Gene ZK666.8 (Nematode worm)
ZK666.8
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| ZK666.8.AA | Protein | Genbank | 366 | None | Fasta, JSON |
| ZK666.8.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 279 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of ZK666.8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | ZK666.8.AA | TTBKL | 68-332 | 35 | 2.9e-137 | 462.29 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 68-332 Range on HMM: 1-288/288 Sequence Identity: 35% (102 aa) WHIEGIIGKGGYGEIYLAIDMKLAEEVAIKAEPLVRKGKIARRMILEQAVLVKLQ--GKPHVPWIFGSGHTENFNFIVLQLLSANLGDIRRMSPTRK-LS |.|...||.||.|..|...||| ....|.. |.. |.... .||..|. ||.||| |.||.|.. .||.....||.|..|.. ||.|.|.|.|..| .| WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS KSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKT---RHVLMLLDFGLVRRYKDPDGEW-----------RTHRV---KAGFRGTQRYVSTRV .....||..| ..||...||.|..|||.||.|.|.|..... .....|.|||..|.|...|||| |..| ||.|||| ||.|... DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HRRLEQTPTDDMVSLLYTLIELLAGELPWRNIENSDAIWKMKDELHHGQID--HF--HESSQELIEFSQLVSRLDPMSELPYTTLQASV |.|.||.. ||..|..|..|||..| |||.|.|. . |..|| .... .. .. |.. .|. .| . ...|..... .|. ... HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | ZK666.8.AA | CK1 | 68-328 | 28 | 1.3e-102 | 347.16 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 68-328 Range on HMM: 1-339/339 Sequence Identity: 28% (96 aa) WHIEGIIGKGGYG-EIYLA-----IDMKLA-----EEVAIKAEPLVRKGKIARRMILEQAVLVKLQG-------------------KPHVPWIFGSGHTE | .. ||.||.| .||.. .||| ||.|.|.|| .|. ..|...| .. . .| .||.. . .|... WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED N-FNFIVLQLLSANLGDIRR--MSPTRKLSKSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGIT------------SKTRHVLMLLDFGLVR-RYK . .|..|..|| ||.|.|. . ..||.|.... .||.| . ||...|| |..||||||.|.|.|. ....... ..|||..| .|. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DPDGEW------------RTHRV---KAGFRG-TQRYVSTRVHRRLEQTPTDDMVSLLYTLIELLAGE--LPWRNIENSDA-----IWKMKDELHHGQID |.||.. |. | |.|||| | ||.| ..|.. ||.. ||..|..|.|||.| |. |||.|.. . . ||| | .. . DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM HF----------HESSQELIEFSQLVSRLDPMSELPYTTL .. |.. ||. .. . .. |.. .. .| . STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | ZK666.8.AA | TTBK | 68-294 | 43 | 1.5e-68 | 234.02 | In-house | 1-225 (257) | Show / Hide |
Range on Protein: 68-294 Range on HMM: 1-225/257 Sequence Identity: 43% (99 aa) WHIEGIIGKGGYGEIYLAIDMKLA-EEVAIKAEPLVRKGKIARRMILEQAVLVKLQGKPHVPWIFGSGHTENFNFIVLQLLSANLGDIRRMSPTRKLSKS | . || ||.|||| | || |.|||| | . . . .| ||| ||||..|| .| | ..||..|.||. || | || | . | | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLK---MEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLS SVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHVLMLLDFGLVRRYKDPDGEWRTHRVKAGFRGTQRYVSTRVHRRLEQTPTDDMVSLLYTL . |. || . ... |.||.||||||| | | ...|. .||||| |.| || |. | |||||| || | || | ||. || | | TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML IELLAGELPWRNIENSDAIWKMKDELHH .| . | |||| | | . .||.. | VEFVQGQLPWRKIKDKDQVGEMKEKYDH |
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| Kinase | ZK666.8.AA | Worm6 | 68-284 | 34 | 1.4e-57 | 197.56 | In-house | 1-229 (279) | Show / Hide |
Range on Protein: 68-284 Range on HMM: 1-229/279 Sequence Identity: 34% (80 aa) WHIEGIIGKGGYGEIYLAIDMKLAE--EVAIKAEPLVR--KGKIARRMILEQAVLVKLQGKP--HVPWIFGSGHTEN--FNFIVLQLLSANLGDIRRMSP | .. ||.||.| .|.. | . . ..|.|.| . .. . .| .|| .. .. |.. |. | ..| ||.||..|. ||.|.|. .| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCE---KQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP TRKLSKSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGI----TSKTRHVLMLLDFGLVR--RYKDPDGEWRTHR-VKAGFRGTQRYVSTRVHRRLE .||.| . .|| | ..|..||| .|..|||.|||| |.| .. .| . .||||. | .|.. ..| || | ..||||| || . |.. | DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQE QTPTDDMVSLLYTLIELLAGELPWRNIENSDA | . ||. | .| ..|.. |.||||... .|. QCRKDDCESWFYMMVEMIVGCLPWRHMKDHDH |
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| Kinase | ZK666.8.AA | CK1-Unclassified | 68-279 | 35 | 2.8e-32 | 92.59 | In-house | 1-219 (244) | Show / Hide |
Range on Protein: 68-279 Range on HMM: 1-219/244 Sequence Identity: 35% (80 aa) WHIEGIIGKGGYGEIYLAIDMKLAEEVAIKAEPLVRKGKIARRMILEQAVLVKLQGKP-------HVPWIFGSGHT--ENFNFIVLQLLSANLGDIRRMS .. || | ||||..|.|. |||||| | | . | .. ||. ..| .. .| ...|..|. || .| |. | YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK---HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC PTRKLSKSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHVLMLLDFGLVRRYKDP--DGEWRTHRVKAGFRGTQRYVSTRVHRRLEQTPT ||.| | || | | . || ...|||||| | . | . | .|.. . |||| ||.|. .|. . | . .. || || | . |. .|| -NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRR DDMVSLLYTLIELLAGELPWRNI ||. || |.|| .| |.||| || DDLESLGYVLIYFLKGSLPWQNI |
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| Kinase | ZK666.8.AA | CK1-D | 68-276 | 33 | 4.6e-31 | 106.77 | In-house | 1-205 (261) | Show / Hide |
Range on Protein: 68-276 Range on HMM: 1-205/261 Sequence Identity: 33% (70 aa) WHIEGIIGKGGYGEIYLAIDMKLAEEVAIKAEPLVRKGKIARRMILEQAVLVKLQGKPHVPWIFGSGHTENFNFIVLQLLSANLGDIRRMSPTRKLSKSS . | || | .|.||. ... |||||| |.. | . .| . .|| .| | |. ..| .|..|| | |. || | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTK---HPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKT VGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHVLMLLDFGLVRRYKDPD-GEWRTHRVKAGFRGTQRYVSTRVHRRLEQTPTDDMVSLLYTL | .| | |. . .| ..|||||| | |. | .. ..|||| .||.|. . | . || || | |. .|| ||. || | | VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLG-KRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL IELLAGELPW . | ||| MYFNRGSLPW |
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| Kinase | ZK666.8.AA | CK1-A | 68-280 | 33 | 1.6e-30 | 105.0 | In-house | 1-209 (261) | Show / Hide |
Range on Protein: 68-280 Range on HMM: 1-209/261 Sequence Identity: 33% (72 aa) WHIEGIIGKGGYGEIYLAIDMKLAEEVAIKAEPLVRKGKIARRMILEQAVLVKLQGKPHVPWIFGSGHTENFNFIVLQLLSANLGDIRRMSPTRKLSKSS ... || | .|.|||.| .. |||||| | . .| | | ||| . .| . |. ..| .|..|| | |. . .|. . YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKAR---HPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKT VGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHV--LMLLDFGLVRRYKDPDGEWR-THRVKAGFRGTQRYVSTRVHRRLEQTPTDDMVSLLY | .| | |. . .| ...|||||| | || || | |.|||| ..|.|. . | || || | | .||. ||| |. | VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI---GRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGY TLIELLAGELPWRNIE .. |.||| .. VMMYFNRGKLPWQGMK |
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| Kinase | ZK666.8.AA | CK1 | 68-279 | 33 | 9.7e-27 | 89.19 | In-house | 1-219 (271) | Show / Hide |
Range on Protein: 68-279 Range on HMM: 1-219/271 Sequence Identity: 33% (76 aa) WHIEGIIGKGGYGEIYLAIDMKLAEE---VAIKAEPLVRKGKIARRMILEQAVLVKLQG------KPHVPWIFGSGHT--ENFNFIVLQLLSANLGDIRR .. || | |.|||.|.| .| |||| |. .| | . | .. ||| ...| . .| ...|..|. || .| | YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEK--NKSK-HPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN MSPTRKLSKSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHVLMLLDFGLVRRYKDPD-GEWRTHRVKAGFRGTQRYVSTRVHRRLEQTP . ||.| | || | | . .| ...|||||| | . |.. | |.. . |||| ||.|.. .. | . .. || || | | .|| FC-NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSR TDDMVSLLYTLIELLAGELPWRNI ||| || | |. .| |.||| .. RDDMESLGYVLMYFLRGSLPWQGL |
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| Kinase | ZK666.8.AA | CK1-Unique | 68-277 | 21 | 1.4e-22 | 75.12 | In-house | 1-233 (337) | Show / Hide |
Range on Protein: 68-277 Range on HMM: 1-233/337 Sequence Identity: 21% (51 aa) WHIEGIIGKGGYGEIYLAIDMKLA------EEVAIKAEPLVRKGKIARRMILEQAVLVKLQGKP-------HVPWIFGSGHTENFNFIVLQLLSANLGDI | . ||.|||| . |. . . . | | .. |. | |..|. . |.. . .. . .||.... .. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTE-QHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEEC RRMSPTR-KLSKS------SVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITS-KTRHVLMLLDFGLVRR--YKDPDGEWRTHRVKAGFRGTQRYVS ..| . . . .. ... . | ... | .|..||..||.| | . | |.. ||.| || .. .. | | .. |||. .| . CMM-MKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCP TRVHRRLEQTPTDDMVSLLYTLIELLAGE--LPWR |. |.. ||| |..|.|. |. .. | |. CSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK |
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| Kinase | ZK666.8.AA | Dual | 140-291 | 30 | 6.4e-21 | 66.98 | In-house | 87-240 (282) | Show / Hide |
Range on Protein: 140-291 Range on HMM: 87-240/282 Sequence Identity: 30% (48 aa) NFIVLQLLSANLGDIRRMSPTRKLSKSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHVLMLLDFGLVRRYKD-PDGEWRTHRVKAGFRG ...| . .. | .||| ||.. .| | . |..||| .|||||.||| | |. . | | .||..|| | | .. || | | . | KYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYM-QDFRIVRKYIDPENKKHRTARKKVKMYG TQRYVSTRVHRRLEQTPTDDMVSLLYTLIELL-AGE-LPWRNIENSDAIWKMKDE . || . .| ||. . |.. |. . ..||. .. . | ||. CGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDN |
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| Kinase | ZK666.8.AA | Pkinase | 68-310 | 18 | 1.4e-15 | 56.12 | Pfam | 1-269 (293) | Show / Hide |
Range on Protein: 68-310 Range on HMM: 1-269/293 Sequence Identity: 18% (51 aa) WHIEGIIGKGGYGEIYLAIDMKLAEEVAIKAEPLVRKGKIARRMIL---EQAVLVKLQGKPHVPWIFGSGHTENFNFIVLQLLSANL---GDIRRMS--P .||...||.|..|. |.... . ..||.| ..... . .. . | ... .| . |.. .... .... .|. .. | ...| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR TRKL--SKSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHVLMLLDFGLVRRYKDPDGEWRTHRVKAGFRGTQRYVSTRVHR-RLEQTPT ... | . ... | . .| .|. | .|||.|| | . . . . . |||| . .. . . .| || .|.. |.| . . .| HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK DDMVSLLYTLIELLAGELPWRNI----ENSDAIWKMKDELH---HGQIDHFHESS-----------------QELIEF || |. .|.|.| |..|... . | ..... .. | ... .. | .|...| VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF |
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| Kinase | ZK666.8.AA | S_TKc | 68-326 | 19 | 2.2e-15 | 48.65 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 68-326 Range on HMM: 1-231/231 Sequence Identity: 19% (54 aa) WHIEGIIGKGGYGEIYLAIDMKLAEEVAIKAEPLVRKGKIARRMILEQAVLVKLQGKPHVPWIFGSGHTENFNFIVLQLLSA---NLGDIRRMSPTRK-- ..| .||||..|. |.... | ..|||| . .... | ..| | . |.. .... .. .. ..|. ... .| |. . .... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LSKSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHVLMLLDFGLVRRYKDPDGEWRTHRVKAGFRGTQRYVSTRVHRRLEQTP-TDDM .. . ... | . || .|. | .|||.|| | . .... |||| |.. | || |.. | .. |. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDW VSLLYTLIELLAGELPWRNIENSDAIWKMKDELHHGQIDHFHESSQELIEFSQLVSRLDPM-------SE-------LPYT |. .|.|.|.|. |.. . ....|. |.|...| . . || . |. WSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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| Kinase | ZK666.8.AA | TyrKc | 68-317 | 15 | 0.000115 | -147.19 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 68-317 Range on HMM: 1-280/280 Sequence Identity: 15% (49 aa) WHIEGIIGKGGYGEIYLAIDMKLAEEVAIKAEPLVRKGKIARRMILEQAVLVKLQ--GKPHVPWIFGSGHTE--NF---NFIVLQLLSANLGD----IRR . . ..| | .||.|... .| ..||.| |..... | . . |.. ..| .. || . . . . .|| .|. ITLGKKLGEGAFGEVYKGT-WK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK MSPTRKLSKSSVGRIAVQAIAALRDLHDVGYLHRDIKPGNMCFGITSKTRHVLMLLDFGLVRRYK--DPDGEWRTHRVKAGFRGTQRYVSTRVHRRLEQT |. |. . ...|. . . ||. .. |||. | | .... . |||| | . | | .|. . | | HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN-CL-VGENH--TVKISDFGLSRDIYDDDQQG-----------------ESKDYYRKKEHK PTDDMV--------SLLYT--------------LIELLA-GELPWRN-----IENSDAIWKMKDELHHGQIDH--------FHESSQELIE--------- ...|. .. | . |.. |. |. . ..|...| . |. | .. .. .... GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED ---FSQLVSRL ||...... RPTFSEIHECF |
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