Gene Y18D10A.5 (Nematode worm)

Y18D10A.5

Species: Nematode worm
Alias: Y18D10A.f, CE21401, Y18D10A.5, aSWK183
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:16.22, WormBase Physical Map location: I: 12827262-12832853

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
Y18D10A.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
Y18D10A.5.AA Protein Genbank 362 None Fasta, JSON

Protein domain

Protein domains of Y18D10A.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y18D10A.5.AA GSK 36-320 60 1.8e-230 712.07 In-house 1-328 (328) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-328/328
Sequence Identity: 60% (200 aa)

YYDQKVIGNGSFGVVFLAKLS----TTNEM----VAIKKVLQDKRFK-NRELQIMRKL---NHPNIVKLKYFFYSSGEKKDE--LYLN-LILEYVPETVY
| . ||||.||||||. |...    .|.|.    ||||||.||||.| |||||||..|   .|||||.||||||...|||||  .|.| |..||.|.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVR--NEPNVSYICSRYYRAPELIFGATNYTNSI
.|.|||.|..||.|.|..||||||..|.|||.||.|||||||||||.|.||..||||.|||||||.|..  ||||.||||||||||||||||.||||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFP-----QIKAHPWNK-------------------VFRV-HTPAE-
||||.|.||||.|.|||.|||||.|||||||||.|||||.||||||||.|.|||||     |||.|||.|                   .|.. ||... 
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

AIDLISKIIEYTPTSRPTPQAACQHAFF
.||||||. .|.|..|..|  ||.| ||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase Y18D10A.5.AA CMGC 36-320 23 5.5e-129 426.35 In-house 1-513 (513) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-513/513
Sequence Identity: 23% (121 aa)

YYDQKVIGNGSFGVVFLAKL--------------STTNEMVAIKKVLQDKRFKN----------------RELQIMRKLN-----------------HPN
|   |.|| |..|||. ..                 |||.|||||. ... ...                ||..|...||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLKYFFYSSGEKKDEL-----------YLNLILEYVPETVYRVARHYSK------------------------QRQQIPMIYVKLYMYQLLRSLA--Y
||||...||.......|            .|.|. ||.. . |.. .....                        . . ... ... ||||.||.|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHSIG--ICHRDIKPQNLLIDPE-------------------SGVLKLCDFGSAK-YLVR---------------------NEPNVSYICSRYYRAPELI
.|| .  |.|||.||.|.||...                   .|.||.||||.|. | ..                     |.|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGA---------TNYTNSIDVWSAGTVMAELLLG--------QPIFPGDSG-----------VDQLVEIIKVLGTPT---------------REQIQSMN
.|.         ..|| .||.||.| ..||...|        .|.|||.|.           .||| .|.|||||||                |.. .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PNYKEFK---------------------------FPQIKAHPWNKVFRVHTP----------------------------------AEAIDLISKIIEYT
...  .|                           ||... .||...|  | .                                   .||||..|. .| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PTSRPTPQAACQHAFF
|. |.|.. |.|| .|
PDKRITAEQALQHPYF
Kinase Y18D10A.5.AA Pkinase 36-320 32 1.2e-99 342.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-293/293
Sequence Identity: 32% (100 aa)

YYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNR--------ELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHY-
|   ..|| ||||.|....   |...||.|..  ... ..         |.|||..|||||||.|...|..    ||..|  ...||.. ..| |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIY--MVMEYCEGGLY-VMDLFD

---SKQRQQI--PMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVL----KLCDFGSAKY--LVRNEPNVSYICSRYYRAPELIFGATNYT
    ...  .  ..  .| ||||.|| |.|.|| ||.|||.||.|.||| . |..    |.||||.||   . .|. . .. ....|.|||.| |.. |.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

NSIDVWSAGTVMAELLLGQPIFPGD----SGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTP
 ..|.||.| ...|.|.|.|.|||.    . .||.. | ...|.|......  .... .| |.. . |. ...| . .. |..|.|...... |..|||.
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

QAACQHAFF
. ..|| .|
EQILQHPWF
Kinase Y18D10A.5.AA S_TKc 36-320 28 2.8e-89 303.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPE---TVYRVARHYSKQR--
|   ..|| |.||.|....   |.. ||||..    .   ||.||..| .|||||||...|..        .| ...||..    ..... ... ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTN-SIDVWSAGTVMAE
...|   .. ||||... |.|.|| ||.|||.||.|.|.|    ..|.||||.|. |       ... ...|.|||..     |.  ..|.|| | ...|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQ-------HAFF
.| |.| ||      |. ...|..|                                   . ||.|.|.|. .. |. |||   | |       | .|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y18D10A.5.AA RCK 36-320 32 2.8e-88 280.19 In-house 1-298 (298) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-298/298
Sequence Identity: 32% (101 aa)

YYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKN-------RELQIMRKLN-HPNIVKLKYFFYSSGEKKD--ELYLNLILEYVPETVYRVARH
|   | .| |..|.|..|.  .|.| |||||    ..|..       ||.. .|||| ||||.|||  ..     .|  .||  ...||. . .|   ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR----DNDTYQLY--FVFEYMDMNLYQMMKD

YSKQRQQ-IPMIY--VKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPE--------SGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNY
. . |.. .| .   .| .|||.| .||..|. |. |||.|| |... ..        ....|..|||...    . |.  |. .|.|||||..  .|.|
FKE-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYY

TNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMN--PNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQ
.  .|.|. | .|.||   .| ||| | .||. .|.||.|||. .         . ..|.||| |. | ....    . ..|.|. |   . |  |.|.|
NSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQ

AACQHAFF
.|.|| .|
QALQHPYF
Kinase Y18D10A.5.AA CDK 36-320 30 8.9e-78 248.39 In-house 1-284 (284) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-284/284
Sequence Identity: 30% (99 aa)

YYDQKVIGNGSFGVVFLAKLSTTN-----EMVAIKKVL--------QDKRFKN---RELQIMRKLNHPNIVKLKYFFYSS-----GEKKD-ELYLNLILE
|   . || |..|||. |.   |.     ..||.||.          .  |     ||  ....| |||||||.  ....     . |   |  | .. |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGV-----LKLCDFGSAKYLV-------RNEPNVSYICSRY
|..   . . .             .| ||.|||| |.|.|| .| |||.||||.||. . |.     ||. ||| |.           | .  . .  . 
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILIN-NNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLW

YRAPELIFGATNYT--NSIDVWSAGTVMAELLL---GQPIFPGDSGVDQLVEIIKVLGTPTREQIQ--SMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAI
|||||| .|...|.   .||.||.| ..||...   ..|.|||||  |||  |....|||| ..    .  |.|                          
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------

DLISKIIEYTPTSRPTPQAACQHAFF
||..|   | |. | . ..| || .|
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Y18D10A.5.AA CDC2 36-320 32 1.4e-75 231.62 In-house 1-301 (301) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-301/301
Sequence Identity: 32% (100 aa)

YYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKN--------RELQIMRKLN-HPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHY
|   . || |..|||. .|   ||..||.||.  .             ||. .. .|. |||||||.  ...       ||  .. ||.     .  . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLY--MVFEYLDMDLKKYMDMS

SKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICS-----RYYRAPELIFGATNYTNSIDVW
 ......| ..|| ||||.|. ... |. .| |||.||||.||| ..|..|. ||| |.    . |   |        . |||||. .|.  |. ..|.|
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

SAGTVMAEL---LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSM--NPNYKEFKFPQIKAHPWNKVFRV--------HTPAEAIDLISKIIEYTPTSR
| | ..||.       |.|.|||  |||  | ..||||. .  ...  .| ||. .||. |.    |..           .. |.|||..... | |  |
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

PTPQAACQHAFF
 . ..| || .|
ISAKEALQHPYF
Kinase Y18D10A.5.AA CDKL 37-320 36 9.6e-65 220.27 In-house 1-286 (286) Show / Hide 
Range on Protein: 37-320
Range on HMM: 1-286/286
Sequence Identity: 36% (107 aa)

YDQK-VIGNGSFGVVFLAKLSTTNEMVAIKKVLQ---DKRFK---NRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQ
|..  ..| || |||.  .   |.. ||||| .    |.  |    ||. . . | |.||| |.  |     .| .|.  |  ||.  ||  .  .   .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVF----RRKRKLH--LVFEYCDHTVLHELEE---Y

RQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLV-RNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMA
 . ..   |. ||.|.|..... |.  . |||||| |.|| | .|..|||||| |. |   .|    |   | ||||||  | | |  ..|.|..| |||
PNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMA

ELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIQSMNPNYKEFKFPQIK-AHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFF
|.. |||..||.| .|||  |.|.||  .|  ..| |.|| ..  |||.|.   |  | ..    ..|.|.. |  .  |. |.| . . .| .|
EMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase Y18D10A.5.AA CDK5 36-320 34 9.2e-62 193.73 In-house 1-287 (287) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-287/287
Sequence Identity: 34% (102 aa)

YYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKR------FKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQ
|     ||.| .|.|. |.  .| |.||.|.|  |           ||  ... | |.||| |     |  |||    | |. |.. .   .        
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHS--EKK----LTLVFEFCDQDLKKYMDSCNG-

RQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYL---VRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTV
  .. |  .| .|||||. ||. |.  . ||| |||||||    | ||| ||| |      ||.    . .    ||.|   .|.  |. |||.||.| .
--EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN-KNGELKLADFGLARAFGIPVRC--YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

MAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMN--PNYK--EFKFPQIKAHP-WNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFF
.||.   |.| ||| .  |||  | |..|||. ..  |.   |.||    ..|   ||. | .. .    ..  || .|.... |  | . .|| .|..|
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Y18D10A.5.AA CDK-Unclassified 36-320 29 4.2e-60 196.35 In-house 1-324 (324) Show / Hide 
Range on Protein: 36-320
Range on HMM: 1-324/324
Sequence Identity: 29% (97 aa)

YYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDK-------------RFK---NRELQIMRKLNHPNIVKLKYFFYSSGEKK-----DELY--LNLIL
|  |...| | || |..|    |.  |||||.                 ..|   .||. ... .|| || |.   .|.    .     | |   . ...
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPES----GVLKLCDFGSAKYLV----------RNEPNVSY--
||.| | | .       |    |  .. .| |.| ..||.|. .| ||||||||..|.        .||. |||.|                .|. .|  
EYMPYTWYNQ---LHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYST

-ICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ---IQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAE
 .  | |||||| ||   |.  .|.||.| ..||.. | |||.| . ..|.  |.|.||||. ..   . .| | |    |..     |   |   . | 
QVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYM-PDYCKIFFKYKQKFHWWNRFPKCKHAS

AIDLISKIIEYTPTSRPTPQAACQHAFF
 .....    | |  |.. . . ||  |
ENNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase Y18D10A.5.AA MAPK 128-320 33 6.4e-55 188.31 In-house 107-328 (328) Show / Hide 
Range on Protein: 128-320
Range on HMM: 107-328/328
Sequence Identity: 33% (76 aa)

KQRQQIPMIYVKLYMYQLLRS--LAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNV-------------------SYICSRYYRAPE
|..|.   . ..  |||.||   | |||| .. |||.|| |.|.. | . ||.||||    | | . .                     |.  |.|||||
KSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFG----LARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPE

LIFG--ATNYTNSIDVWSAGTVMAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMN-P-NYKEFKF-----PQIKAHPWNKVFRV---HTPAEA
....  ...|| ..|.||.|  .||.|  ..|.|||.. .||.  |..|||||..| || .  . .....       |. ...|| |.|     ..  .|
IMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQA

IDLISKIIEYTPTSRPTPQAACQHAFF
|||..|  .  |  | | . | || .|
IDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Y18D10A.5.AA ERK 142-320 34 1e-48 168.13 In-house 114-307 (307) Show / Hide 
Range on Protein: 142-320
Range on HMM: 114-307/307
Sequence Identity: 34% (68 aa)

MYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLV-RNEPNV--------SYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLL
|||.|. | |||| .. |||.|| |.|.  . ..|| |||| |  .    ..|.         |. .|.|||||..  ...|| ..|.||.|  .||.| 
MYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLG

GQPIFPGDSGVDQLVEIIKVLGTP-TREQIQSM-NPNYKEF--KFPQ--IKAHPWNKVFRVHT--PAEAIDLISKIIEYTPTSRPTPQAACQHAFF
..|.||| . |.|. .|....||| . |..|   ..|....  ..|   ... || ..|  .   | .||||..| ..  |. | |   . .| .|
RKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNP-QAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase Y18D10A.5.AA TyrKc 36-318 21 5.6e-15 19.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-318
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKN---RELQIMRKL--NHPNIVKLKYFFYSSGEKKDE---LYLNLILEYVPETVYRVARHYS
    |..|.| ||.|......   ..||.|..  |.  .    ||..||.||  .|||||.|     ..|..        | ...||.|    .   ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKH

KQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRN----EPNVSYI-----CSR-----YYRAPELIFGATN
. .  ..|     ...|  .  .|.|| .. |||.   | |.. .  . | .||| ....       |    |      ...        ||| |   ..
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYG

-YTNSIDVWSAGTVMAELL-LGQPIFPGD----SGVDQLVEIIKVLGTPTREQI----QSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEY
 .|   |||| | .| |.. .||.  ||.       ....| .|  . . . .                            | |. |.|  .....  ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F-VCCPDEMYQIMKQCWHE

TPTSRPTPQAACQHA
 | .||| .. ..  
DPEDRPTFSEIHECF
Pkinase_Tyr Y18D10A.5.AA Pkinase_Tyr 34-116 28 2.4e-13 45.8 Pfam 1-90 (270) Show / Hide 
Range on Protein: 34-116
Range on HMM: 1-90/270
Sequence Identity: 28% (27 aa)

ISYYDQKVIGNGSFGVVFLAKLS----TTNEMVAIKKVLQDKRFKN-------RELQIMRKL-NHPNIVKLKYFFYSSGEKKDELYLNLILEYVP
|.    |..| |.||.|.....      |.  ||.|.. ..   ..       ||..||..| .|||||.|    .. || .   .. ...||.|
ITFG--KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMP
Kinase Y18D10A.5.AA MAPK 36-93 32 8e-11 33.44 In-house 1-71 (328) Show / Hide 
Range on Protein: 36-93
Range on HMM: 1-71/328
Sequence Identity: 32% (23 aa)

YYDQKVIGNGSFGVVFLAKLST------TNEMVAIKKV---LQDKRFKN---RELQIMRKL-NHPNIVKLK
| ..| || |..|||. |.         ... |||||.    |.. .     ||. ..| . .|.||.||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLL
Kinase Y18D10A.5.AA ERK 36-93 31 2.4e-09 31.15 In-house 1-70 (307) Show / Hide 
Range on Protein: 36-93
Range on HMM: 1-70/307
Sequence Identity: 31% (22 aa)

YYDQKVIGNGSFGVVFLAKLST-----TNEMVAIKKV---LQDKRFKN---RELQIMRKLN-HPNIVKLK
| . | || |..|||. |.        |.. |||||.     .... .   ||. ..| .. |.||..|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLF