Gene CDC2 (Human)

CDC2

Species: Human
Alias: DKFZp686L20222, CDC28A, MGC111195, CDK1, p34cdc2, CDC2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 10q21-21.2,

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
CDC2.NA RNA Sugen Kinome 1923 None Fasta, JSON
CDC2.AA Protein Sugen Kinome 297 None Fasta, JSON
CDC2.kin_dom Protein Kinase Domain Sugen Kinome 284 None Fasta, JSON

Protein domain

Protein domains of CDC2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2.AA CDC2 4-287 68 4.1e-236 734.02 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-301/301
Sequence Identity: 68% (206 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG--VPSTAIREISLLKELR-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQY
|.|||||||||||||||.... |.|.||.||||||.|.||  ||||||||||.||||. |||||.|.||..| ..||..||.|.||||||.| |||....
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT--HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL
|...|||||.||||||. |||.||..||||||||.|||.||.||.||||||||||||||.||  |||||||||.||.|||. |||||||.|||| ||||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKN---------LDENGLDLLSKMLIYDPAKRISGKMALNHP
   .||||||||||||||||.||| |||||.. ||.|..|.|||||||.|||  | ....|         ||..|.|||..||.|||.|||| |.||.||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase CDC2.AA CDK 4-287 52 1.6e-189 611.74 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-284/284
Sequence Identity: 52% (168 aa)

YTKIEKIGEGTYGVVYKGRHKTTG-----QVVAMKKIRLES-----EEEGVPSTAIREISLLKELRHPNIVSLQDVLMQD-----------SRLYLIFEF
| |.|||||||||||||.|.| ||     |.||.||||.|.     |.||.|.|||||||||||| |||||.| || ...           ..||..||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT-----IKLADFGLARAFGI------PIRVYTHEVVTLWYRS
. .|||||.|            .|.|..|.|.|. .|||....||||||||.||...|.     .|.|||||||||||      |.|.|||||||||||.
MDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRA

PEVLLGSARYS--TPVDIWSIGTIFAELAT---KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSK
||.|||| .||  ||.|.||.| ||||..|   .||||.|||||||||.||| .|||. ..||.|..|.||                        |||.|
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNK

MLIYDPAKRISGKMALNHPYF
|| |||.|||| . ||.||||
MLCYDPKKRISAEQALQHPYF
Kinase CDC2.AA CDK5 4-287 58 1.3e-181 579.1 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 58% (168 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSS
| |.|||||||||.|||.| |.|. .||.|..||.|| |||||||||||.|||||.|.||| | ||.  . .| |.|||.  |||||.||.    .||  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG--EMDMH

LVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELA-TKKP
..||..|| |.|. |||...|||||||||||||  .|. ||||||||||||||.| |.||||||||| | ||.||  |||..|.||.| ||||.| . .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK---NTFPKWKPGS-LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
|| | .. |||.|||. .|||. . || .  | |||   . .|.. .   ....|..|||.|.|||.|||...|..||| | ||.||||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDC2.AA CMGC 4-287 28 2e-154 511.54 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-513/513
Sequence Identity: 28% (144 aa)

YTKIEKIGEGTYGVVYKGRH--------------KTTGQVVAMKKIRLES---------EEEGVPSTAIREISLLKELR-----------------HPNI
|..|.||||||||||||.|.              . |...||.|||...          |..|.|..|.|||..||.|.                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VSLQDVLMQDS-----------------RLYLIFEFLSMDLKKYLDSIPP------GQYMDSSL------------VKSYL------YQILQGIV--FCH
|.|.|... .                   |||.||.. .||..|... ..      .....               .|...      ||||.|.   .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SRR--VLHRDLKPQNLLIDDK--------------------GTIKLADFGLARAFGIP---------------------IRVYTHEVVTLWYRSPEVLLG
|..  ..||||||.|.||...                    |..|..||||||.....                      | |||.|||.|||.||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SARYS---------TPVDIWSIGTIFAELATK--------KPLFHGDSE-----------IDQLFRIFRALGTPN---------------NEVWPEVESL
. .|.         ||.|.||.| ||||. |.        ||||.|.||           |||||.||. ||||.                | ||.. .|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

QDYKN--------------T------------FPKWKPGSLASHVKN-----------------------------------LDENGLDLLSKMLIYDPA
..|..              .            ||.|.| .. . ...                                   .|. ..|||.|||.|||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISGKMALNHPYF
|||. . ||.||||
KRITAEQALQHPYF
Kinase CDC2.AA CDK7 4-287 44 5.4e-148 397.44 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-288/288
Sequence Identity: 44% (129 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR-LESEEE---GVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYL--DSIPPG
|.||..||||....|||.. . |||.|| |||. | . .|   |.  |||||| .|.|..|.|.. | |..|. | ..|.|.|.  ||       ||   
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSI---

QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL
  .  . .|.|  ..|||. .||   .||||||| |||..  | .|.|||||||..| | |.||| ||| |||.|| | |   | | ||.||.| |||||
-ILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL

ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
    | . |||.|||| |||..||||. | ||.. ...|| ..| .. .     |        .  |||...|.  .| ||..   .|..|||
MLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY-IKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC2.AA PCTAIRE 4-287 50 8.20000000001e-139 467.46 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-291/291
Sequence Identity: 50% (147 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSS
|.|..| |||||  |||.| | |. .||.| ||||  ||| | |||||.||||.|.| |||.| |.. ..  | |.||.. ||||.|.|    |. |.. 
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDC--GNIMNMH

LVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPL
 || .|.|.| |  .|| |..||||||||||||. .|  ||||||||||  .| ..| |||||||||.|.||.||  |||..|.| .| ||.|..| .||
NVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPL

FHGDS------EIDQLFRIFRALGTPNNEVWPEVESLQDYKN-TFPKWKPGSLASHVKNLD---ENGLDLLSKMLIYDPAKRISGKMALNHPYF
| |          |||  ||| |||| .. ||.|.|......  ||.... .| .|   ||   ... |||...| | . .|.|   |..||||
FPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase CDC2.AA PITSLRE 4-287 43 3.2e-128 432.26 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-295/295
Sequence Identity: 43% (127 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREIS-LLKELRHPNIVSLQDVLM--QDSRLYLIFEFLSMDLKKYLDSIP-PG
. .. .|.||||||||... | |. .||.|.. .|   | || | |..|||. .|..|.|||||..  ..|       |...|..  |||  .. .    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL
|    . .|. . | | |. . |.  ..|||||  |||.  ||  |..|||||| .| ||. ||  |||||||.||.|||.  ||||||.||.| ||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN-T-FPKWKPGSLASHVK---NLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
 |.|||| |.|||||. .|| ..|||.   || . .|   |. . ||. ... | ....    . ..|.||| .|| |.|..||.   || ||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDC2.AA PFTAIRE 4-287 48 1.9e-123 416.4 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 48% (142 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSS
| |.|| |||.|  ||||. . ..|.||.| |||. .|||.| ||||| ||||.|.| ||| | |.   .  | ..||..  ||..|.|. | |  |.  
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGG--MHPN

LVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPL
 |. .|.| | |  .|| ||||||||||||||| ..|  ||||||||||  .| . | ||||||||| | |||||  ||| .|.| .| || |. . .|.
NVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPA

FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK---WKPGSLASHVKNLD--ENGLDLLSKMLIYDPAKRISGKMALNHPYF
| |     ||| .||. ||||. . || | .|  ||    .    || .|   .  ..   .. ||..||| . | .|.| . |. ||||
FPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDC2.AA Pkinase 4-287 35 4.8e-113 386.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-293/293
Sequence Identity: 35% (106 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR--EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-----DLKKYLDSIPP
|....|||.|..|.|||..|| ||..||.|.|....|..... |..|  ||...|.|.||||| | |. . ....|...|.. .     ||. |.     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

GQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI----KLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWS
.  .  .   .|.|.||||.|. .|||....||||||.|.|||..|.|    |..|||||. |   . . .|. ..|.||..|||..|.  |...||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGTIFAELATKKPLFHGD----SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHP
.| |..|.....|.| |.    . .||...|.| .|.|. . ||.  |  ... ... | .  .    .|..|...|.....| .||.||.. . .|.||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase CDC2.AA CDK4 4-287 45 2e-107 363.18 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-290/290
Sequence Identity: 45% (136 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE--GVPSTAIREISLLKELR---HPNIVSLQDV--LMQDSR----LYLIFEFLSMDLKKYLD
| ..  |||| || ||. |   ||. || |..|  ..||  |.|   |||||... |    |||||.| ||   |   |    . ..||    ||. |||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SIPP-GQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIG
 .|| |  |    .|    |.| |. | || |. ||||||||.|.   |..||||||||| ..      |  |||||||.||||| |  | ||||.||.|
KCPPPG--MPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMAL-TPVVVTLWYRAPEVLLQSY-YNTPVDMWSVG

TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
 ||||.   .||| | || ||| .||   |.|  . ||   ||      ||  .| .. . .  ... |.||| ||| |...||.|   .|.||||
CIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDC2.AA S_TKc 4-287 31 2.8e-107 363.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-231/231
Sequence Identity: 31% (93 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM---DLKKYLDSIPPG---
|....|||.|..|.|||.||| ||..||.|.|.          ...|||..||. .||||| | ||    ..||...|...    ||..|... ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST-PVDIWSIGTIFAE
....   ...|.|||.... .|||....||||||.|.|.|.  .||..|||||| .       |. ..|.||..||||     |.. ..|.||.| |..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN-------HPYF
... .|.|.      |....|. .|                                   .. ..|...|.| .||.||..   ||.       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2.AA CRK7 4-287 35 6.30000000001e-106 358.21 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-343/343
Sequence Identity: 35% (124 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE---EEGVPSTAIREISLLKELRHPNIVSLQDVLMQ--------DSR--LYLIFEFLSMDLKKY
| .|. ||||||| ||| . | ||. || ||.|.. |   .|| | |||||| .|..| |.||| | ..           . .   |..||    ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDSIPPG--QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI--RVYTHEVVTLWYRSPEVLLGSARY-----
|.|   .  ..   . .|... |.| |.  || . .||||.|  |.|.. .| .|.||||||| .      | ||  |.||||| || |||  ||     
LES---KEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKW--KP
                                  . .|.|| | |..||.||||.| |  |..||  |..  |.|| ..||||  |. ..   ||   . 
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNR

GSLASHV---K--NLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
 ..   .   |  ....  |||| ||| .|| ||.. . .|.|..|
RLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDC2.AA Pkinase_Tyr 4-152 32 3e-26 89.54 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-152
Range on HMM: 1-160/270
Sequence Identity: 32% (53 aa)

YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGVPSTA------IREISLLKEL-RHPNIVSLQDVLM-QDSR--LYLIFEFLSM-DLK
 |...|.||| .|.||||. |     |.. || |...     ||  . .      .||....|.| .|||||.|  | . |.    .|...|.    ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYLDSI-PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARA
.|| .  ...|  . .   .. .|| .|  . .|..  ||||   | |.......| .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDC2.AA TyrKc 4-234 23 5.9e-15 19.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-234
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL--RHPNIVSLQDVLMQD-------SRLYLIFEFLSM-DLKKYL-D
 |...|.||| .|.||||. |   . || |... ..         .||......|  .||||| |  | .|.         |....|. .  |||.|| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--------VYT-----HEV--VTLWYRSPEVLLG
. |       .   |. .|| .|  . ||... ||||   | |.....|.| .||||.|.  |           .|.     ..   . .   .||..  
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

SARYSTPVDIWSIGT----IFAELATKKPL----FHGDSEIDQLFRIFRALGTPNN------------------EVWPE-----------VESL
  ...|  |.|| |     ||   ..  |     .  ..|. .. .  . .  | |                  . | |           .| .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF