Gene MRK1 (Bakers Yeast)

MRK1

Species: Bakers Yeast
Alias: MRK1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
MRK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
MRK1.AA Protein Refseq_NP 501 putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy; Mrk1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of MRK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MRK1.AA GSK 164-447 51 9.60000000001e-200 616.46 In-house 1-328 (328) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-328/328
Sequence Identity: 51% (168 aa)

YPTTEVVGHGSFGVVVTTVII----ETNQK----VAIKKVLQDRRYK-NRELETMKML---CHPNTVGLQYYFYEK-DEEDE--VYLN-LVLDYMPQSLY
|....|.||||||||. ....    ||...    ||||||.||.||| ||||. ||||   .||| | |.|.||.. ...||  ||.| ||..|||| ||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

QRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKP--DQPNVSYICSRYYRAPELMFGATNYSNQ
|..||.|..|.|||...|| |.||.|..|.|||    ||||||||||.|||| | . |||||||||.|.|  ..||.|||||||||||||.||.|||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHG-ICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQ

VDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFP-----NIKPITLAE-------------------IFKA--EDPD
.||||  ||.||.|.|.|||.|.|..||||||||..| |||..|. |||.|. . ||     .|||. .                     .||.  .|..
IDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQ

-TLDLLTKTLKYHPCERLVPLQCLLSSYF
 ..||..|.|.|.|..|| ||..... .|
DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase MRK1.AA CMGC 164-447 21 3.4e-111 366.82 In-house 1-513 (513) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-513/513
Sequence Identity: 21% (109 aa)

YPTTEVVGHGSFGVVVT--------------TVIIETNQKVAIKKVLQDRRYKN----------------RELETMKMLC-----------------HPN
|   ...|.|..|||.               .. .|||..|||||. ..  |..                ||.. .|.|                  |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

TVGLQYYFYEKDEEDE------------VYLNLVLDYMPQSLYQRLRHFV------------------------NLKMQMPRVEIKFYAYQLFKALN--Y
 |.|...|| |... .            ..|.|| .||...||| ...                          ...  ..   |. |.||....|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHNVP-RICHRDIKPQNLLVDPTTFSF-------------------KICDFGSAKCLKPD----------------------QPNVSYICSRYYRAPELM
.|    .|.|||.||.|.|..... ..                   ||||||.|. . |                       .|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGATNYS---------NQVDVWSSACVIAELLLG--------KPLFSGESG-----------IDQLVEIIKIMGIPT---------------KDEISGMN
.|...|.          ..|.|| .|..||...|        |||| |.|.           |||| .|.|..| ||               ..|. .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PNYEDHV---------------------------FPNIKPITLAEIFKA-----------------------------------EDPDTLDLLTKTLKYH
.... .                            ||...|... ..|.                                    .||. .||| | |.| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PCERLVPLQCLLSSYF
| .|. . |.|   ||
PDKRITAEQALQHPYF
Kinase MRK1.AA S_TKc 164-447 25 6.9e-74 252.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-231/231
Sequence Identity: 25% (76 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKNRELETMKMLCHPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQ---SLYQRLRHFVN--LKM
|   ...|.|.||.|   . ..|...||||..    .   ||.. .|.  ||| | | ..|..       .| .|..|...   .|......     |. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

QMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSN-QVDVWSSACVIAE
..|  ...||.||...||.|.|.  .|.|||.||.|.|.|      ||||||.|. |       ... ...|.|||..     |.   .|.||  |...|
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPCERLVPLQCLL-------SSYF
.| |.|.|.      |. ...|..|                                  .|. .|.. | |.. | .|.   ..|          .|
MLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MRK1.AA Pkinase 164-447 27 1.1e-71 249.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-293/293
Sequence Identity: 27% (86 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKNR--------ELETMKMLCHPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQ-----SLYQRL
| . ...| ||||.|   . . |...||.|..  ... ..         |.. ||.|.||| | | ..|..   .|..|  .|..|..      .|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY--MVMEYCEGGLYVMDLFDYI

R---HFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSF----KICDFGSAKC--LKPDQPNVSYICSRYYRAPELMFGATN
.   | . . ...   |.|||.||....|.|.|.  .|.|||.||.|.|.|  .       ||||||.||.  . ... . .. ....|.|||.  |.. 
STWRHGCFY-FSEW--ECKFYMYQILRGLEYCHSM-GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YSNQVDVWSSACVIAELLLGKPLFSGE----SGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPCERLV
|.  ||.||  |...|.|.|.|.|.|.    . .||.. | .||| |.. ...  .... .. |.  .  . .. |.. ... .|.... |.. | .|. 
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTFHNWSEECKDFIKWCLCKDPKKRPT

PLQCLLSSYF
. |.| . .|
AEQILQHPWF
Kinase MRK1.AA RCK 164-447 28 6e-62 195.24 In-house 1-298 (298) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-298/298
Sequence Identity: 28% (90 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKN-------RELETMKMLC-HPNTVGLQYYFYEKD--EEDEVYLNLVLDYMPQSLYQRLRHF
| ... .| |..|.|.  . .||...|||||    .....       ||.  .. |  ||| . |   ....|  .     | .|. || . ||| ...|
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQ-----LYFVFEYMDMNLYQMMKDF

VNLKMQ-MPRVE--IKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPT--------TFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNY
   . . .|  .  ||.. ||....|...|.   . |||.|| |... .         ..  ||.|||....    .|.  |. .|.|||||.   .|.|
KE-RRKYLPENQRSIKNIMYQILQGLAHMHKHG-FFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYY

SNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHV---------FPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPC
. ..|.|.  |...||   .||| | | |||. .|.|.||.|.|.        ..| .         ||. |.. | ...    .|...|..| |.. | 
NSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKK-------DWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQ

ERLVPLQCLLSSYF
.|  . |.|   ||
KRITAQQALQHPYF
Kinase MRK1.AA CDK 164-447 30 4.7e-60 190.75 In-house 1-284 (284) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-284/284
Sequence Identity: 30% (98 aa)

YPTTEVVGHGSFGVVVTTVIIETN-----QKVAIKKVLQDR--------RYKN---RELETMKMLCHPNTVGLQYYFYEKDEEDE------VYLNLVLDY
|   | .| |..|||      .|.     | ||.||.  .                ||  ..| | ||| | |   .. |. ...        | .| .|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTF----SFKICDFGSAKCLK-------PDQPNVSYICSRYY
|.. |.. ..             || | .|| ..|.|.|   .| |||.||||.|.. .      . || ||| |.          | ..  . .  . |
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSN-WIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELMFGATNYS--NQVDVWSSACVIAELLL---GKPLFSGESGIDQLVEIIKIMGIPTKDEISGM--NPNYEDHVFPNIKPITLAEIFKAEDPDTLDL
||||| .|...||   ..|.||  |..||...   .|||| |.| ||||  |..|.| || |   |.   |.|                         ||
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DL

LTKTLKYHPCERLVPLQCLLSSYF
| | | | |. |.   |.| . ||
LNKMLCYDPKKRISAEQALQHPYF
Kinase MRK1.AA CDC2 164-447 32 9.1e-57 172.74 In-house 1-301 (301) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-301/301
Sequence Identity: 32% (102 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKN--------RELETMKMLC-HPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFV
|   | .| |..|||      .||| ||.||.  ..            ||. ..| |  ||| | |.  ...        | .| .|. . | . ..   
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ------NKLYMVFEYLDMDLKKYMDMSI

NLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLK-PDQPNV--SYICSRYYRAPELMFGATNYSNQVDVWSS
  . .||   .| |.||. ......|   || |||.||||.|.| .    || ||| |.    |  .      .  . |||||...|.  ||  ||.|| 
PKNKHMPPQLVKSYMYQILQGVHFCHQR-RIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSI

ACVIAEL---LLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGM--NPNYEDHVFPNIKPITLAEIFKA---------EDPDTLDLLTKTLKYHPCERLV
 |..||.      ||||.|.| ||||  | .|.| |. ..  |.  .| |    ||. ||. | .|..           ||. .||| . | | |  |. 
GCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYK-NTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

PLQCLLSSYF
  . |   ||
AKEALQHPYF
Kinase MRK1.AA CDK-Unclassified 164-447 26 4.8e-51 166.1 In-house 1-324 (324) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDR-------------RYK---NRELETMKMLCHPNTVGLQYYFYEKDEED--------EVYLNLVL
| . ...| | || |.     .|...|||||.                 . |   .||. ... . | |   .   .|  |              . .|.
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

DYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTT----FSFKICDFGSAKCLK----------PDQPNVSY-
.|||. .| .|   ..      . .|. .. |... ..|||    | ||||||||.... ..       || |||.|              |  |. .| 
EYMPYTWYNQLHNNRY---NLSMCQIRNFMHQMLEGIAYLHCN-KIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYS

--ICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKD---EISGMNPNYEDHVFPNIKPIT-LAEIFKAEDP
  .  | ||||||.||   |   ||.|| .|..||.. |||.|.| . |.|.  |.|..| |. |   ... | | |.   |..  ..    .. |    
TQVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYM-PDYCKIFFKYKQKFHWWNRFPKCKHA

DTLDLLTKTLKYHPCERLVPLQCLLSSYF
  ....   . | | .|.   . | ...|
SENNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase MRK1.AA CDK7 264-447 38 1.9e-50 132.34 In-house 103-288 (288) Show / Hide 
Range on Protein: 264-447
Range on HMM: 103-288/288
Sequence Identity: 38% (73 aa)

EIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCL-KPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGK
.|| |. .. . | |.| .  | |||.|| |||...     || ||| |.    | .   . .  |.|||||| |||  |   ||.||  |..|||.|  
HIKAYMMMTLQGLEYCH-RNWILHRDLKPNNLLMNENG-QLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFSGESGIDQLVEIIKIMGIPTKDE---ISGMNPNYEDHVFPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPCERLVPLQCLLSSYF
| . |.| ||||. | ...| ||  |   .. |.   .   ||    . | .|| |   | |||. . .   ||.|.   ||| . ||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase MRK1.AA CDKL 265-447 38 4e-47 159.15 In-house 100-286 (286) Show / Hide 
Range on Protein: 265-447
Range on HMM: 100-286/286
Sequence Identity: 38% (73 aa)

IKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLK-PDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKP
.. | .|. ||.|..|.   . |||||| |.|. |     |.|||| |. |. |.     |   | ||||||. | | |.  ||.|. .||.||.. | |
VRKYMWQILKAINFCHKH-NCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQP

LFSGESGIDQLVEIIKIMG--IPTKDEISGMNPNYEDHVFPNIK-PITLAEIFKAED-PDTLDLLTKTLKYHPCERLVPLQCLLSSYF
|. |.| ||||  |.| .|  ||   ||  .|| . . .|| |. . .| . . .   . .||.. | |.  | ||.   |.. ..||
LWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase MRK1.AA MAPK 164-447 26 8.6e-47 159.76 In-house 1-328 (328) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-328/328
Sequence Identity: 26% (89 aa)

YPTTEVVGHGSFGVVVTTVIIE------TNQKVAIKKV---LQDRRYKN---RELETMKML-CHPNTVGLQYYFYEK----DEE----DEVYLNLVLDYM
|   . .|.|..|||.  .  .      ...||||||.    |.  .     ||.  .... .|.| ..|.  |. .    ...    ...|  .| ..|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY--IVMELM

PQSLYQRLRHFVNLKMQ-MPRVEIKFYAYQLFKA--LNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPD--QPNV-------------SY
   |.|     .   .| .    |..  ||. ..  | |.|   .. |||.|| |.||. .    |||||| | .. |.  ...               |
ETDLHQ-----IIKSQQPLSDDHIQYFMYQILRGLKLKYIHSA-NVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEY

ICSRYYRAPELMFG--ATNYSNQVDVWSSACVIAELLL-GKPLFSGESGIDQLVEIIKIMGIPTKDEISGMN-P-NYEDHVF-----PNIKPITLAEIFK
.  |.|||||.|..  ...|. .||.||  |  ||.|  .|||| |.. |||.  |....| |... |. .  . .. . .      |. ........|.
VATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFP

A----EDPDTLDLLTKTLKYHPCERLVPLQCLLSSYF
      .|. .||| | |   | .|.   ..|   ||
NANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase MRK1.AA ERK7 164-447 29 2.3e-43 145.99 In-house 1-292 (292) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-292/292
Sequence Identity: 29% (90 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKN------RELETMKMLC-HPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNL
|   . .| | .|.|   .   | | ||.||.    | .       ||   .. .  ||| . |   .  . . | .|  || ..|   |    |.   |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRD-IY--LVFEFMETDLHAVIRKGNIL

KMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCL------KPDQPNVS-YICSRYYRAPELMFGATNYSNQVDVW
|     .  ..  |||..|. |.|   .. |||.|| |.|.| .    |.|||| |  .      ....| .  |.  | ||||| . |...|   || |
KD----IHKQYIMYQLLRAIKYMHSG-NVIHRDLKPSNILLD-SECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMW

SSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNI---KPITLAEIFKAEDPDTLDLLTKTLKYHPCERLVPLQCLLSSY
|  |...|.| |||.| | | ..|.  |..... ||. .|  ....|   .  ..   |. || ....   .| .||| . | . | .||   |.|   |
SIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPY

F
 
V
Kinase MRK1.AA TyrKc 164-447 18 6.7e-10 -62.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 164-447
Range on HMM: 1-280/280
Sequence Identity: 18% (60 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKN--RELETMKML--CHPNTVGLQYYFYEKDE---EDEVYLNLVLDYMPQSLYQRLRHFV-N
    .. |.| ||.|.  . .   ..||.|..  |   .   ||.. |..|   ||| | |  .  .. .   ..| .. .|. |||   .  |...  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM-IVMEYMP---HGDLKDYLRK

LKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPD----QPNVSYI-----CSR-----YYRAPELMFGATN
 . . .  .   ...|  .  .|||   .. |||.   | ||.      ||.||| .. .. |         |      ...        ||| .   ..
HRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYG

-YSNQVDVWSSACVIAELL-LGKPLFSGE----SGIDQLVEIIKIMGIPTKDEI----SGMNPNYEDHVFPNIKPITLAEIFKAEDPDTL-DLLTKTLKY
 .. . ||||   .. |.. .|..  .|.       ....| .|  . . . .     |                      |  . || . .. ..  ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F-VCCPDEMYQIMKQCWHE

HPCERLVPLQCLLSSYF
 | .|    ..   ..|
DPEDRPTFSEI--HECF
Kinase MRK1.AA CDK7 164-195 37 4.7e-08 17.08 In-house 1-32 (288) Show / Hide 
Range on Protein: 164-195
Range on HMM: 1-32/288
Sequence Identity: 37% (12 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKV
| . . .| | |..|      .|.|.|||||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase MRK1.AA CDKL 164-220 41 0.001979 7.59 In-house 1-63 (286) Show / Hide 
Range on Protein: 164-220
Range on HMM: 1-63/286
Sequence Identity: 41% (26 aa)

YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQ---DRRYK---NRELETMKMLCHPNTVGL
| .  .|| || |||      ||.| ||||| .    |.  |    ||.   |.| |.| |.|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNL