Gene ABL1 (Human)

ABL1

Species: Human
Alias: v-abl, c-ABL, JTK7, ABL, p150, ABL1, c-ab1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 9q34.2,

Classification

Group: TK
Family: Abl

Sequence

Name Sequence Type Origin Length Description Download
ABL1.kin_dom Protein Kinase Domain None 252 None Fasta, JSON
ABL1.AA Protein Sugen Kinome 1149 None Fasta, JSON
ABL1.NA RNA Sugen Kinome 5881 None Fasta, JSON

Protein domain

Protein domains of ABL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 ABL1.AA SH3 83-139 30 2.8e-18 67.98 SMART 1-58 (58) Show / Hide 
Range on Protein: 83-139
Range on HMM: 1-58/58
Sequence Identity: 30% (18 aa)

NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK--NGQGWVPSNYITPVN
  ..||||. |.... ||..||....||  . ...|.... .  . .||.||||.....
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 ABL1.AA SH3_1 86-132 32 2.3e-17 61.5 Pfam 1-49 (49) Show / Hide 
Range on Protein: 86-132
Range on HMM: 1-49/49
Sequence Identity: 32% (16 aa)

VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK--NGQGWVPS
|||||..|.... ||..||... |.  .....|.... .  . .||.||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 ABL1.AA SH3_2 84-138 18 1.3e-10 40.0 Pfam 1-68 (68) Show / Hide 
Range on Protein: 84-138
Range on HMM: 1-68/68
Sequence Identity: 18% (13 aa)

LFVALYDFVA-SGDNT-----LSITKGEKLRVL---GYNHNGEWCEA-QT--KNGQ--GWVPSNYITPV
..... |.|. .. |      |...||....|.   ... . .|...  |  ..    ||.||... ..
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-NWWWCWETIWGGRRMRGWFPSQWVEEC
SH3_3 ABL1.AA SH3_3 100-136 26 0.000132 17.03 Pfam 18-55 (55) Show / Hide 
Range on Protein: 100-136
Range on HMM: 18-55/55
Sequence Identity: 26% (10 aa)

SITKGEKLRVLGYNHNGEWCEAQTKNGQGWV-PSNYIT
.. .|.|. |.|   .. |.. . ... |||  |.|..
QLPNGTKVNVIGCQNGYGWYKINYNGKTGWVLSSDYVS
SH2 ABL1.AA SH2 146-221 46 1.6e-41 123.72 Pfam 1-81 (81) Show / Hide 
Range on Protein: 146-221
Range on HMM: 1-81/81
Sequence Identity: 46% (38 aa)

WYHGPVSRNAAEYLLSS--GINGSFLVRESESSPGQRSISLRYEG---RVYHYRINTASDGKLYVSSESRFNTLAELVHHH
||||..||. || || .  . .|.||||||||.||. ..|.|..|   ||.||||..  .|..|.. . .|..|.|||.|.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 ABL1.AA SH2 144-227 44 2.7e-34 121.15 SMART 1-87 (87) Show / Hide 
Range on Protein: 144-227
Range on HMM: 1-87/87
Sequence Identity: 44% (39 aa)

HSWYHGPVSRNAAEYLLSS--GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSS--ESRFNTLAELVHHHSTVADG
. ||||..||  || || .  . .|.||||.|||.||. ..|.|..|.|.||||..  ||| |.    . .|..| |||.|... ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase ABL1.AA Abl 261-512 85 6.2e-203 680.47 In-house 1-252 (252) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-252/252
Sequence Identity: 85% (215 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLL
|.|||||||||||||||||||....||||||||||||||.|||||||.|||.|||||||||||||||||||||||||.|||||||||||.|.|..|||||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYP
||||||.|.|.||||..|||||||||||||||.|.||||||||.|.|..|||||||||||||||||||||||||||.|||||||||||||||||||||||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

GIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAF
|||||.||..|||.||||||||||.|||||||.||||...|||||.|||.|.
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ABL1.AA Pkinase_Tyr 261-512 51 7e-157 531.94 Pfam 1-270 (270) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-270/270
Sequence Identity: 51% (139 aa)

ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLKEDTMEV----EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPP--FYIITEFMTYGNLLDYLRE
||. .||| |..||||.|.||    .  ..||||.|||..|.     |.|..||..||.. .|||.|.|.|||| .. |   ||..|.| .|.||||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

C--NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTY-TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAF
   ..| ..   || |..||...||||| ||.||||||||||||.||. ||..||||.|..   |.| ... |.|.||||.|||...|.||..|||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLLWEIATYGMSP-YPGIDLSQVYELL-EKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAF
|||.||| |||..| |||.. ..|||.. |. |||..||.||...|.||. ||...|.|||.|.|||. .
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ABL1.AA TyrKc 261-512 45 2.3e-151 510.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-280/280
Sequence Identity: 45% (131 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI--KHPNLVQLLGVCTRE-------PPFYIITEFMTYGNLLDYLRECNR
||...||| |..||||.|.||   ..||||.||||.  .|.|..|| .|...  .|||.|.|.|||| .       .| .|..|.| .|.|.||||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD--------TYTAHA--GAK--FPIKWTAPESLAYNKFSIKS
. ..   ||....||.. ||||..||.|||||||||||||||| ||..||||||  . |        .|..    |.|  .||.|.|||.. |.||..||
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWAFGVLLWEIATYGMSPYPG-----IDLSQVYELLEKDYRMERPEG--------CPEKVYELMRACWQWNPSDRPSFAEIHQAF
|||.|||..||| |||..||||     .. ..|.|.... |||..|.         ||...|..|. ||. .|.|||.|.|||. |
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ABL1.AA SFK-Src 261-516 53 3.8e-150 448.55 In-house 1-259 (259) Show / Hide 
Range on Protein: 261-516
Range on HMM: 1-259/259
Sequence Identity: 53% (138 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLL
| .. ||| ||.|.|. |.| . .  |||||||  .|  ||||.||.|||  .||||.||  |||   | ||||| | || |||||.| . .  .   | 
IRLEKKLGSGQFGDVWKGRWNN-TTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLV

YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDT-YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP
 || |. . | ||| .||.|||||||| |||.|  .||.|||.|| |   |  |||| ||||||||||||   .|.||||||||.||.|. || |||  |
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YPGIDLSQVYELLEK--DYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF
|||     |   ...   |||. | .||.. |..|..||| .|.||| |       |  |
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase ABL1.AA SFK-Abl 261-512 54 2.5e-145 477.46 In-house 1-251 (251) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-251/251
Sequence Identity: 54% (139 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-ECNRQEVNAVVL
| . | ||.||||||| |.|     .||.|| |.. ||  .|.||| .|| ..|||||.|.|||||| | ||..||| ||||||||. .  | ..  | .
IILGHRLGEGQYGEVYKGIWNNH--RVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSM

LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY
.. | ||   |  || ..||||||||||||||.|  .||||||. |.   | |.|  | |.||||||||||.|  |.||||||.||. ||||||||  ||
MHCAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPY

PGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAF
|||. ..| . |.  ||| ||..||  .|. |  ||  ||  |||| .  .  
PGIHHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase ABL1.AA Src 261-512 51 1.5e-139 469.9 In-house 1-255 (255) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-255/255
Sequence Identity: 51% (132 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-ECNRQEVNAVVL
|... ||| ||.|||..|.|.. .  |||||||..||..| ||.|| .||. .|..||||. ||..| |.||.||.|. |.|||||. .   ....   |
IKLCRKLGQGQFGEVWMGYWNG-NTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQL

LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT--GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMS
..||.|... |.|||..|.||||||||| ||||| ..||||||| ||.    | |.|. |||||||||||| . |..|.|||||| ||.||.|| |||  
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGIDLSQVYELLEKDYRMERPEGCPEKVYE-LMRACWQWNPSDRPSFAEIHQAF
|||| .  .| . .|. ||| .|..||...|| .|. ||.  | .|| |. ... .
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ABL1.AA TK 261-512 27 6.8e-130 437.83 In-house 1-486 (486) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-486/486
Sequence Identity: 27% (133 aa)

ITMKHKLGGGQYG---EVYEGVWKKYS-------------------------LTVAVKTLKED-TMEVEE--------------FLKEAAVMKEIK----
||. .||| ||.|   |||.| |.  .                          .||||.|||. .|. ||              ||.||..||  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQLLGVCTRE------------PPFYIITEFMTYGN----LLDYLREC-----------------------------------------------
 |||.|.|.||||..            .|..|..|.| .|.    |.||||.|                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------NRQEVNAVVLLYMATQISSAMEYLEKK------NFIHRDLAARNCLVGENHL-----------VKVADFG---
                           ..  ..   || |. ||...||||..|      ||.||||||||||||||.            .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRLM-TGDTYTAHA------------------------GAKFPIKWTAPESLA---------YNKFSIKSDVWAFGVLLWEIATYG-MSPYPGI
     |.| .  .| |...                         |.|.||.|.|||.|.         |.||..|||||.||||.||| ||| . .|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DL---------SQVYELLEKD--------------YRMERPEGCP--------------EKVYELMRACWQWNPSDRPSFAEIHQAF
.           .|.|.|..               .||..|..||              | .|.||. ||...|.|||.|...|...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ABL1.AA Src-Unclassified 261-512 43 1.8e-122 413.17 In-house 1-284 (284) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-284/284
Sequence Identity: 43% (125 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED---TMEVEEFL--------KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC
.  . ||| || |||. | |.  .  |||||....   ||  | ||        .||..||. .|.|||.|..||..| |.|||||.|. | ||..||| 
VHLLRKLGRGQFGEVWYGKWRG-KVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREG

NRQEVNAVVL------------LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH-----LVKVADFGLS--RLMTGDTYTAHAGAKFPIKWTAPESL
  |      .             ..|.|. | |.||| |  .|||||||| |.|.|      .|||.||||   .||  | | .  ||.||.||.|||  
GGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECF

AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP--EGCPEKVYE-LMRACWQWNPSDRPSFAEIHQAF
 | .|||||||| .|.|||||.|.|  |||| .   | | .|  ||| .|  ..||. .|| .|  ||   |  || |      |
IYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase ABL1.AA Tec 261-514 44 5.8e-119 401.53 In-house 1-254 (254) Show / Hide 
Range on Protein: 261-514
Range on HMM: 1-254/254
Sequence Identity: 44% (114 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAV-VL
.|.   || ||.| |  | |.  .  ||.|..|| .|  |.|. || ||..  ||.|||| |||. . | ||.||.|. | ||.||||   .   .. .|
LTFMKELGSGQFGVVHLGKWRH-QYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAIL

LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY
|.|  ... .|.|||...||||||||||||||... |||.|||..|    | ||   |.|||.|| .|| . |...| |||||||||| ||. . |  ||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFET
.  . |.| |   . .|..||. |....|. |  ||.  | .||.|..  .. . 
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase ABL1.AA Frk 261-516 49 6.7e-110 371.41 In-house 1-260 (260) Show / Hide 
Range on Protein: 261-516
Range on HMM: 1-260/260
Sequence Identity: 49% (130 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR--ECNRQEVNAVV
| . ..|| ||.|||.|| |   .  |||||||  ||. ..||.|| .||...|| |.||  |||.| | ||||| |  | |..||.  . . ....   
IQLIRRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQ

LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDT--YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG
|. || |. . | |||..|.||||||||| ||||.  .|.||||| | ||  .   | .. ||.|||||||||   ||||.||||||.||.|| || |||
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG

MSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF
  ||||.   .| . ....||| .| .||...||.|  ||. .|  || |  ..  .|  |
RMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase ABL1.AA UTK 261-512 36 1.2e-108 367.24 In-house 1-296 (296) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

ITMKHKLGGGQYGEVYEGVWKK-----YSLTVAVKTLKEDTM---EVE---EFLKEAA---VMKEIK-HPNLVQLLGVCTREPPFYIITEFMTYGNLLDY
.    .|| |..|||... ...     | . ||||..... .   | |   .|..||.   .||  . |||...|.||||.| |..|.||.|  |.|..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRECNR-QE-----VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH-------LVKVADFG---LSRLMT---------GD-TYTAHAGAK
|| . . ..     ..   .|.|| .|...|.||. ..|.|||||||||||....       ..|.||||   .||..          ..  |.|.   .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWTAPESLAYN-KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD--YRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAF
 ||.|.|||.|... .|..|||||.|||..||| |.|  ||||.   || . ...   |||..|..||. ||.||..||. .|..||.| .. |..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ABL1.AA Csk 261-512 46 2.4e-106 359.59 In-house 1-251 (251) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-251/251
Sequence Identity: 46% (118 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED-TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREP-PFYIITEFMTYGNLLDYLRECNRQEVNAVV
...  . | | .| |  | ..     |||| .|.|    .. || ||.|| ...|||||||.||   ..   ||..|.|  |||.||||   |. ..   
LHLGECIGHGEFGDVMQGEYQ--NRKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQ

LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH--AGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGM
||  |  . ..|.|||.|.|.|||||||| || |    || ||||..    .... .  .. |||||||||| |   ||| ||||| ||.|||||  .| 
LLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKE---ECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGR

SPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAF
 ||| | |. | .  || |||| |||||..||..|. ||. || .||.|... .  
VPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase ABL1.AA S_TKc 261-516 25 1.4e-62 215.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 261-516
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY--GNLLDYLRECNRQE----V
 ..  |.| | .|.|| ...||    ||.| .|      | ...| ...|. .|||.|.|..|.     .|...|..    |.|.||.....|.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSI-KSDVWAFGVLLWEIAT
.  .  ... || .|.||. ....|||||   | |. |   .|..||||.|..                . ||| |   ...  |.|.|..|..|.| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAF-----ETMF
 |  |.|  .. ......            .. . ...| |.|..|..||.  |. |.         |
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ABL1.AA Pkinase 261-512 22 3.4e-50 177.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 261-512
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE---FLK--EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG----NLLDYLRECNR
.. . |.| | .|.||....|... .||||..| .. . ..    ..  |...||...||| |.|........  |...|..  |     | ||..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QEV--NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV----KVADFGLSRLMTGDTYTAHAGAKFP---IKWTAPESLA-YNKFSIKSDV
  .     ..  ...|| ...||. ....|||||   |.|. .|  .    |..||||....    |     .. .   . . ||| .  ... . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAFGVLLWEIATYGMSPYPGI-------DLSQVYELLEKDYRMERPEGCP-------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
|..|..|.| .. |  |.||        ..  ... ...... ..|. |.                   |   .... |....|..||....| |   |
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
F_actin_bind ABL1.AA F_actin_bind 972-1149 75 5.2e-140 476.22 Pfam 1-179 (179) Show / Hide 
Range on Protein: 972-1149
Range on HMM: 1-179/179
Sequence Identity: 75% (135 aa)

EGLKKPVLPATPKPQS-AKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMA
||.||||.||.||||. |.|.|.|....|||.|.||.|....|.|||||||||||||||||||||||||||||..|||.||||.|.|||.||.||||||.
EGGKKPVPPAVPKPQKTARPVGMPPPQVPVPTTSPSPSKMANGTQPSSTAFIPLISTRVSLRKTRQPPERIASDKITKEVVLDCTDALCSAITRNSEQMV

SHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
.||.|...|..||..||||||.|||||||||||||||||||||||||||||||||.||..|||.||||.|.||||||||
PHSQVVDTGHQLYDYCVSYVDCIQQMRNKFAFREAINKLENNLRELQICPATAGSVPATNQDFNKLLSCVQEISDIVQR
FABD ABL1.AA FABD 1023-1149 43 2.6e-72 247.44 SMART 1-153 (153) Show / Hide 
Range on Protein: 1023-1149
Range on HMM: 1-153/153
Sequence Identity: 43% (67 aa)

PLISTRVSLRKTR--------------QPPERIASGAITKGVVLDSTEALCLAIS------RNSEQMASHSAVL---EAGKNLYTFCVSYVDS-IQQMRN
|.|...|.|||||              ||.|||.|..|.|...|..||.||.|..      ..||||.||...|   ..|..|...|..|.|. |.||.|
PQIMHKVALRKTRTQLTIYATPIAKLTQPAERIPSDKISKDMILECTECLCSAFHNLFNLATHSEQMVSHQQWLQMSDKGHQLHNYCMGYADCGIMQMHN

KFAFREAINKLENNLRELQICPATAGS--GPAATQDFSKLLSSVKEISDIVQR
||.|||....|||..|.|..|...|||  .|...|||..|.|.||||||.|||
KFQFRELVTRLENQNRQLRFCSTSAGSRNSPNNNQDFMNLHSCVKEISDVVQR