Gene ZC449.6 (Nematode worm)

ZC449.6

Species: Nematode worm
Alias: ZC449.3, CE29623, aSWK315, ZC449.6
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: X:-6.26, WormBase Physical Map location: X: 4978614-4987044,

Classification

Group: STE
Family: STE7
Subfamily: MEK4

Sequence

Name Sequence Type Origin Length Description Download
ZC449.6.AA Protein Genbank 1218 None Fasta, JSON
ZC449.6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ZC449.6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
3Beta_HSD ZC449.6.AA 3Beta_HSD 8-24 52 1.4e-05 17.94 Pfam 1-17 (298) Show / Hide 
Range on Protein: 8-24
Range on HMM: 1-17/298
Sequence Identity: 52% (9 aa)

VITGGGGFLGAHLIAAL
..|||.||||.|.. .|
LVTGGCGFLGQHIVRML
3Beta_HSD ZC449.6.AA 3Beta_HSD 63-223 28 2.3e-25 81.5 Pfam 98-268 (298) Show / Hide 
Range on Protein: 63-223
Range on HMM: 98-268/298
Sequence Identity: 28% (49 aa)

HREYVYAFNVTGTKFLIEKCKFFGVPRFIYSSSIAVVFV---GKPIYNCDESEPYPLKSEYLDIYSSSKAEAEAFVRSQST-----I-QFKTTCLRFRAI
.|. ... ||.||. .|. |.  ||.||.| ||. ||.    |.||.| ||..||. . .  . |. |||.||..| .        .  . | .||  .|
YRDRCMKVNVQGTQNVIDACVQCGVRRFVYTSSMEVVGPNCYGQPIHNGDEHWPYESCDDHQHPYPCSKAMAEQLVLKANGWMMKNGGRMYTCALRPMGI

YGPQDVTVAEKVVQMVRKNLFMVKISRHGRESVSNMSSGENCGLALHLANQELSKK---EGSHGEVYFITDGE
||. . .   ...| |. .. |..|..   . ... .  .|  ..  || ..|      .   |..||..|..
YGEGCQFLFPFIRQCVKHGHHMFRIGDK--NNIHDWVYVGNVAWMHILAARALQDPKKMPHICGQFYFCYDDT
Kinase ZC449.6.AA MEK4 778-1047 57 2.4e-211 696.32 In-house 1-275 (275) Show / Hide 
Range on Protein: 778-1047
Range on HMM: 1-275/275
Sequence Identity: 57% (158 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHDI
||.|...|||.||.|.||.|..|...||||.|...|..|||||.|...|...|........||..||..||..|.||..|.||||||.|.||.|......
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

QKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAP--NGDGYDIKSEVWSLGI
||..|||.|.|...|.|..||..||.||.|||||.||||||||||||||||||||||.|..|.|...|.||||||||||..|  |.|||||.|.||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TMVEVANGKYPYDGFMDAPILDQVRMVVYGDPPILDSDHE---VSMSMKRFIALCTIKDRNLRASFDDLKKTNIY
||.|||.||.||....||...||..|||.||||||..||.   .||.|.|||..|..||||.|...|.|||.. |
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase ZC449.6.AA STE7 778-1047 41 1.9e-154 519.4 In-house 1-288 (288) Show / Hide 
Range on Protein: 778-1047
Range on HMM: 1-288/288
Sequence Identity: 41% (122 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGV--AWMCMELMD-LSLDKLYMIA
|. .. ||.|..|||.||.|.||.. ||||.| | ||.     .......  |... .  ..|. ||..||  ..||    |.|||.||  .|||.|...
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNND-----PEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRV

HDI----QKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSV-AQSVDVGCRPYMAPERLAPNGDGYDIKSE
...    .|  ||||||| .|||.|..|..|...|.|||||.||||||....|.||||||||||.|..|. |....|||.|||||||. .| ..||..|.
KKVYRGIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSD

VWSLGITM-VEVANGKYPYDGFMDAP---------------ILDQVRMVVYG-DPPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDLKK-TNIY
|||||||| .|.|.|.|||......|               |..|....|.. .||.|.   . |.....|...|..||.| |.....|.|    .
VWSLGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP---KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase ZC449.6.AA STE 778-1047 29 2.8e-88 299.59 In-house 1-359 (359) Show / Hide 
Range on Protein: 778-1047
Range on HMM: 1-359/359
Sequence Identity: 29% (107 aa)

LQELELLGNGSFG-VVRKMLHRPSNVE--------------MAVKQISLINNGP----------DDAFNKSMQRFRLEVEATKAASN-CDEIVRYYGITF
.. .| .|.|.|| |...| | ..| .              ||.||..| |. .          .. ... ||..  |..  |  .. .. ||.|||  |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NEG-------VAWMCMELMD-LSLDKLYMIAHDIQK---------VEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICG
.||         |.|||.||  |||...   . ..|           .||.............| ...  ||||||||||.||||     |||||||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

YLQNSVA----------------QS-VDVGCRPYMAPERLAPNG----DGYDIKSEVWSLGITMVEVANGKYPY---DGF---MDAP--I-----LDQVR
 |..|.|                ..  .||.  .||||.. .||    .|||.|. .||||.|..| |.||.|.     .   . .|  .     ..|. 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

MVVYGDPPILDSD-----------------HEVSMSMKRFIALCTIKDRNLRASFDDLKK--TNIY
..|.|.|| | ..                 |..| ..| ||..| .|| | |.. ..| |      
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase ZC449.6.AA MEK3 778-1047 40 3.2e-87 296.07 In-house 1-264 (264) Show / Hide 
Range on Protein: 778-1047
Range on HMM: 1-264/264
Sequence Identity: 40% (111 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQI-SLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHD
.  .. || | .|.| || ||.|   |||| | . .|        ..  |   .  .    | |   |..||  | ||  | |||.|| .|||.|  . .
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVN-------SQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYK

IQKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAPNGDG--YDIKSEVWSLG
 ..  ||| ||| .|.  ..||.....   .||||.||||.|. .|| ||.||||| ||| .|.|  .| ||.|||||||  | .    ||.|| |||||
PHGMHIPEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLG

ITMVEVANGKYPYDGFMDAPILDQVRMVVYGDPPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDLKKTNIY
|||.|.| | ||||   .    .| . || . || |  .   |  .. ||. |  |. . | |.  | .    
ITMIEMAIGRYPYDNWHT--PFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase ZC449.6.AA STE7-Unclassified 778-1041 33 2.3e-77 263.33 In-house 1-294 (301) Show / Hide 
Range on Protein: 778-1041
Range on HMM: 1-294/301
Sequence Identity: 33% (101 aa)

LQELELLGNGSFGVVRKMLHRP------SNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGV---AWMCMELMDL-SL
|. |. ||.|..|.|.| || .      ... || |.| ...|      |. |.    |... .  . .. ||.|||  ..|.      .|||.||. ||
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDND-----NEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSL

DKLYMIAHDI------QKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSV-AQSVDVGCRPYMAPERLAPN
|..  |           .  |||..|| .| . |..|..|.  ||||||||||.|||..  | ||.||||.|| |.|..  ..  |||  ||.|||.  .
DNKIDIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERI--Q

GD-----GYDIKSEVWSLGITMVEVANGKYPYD------GFMDAP------ILDQVRMVVYGDPPILDSDH---EVSMSMKRFIALCTIKDRNLRASFDD
|.     .| .||..||||.|  |.|.|||||.      .  . .      ... . ..|    |.|..|      | ... ||. |..|. . |... .
GQMPHRPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQ

L
|
L
Kinase ZC449.6.AA MEK7 778-1047 38 6.9e-73 246.62 In-house 1-269 (269) Show / Hide 
Range on Protein: 778-1047
Range on HMM: 1-269/269
Sequence Identity: 38% (106 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHDI
|. ....|.|| | | || |. |.| |||||     |         . |    .       .|  ||. .|    .   | |||.|   .|||       
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGN------KEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHP

QKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAP---NGDGYDIKSEVWSLG
.   |||||.| . ||.| ||. ||. | |.|||.||||||||  | .||||||| | .  | |..   || .||||||. |   | . ||| . |||||
KLDFIPEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLG

ITMVEVANGKYPYDG-FMDAPILDQVRMVVYGDPPILDSDHE--VSMSMKRFIALCTIKDRNLRASFDDLKKTNIY
||.|| | |.||| |  |.  ..  .      .|| |.       |     |. .|  ||   |  .. | .   .
ITLVELATGQYPYPGCDMEFEMMTKILNDNL-EPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase ZC449.6.AA S_TKc 778-1047 24 5.8e-54 186.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 778-1047
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHDI
 . |...| |.||.|.|  |. .. ..|.|.|.              ...| |..  |   ... ||..|..  . .  .|.||..| .|  |. . .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

QKVE----IPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAPNGDGYDI-KSEVWS
..      .||     ..  ...|||..    .|||||.||.|||||.  ..|.||||..  |      .  .| . ||||| |     ||.  |. .||
GRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCKCDWWS

LGITMVEVANGKYPYDGFMDAPILDQVRMVVYGDPPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDLKK-------TNIY
.|... | . |. |..   .. ......                | ..| ||  |  || . | .  .. .           
CGCILYEMLCGYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ZC449.6.AA MEK1 778-986 40 1.7e-50 170.6 In-house 1-195 (297) Show / Hide 
Range on Protein: 778-986
Range on HMM: 1-195/297
Sequence Identity: 40% (85 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMD-LSLDKLYMIAHD
..... || |  ||| |. ||.. . || | | |           ....  .   .     |   || .||  ...|   .||| || .||| .   |  
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHL-------EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA--

IQKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAPNGDGYDIKSEVWSLGIT
     |||.||| |.|| .| |  |.  |.|.|||.||||||   .| .||||||. | |  |.| |  || | ||.||||   |  | ..|..||.|. 
---GRIPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQ--GTHYTVQSDIWSMGLS

MVEVANGKYP
.||.| |.||
LVEMAIGRYP
Kinase ZC449.6.AA Pkinase 778-1044 25 2.9e-39 139.89 Pfam 1-290 (293) Show / Hide 
Range on Protein: 778-1044
Range on HMM: 1-290/293
Sequence Identity: 25% (76 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFR-LEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHD
.. .. .| ||||.|.|  |. .. . |||.|..    ...  .| ....|  |..  |   |.. |||.|..  ...  .|.||...  |  .   .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK----RHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDY

IQ---KVEI--PEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCV----KLCDFGICGY--LQNSVAQSVDVGCRPYMAPERLAPNGDGYD
|.   .  .  .|. .  ..  ..|.||..   . |||||.||.|||.|..| .    |.||||..    . |..  .. .| ..||||| .   | .|.
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYG

IKSEVWSLGITMVEVANGKYPYD--GFMDAPILDQVRMVVYGDPPILDSDHEVS---------------------MSMKRFIALCTIKDRNLRASFDDLK
 |. .||.|... |...|. |..  .  . . .||  |..   .|.|..| . .                      ..| ||  |  || . | ......
PKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

KT
. 
QH
Kinase ZC449.6.AA TKL 784-1045 18 1.7e-37 130.85 In-house 1-364 (364) Show / Hide 
Range on Protein: 784-1045
Range on HMM: 1-364/364
Sequence Identity: 18% (71 aa)

LGNGSFGVVRKMLHRPSN--------VEMAVKQISLINNGPDDA-----------------FNKSMQRFRLEVEATKAASN--CDEIVRYYGITFNEGV-
.| |.||.| |  .|  .         ..|||...  |.  ..                   ..... .  |.| ..  |.  .. ||...|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AWMCMELM-DLS-LDKLYMIAHDIQKVEIPEQILGAVAVATIRALEHLKTTHH-------IIHRDIKPSNILLDRHGC----------
             .. ||..   | |. |              . .   |  . |....| . .        |||||.|..|||.|...           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----VKLCDFGICGYLQNSV--------------------AQSVDVGCRPYMAPERLAPNGD--------------GYDIKSEVWSLGITMVEVANGKYP
    .|.||||..  ...|                     . .  .|   .|||| |  ...               |. |. |.| || . |.. .. |
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

YDGFMDAPIL------DQVRMVVYG--DPPIL---------DSDHEVSMSMKRFIALCTIKDRNLRASFDDLKKTN
|....  |..      .   ||..    |||             . .  |||. .  |   | . | ||....|. 
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ZC449.6.AA MEK5 778-1047 34 3.1e-36 126.72 In-house 1-254 (254) Show / Hide 
Range on Protein: 778-1047
Range on HMM: 1-254/254
Sequence Identity: 34% (94 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDE--IVRYYGITFNEGVAWMCMELMDLSLDKLYMIAH
..  . || |  | | |  | ||   .||| | |      |   .  ..   |.|       ||   |. .||  | |    .| | ||     .|    
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL------DITLELQKQIMSELEILY---KCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC--

DIQKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAPNGDGYDIKSEVWSLGI
      |||.||| ..|| .. |. |     |.|||.||||.|   .| .||||||.   | ||...   .|   ||||||.   || | | |.||||||
------IPEHILGRMTVAIVKGLNYLWNL-KIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERIS--GDQYGIHSDVWSLGI

TMVEVANGKYPYDGFMDAP----ILDQVRMVVYGDPPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDLKKTNIY
 ..|.| |..||            .  .  .|  .|| | .| . |     ||  |  |    |   .|| .    
FFMEMATGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVD-KFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase ZC449.6.AA STE20 778-1043 28 1e-27 98.44 In-house 1-284 (288) Show / Hide 
Range on Protein: 778-1043
Range on HMM: 1-284/288
Sequence Identity: 28% (85 aa)

LQELELLGNGSFGVVRKMLHRPSNVE----MAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNE----GVAWMCMELMDL-SLD
 . || .|.||.|.| |  |.|.. .     |.|...| .  .     ....    |.   |    .  ||.|||  . .       |..||...  || 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ---DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLT

KLYM--IAHDI-QKVE--IPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQN-------SVAQSVDVGCRPYMAPER
 ..   . ... .|    . |.   ..   . ..|..|   .||||||||  ||||. .| |||.||| |. |..       .  ... ||   .|||| 
DIMKHCMKCGKNHK-GHPMNEEQIAYICREVLQGLDYL-HSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTF-VGTPYWMAPEV

LAPNG---DGYDIKSEVWSLGITMVEVANGKYPYDGFMDAPILDQVRMVVYG--DPPILDS--DHEVSMSMKRFIALCTIKDRNLRASFDDLKK
.. ..    ||| |. .||||||  | |.|. ||   .| . .    |.  .  .|| | .   |  | . . |...|  || . |.. ..| |
IQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPY---FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLK
Kinase ZC449.6.AA TyrKc 778-1051 19 1.7e-13 -4.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 778-1051
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAA-SNCDEIVRYYGITFNE-------GVAWMCMELMDL-SLD
.. .. ||.| ||.|.|   .   .. ||| .              .. |. | .  .    . . ||| ||.   .       .  .. ||.|.. .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

KLYMIAHDIQKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNS----VAQSVDV-----GCRP-----YMAP
.     ..   .  .. .  .. .|  .  |.|   ...||||.   |.|... ..|| .||| . .. .     ..... .     |..       |||
DYLRKHRPK--LCMKDLLSFCWQIA--CGMEYL-HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ERLAPNGDGYDIKSEVWSLGITMVEVA-NGKYPYDG-----FMDAPILDQVRMVVYGDPPILDSDHE-----VSMSMKRFIALCTIKDRNLRASFDDLKK
| .  |   . .|| ||| |..| |.  .|. || |       .. .. .|.   . ..|  |   .      .  | . .  |   | . | .| ..  
ECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--

TNIYRDYI
    ....
----HECF
Kinase ZC449.6.AA Pkinase_Tyr 905-1000 26 2e-06 22.72 Pfam 130-230 (270) Show / Hide 
Range on Protein: 905-1000
Range on HMM: 130-230/270
Sequence Identity: 26% (28 aa)

HHIIHRDIKPSNILLDRHGCVKLCDFGICGYL-----QNSVAQSVDVGCRPYMAPERLAPNGDGYDIKSEVWSLGITMVEVAN-GKYP-YDGFMDAPILD
...||||.   |.|... ..|| |||| . ..       .....      . |||| .. .   . .|| ||| |..| |.   |. | | |  .. ...
KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYE

QV-R
.. .
YIYE
Kinase ZC449.6.AA Pkinase_Tyr 778-794 41 0.041056 7.78 Pfam 1-17 (270) Show / Hide 
Range on Protein: 778-794
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

LQELELLGNGSFGVVRK
.. .. || |.||.|.|
ITFGKKLGEGAFGEVYK
Kinase ZC449.6.AA MEK1 1002-1047 26 0.100345 1.07 In-house 253-297 (297) Show / Hide 
Range on Protein: 1002-1047
Range on HMM: 253-297/297
Sequence Identity: 26% (12 aa)

VVYGDPPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDLKKTNIY
.| . || |..    |  .. |.  | ||  . ||    |.     
IVNEPPPKLPHRV-FSEEFQDFVDKCLIKNPDERADLKQLMVHTFI