPSSALREICLLKELK-----------------HKN
||...||||||||.|.|...              .|| ||||.|.....  .|          |.|..||||| .||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLHDVLHSDK-----------------KLTLVFEFCDQDLKKYFDSCNG--------DLDPEI------------VKSFL------FQLLKGLG--FC
||.|.|......                 .| ||||..|.||..| .....         |..              .|.|.      .|.|.||   .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSRN--VLHRDLKPQNLLINRNGEL--------------------KLADFGLARAFGIP---------------------VRCYSAEVVTLWYRPPDVLF
||..  ..||||||.|.||| |.||                    |..||||||.....                     .| |. .|||.|||.| .|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GAKLYS---------TSIDMWSAGCIFAELANA-------GRPLFPGNDV-----------DDQLKRIFRLLGTPT---------------EEQWPSMTK
|.| |.         |.|||||.||||||. .        |.|||||..             |||..||..|||||               ||.||.|.|
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LPDYKP---------------------------YPMYPAT--TSLVNVVPK--------------------------------LNATGRDLLQNLLKCNP
||.|..                           .|..|    ..|.   |.                                ..  ..|||...|...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

VQRISAEEALQHPYF
 .||.||.|||||||
DKRITAEQALQHPYF
Kinase CDK5.AA PFTAIRE 4-286 53 2.3e-152 512.47 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 53% (156 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIV
|||||| |||.| ||.|.. . .  .|||| .|| ...||.|  | ||  |||.||| ||| |||. | .. ||.|||. . ||..| |...| ..|. |
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRL-QQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLF
. |||||| || .|| | |||||||||||||   |||||||||||||  .| . || ||||||||||||| |.  |||..||| .|||| |.  .|.|.|
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMM-WGQPAF

PGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY---PATTSLVNVVPKLN--ATGRDLLQNLLKCNPVQRISAEEALQHPYF
||  |. ||| .||..||||||. ||  ..|| |||. .    .   .| ...|..   . . ||....|.|.| .|.||.||.|||||
PGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK5.AA PCTAIRE 4-286 54 8.99999999999e-151 507.19 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-291/291
Sequence Identity: 54% (161 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIV
| ||.| ||||| ||.| . . |  .|||| .|| . .|| |  | ||. |||.||| ||| |||..| .. ||||||. |.|||.| | |   ..   |
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRL-EHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNV

KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLF
| |||||| || .|| | .|||||||||||||  |||||||||||||  .| . || ||||||||||||| |   |||.||||  ||||.|.. .|||||
KLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMC-TGRPLF

PGND------VDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY--PMYPATTSLVNVVPKLN---ATGRDLLQNLLKCNPVQRISAEEALQHPYF
||        | |||  |||.||||.|..||  . ......|  | |..  .|.|. |.|     .. |||..||.  . .|.|||.|..||||
PGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYRE-QPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase CDK5.AA CDK7 4-286 43 2.5e-140 376.63 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-288/288
Sequence Identity: 43% (125 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR----LDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD
|||...||||...||.||   .| .||| |...     .. . |.  .|.||| .|.|..| |.. | |..     . |||.| | ||          | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAG
|  .|..  ..|.|| .||   .||||||| |||.| ||.||.|||||||..| | | |.  ||| ||| |  ||||. | |..|||| |||||||    
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM-LR

RPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
 | .||    |||.|||. |||||||.|| |....||     .|.   | | ..         ||.. ..  ||..|... ..|..|||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK5.AA PITSLRE 4-286 42 4.6e-114 385.25 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-295/295
Sequence Identity: 42% (127 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD--DDDEGVPSSALREIC-LLKELKHKNIVRLHDVL--HSDKKLTLVFEFCDQDLKKYFDSCN---
...| .|.||||| |..||...| |||||||. ..   . || |  .||||  .|..|.| ||| .  ..      |  .|.|. . |||   .  .   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL
    |  .|... |||.|  . |.  ..|||||  |||.. .| ||..|||||| .| |.. |.  ||||||| | .| |.|.||| .|||| ||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP---MYPATTSLVNVVP---KLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
   ..|||.|.   ||...|| ..|||||  ||  |.||  |       ||    | . .|   ... || |||. .|  || .||.|..||.||.|
I-TMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK5.AA CDK4 4-286 44 3.4e-106 359.12 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-290/290
Sequence Identity: 44% (130 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE--GVPSSALREICLLKELK---HKNIVRLHDV---LHSDK---KLTLVFEFCDQDLKKYFD
|...  |||| ||||..|   .|  .||||.||    .|  |.| | .||| ... |.   | |||.| ||   .  |    |.|.||| ||.||. | |
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SCNG-DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCI
 |    . |. .|   .||| |. | ||  . ||||||||.|....|..||||||||| ..      .  ||||||| | ||  .  | | .||||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

FAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
|||. .  ||||.|.   ||| .|| . |.|.|..||.   ||    .| . . ...  ..| .   | ||||  |  |.  |.||...||||||
FAEMYCR-RPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP-WDHFPQRHP-RPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK5.AA Pkinase 4-286 32 6.8e-104 356.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR--EICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC-------
|....|||.|..|.|.|.... | .|||.|............ ...|  ||...|.|.|.|||||.|. ...... .|.|.|. .|.  .| .       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

NGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL----KLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWS
.| .  ... .|... |.|.|| .|||....||||||.|.||..||..    |..|||||. |   . . ..  ..|.||..| |. |.. |....||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGCIFAELANAGRPLFPGN----DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH
.|||..|... |||.|||     . .||...|.| .|.|....||     ....  .  . .. .  . .... ...|.. ..|. .| .|..||..|||
CGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PYF
|.|
PWF
Kinase CDK5.AA S_TKc 4-286 29 2.4e-103 350.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 29% (88 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ---DLKKYFDSCNGD---
||.|.|||.|..|.|.|.....|..|||.|...          ...||| .||. .|.|||.|.|| .. ..| .|.|.||.   ||..| .....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST-SIDMWSAGCIFAE
  ...  ..... |....| .|||....||||||.|.|...  ..|..|||||| .       .  ..|.||..| ||     |.. ..|.|| |||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ-------HPYF
..  |.|.||      |....|...|                                      ..|.....|. .| .|..| ||||       ||.|
MLC-GYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK5.AA CRK7 4-286 36 1e-101 344.23 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-343/343
Sequence Identity: 36% (127 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD---DEGVPSSALREICLLKELKHKNIVRLHDVLHSD------KKLT----LVFEFCDQDLKKY
||... ||||||| | |||| .| |.||||.||.|..    || |  | ||| .|..|.|.|||.|...  ..      ||      .|||  | ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

FDSC-NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV--RCYSAEVVTLWYRPPDVLFGAKLY--------
 .|    .  .. .|.|. ||| |.  || .|.||||.|  |.|.| .||.|.||||||| .      | |   |.|||||||  | |.. |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP---DYKPYPMYPATT
                               ..||||| |||..||.. ..|.|.||   .||  |... |.|. . ||  .|||   . ||  .|  ..
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFT-KKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQY--NR

SLVNVVP------KLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
 |.. .        . .   ||| ..|  .|  |..|||.|||..|
RLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK5.AA Pkinase_Tyr 4-150 29 6.1e-21 71.55 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-150
Range on HMM: 1-160/270
Sequence Identity: 29% (47 aa)

YEKLEKIGEGTYGTVFKAKNR----ETHEIVALKRVRLDDDDEGV--PSSALREICLLKEL-KHKNIVRLHDVLH-SDKK--LTLVFEFCDQ-DLKKYFD
 ....|.||| .|.|.|.. .    .|.  || | .  .. ..      . .||. ..|.| .|.|||||. |    ..   . .|.|..   ||..|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SC---NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARA
.    .. |...   .. .|  ||. . .|.|  ||||   | |...|.  | .||||||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDK5.AA TyrKc 4-286 22 4.9e-14 4.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 22% (75 aa)

YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL--KHKNIVRLHDVLHSD-------KKLTLVFEFCDQ-DLKKYFDS
 ....|.||| .|.|.|.. .   . || | .. |          .||. ....|  .|.|||||. |  ..       . | .|.|...  |||.|  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--------------------G---IPVRCYSAEVVTLWYRPP
. ..| ..   || .|  .|  . ||.|. ||||   | |...|.  | .||||.|.                     |   .|.| .. |.        
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------

DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG--------NDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDL
      . ..|  | || |    |.   | .  ||         .|  ..|. .|.   |  .  | |                           .  | 
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS-----------------------F-VCCPDE

LQNLLKC----NPVQRISAEEALQHPYF
. .. |.    .| .| . .|   | .|
MYQIMKQCWHEDPEDRPTFSEI--HECF