Gene AKT3 (Human)

AKT3

Species: Human
Alias: STK-2, PRKBG, RAC-GAMMA, AKT3, DKFZP434N0250, PKBG, RAC-gamma, RAC-PK-gamma
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1q43-q44,

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
AKT3.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON
AKT3.NA RNA Sugen Kinome 3588 None Fasta, JSON
AKT3.AA Protein Sugen Kinome 479 None Fasta, JSON

Protein domain

Protein domains of AKT3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH AKT3.AA PH 6-107 27 2.3e-19 72.48 Pfam 1-92 (92) Show / Hide 
Range on Protein: 6-107
Range on HMM: 1-92/92
Sequence Identity: 27% (28 aa)

IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERP-KPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQA
..||||. |.| ..|.|..|.| |.. .  . ||...       |   ... .||. |.... .|..| ||. ..    . .|. ...||...| .|||.
VIKEGWLHKKG-KRKSWKKRWFVLFN-NCLYYYKDDK-----YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR---RTYYFQAESEEEMNDWMQAIQS

VAD
.. 
ACR
PH AKT3.AA PH 6-109 24 1.4e-18 69.02 SMART 1-82 (82) Show / Hide 
Range on Protein: 6-109
Range on HMM: 1-82/82
Sequence Identity: 24% (25 aa)

IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAV
..||||. |..    .|..|.| |.. .... ||.|  .   ..||.. .| .            .| |.. ..    . .|. ...||..|| .|||..
VIKEGWLYKKS--K-RWKKRWFVLFN-DCLYYYKDK--KPKGSIPLSDCTVRE-P----------CFEIHH-DR----TYYFQCESEEEMQEWMQAIQKA

ADRL
....
IHNN
Kinase AKT3.AA Akt 148-405 62 2.2e-210 678.86 In-house 1-264 (264) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-264/264
Sequence Identity: 62% (164 aa)

FDYLKLLGKGTFGKVILVREKASGKYY-AMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED
||.||.||||.||||.||..|...|.| |||.|||..||.|..|.||.|| ..|....|||...|.|||||.|.|.|||.|.||||||.||.|.|.||||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RTRFYGAEIVSALDYLHSGKIVYRD-LKLENLMLDKDGHIKITDFGLCKEG-ITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG-LGVVMYEMMCGR
|.|||.|||..|...|||  |.||| ||.||...||||||..||||||||. |.|  ..|||||||||||||.|..|....|||||| ||.|||||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

LPFYNQDHEKLFELILMEDIKFP--RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
.|||||||...|..|.....|||  ...| ..|.|.|||| |||.|||||||.||.||.|| .|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase AKT3.AA AGC 148-405 38 1.1e-201 527.61 In-house 1-395 (395) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-395/395
Sequence Identity: 38% (152 aa)

FDYLKLLGKGTFGKVILVREK------ASGKYYAMKILKKEV-IIAKD--EVAHTLTE------------SRVLKNTR----------HPFLTS-LKYSF
|. ||..|||.||||.|||.|      ..|||||||.|||.. |. |.  .|.||.||             ..|.. .          |||... |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKDR--LCFVME----YVN-----GG-ELFFHLS---RERVFSEDRTRFYGAE-------IVSALDYLHS-GKIVYRD-LKLENLMLDKDGHIKITDFG
|.||.  |.||||    |||     || |||.||    .|..|.|.|.||| ||       ||.||.||||  .|..|| ||.||..||.|||||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGITDA--------------------------------------------------ATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWG--LGVVMY
|||||..|                                                   .. .||||  ||||.|||.|    ||.|.|||.  ||..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMCGRLPFYNQ----------DHEKLFELIL------MEDIKFP----------RTLSSDAKSLLSGLLIKDPNKRLGGGPDD-----AKEIMRHSFF
||..|. |||..          .....|..|.      ....|||          | .|..||.|...|| |||.|||| |..|     |.||..| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase AKT3.AA SGK 148-405 51 2.4e-161 502.39 In-house 1-283 (283) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-283/283
Sequence Identity: 51% (145 aa)

FDYLKLLGKGTFGKVILVREKAS------------------GKYYAMKILKKEVII-------AKDEVAHTLTES-RVLKNTRHPFLTSLKYSFQTKDRL
||.||..||| |||| .|. |.                   .| ||||.|.|. ||       .| |. |...|   .||| .|||. .|.|.||||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN
 |||.||||||.|.|| ||. |.||| ||| ||||.||.|||| .|.||||| ||..|| .||...|||||||||| .  | .||||||||||||||   
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
 ..|.|||| || |.|||| |  |||..... ... |. .....|.  |.||..|. ||| ||| ||||   .|. || .| ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase AKT3.AA PKC 148-405 53 7e-145 472.66 In-house 1-262 (262) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-262/262
Sequence Identity: 53% (139 aa)

FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED
|. || |||| ||||.|.. | . .|||.|.|||.|||  | |  |.|| |||   ..|||||.|  .|||.||| ||||||||| | ||  . | |.| 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF
..|||.|||..|| .||.  |.||||||.| .||..|||||.|||.|||.... .| .||||||.|.|||.|.  .|| .|||| .|| |||||.|. ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDD---AKEIMRHSFF
  .| . ||. |..... .||.|| .|.|...|.. |.|.|||| .|..   ...|..| ||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase AKT3.AA RSK 151-405 43 6.8e-128 431.19 In-house 1-278 (278) Show / Hide 
Range on Protein: 151-405
Range on HMM: 1-278/278
Sequence Identity: 43% (122 aa)

LKLLGKGTFGKVILVREK---ASGKYYAMKILKKEVIIAKDE-VAHTLTESRVLKNTR-HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERV---
||.||.| .||| |.|..   ..|..||||.||| .|....  ..||.|| ..|. .. |||. .|.|.|||.. |  .|||..||||| ||..|.    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDK---DGHIKITDFGLCKEGITD-AATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGV
||||. .|| ||||.|...||. .|..||||.|| ..|    .||||.||||.||..  |    ..|||.| ||.|||.|     .. ...|.||| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VMYEMMCGRLPFYN---QDHEKLFELILMED--IKFP--RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
.||||  |..||..   ........ |.  .   ..|   .|| .||.|....| .||.||||.||.||.|| .|..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AKT3.AA AktR 148-405 46 8.8e-127 427.5 In-house 1-268 (268) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-268/268
Sequence Identity: 46% (125 aa)

FDYLKLLGKGTFGKVILVREK-ASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE
|...|.||||.||||.||..|  ..|.||||..||. || .    ||.||  ...   .|||.  |.|.||||. | |.|||. |||||.||.... |||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DRTRFYGAEIVSALDYLHSG-KIVYRDLKLENLMLDKDGHIKITDFGLCK-EGIT-DAATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMC
...||| |.|. ||.|||.  .|.||||| ||..||.|||.||||||| | ...  .  . ..|||||||.|||..     ....|||| .|.. |||. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRLPFYNQDHEKLFELILMED-IKFPRT--LSSDAKSLLS-GLLIKDPNKRLGGGPDDAKEIMRHSFF
|  |||..... .|..|. .. .||| .  .|| .|.|.  .|| |.|||||| .  ...|| .| .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase AKT3.AA Eta 148-405 52 1.2e-121 410.41 In-house 1-261 (261) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-261/261
Sequence Identity: 52% (136 aa)

FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED
|...| |||| ||||.| . |  .  ||.|.|||.|||  |.|  |.|| |.|    .|||||.|  .||||||| |||||||||.| |.. | | | | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF
|.||| ||...|| .||   ..||||||.|..||..|| |. |||.||||| .  |  ||||||.|.|||.|.. .|| .|||| .||.|||||||. ||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGP--DDAKEIMRHSFF
  .  . ||| || .|. .|  |. .| |.| . . | |.||||     .. ..| .|.||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase AKT3.AA PKA 148-405 46 4.5e-118 398.57 In-house 1-263 (263) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-263/263
Sequence Identity: 46% (124 aa)

FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLT-SLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED
|. ...||.|.||.| |.|.| ||.|||||.|||. |.    | |...| ..|.|..|||.  .....||. . | .|||||.|||.| .| ... ||..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RTRFYGA-EIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRL
 ..|| | .||.||.||||  |.||||| ||...||.|||||||||  |. ..|  |. | ||||||||||..     .|..|||| ||.. |||. |  
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD-RTW-TLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYNQ--DHEKLFELILMEDIKFPRTLSSDA---KSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
|||.   |  ...| |.  .||||| ..|||   |.|.. || .|..||.|   ...  | .| .|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase AKT3.AA Alpha 148-405 50 7e-116 391.29 In-house 1-259 (259) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-259/259
Sequence Identity: 50% (130 aa)

FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED
| .|. |||| ||||.|   | .   || ||||| |||  | |  |..| |||    . |||...   ||| ||| ||||||||| | .|. .   | | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF
   || |||  .| .||.  |.|||||| | ||| .|||||.|||.|||.... .| .||||||.|.|||.   . ||..||||  || .|||| |  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
   | . ||. |      .|. .|  |...  |.|.| |||||| |||. ..|  | ||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase AKT3.AA Delta 148-405 48 1.2e-113 383.82 In-house 1-259 (259) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-259/259
Sequence Identity: 48% (125 aa)

FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED
| ..|.|||| ||||.|.  |   ||||.| |||.|..  |.|  |. | |||   ..||||. |  .||||. | |||||.|||.| .|.   . |.| 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF
|.|||..||...| .||.  |.||||||.|..||.|||||| |||.||| ..  .. .||||||.|.|||... . | ..||||  ||.||||. |  ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
  .| ..||. |...   .||... .||..|..|. .||.||||     . .| .| ||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase AKT3.AA Pkinase 148-405 33 1.7e-109 374.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-293/293
Sequence Identity: 33% (100 aa)

FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTL-TESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGG----ELFFHLS--RE
.  .. .|.|.||.| . ..| .|| .|.||.||. .  . ...|.. .| ...|. .||.   |...|..||....||||..||    .|| ..|  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RVF--SEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHI----KITDFGLCKEG-ITDAATMKTFCGTPEYLAPEVLE-DNDYGRAVDWWGL
..|  ||.  .||  .|...|.|.|| .|..||||.||...|..|||    ||.||||.|   .     |.||||||.|.||||.  ...||..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVMYEMMCGRLPFYNQ------DHEKLFELILMEDIKFPRTLS---------------------SDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
|...|||.|||.||...      |. .....|.. ...|..  .                     ...|......| |||.||..     |..|. | .|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase AKT3.AA S_TKc 148-405 37 2.1e-108 367.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-231/231
Sequence Identity: 37% (101 aa)

FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNG--GELFFHLSRERV---
.. |...|||.|||| ..|.| .|...|.||.|           |.. | ..||. .||..  |...||. |.|..||||..|  |.|| .. . .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR-AVDWWGLGVVMYE
   |.| ..||| ..|..||.|.|| .|..|||| ||..||.  ||||.||||...        .||||||.|.|||||    ||. ..||| .|...||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDA--KEIMRHSFF
|.||. ||.  .....|..|.          |..||......| |||.||..     .   .|. | .|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AKT3.AA S_TK_X 406-475 28 4e-19 70.78 SMART 1-79 (79) Show / Hide 
Range on Protein: 406-475
Range on HMM: 1-79/79
Sequence Identity: 28% (24 aa)

SGVNWQDVYD--KKLVPPFKPQVT----SETDTRYFDEEFTAQTITITPPEKYDED-GMDCMDNER------RPHFPQFSYSA
.|..|...|   |.. |||||...    |.|||..||.||| .|..    .. |..  ...|...       ...|..|.|..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM----LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase AKT3.AA Pkinase_Tyr 148-358 23 2.3e-15 52.63 Pfam 1-228 (270) Show / Hide 
Range on Protein: 148-358
Range on HMM: 1-228/270
Sequence Identity: 23% (55 aa)

FDYLKLLGKGTFGKVILVREKASGKYY----------AMKILKKEVIIAKDE--VAHTLTESRVLKNT-RHPFLTSLKYSFQ-TKDR--LCFVMEYVNGG
   .| ||.| ||.| .      |...          | |.| ||    ...   .  . | ...|.  .|| . .|       ..   .. ||||. .|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

ELFFHLSR----ERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEG-ITDAA-TMKTFCGTP-EYLAPEVLEDNDYG
 |  .| .    .. ..  .   . ..| ....||.| ... |||   | ........||.||||..    .|   .... .  |   .|||.. .. . 
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

RAVDWWGLGVVMYEMMC-GRLP-FYNQDHEKLFELI
 . | |  ||.|.|..  |. | ... . | ..|.|
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase AKT3.AA TyrKc 148-405 21 4.3e-14 5.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 148-405
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT--RHPFLTSLKYSFQTK-------DRLCFVMEYVNGGELFFHLS
   .| || | ||.| . . |      | | ||..       ..  . | |....   .|| .  |     ..       . |. ||||. .| |  .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RERV-FSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITD-------AATMKTF--CGTP----EYLAPEVLEDNDYG
. |  .. .    .   | .  .|||| ... |||   | ........||.||||....  |          .|.   .|        .|||.. .. . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RAVDWWGLGVVMYEMM-CGRLPFYN-----QDHEKLFELILMEDIKFPRTL---------SSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
 . | |  ||.|.|..  |  | ..      . . ..|..   .   .            ...  .. .     ||..|        .||  |..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase AKT3.AA Pkinase_C 425-477 37 2e-13 50.5 Pfam 1-46 (46) Show / Hide 
Range on Protein: 425-477
Range on HMM: 1-46/46
Sequence Identity: 37% (20 aa)

QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASG
||.|.|||..||.||| .. . ||    |.. |  .|.|   .| .|.|... 
QVKSPTDTSNFDPEFTDEPPMDTP---PDWR-MSSGDQE---PFRGFTYVNPD