Gene ISR1 (Bakers Yeast)

ISR1

Species: Bakers Yeast
Alias: ISR1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
ISR1.AA Protein Refseq_NP 443 Inhibition of staurosporine resistance; Isr1p [Saccharomyces cerevisiae] Fasta, JSON
ISR1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 277 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ISR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ISR1.AA Other-Unique 157-407 14 4.4e-29 95.99 In-house 1-249 (249) Show / Hide 
Range on Protein: 157-407
Range on HMM: 1-249/249
Sequence Identity: 14% (38 aa)

SSRCNNDSGVVLKFAKSQHKSKVILQEALTLAYLQYMSPSTNESHIIPFYGLTYITKSHFRRLRSNECVPGLILPKCEMSLYHFNTAVSHKLSLITKRKI
    .. .  . . .... |.|.  .    . . ..|.  .|...   .... .|.  .|..  .|.|...... .|.  ..... ...|.... . .. 
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKRE-QIYHYQ-IIH-CIFYWT-MNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCE

WWRLMKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHC---------KDFDFYLADFTSAFHINQTPTDLNTTVEYCAPELIDSSSDHVPTFESD
.|. ...|| .|..|  |..||.||.  ||.|......   .|         ....... || .  . . .  . . . ..| || .|  .. .  .. .
HWMNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYH

LYAVGLCLLSFISQHEPYNELQALVSHGSSPGIGSSSIQQSQWLINALLKKDPINLNMLR
.    ... ... .... .  | . .| |.. | ...|.|........ .. . |.|...
FGCYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase ISR1.AA Ciliate-E2 259-355 18 4.9e-13 41.07 In-house 149-286 (365) Show / Hide 
Range on Protein: 259-355
Range on HMM: 149-286/365
Sequence Identity: 18% (28 aa)

RLMKQMID---------------ALKSLKTNG-IIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQ----------------------TPT
..||| ..               ||..|. .. ||| |||  |||.                 ..||  .  ...                      ||.
YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPG

DL------NT------TVEYCAPELIDSSS------DHVPTFESDLYAVGLCL
..      |.      | .| ||| . . .       .  ....|....| .|
YMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase ISR1.AA Ciliate-E2b 261-367 26 6e-12 32.75 In-house 108-212 (272) Show / Hide 
Range on Protein: 261-367
Range on HMM: 108-212/272
Sequence Identity: 26% (30 aa)

MKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPTDL--NTTV----EYCAPELID--SSSDHVPTFESDLYAVG
..... .|. | ...||..|||  ||....      |..|     |.|.  | |. .    .  ..|.    .| |||.|          |...|...||
IASICLCLEYLHNQNIIYRDIKPENIMVDHK-----GYMK-----LIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVG

LCLLSFISQHEPYNE
 ||  |..   |. |
ICLYEFMCGYVPWAE
S_TKc ISR1.AA S_TKc 135-411 16 1e-11 -5.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 135-411
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)

LPSNKLVGQGSYSYVYPISSSASSRCNNDSGVVLKFAKSQHKSKVILQEALTLAYLQYMSPSTNESHIIPFYGLTYITKSHFRRLRSNECVPGLILPKCE
    ...|.|... ||            .  | .|  |     . |..|   |          .  .|. .|.  .           ..    ...  |.
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-----EHIRREIQILKK--------HHPNIVKLYDVFQD----------DHLY--MVMEYCD

M---SLYHFNTAVSHK-----LSLITKRKIWWRLMKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPTDLNTTV
    .|...     ..     ..  . |..    |.|...||. .  .|||| |.| .|||..|               ..|| .| ..    | .  | 
GDLGDLFDYIKKRGRHGLRFPFPE-HARFY----MYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL----TTFCGTP

EYCAPELIDSSSDHVPTFESDLYAVGLCLLSFISQHEPYNELQALVSHGSSPGIGSSSIQQSQWLINALLKKDPI----NLNMLR-------NDLF
.|.|||..     .  ....| ...| .|  ...   |.   .... .         | .  . .|. .|.|||         |.          |
WYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ISR1.AA Ciliate-E1 259-349 27 1.5e-10 31.01 In-house 113-202 (202) Show / Hide 
Range on Protein: 259-349
Range on HMM: 113-202/202
Sequence Identity: 27% (27 aa)

RLMKQMIDALKSLKTNGIIHGDIKTANILI--TEMHVLNGGHCKDFDFYLADFTSAFHINQTPTDLNTTVEYCAPELIDS-----SSDHVPTFESDLY
....|.||.|  |. ..|||.||| .||||   . .|..       ||....|     ..|.  . . |  |. || . .       .   ...||.|
QIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC-------DFGISKFLKNNQNQQCQYK-GYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase ISR1.AA Ciliate-C8 263-355 29 1e-09 31.33 In-house 127-238 (238) Show / Hide 
Range on Protein: 263-355
Range on HMM: 127-238/238
Sequence Identity: 29% (33 aa)

QMIDALKSLKTNGIIHGDIKTANILITEM--HVLNGGHCK-----DFDF--YLADFTSAFHINQ---TPTDLNT----TVEYCAPELIDS-SSDHVPTFE
|||| .  |. . |.| |||  |.|  .    ..    |.     ||.|  .| .  | .|. .   | . .      .. |.|||...  | .    | 
QMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFS

--SDLYAVGLCL
  ||.| |||.|
KKSDSYSVGLVL
Kinase ISR1.AA CMGC 260-317 24 2.2e-09 26.05 In-house 179-256 (513) Show / Hide 
Range on Protein: 260-317
Range on HMM: 179-256/513
Sequence Identity: 24% (19 aa)

LM------KQMIDALK--SLKTNG--IIHGDIKTANILITEMHVL-----------NGGHCKDFDFYLADFTSAFHINQ
.|      .|.. .||   .  ..  ||| |.| .||||..   |           |    |..   ..|| .| ....
FMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC-QKNGRLKICDFGLARWYHP
Kinase ISR1.AA AGC 263-352 18 2.8e-09 18.62 In-house 161-292 (395) Show / Hide 
Range on Protein: 263-352
Range on HMM: 161-292/395
Sequence Identity: 18% (28 aa)

QMIDALKSLKT-NGIIHGD-IKTANILITEMHVLNGGHCKDFDFYLADF-TSAFHIN-------------------------------------------
... || .|   .|||| | .|  |||..|      ||.|     |.||  .   .|                                           
CIVLALEYLHSHMGIIHRDYLKPENILLDED-----GHIK-----LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQ

---------QTPTDLNT--TVEYCAPELIDSSSDHVPTFESDLYA--VG
         .. . .    | || ||| .        ... | ..  .|
EDDTTRKKRDRTWTFCGPCTPEYMAPEIL-------YGKACDWWSFGLG
Kinase ISR1.AA Ciliate-E2-Unclassified 259-355 19 7e-09 26.97 In-house 147-260 (352) Show / Hide 
Range on Protein: 259-355
Range on HMM: 147-260/352
Sequence Identity: 19% (24 aa)

RLMKQMIDALKSLKTNG-IIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQ----TPTD------------LNTTV---EYC----APELI
....| ...|..|  .. ||| |||  |||... .         .   ..|| .. ...|    . |.            ..|..   .|     |||..
FYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-------NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL

DSSSDHVPT-FESDLYAVGLCL
..     .. ...| ...| .|
QGQNYDHSKAYKCDIWSLGVIL
Kinase ISR1.AA C8 263-355 27 7.3e-09 27.01 In-house 131-226 (226) Show / Hide 
Range on Protein: 263-355
Range on HMM: 131-226/226
Sequence Identity: 27% (28 aa)

QMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPT---DLN----TTVEYCAPELIDS--SSDHVPTFESDLYAVGL
|||| .  ..   |.| |||  |.|. .    .      |   |.||  | .. .      . .     | .| ||| .          . .|||. |||
QMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYG------FEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGL

CL
 |
VL
Kinase ISR1.AA STE 262-335 22 5.4e-08 24.44 In-house 158-235 (359) Show / Hide 
Range on Protein: 262-335
Range on HMM: 158-235/359
Sequence Identity: 22% (21 aa)

KQMIDA-LKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQT--------------PTDLNT-----TVEYCAPELID
.| . . |. |  ..||| ||| ||||.                 |.||  .  ....               .. ..     |  . ||| |.
RQILKGLLYYLHSHHIIHRDIKPANILL---------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ
Kinase ISR1.AA Pkinase 259-365 25 7e-06 21.8 Pfam 112-212 (293) Show / Hide 
Range on Protein: 259-365
Range on HMM: 112-212/293
Sequence Identity: 25% (28 aa)

RLMKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSA----FHINQTPTDLNTTVEYCAPELIDSSSDHVPTFESDLYAVGLC
. |.|.. .|. .  .|||| |.| .|||| .  ...       .. ..|| .|       |. .|..  | .|.|||.| .....  . ..| ...|. 
FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY--GPKVDMWSCGCI

LLSFISQHEPY
|  ... . |.
LYEMLCGRPPF