Gene AKT2 (Human)

AKT2

Species: Human
Alias: PRKBB, AKT2, RAC-BETA, PKBBETA
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19q13.1,

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
AKT2.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON
AKT2.NA RNA Sugen Kinome 5285 None Fasta, JSON
AKT2.AA Protein Sugen Kinome 481 None Fasta, JSON

Protein domain

Protein domains of AKT2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH AKT2.AA PH 6-108 32 4.9e-24 89.32 Pfam 1-92 (92) Show / Hide 
Range on Protein: 6-108
Range on HMM: 1-92/92
Sequence Identity: 32% (34 aa)

VIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERP-RPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQ
|||||||||.| ..|.|..|.| |.. .  . ||...        |   ... .||. |.... ||..|.||. ..    . .|. .|..|...||.|||
VIKEGWLHKKG-KRKSWKKRWFVLFN-NCLYYYKDDK------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR---RTYYFQAESEEEMNDWMQAIQ

MVAN
... 
SACR
PH AKT2.AA PH 6-110 25 8.8e-21 76.29 SMART 1-82 (82) Show / Hide 
Range on Protein: 6-110
Range on HMM: 1-82/82
Sequence Identity: 25% (27 aa)

VIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQM
|||||||.|..    .|..|.| |.. .... ||..         |   ... .|.. . .     .| |.. ..    . .|. .|..|..|||.|||.
VIKEGWLYKKS--K-RWKKRWFVLFN-DCLYYYKDK--------KPKGSIPLSDCTVRE-P-----CFEIHH-DR----TYYFQCESEEEMQEWMQAIQK

VANSL
.....
AIHNN
Kinase AKT2.AA Akt 152-409 60 8.10000000001e-212 683.51 In-house 1-264 (264) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-264/264
Sequence Identity: 60% (159 aa)

FDYLKLLGKGTFGKVILVREKATGRYY-AMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEE
||.||.||||.||||.||..|.|...| |||.|.|..||.|..|.||.|| ..||...|||.. |.|.|||.|.|.|||.|.||||||.||.|.|.|.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RARFYGAEIVSALEYLHSRDVVYRD-IKLENLMLDKDGHIKITDFGLCKEG-ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG-LGVVMYEMMCGR
|||||.|||..|.|.|||....|||  |.||...||||||..||||||||. |.|. ..|||||||||||||.|..|....|||||| ||.|||||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

LPFYNQDHERLFELILMEEIRFP--RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
.|||||||...|..|......||  ...|||.|.|. |||.||||.||||||.||.|...| .|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase AKT2.AA AGC 152-409 37 8.70000000001e-200 522.61 In-house 1-395 (395) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-395/395
Sequence Identity: 37% (148 aa)

FDYLKLLGKGTFGKVILVREK------ATGRYYAMKILRKEV-IIAKD--EVAHTVTE------------SRVLQNTR----------HPFLTA-LKYAF
|. ||..|||.||||.|||.|      .||.|||||.|.|.. |. |.  .|.|| ||             ..|.. .          |||..  |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTHDR--LCFVMEYAN---------GG-ELFFHLS---RERVFTEERARFYGAE-------IVSALEYLHS-RDVVYRD-IKLENLMLDKDGHIKITDFG
|. |.  |.|||||..         || |||.||    .|..|.||||||| ||       ||.||||||| .....|| .|.||..||.|||||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGISDG--------------------------------------------------ATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWG--LGVVMY
|||||..||                                                  .. .||||  ||||.|||.|    ||.|.|||.  ||..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMCGRLPFYNQ----------DHERLFELIL------MEEIRFP----------RTLSPEAKSLLAGLLKKDPKQRLGGGPSD-----AKEVMEHRFF
||..|. |||..          ... .|..|.      .....||          | .|||||.|. .||.|||..||| |..|     |.|...| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase AKT2.AA SGK 152-409 49 1.6e-157 490.36 In-house 1-283 (283) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-283/283
Sequence Identity: 49% (140 aa)

FDYLKLLGKGTFGKVILVREKAT------------------GRYYAMKILRKEVII-------AKDEVAHTVTES-RVLQNTRHPFLTALKYAFQTHDRL
||.||..||| |||| .|. |..                  .  ||||.|.|. ||       .| |. |. .|   .|.| .|||.  |.||||| . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN
 |||.|.||||.|.|| ||. | | ||||| ||||.||||||| |..||| | ||..|| .||...|||||||||| .  | .||||||||||||||   
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
 ..|.|||| || |.|||| |  |||..... ... |. .....|.  |..|..|. |||.||||.|||    |. |. .| ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase AKT2.AA PKC 152-409 53 6.7e-145 472.71 In-house 1-262 (262) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-262/262
Sequence Identity: 53% (139 aa)

FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEE
|. || |||| ||||.|.. | | .|||.|.|.|.|||  | |  | || ||| . ..|||||.|   ||| ||| ||||| ||| | ||  . | | ||
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF
.||||.|||..|| .||.....||| ||.| .||..|||||.|||.|||.. .|.| .||||||.|.|||.|.  .|| .|||| .|| |||||.|. ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSD---AKEVMEHRFF
  .| . ||. |.......||.|| ||.|.. |...|.|..||| .|..   .....|| ||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase AKT2.AA RSK 155-409 43 1.4e-128 433.43 In-house 1-278 (278) Show / Hide 
Range on Protein: 155-409
Range on HMM: 1-278/278
Sequence Identity: 43% (120 aa)

LKLLGKGTFGKVILVREK---ATGRYYAMKILRKEVIIAKDE-VAHTVTESRVLQNTR-HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV---
||.||.| .||| |.|..   .||..||||.|.| .|....  ..|| || ..|. .. |||.  |.||||| . |  .||| .||||| ||..|.    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDK---DGHIKITDFGLCKEGISD-GATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGV
|.|..|.|| ||||.|.|.||......||.|.|| ..|    .||||.||||.||..  | .  ..|||.| ||.|||.|     .. ...|.||| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VMYEMMCGRLPFYN---QDHERLFELILMEE--IRFP--RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
.||||  |..||..   .... ... |.  .   ..|   .||.|||.|. ..|..||..|||.||.||.|. .| .|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AKT2.AA AktR 152-409 43 9.69999999999e-124 417.39 In-house 1-268 (268) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-268/268
Sequence Identity: 43% (117 aa)

FDYLKLLGKGTFGKVILVREK-ATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ-NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE
|...|.||||.||||.||..|  ....||||...|. || .    || ||  ...   .|||.  |.|.||| . | |.|||  |||||.||.... |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ERARFYGAEIVSALEYLHSR-DVVYRDIKLENLMLDKDGHIKITDFGLCK-EGIS-DGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMC
|.|||| |.|. ||||||.. ...|||.| ||..||.|||.||||||| | ...  .  . ..|||||||.|||..     ....|||| .|.. |||. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRLPFYNQDHERLFELILMEE-IRFPRT--LSPEAKSLLA-GLLKKDPKQRLGGGPSDAKEVMEHRFF
|  |||.......|..|. .. ..|| .  .|...|.|.  .||.|.|..||| . ....|. .| .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase AKT2.AA Eta 152-409 51 7.79999999999e-120 404.42 In-house 1-261 (261) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-261/261
Sequence Identity: 51% (134 aa)

FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ-NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEE
|...| |||| ||||.| . | |.  ||.|.|.|.|||  |.|  |.|| |.|    .|||||.|  .|||.||| ||||| |||.| |.. | | | | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF
||||| ||...|| .|| ..|.|||.||.|..||..|| |. |||.||||| .| |  ||||||.|.|||.|.. .|| .|||| .||.|||||||. ||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGP--SDAKEVMEHRFF
  .  . ||| || ... .|  |. || |.| . . | |..|||      . ... .| ||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase AKT2.AA Alpha 152-409 48 1.2e-115 390.55 In-house 1-259 (259) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-259/259
Sequence Identity: 48% (126 aa)

FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ-NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEE
| .|. |||| ||||.|   | |   || |||.| |||  | |  | .| |||    . |||...   ||| ||| ||||| ||| | .|. .   | | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF
 | || |||  .| .||.....||| || | ||| .|||||.|||.|||.. ...| .||||||.|.|||.   . ||..||||  || .|||| |  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
   | . ||. |   .  .|. .| ||...  |.| | | .||| ||.. ... || ||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase AKT2.AA PKA 152-409 43 1.7e-113 383.39 In-house 1-263 (263) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-263/263
Sequence Identity: 43% (116 aa)

FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTA-LKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEE
|. ...||.|.||.| |.|.| .|.|||||.|.|. |.    | |. .| ..|||..|||.   ... ||. . | .||||..|||.| .| ... |.. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RARFYGA-EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRL
 |.|| | .||.||||||| . .||| | ||...||.|||||||||  |. . |  |. | ||||||||||..     .|..|||| ||.. |||. |  
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD-RTW-TLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYNQ--DHERLFELILMEEIRFPRTLSPEA---KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
|||.   |   ..| |.  .|.||| ... |   |.|.  || .|...|.|   ...  . .|..|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase AKT2.AA Delta 152-409 46 2.3e-112 379.58 In-house 1-259 (259) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-259/259
Sequence Identity: 46% (120 aa)

FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ-NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEE
| ..|.|||| ||||.|.  | . .|||.| |.|.|..  |.|  |. | |||   ..||||. |  .|||.. | ||||| |||.| .|.   . | |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF
|||||..||...|..||.....|||.||.|..||.|||||| |||.||| .   .. .||||||.|.|||... . | ..||||  ||.||||. |  ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
  .| . ||. |....  .||... |||..| .|...||..|||   . . .. .| ||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase AKT2.AA Pkinase 152-409 31 1.3e-110 378.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTV-TESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGG----ELFFHLS--RE
.  .. .|.|.||.| . ..| ||. .|.||..|. .  . ...|.  .| ..... .||.   |...|...|....||||..||    .|| ..|  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RVF--TEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHI----KITDFGLCKEG-ISDGATMKTFCGTPEYLAPEVLE-DNDYGRAVDWWGL
..|  .|. ..||  .|...|||.||. ...||.|.||...|..|||    ||.||||.|   .  .  |.||||||.|.||||.  ...||..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVMYEMMCGRLPFYNQ------DHERLFELILMEEIRFPRTLS---------------------PEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
|...|||.|||.||...      |.  ....|.. ...|..  .                     .|.|... ..|.||||.|..     |.....| .|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase AKT2.AA S_TKc 152-409 37 5.4e-109 369.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-231/231
Sequence Identity: 37% (103 aa)

FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANG--GELFFHLSRERV---
.. |...|||.|||| ..|.| |||..|.||..           |.  | ..|.. .||..  |...||. |.|..||||..|  |.|| .. . .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGR-AVDWWGLGVVMYE
   |.| .|||| ..|..||||.||. ...||.| ||..||.  ||||.||||...        .||||||.|.|||||    ||. ..||| .|...||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVME-------HRFF
|.||. ||.  .....|..|.          |||||... ..|.|||..|..     | |...       | .|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPT-----A-EALQDEWDIKCHPWF
Kinase AKT2.AA S_TK_X 410-477 29 8.4e-17 63.07 SMART 1-79 (79) Show / Hide 
Range on Protein: 410-477
Range on HMM: 1-79/79
Sequence Identity: 29% (23 aa)

LSINWQDVVQ--KKLLPPFKPQVT----SEVDTRYFDDEFTAQSITITPPDRYDSLGLLELD-----QRTHFPQFSYSA
 .|.|... .  |.. |||||...    |. ||..||.||| .... ||.|.  | .  . .      ...|..|.|..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase AKT2.AA Pkinase_Tyr 152-362 23 3.9e-15 51.89 Pfam 1-228 (270) Show / Hide 
Range on Protein: 152-362
Range on HMM: 1-228/270
Sequence Identity: 23% (55 aa)

FDYLKLLGKGTFGKVILVREKATGRYY----------AMKILRKEVIIAKDE--VAHTVTESRVLQNT-RHPFLTALKYAFQ-THDR--LCFVMEYANGG
   .| ||.| ||.| .      |...          | |.| ||    ...   .    | ... .  .|| .  |  .     .   .. ||||. .|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

ELFFHLSR----ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGAT--MKTFCGTP-EYLAPEVLEDNDYG
 |  .| .    .. .| ..   . ..| ...|||.|.  . ||.   | ........||.||||..   .|.    ... .  |   .|||.. .. . 
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

RAVDWWGLGVVMYEMMC-GRLP-FYNQDHERLFELI
 . | |  ||.|.|..  |. | ... . |...|.|
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase AKT2.AA TyrKc 152-409 20 2.2e-14 9.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 152-409
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT--RHPFLTALKYAFQTH-------DRLCFVMEYANGGELFFHLS
   .| || | ||.| . . |   .  | | |...       ..    | |.. .   .|| . .|  .  ..       . |. ||||. .| |  .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RERV-FTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD-------GATMKTF--CGTP----EYLAPEVLEDNDYG
. |  .. .    .   | .  |||||. .. ||.   | ........||.||||.... .|          .|.   .|        .|||.. .. . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RAVDWWGLGVVMYEMM-CGRLPFYN-----QDHERLFELILMEEIRFPRTL---------SPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
 . | |  ||.|.|..  |  | ..      . ....|..   . . .            ..|  ..     . ||..|        .|.  |..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase AKT2.AA Pkinase_C 429-479 35 2.2e-12 46.82 Pfam 1-46 (46) Show / Hide 
Range on Protein: 429-479
Range on HMM: 1-46/46
Sequence Identity: 35% (18 aa)

QVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASI
||.|. ||..||.||| .. . ||    |.  . . ||. .| .|.|... 
QVKSPTDTSNFDPEFTDEPPMDTP---PDWR-MSSGDQE-PFRGFTYVNPD