Gene GCN2 (Bakers Yeast)

GCN2

Species: Bakers Yeast
Alias: GCN2
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
GCN2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
GCN2.AA Protein Refseq_NP 1659 Derepression of GCN4 expression; Gcn2p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of GCN2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD GCN2.AA RWD 17-128 31 6.5e-37 129.86 SMART 1-128 (128) Show / Hide 
Range on Protein: 17-128
Range on HMM: 1-128/128
Sequence Identity: 31% (40 aa)

NELEAIRSIYMDDFTDLTKRKSSWDKQPQIIFEITLRSVD-----------KEPVESSITLHFAMTPMYPYTAPEIEFKNVQ-NVMDSQL--QMLKSEFK
.||||. |||.|||...  . . |.....| ..|.... .           .|. . .||||| ....||..||.|...|.| ...|.|.  |.|.....
MELEALESIYPDDFECIDEDRHHWVINCCIQIHIHPHEDEMQITNYDNFYEGEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQKHLQ

KIHNTS--RGQEIIFEITSFTQEKLDEF
.|...   ||...|||.... ||.|.|.
EIWEENWCRGMCMIFEWVQWVQEFLSEH
RWD GCN2.AA RWD 10-125 28 1.1e-29 109.7 Pfam 1-119 (119) Show / Hide 
Range on Protein: 10-125
Range on HMM: 1-119/119
Sequence Identity: 28% (35 aa)

QYYEIQCNELEAIRSIYMDDFTDLTKRKSSWDKQPQIIFEITLRSVDKEPVESSITLHFAMTPMYP-YTAPEIE-FKNVQNVM---DSQLQMLKSEFKKI
 . |.| .||||..|||.|||.| ......|.. .. .|.|.. . . .. . ...||| ... || ...|.|. ... .|.    |.|.| |... ...
MCQEEQEDELEALESIYPDDFED-LRGTICWTEISPWHFTIKI-DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQQLCKKLQEY

HNTSR-GQEIIFEITSFTQEKL
 ...  |...|||. .. || |
WEENCHGMVMIFEWIEWLQENL
Kinase GCN2.AA Ciliate-E2 502-527 32 2e-06 18.28 In-house 335-365 (365) Show / Hide 
Range on Protein: 502-527
Range on HMM: 335-365/365
Sequence Identity: 32% (10 aa)

DLLSK----MLNNDPKKRLG-TLELLPMKFL
||..|    ||. ||.||..   ..|  ...
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GCN2.AA GCN2 463-527 25 7e-06 16.01 In-house 434-511 (511) Show / Hide 
Range on Protein: 463-527
Range on HMM: 434-511/511
Sequence Identity: 25% (20 aa)

DIWQL-GVLFIQIISG-SDIVMN----------FETPQEFLDSTSMDET-LYDLLSKMLNNDPKKRLGTLELLPMKFL
|.. | |..|  .. . ..  |           .| || |      . .  .|.....|| ||.||. . .||  .||
DMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase GCN2.AA PEK 500-527 28 1e-05 15.16 In-house 628-655 (655) Show / Hide 
Range on Protein: 500-527
Range on HMM: 628-655/655
Sequence Identity: 28% (8 aa)

LYDLLSKMLNNDPKKRLGTLELLPMKFL
..|....||..||..|  . ..|  .|.
QADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase GCN2.AA Pkinase 443-527 15 1.2e-05 20.99 Pfam 175-293 (293) Show / Hide 
Range on Protein: 443-527
Range on HMM: 175-293/293
Sequence Identity: 15% (18 aa)

STWIAPELLKFNNAKPQRLTDIWQLGVLFIQIISG-------------SDIVMNFETPQ-----EFLDSTSMD-----------------ETLYDLLSKM
. ..|||......  . .  |.| .|..... ..|             ....| ... .     ..  . |.                  |.. |.....
PWYMAPEVIRGGQYYG-PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LNNDPKKRLGTLELLPMKFL
|. |||||..  ..|  ...
LCKDPKKRPTAEQILQHPWF
Kinase GCN2.AA Ciliate-E2-Unclassified 342-471 19 1.4e-05 15.34 In-house 95-260 (352) Show / Hide 
Range on Protein: 342-471
Range on HMM: 95-260/352
Sequence Identity: 19% (32 aa)

KIRLLTEYCNYYPLGDLIQSVGF-----------------VNLATAR-----IWMIRLLEGLEAIHKLG-IVHKCINLETVILVKD--------ADFGST
.| . .|||..  | . |.. ..                 .    |.      ..  .|.||| .|. . |.|  | .| ... ..        .|||. 
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

IPKLVHSTYGYTVL-NMLSRYPNKNGSSVELSPSTWI---APELLKFNNAKPQ--RLTDIWQLGVLF
.     . .  |   . ........ ...  .|.. .   |||.|. .|   .     ||| |||..
KKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
Kinase GCN2.AA NEK 502-527 38 0.000107 12.92 In-house 261-286 (286) Show / Hide 
Range on Protein: 502-527
Range on HMM: 261-286/286
Sequence Identity: 38% (10 aa)

DLLSKMLNNDPKKRLGTLELLPMKFL
.|.|.||. ||..|  . ..| | |.
NLISQMLQKDPEQRPSCNQILEMPFI
Kinase GCN2.AA Ciliate-E2-Unclassified 502-527 38 0.000118 12.09 In-house 327-352 (352) Show / Hide 
Range on Protein: 502-527
Range on HMM: 327-352/352
Sequence Identity: 38% (10 aa)

DLLSKMLNNDPKKRLGTLELLPMKFL
|||.|||...|.||..  ..|   ..
DLLQKMLKKNPNKRITFEQILNHPWF
Kinase GCN2.AA Ciliate-E2 342-391 19 0.000935 8.75 In-house 108-184 (365) Show / Hide 
Range on Protein: 342-391
Range on HMM: 108-184/365
Sequence Identity: 19% (15 aa)

KIRLLTEYCNYYPLGDLIQSV----GFV-------NLATARIWMIRLLE---------------GLEAIHKLG-IVH
.| | .|||..  | |.|..     ..        ..  ..  |  .|.               .|| .|. . |.|
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH
Kinase GCN2.AA STE-Unique 444-484 20 0.025622 3.36 In-house 513-556 (616) Show / Hide 
Range on Protein: 444-484
Range on HMM: 513-556/616
Sequence Identity: 20% (9 aa)

TWIAPELLKFN---NAKPQRLTDIWQLGVLFIQIISGSDIVMNF
....|| .  .   |    .  ||| || ... ...|..  ...
CYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQR
Kinase GCN2.AA Pkinase 345-391 29 0.030491 9.01 Pfam 77-131 (293) Show / Hide 
Range on Protein: 345-391
Range on HMM: 77-131/293
Sequence Identity: 29% (16 aa)

LLTEYCNYY----PLGDLIQ--SVGFV--NLATARIWMIRLLEGLEAIHKLGIVH
. .|||.       | |.|.  . | .     ... .|  .|.||| .|. ||.|
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase GCN2.AA STE 502-527 35 0.035357 3.64 In-house 332-359 (359) Show / Hide 
Range on Protein: 502-527
Range on HMM: 332-359/359
Sequence Identity: 35% (10 aa)

DLLSKMLNNDPKKRLGTLELLP--MKFL
| ..| |. ||.||  . .||    .|.
DFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GCN2.AA WEE 500-527 32 0.046047 2.8 In-house 270-297 (297) Show / Hide 
Range on Protein: 500-527
Range on HMM: 270-297/297
Sequence Identity: 32% (9 aa)

LYDLLSKMLNNDPKKRLGTLELLPMKFL
| .|.  |.. ||..|  . .||    |
LKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GCN2.AA STE 295-391 15 0.228568 0.74 In-house 53-175 (359) Show / Hide 
Range on Protein: 295-391
Range on HMM: 53-175/359
Sequence Identity: 15% (20 aa)

NTSNGK------------KEIANLEKELETVLKAK--HDNVNRLFGYTV----ERMGRNNATFVW--KIRLLTEYCNYYPLGDLIQ---SVGF-------
|... .            .|. ...||...  | .  |.|. . .|. .    .          .  .. .  ||...  | |.|.   ..|.       
NNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN--------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ

----VNLATARIWMIRLLEG-LEAIHKLGIVH
    ..    ..    .|.| |. .|...|.|
HQHRFPESQIAYICRQILKGLLYYLHSHHIIH
Kinase GCN2.AA GCN2 599-981 32 1.9e-162 545.97 In-house 1-511 (511) Show / Hide 
Range on Protein: 599-981
Range on HMM: 1-511/511
Sequence Identity: 32% (169 aa)

FEEIAVLGQGAFGQVVK-ARNALDSRYYAIKKIRH--TEEKLST---ILSEVMLLASLNHQYVVRYYAAWLE--------------------EDSMDENV
||||..||.|.|||||| .||..|.|||||||...  ...||..   |..||.||..|.||.|||||.||.|                    ...  . .
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

FESTDEESDLSESSSD--FEENDLLDQSSIFKNR------TNHDLDNS--------------------------------------------NWDFISGS
|.. .|... ...|.   ..|     ..|.  |       .| ... .                                            .|| | . 
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWD-IESN

GYPDIVFEN--SSRDDENEDL-------------DHDTSSTSSSESQDDTDKESKSIQNVPRRRNFV----KPMTAVKKKSTLFIQMEYCENRTLYDLIH
   |  ...  ......|...             | . . .. ||.|.    ..... .. .  | |    ..   .|.  .|.|||||||..||...|.
NVRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYID

SENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKN-------------------------VHRSLDILKLDSQNLPG
........||.||.||||||.|.||||||.|||||||.|||.|...||||||||||.|                         .....| .... |. ..
NHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFS

SSD------NLTSAIGTAMYVATEVLDGTGHYNEKIDMYSL-GIIFFEMIYP-FSTGMERVNILKKLRSVSIEFPPDFD---DNKMKVEKKIIRLLIDHD
..|      ..|...||..|...|..  ..|||.|.||||| |||||||.|| |.|.||||.|||.||  |.|||.|||   ||..| ....|| ...||
QWDQQDEQVHHTGKVGTPFYMCPEQQ--KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR--SCEFPQDFDKKVDNHHKDQQDMIRWCLNHD

PNKRPGARTLLNSGWL
|.||| |..||....|
PQKRPSAQQLLQHEFL
Kinase GCN2.AA PEK 599-981 24 7.79999999999e-148 497.43 In-house 1-655 (655) Show / Hide 
Range on Protein: 599-981
Range on HMM: 1-655/655
Sequence Identity: 24% (161 aa)

FEEIAVLGQGAF-GQVVKARNALDSRYYAIKKIRHTEEK-----------------LST-ILSEVMLLASLNHQYVVRYYAAWLE--EDSMDENVFESTD
||||..||.|.| |||.|..|.||..|||||.|..   .                 ... .| ||..||.|||...|||..||.|  |. . ... |...
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

EES----------------------------------------------DLSESSSDFEENDLLDQSSIFKNRTNHDLD--------------NSNWDFI
..|                                              . ...|....... ...|.....    | .              ..| .  
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

SGSGYPDIVFENSSRD-----------------------------------------------------------DENEDLDHDTSSTSS----------
. | . ..|...|| |                                                           ....| .|...  .|          
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

------SESQDDTDKE--------SKSIQNVPRRRNFVKPMTAVKKKS--------TLFIQMEYCENRTLYDLIHSEN----------------------
      ...||..| .        |.| ..  .  |. .  . .|..         .|.|||||||  || |.|.. .                      
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIM

---------------------LNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRN-----VKIGDFGLAKN-------------------
                     .....|..||.||||||.| ||||||.|||||||.|||.| . .     |||||||||.|                   
NQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYW

---VHRSLDILKLDSQNLPGSSD---------------------NLTSAIGTAMYVATEVLDGT----GHYNEKIDMYSLGIIFFEMIYPFSTGM-ERVN
   .. ...... ..||.|...|                     ..|...||..|.. |.|.|.    .|||.|.||||||||||||.|||.| | |||.
KYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVK

ILKKLRSVSIEFPPDFD----DNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
.|..||..||.|| ||.    |||.......|.....||| .|| |  .|.....
TLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase GCN2.AA S_TKc 599-981 20 5.8e-64 219.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 599-981
Range on HMM: 1-231/231
Sequence Identity: 20% (84 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVRYYAAWLEEDSMDENVFESTDEESDLSESSSDFEENDLLDQS
.| . ..|.||||.| |.|.  . |..|||.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

SIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQNVPRRRNFVKPMTAVKKKSTLFIQMEYCEN--RTL
                                                      ... .| .  ..  .  | ||   .    . |.. ||||..   .|
------------------------------------------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

YDLIHSENLN-----QQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSAIGTAMYV
.|.|.. . .         . .....||..|| |.||.||||||||| ||..||  ..||.|||||. .                     |. .||  |.
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------TTFCGTPWYM

ATEVLDGTGHYNE-KIDMYSLGIIFFEMIY---PFSTGMERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN-------SGW
| |||    .|.  |.|..|.|.|..||..   ||.   .   ..||..               .  | .|| . . ||.|||.|  .|.         |
APEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F
Kinase GCN2.AA STE 599-981 18 9.1e-59 201.55 In-house 1-359 (359) Show / Hide 
Range on Protein: 599-981
Range on HMM: 1-359/359
Sequence Identity: 18% (89 aa)

FEEIAVLGQGAFGQVVKARNAL---------------DSRYYAIKKIRHTE------------------EKLSTILSEVMLLASLN--HQYVVRYYAAWL
.| | ..|.||||.|.||.|                   ...|||.... .                  |..  || |. ..  .|  |...|.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EEDSMDENVFESTDEESDLSESSSDFEENDLLDQSSIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQ
 |.                                                                                                 
KEGHN-----------------------------------------------------------------------------------------------

NVPRRRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHS-----ENLNQQR--------DEYWRLFRQILEA-LSYIHSQGIIHRDLKPMNIFIDESRNV
               | ...|.| |||... .| |.|..     ..||..|        ..  .  ||||.. |.|.||..|||||.|| ||..     |
--------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----V

KIGDFGLAKNVHRSLDILKLDSQNLPG-------SSD-NLTSAIGTAMYVATEVLDG-----TGHYNEKIDMYSLGIIFFEMI---YPFST-GMERVNIL
|. |||.....  |.. . . |    .       ... . .. .||  . | ||...      ..|..| |..|||.   ||.   .|...    |.  .
KLCDFGVCGQLTDSMANI-Q-S----NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFM

KKLRSVSIE----------FPPDFDD-------------------NKMKVEKKIIRLLIDHDPNKRPGARTLLN--SGWL
.   ... .           || . |                   .  .  |  |..  . |||||| |  ||.    ..
IPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GCN2.AA Ciliate-E2 779-981 23 1.5e-46 157.76 In-house 104-365 (365) Show / Hide 
Range on Protein: 779-981
Range on HMM: 104-365/365
Sequence Identity: 23% (66 aa)

KKKSTLFIQMEYCENRTLYDLIH--SENLNQQRD--------EYWRLFRQILE---------------ALSYIHSQG-IIHRDLKPMNIFIDESRNVKIG
|....... ||||.  .|.|.|   . . |....        |  ....|||.               || |.||.. |||||.|| ||..     .|| 
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII

DFGLAKNVHRSLD---------ILKLDSQNLPGSSDNL---------TSAIGTAMYVATEVLDGTG--------HYNEKIDMYSLGIIFFEMI---YPFS
||||.|... . .         ...  ...  ... ..          . .||..|.| |.| | .        .|..|.|..|||.|..||.   .|| 
DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-

TGMERVNILKKLRSVSIEFPPDF-------------DDNKMKVE-KKIIRL----LIDHDPNKRPG-ARTLLNSGWL
        ...     |.||. .             . .|   | | .|.     ... ||.||.. .  .||  |.
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GCN2.AA Ciliate-E2-Unclassified 599-981 16 2.9e-45 154.96 In-house 1-352 (352) Show / Hide 
Range on Protein: 599-981
Range on HMM: 1-352/352
Sequence Identity: 16% (80 aa)

FEEIAVLGQGAFGQVVKARNALDSRYY-----AIKKIRHTEEKLSTILSEVMLL----ASLNHQYVVRYYAAWLEEDSMDENVFESTDEESDLSESSSDF
.. | ..|||.||.| |...  .  .|     ..|..     .  .   | |.      .... |..|                                
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQR-K------------------------------

EENDLLDQSSIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQNVPRRRNF---------------VKP
                                                                                .                || 
--------------------------------------------------------------------------------YNKIMQQILLNHPHPFIVKM

MTAVKKKSTLFIQMEYCENRTLYDLIHS------------ENLNQQR---DEYWR------LFRQILEALSYIHSQG-IIHRDLKPMNIFIDESR---NV
. . ..| ...| |||||. .| . | .            .|..|..   ..  .      .|.|||..|.|.|... |||||.|| ||..|..    ..
FYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYI

KIGDFGLAKNVHRSLDILKLDSQNLPGS---------SDNLTSAIGTAMYV----ATEVLDGTGHYN---EKIDMYSLGIIFFEMI---YPFS--TGME-
|| |||..|        .. ....  ..         ...... .|| .|     | |||.| ....   .|.|..|||.|..||.   |||.  .  . 
KIIDFGISK-------KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQH

------------RVNILKKLRSVSIEFPP--------DFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
            | .....     |.||.        . ...     ..... ... .||||...  .||  |.
QQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GCN2.AA Pkinase 781-981 28 8.6e-44 155.93 Pfam 72-293 (293) Show / Hide 
Range on Protein: 781-981
Range on HMM: 72-293/293
Sequence Identity: 28% (69 aa)

KSTLFIQMEYCENR----TLYDLIH-SENLNQ--QRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNV----KIGDFGLAKNVHRSLDILKL
|. . . |||||.      |.|.|. ... .   . .|  . ..|||..| |.||.||||||||| ||.||.  ..    ||.|||||| .         
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------

DSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGM----ERVNILKKLRSVSI---EFPPDFDDNKM--------
       ..  .|.  ||  |.| ||. |  .|  |.||.|.|.|..||.    ||. |     . .. ..... .     .|. . .....        
-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH

---------KVEKKIIRLLIDHDPNKRPGARTLLNSGWL
         .  |..|. ... ||.|||.|. .|.. |.
FHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GCN2.AA STE-Unique 779-981 24 5.3e-42 145.86 In-house 364-616 (616) Show / Hide 
Range on Protein: 779-981
Range on HMM: 364-616/616
Sequence Identity: 24% (63 aa)

KKKSTLFIQMEYCENRTLYDLIHSENLN--------QQRDEYWRLFRQILEALSYIHSQG--IIHRDLKPMNIFIDESR-----NVKIGDFGLAKNVHRS
| . .. |.|||||. || ..| .             . .|  .. .||||.| |.|||.  |||||||| |||.. .      .|||.|||.|.     
KEQNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPD

-----LDILKLDSQNLPGSS-------------------DNLTSAIGTAMYVATEVLDGT----GHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILK--
     .    . . .    .                    .... .||  | . ||. .      .|. | |..|||...|.|.  . . ..| ...   
HFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYI

KLRSVSIEFPP-----DFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
 ..  .   ||     .  .   .    .|..... .|..|| |  || ..||
EMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase GCN2.AA HRI 814-981 36 1.2e-35 123.06 In-house 437-613 (613) Show / Hide 
Range on Protein: 814-981
Range on HMM: 437-613/613
Sequence Identity: 36% (68 aa)

RLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRN----VKIGDFGLAKNVHRSLDILKLD--------------SQNLPGSSDNLTSAIGTAMYVATEV
..| ||.| . |||  .|.|||.|| |||  .  .    |||||||||       |||.                .   |  .   || .|| .| . | 
KIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACE-----DILQEPKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQ

LDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
|||.  |  | ||||.|.| ||.  || | ||| ..|  .|   |   |.    .  |  | | .|      .|| |  || |   
LDGS-QYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQI---PESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase GCN2.AA NEK 779-858 37 1.1e-27 94.75 In-house 76-171 (286) Show / Hide 
Range on Protein: 779-858
Range on HMM: 76-171/286
Sequence Identity: 37% (37 aa)

KKKSTLFIQMEYCE-NRTLYDLIHSENLNQQR--------DEYWRLFRQILEALSYIHSQ-----GIIHRDLKPMNIFIDESRN----VKIGDFGLAK
.....|.| ||||| . .||..| |  ...|.        .. |. | |.. || |.|..      |.|||.||.|||.. ..|    |||||||..|
EQNNCLCIVMEYCEGGGDLYQKIKS--IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISK
Kinase GCN2.AA WEE 781-918 26 4.3e-26 84.58 In-house 77-229 (297) Show / Hide 
Range on Protein: 781-918
Range on HMM: 77-229/297
Sequence Identity: 26% (45 aa)

KSTLFIQMEYCEN--RTLYDLI-HSENLNQ--QRDEYWRLFRQILEALSYIHSQ-GIIHRDLKPMNIFIDESR--------------------NVKIGDF
.....||||||..    |...| ...| |.  . .. | ....|...|..|||. |..| |.|| |||| .                      . |||||
DDHMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDF

GLAKNVHRSLDILKLDSQNLPGSSDNLTSA-IGTAMYVATEVLDG--TGHYNEKIDMYSLGIIFFEM
|.....                 . | ...  | . | | |.| |  .  .. | | .|||| ..|.
GHVTDMNS--------------NNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYEL
Kinase GCN2.AA PEK 724-858 25 3.2e-25 80.18 In-house 334-514 (758) Show / Hide 
Range on Protein: 724-858
Range on HMM: 334-514/758
Sequence Identity: 25% (48 aa)

DIVFENSSRDDENEDLDHDTSSTSSSESQDDTD-------KESKSIQNVP---------------RRRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIH
.|.|| || .|       ...|| . ..|.  .       ..|||  ..                .  | .  |     . ...|||..|.  || |.. 
SIIFEDSSCEDNKP--KEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNNKNWKMHPTGNCIYMYIQMQLCRKETLKDWMR

S--ENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRN--------------------------VKIGDFGLAK
      .  . .   .| ||.|.. |||| |.||||||| |||   |.                           .|||||||..
NRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFF--SMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLVT
Kinase GCN2.AA PEK 877-981 30 3.8e-25 79.91 In-house 641-758 (758) Show / Hide 
Range on Protein: 877-981
Range on HMM: 641-758/758
Sequence Identity: 30% (37 aa)

SSDNLTSAIGTAMYVATEVLDGT---------------GHYNEKIDMYSLGIIFFEMIYP-FSTGMERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRL
|. . |   ||  | . | . ..               ..||.| | ||||.||||.|.| ||| |||. ....||  .  .|..|.. |   | . | .
SCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLR--NGQWPKWFTQ-KYPQEYEFIQQ

LIDHDPNKRPGARTLLNSGWL
.....|  || |  .. .   
MMSMNPDERPTADQISMHDFF
Kinase GCN2.AA WEE 599-668 37 1.8e-24 79.03 In-house 1-80 (297) Show / Hide 
Range on Protein: 599-668
Range on HMM: 1-80/297
Sequence Identity: 37% (30 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLN-------HQYVVRYYAAWLEEDSM
|.|. ..|.| ||.|.|.|...|.. |||||...   ..|    .| ||  ...|        | ..|||| || | |.|
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHM
Kinase GCN2.AA PEK 599-685 25 8e-22 68.59 In-house 1-132 (758) Show / Hide 
Range on Protein: 599-685
Range on HMM: 1-132/758
Sequence Identity: 25% (34 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTE--------EKLST--ILSEVMLLASLNHQYVVRYYAAWLEED----------------------
||.| .||.| || | .| | .|  .||||.|.            ...    . ||  ||.|.|   |||. ||||..                      
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

-------SMDENVFES------TDEESDLSES
         ..  |.        ||.... |.
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENED
Kinase GCN2.AA STE-Unique 600-667 32 6.2e-21 70.66 In-house 1-77 (616) Show / Hide 
Range on Protein: 600-667
Range on HMM: 1-77/616
Sequence Identity: 32% (25 aa)

EEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK-------LSTILSEVMLLASLNHQYVVRYYAAWLEE--DS
...  .|.|.|| |....|  |....|||.|.    |        . |.||......|.||..|.|| .||..  ||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGGCDS
Kinase GCN2.AA HRI 599-665 40 2.6e-20 67.74 In-house 1-70 (613) Show / Hide 
Range on Protein: 599-665
Range on HMM: 1-70/613
Sequence Identity: 40% (28 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK---LSTILSEVMLLASLNHQYVVRYYAAWLEE
||. ...|.| .|.| | |. ||  .||||||. .. .   .  .. ||  || |.|  .|||  ||.|.
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEH
Kinase GCN2.AA NEK 599-667 33 8.9e-19 63.08 In-house 1-78 (286) Show / Hide 
Range on Protein: 599-667
Range on HMM: 1-78/286
Sequence Identity: 33% (26 aa)

FEEIAVLGQGAFGQVVKARNALDSRY-----YAIKKIRHT---EEKLSTIL-SEVMLLASLNHQYVVRYYAAWLEEDS
.|.| ..|||.||.| |.|   |..      |..|||  .   |..    . .|| .|..|.|...|.|| ...||..
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQN
Kinase GCN2.AA Pkinase 599-668 26 7.2e-16 57.19 Pfam 1-75 (293) Show / Hide 
Range on Protein: 599-668
Range on HMM: 1-75/293
Sequence Identity: 26% (20 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLST----IL-SEVMLLASLNHQYVVRYYAAWLEEDSM
.. . ..|.|.||.| |...  ... .|.|.|.  .|| .     .. ||. ....||| ..||.| .. ..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHI
Kinase GCN2.AA TyrKc 599-981 12 9.3e-12 -32.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 599-981
Range on HMM: 1-280/280
Sequence Identity: 12% (55 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASL--NHQYVVRYYAAWLEE--------------------------DSMDE
 . . .|| ||||.|.|..     .  |.|....    .  ...|  .. .|  .|. .|| |.. ...                           .  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NVFESTDEESDLSESSSDFEENDLLDQSSIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQNVPRRRN
.                                                                                                   
K---------------------------------------------------------------------------------------------------

FVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRS-LDILKL
                                     . ..      || .  .|.||...|||||   |. ..| . |||.||||.....         
------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---

DSQNLPGSSDNLT-----SAI--GTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTG-----MERVNILKKLRSV-SIEFPPD--------
       |.|  .     ..         | |..  .| ...| | .| |.  .|.     .   |     |.   .......    . ||.        
------ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVC

FDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
  |   .. . |..   ..||..||  ...     .
CPD---EMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase GCN2.AA Ciliate-E2 599-666 18 2.1e-10 31.89 In-house 1-105 (365) Show / Hide 
Range on Protein: 599-666
Range on HMM: 1-105/365
Sequence Identity: 18% (19 aa)

FEEIAVLGQGAFGQVVKARNALDSR-----------------------YYAIKKIRHTEEKLSTILSEVM--------------LLASLNHQYVVRYYAA
.. | ..|||.||.| |... .. .                       .||.| ... . .       .|              .| .||| .....| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WLEED
. |.|
FQEKD
Kinase GCN2.AA Pkinase_Tyr 788-860 31 2e-08 29.13 Pfam 86-161 (270) Show / Hide 
Range on Protein: 788-860
Range on HMM: 86-161/270
Sequence Identity: 31% (24 aa)

MEYCENRTLYDLIHSE---NLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNV
|||...  |.|  ..    . .    .     .|| ....| .|...|||||   |. ..|.. |||.|||||. .
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase GCN2.AA Pkinase_Tyr 599-661 23 8.9e-07 23.58 Pfam 1-72 (270) Show / Hide 
Range on Protein: 599-661
Range on HMM: 1-72/270
Sequence Identity: 23% (17 aa)

FEEIAVLGQGAFGQVVKARNA----LDSRYYAIKKI--RHTEEK--LSTILSEVMLLASL-NHQYVVRYYAA
 . . .||.||||.|.|..       .    |.|..   ...|   .   ..|. .. .| .|. .||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV
Kinase GCN2.AA WEE 955-981 33 0.003922 6.44 In-house 271-297 (297) Show / Hide 
Range on Protein: 955-981
Range on HMM: 271-297/297
Sequence Identity: 33% (9 aa)

KKIIRLLIDHDPNKRPGARTLLNSGWL
| .|.. .. || .|| .. ||..  |
KQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GCN2.AA NEK 955-981 22 0.004554 7.11 In-house 260-286 (286) Show / Hide 
Range on Protein: 955-981
Range on HMM: 260-286/286
Sequence Identity: 22% (6 aa)

KKIIRLLIDHDPNKRPGARTLLNSGWL
...|....  || .|| .. .|.   .
QNLISQMLQKDPEQRPSCNQILEMPFI