Gene AurB (Human)

AurB

Species: Human
Alias: AURKB, AIRK2(AIM1, AIM-1, AIK2, AIM1, STK12, IPL1, STK5, AurB, ARK2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 17p13,

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
AurB.NA RNA Sugen Kinome 1253 None Fasta, JSON
AurB.AA Protein Sugen Kinome 344 None Fasta, JSON
AurB.kin_dom Protein Kinase Domain Sugen Kinome 251 None Fasta, JSON

Protein domain

Protein domains of AurB.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AurB.AA Aur 77-327 65 1.1e-241 646.07 In-house 1-257 (257) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-257/257
Sequence Identity: 65% (168 aa)

FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKS--CTFDE
||||.||||||||||||||.||.|||.||||.||.||.|...||||||||.|| || |||||..|.||.|  ||||||||||.|||||||||.    |||
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

QRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSVHAP-SLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPP
||.|..| ....|| ||| |..|||||||||.||. ..|..||.|||||||.| . ||.|.||||||.||||.||.||..|||.||.|||||||..| ||
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FES-ASHNETYRRIV-KVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
|||  .|.|||.||  |||..|| ... .|.|||||.|.|.|..|..|.|. .|||.
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase AurB.AA AGC 77-327 24 6e-101 261.13 In-house 1-395 (395) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-395/395
Sequence Identity: 24% (98 aa)

FEIGRPLGKGKFGNVYLAREKKSH------FIVALKVLFKSQ---IEKEGVEHQLRRE------------IEIQAHLH----------HPNILR-LYNYF
||. ...||| || |||.|.|...       . |.||| |.    | |.  ...  .|             .| ....          ||.| . |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

YDRRR--IYLILEYAP---------RG-ELYKELQ---KSCTFDEQRTATIMEE-------LADALMYCHG-KKVIHRD-IKPENLLLGLKGELKIADFG
 | ..  .|...||.|          | ||.  ||   |. .|||.|.  .. |       .. || | |  ...|||| .||||.||  .| .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WSVHAPSL----------------------------------------------------RRKTMCG--TLDYLPPEMIEGRMHNEKVDLWC--IGVLCY
 .   ..                                                     | .|.||  | .|..||..    ..  .| |.   |.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLVGNPPFESAS----------HNETYRRIV------KVDLKFP----------ASVPMGAQDLISKLLRHNPSERLP----------LAQVSAHPWV
|.|.| ||| . .          ..|.. .|       . ..|||           ..   |.|||.|||  .|..||             .. .||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase AurB.AA S_TKc 77-327 33 3.5e-97 330.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPR--GELYKELQKSCT---
.||.|..||| || ||..|.||.. |||.|..            ..||||.|  . ||||| .|| .|.|  ..|...||..   |.|.. ..|  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNE-KVDLWCIGVLCYELL
   |.| ... .| ....|| ||| ...||||.||||.||    ..||.||| . .      .|.|||..|..||..    ..  |.| | .|.. ||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

VGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSA-------HPWV
.| |||.   .......|.          .  | |.|.|.|. .|..|.   .. .       |||.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AurB.AA CAMK 82-327 21 3.3e-88 284.26 In-house 1-425 (425) Show / Hide 
Range on Protein: 82-327
Range on HMM: 1-425/425
Sequence Identity: 21% (90 aa)

PLGKGKFGNVYLAREKKSH------------FIVALKVLFKSQIEK-------------------------EGVEHQLRREIEIQAH-------LHHPNI
 ||.| || |.|...|..               || |.. |... .                         .  ....||||||  .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLYNYFYDRR-------------------RIYLIL---EYAPRGELYKEL------QKSCT-------------FDEQRTATIMEELADALMYCHGKKV
..|| .. |..                   ..|...   ||.. |||. .|      .....             |.|. .....  ...|. ||| ...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENLLLGLK-----------------GELKIADFGWSVHAPSLR-------------------------RKTMCGTLDYLP-PEMIEG------
.|||.||||.||  .                 . .||.||| . . ..                            ||.|||. | . ||...|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------RMHNEKVDLWCIGVLCYELLVGNPPFESA-------------SHNETYRRIVKVDLKFPAS------------------------VPMGAQD
        . ...|.| | .||..| .|.| |||..              . .|....| | .  || .                        |   ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISKLLRHNPSERLPLAQVSAHPWV
||.|.|. .|..|. ..|. .|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AurB.AA Pkinase 77-327 30 2.6e-84 291.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLR-REIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRG----ELYKELQ--KS
..|||..|.| || ||....|..  |||.|.. |. ....  .. .| .||.| ..|.||||.||| .|.|...||...||.. |    .|.  ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

CTF--DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL----KIADFGWSV---HAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCI
..|  .|.    .| ... .| ||| ...||||.||||.|.  .|..    ||.||| .    . ..   .| |||..|..|| |  |...  ||| | .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLCYELLVGNPPFESA------SHNETYRRIVKVDLKFPASVP---------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV
|...||.| |.||| ..      .... ..|| . .|.|. . .                       ..|.|...|. .|..|.  .|.  |||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AurB.AA CAMKL 77-327 30 3.3e-82 262.12 In-house 1-297 (297) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-297/297
Sequence Identity: 30% (91 aa)

FEIGRPLGKGKFGNVYLARE-KKSHFIVALKVLFKSQIEKEGVEHQ------------LRREIEIQAHLH---HPNILRLYNYFYDRRR------IYLIL
..||. |||| || | ||.  .     || |.. |. | .. . ..            .||||.|. .|.   |||| .||  .....       |||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAPRGE--LYKEL--QKSCT--FDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKG--ELKIADFGWS-----V-HAPSLRRKTMCGTLDYL
||.. ||  |.  .  .. .   ..|  .  .   . .|. ||| ....||||||||.||  .|   .||.||| |     .   |    || ||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEMIEG--RMHN-EKVDLWCIGVLCYELLVGNPPFESAS-------HNETYRRIVKVDLKFPA---SVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
.||...|  . ..  ||| | .||. | ...|. ||. ..       .. ......... ..|    .|.  ..|||.|.| .||..|  . |.  |||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase AurB.AA MARK 77-327 33 5.7e-76 247.84 In-house 1-262 (262) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-262/262
Sequence Identity: 33% (89 aa)

FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFY--DRRR-IYLILEYAPRGELYKELQKS--CT
..... .|.| .. |.||. |...  ||.|.. | .. .      ..|||||  .|.|||| .|. ..   .... ||||.|||..||||  ...     
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKG--ELKIADFGWSVHAPSLR-RKTMCGTLDYLPPEMIEGRMHN-EKVDLWCIGVLCYELL
  |  . .|   .  |. ||| | ..||||||||.|.  .|    ||.|||.|.. |. .  .| |||. | .||.....  .  ||| |  ||. | ..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

VGNPPFESAS--HNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
.|. ||. ..   .| |..|.. . ..|  |. ....||..|| .||.||  . ..  |||.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase AurB.AA PLK 77-327 36 9.1e-75 242.93 In-house 1-258 (258) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-258/258
Sequence Identity: 36% (93 aa)

FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKS-CTFDEQ
.|.|..|||| |  .| ... ... ..| ||  || ..|..    ...||||.  ||||||......| |.  .|. |||.....|   . .   .. | 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

RTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSL--RRKTMCGTLDYLPPEMIEGRM--HNEKVDLWCIGVLCYELLVGNP
 .  .|  .. .| | | ...||||.|. ||.|  . ..||.||| ..       |.||||||  |  ||  .|    |  .|| | .|.  | ||.| |
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFESASHNETYRRIVKVDLKFPAS--VPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
|||... .|||.||.. .  ||..  . . |.||| |.|. ||.||. . |.  ||. 
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase AurB.AA Ciliate-E2 77-327 24 8.8e-74 251.43 In-house 1-365 (365) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

FEIGRPLGKGKFGNVYLARE-----------------------KKSHFIVALKVLFKSQIEKEGVEHQLRREIE----------IQAHLHHPNILRLYNY
... . .|.| || ||...                        |   .|.|.|.. |.|||    | .. |||.          |. .| ||||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY--DRRRIYLILEYAPRGELYKELQKSCT-----------FDEQRTATIMEELAD---------------ALMYCHGKK-VIHRDIKPENLLLGLKGEL
|.  |.  |||..||.  |.|.. ......           |.|.  ..||.....               || |.| |. .|||||||||.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGWSVHAPSLRR---------------------------------KTMCGTLDYLPPEMIEGRM---------HNEKVDLWCIGVLCYELLVGNPP
||.||| |  .   .                                  .| |||. |..||...|           ...|.|.|..||. ||.| |.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FESASHNETYRRIVKVDLKFP------------------ASVPMGAQDLISK----LLRHNPSERLP-LAQVSAHPWV
|        .. | . ...||                   ...  ..|||.|    .|  .|..|.    |.  ||| 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AurB.AA CAMK-Unique 77-327 22 6.8e-71 233.22 In-house 1-363 (363) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-363/363
Sequence Identity: 22% (82 aa)

FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFK--SQIEKEGV---------------EHQLRREIEIQAHLHHPNILRLYNY----FYDRR-------
 . .|..|.| || || .  ..   . | |.. |   ...|  .               . .|.||..|   . ||||..|| .    | ||.       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------RIYLILEYAPRGELYKELQK--------------------SCTFDE--QRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGE-----
        ..|...||.. |.|....||                     . | |    |..|| .|. |. | | ....|||.|.||...   .      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

-----------LKIADFGWSVHAPSLRRK----TMCGTLDYLPP--------------EMIEGRMHNEKV----DLWCIGVLCYELLVGNPPFESASHN-
           .|..||| ..|  . .      |||||..|. |              |.|...   ...    |.| .||. |..|.|.|||.... . 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ETYRRIVKVDL-KFPASVPMG-------AQDLISKLLRHNPSERLPLAQVSAHPWV
       |....| | |. .|. ..  |       | |.. ...   |. |.....   |.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase AurB.AA RSK 80-327 32 2.5e-69 236.63 In-house 1-278 (278) Show / Hide 
Range on Protein: 80-327
Range on HMM: 1-278/278
Sequence Identity: 32% (90 aa)

GRPLGKGKFGNVYLAREK---KSHFIVALKVLFKSQIEKEGV-EHQLRREIEIQAHLH-HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCT---
 . ||.| .| |.| |..   ..  | | ||| |. | .  .     ..|..| ..   ||.| .|.  | .   .|||.|| . |||.. |||  .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGELKIADFGWSVH-APS--LRRKTMCGTLDYLPPEMIE---GRM-HNEKVDLWCIGV
|.| . . .| |.. |. . | ...||||.|||| |.      |..|. ||| .    ..   . .| |.|..|..|||.    ..  |.. .|.|  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LCYELLVGNPPFES---ASHNETYRRIVKVD--LKFP--ASVPMGAQDLISKLLRHNPSERLP-----LAQVSAHPWV
| ||.|.|.||| .   ....|. .|| | .  |..|  ...   |.|||.|.|  .|. ||      .... .||| 
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AurB.AA SAK 77-327 36 7.1e-69 233.64 In-house 1-254 (254) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-254/254
Sequence Identity: 36% (93 aa)

FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSC-TFDEQ
....  |||| |  || |.  . |  ||.|.. |  . | |. .  |.|.|| ..| || || ||||| |   .||.|| .  ||. . ...    | |.
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

RTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPF
  . .|...   ..| |   ..|||.   |.||  . ..||||||    .. |  .  |||||  |. ||..    |  . |.| .| . | ||.| |||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

ESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
.  .  .|  ...  .   || . | ||||| |.||.|| ||. |  |  ||..
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase AurB.AA Pkinase_Tyr 77-220 31 2.5e-21 72.83 Pfam 1-156 (270) Show / Hide 
Range on Protein: 77-220
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQIEKEG-VEHQLRREIEIQAHL-HHPNILRLYNYFY-DRRR--IYLILEYAPRGELYKELQ
 ..|. ||.| ||.||... |    . .  || |.| | .  .|      . ||..|  .| |||||.|||   . ...   ||...||.| | |.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----SCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFG
|       .. ..   .  . |... | . |. ||||.   | |.. ..  ||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase AurB.AA TyrKc 77-327 23 2.3e-16 41.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 77-327
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL--HHPNILRLYNYFYDR-------RRIYLILEYAPRGELYKELQ
 . |. || | || ||... |     || |.| ..       .  ..||..|  .|  |||||.||| .  .          .....||.| | | . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSCT-FDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSL-------RRKTM----CGT----LDYLPPEMIEGRMHN
|.   .  .    ..   |.   | | |..||||.   | |.| ..  ||.||| |    .          ...    .|     .  ..|| |  .. .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKVDLWCIGVLCYELL-VGNPPFES-----ASHNETYRRIVKV-DLKFPAS--------VPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
.| | |  ||...|..  | .| .       |  | .... .   .. |..         |    .....  ...|..|   ...  |   
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF