Gene T11F8.4 (Nematode worm)
T11F8.4
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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T11F8.4.AA | Protein | Genbank | 550 | None | Fasta, JSON |
T11F8.4.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 280 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of T11F8.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | T11F8.4.AA | TTBKL | 22-298 | 39 | 8.3e-133 | 447.51 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 22-298 Range on HMM: 1-288/288 Sequence Identity: 39% (119 aa) WHPVKVLGSGAFGKVVHVVNIVD-GSDGAMKMEKYQ-EGNESVLKGEVEVLRALS--GQKNAIQLLDSGLEPDYRFIVMTLCGMDLQKVYNLLKGQ--FS |. ||..|.|.||.| ||....| .. |||.||.. ||. |..| ||.|| .|. |.. ......|| ..||.|.||||||..||.... .. . || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS DSTVLRVAIRSLHAVKAVWEYYFIGTELFRTKLHEACYIHRDLKPCNVTLDYN----EYSPLIFLIDFGMGRKYAKIDEG--------EYVIRRPRD--- |.|..|..|. |.|.| .... ..||||.||||. ..|. |.. ...|||||| |.||. |.. .. .||||. DGTWSRIGIQCLYALKQMHDC---------------GFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRH ACRFRGTIRYCSPRMHLRREQGRVDDLYAWLYMIVELKVELPWSEVVHPDRIEFLKLEKFDAAMASNP-----LTKSFEPIMDHLKTLRYPDRPNYLMIY . ||||.|||||.||.|.||||.|||..|.|||.||...|||. ......|| .|... | ...... ....|...| ||..||| |||.| ||| KAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIY ELL |.. ECF |
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Kinase | T11F8.4.AA | CK1 | 22-294 | 27 | 2.3e-91 | 309.87 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 22-294 Range on HMM: 1-339/339 Sequence Identity: 27% (97 aa) WHPVKVLGSGAFG-KVVHV-----VNIVDG-----SDGAMKMEKY-QEGNESVLKGEVEVLRALSGQKNAIQ---------------------LLDSGLE | || .|.|.|| . .| ... .. . |||.|. ..| ..|. |......| |.|.. . . ..| | WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE PDYR-FIVMTLCGMDLQKVYN---LLKGQFSDSTVLRVAIRSLHAVKAVWEYYFIGTELFRTKLHEACYIHRDLKPCNVTLDY-------------NEYS .|| ..||||.|..|... . . .. ||..|.|..||. | |.. . . ..||||.||.|. ... |. . DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDC---------------GFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEH PLIFLIDFGMGR-KYAKIDEG---------EYVIRRPRD---ACRFRG-TIRYCSPRMHLRREQGRVDDLYAWLYMIVELKVE---LPWSEVVHPDR--- ...||||| | ||.. |.. ....|.||. .. ||| |.||||...||..||||.|||..|.||..|. . |||. . ... RQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKD --IEFLKLEKFDAAMASNP-----------LTKSFEPIMDHLKTLRYPDRPNYLMI .| | |..| |.| . ..| .||.....|.| |||.| || HQVEKMKYEFIDEKKMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | T11F8.4.AA | TTBK | 22-294 | 33 | 2.3e-37 | 129.61 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 22-294 Range on HMM: 1-257/257 Sequence Identity: 33% (92 aa) WHPVKVLGSGAFGKVVHVVNIVDG-SDGAMKMEKYQEGNESVLKGEVEVLRALSGQKNAIQLLDSGLEPDYRFIVMTLCGMDLQKV-YNLLKGQFSDSTV | || | |.|| . ... |.|.|. | ||| || ||. | |.. . . | . .. ..||.| | | . ..| || || WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQ-PKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT LRVAIRSLHAVKAVWEYYFIGTELFRTKLHEACYIHRDLKPCNVTLDYNEYSP-LIFLIDFGMGRKYAKIDEGEYVIRRPRDACRFRGTIRYCSPRMHLR ||. . | ..... |. . ||| || | . | . ....|||. |.| .|| .| || . ||||.|| | |. LRLGVQILQSIESI---------------HSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNA-CGE--VRPPREVAGFRGTVRYASINAHRN REQGRVDDLYAWLYMIVE-LKVELPWSEVVHPDRIEFLKLEKFDAAMASNPLTKSFEPIMDHLKTLRYPDRPNYLMI || || ||| || || .. ||| . | . .| ||.| | . . . |. |||.| | | |||.| .| REMGRHDDLWSLFYMLVEFVQGQLPWRKIKDKDQVGEMK-EKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | T11F8.4.AA | Worm6 | 148-294 | 36 | 2e-28 | 99.17 | In-house | 120-279 (279) | Show / Hide |
Range on Protein: 148-294 Range on HMM: 120-279/279 Sequence Identity: 36% (59 aa) LHEACYIHRDLKPCNVTLDY-----NEYSPLIFLIDFGMGR-KYAKIDEGEYVIRRPR-DACRFRGTIRYCSPRMHLRREQGRVDDLYAWLYMIVELKVE || . .||||.|| | . .. . |...|||| | |... ...| .| || .|| |||| ||.. | ..||.| ||. |.||.||. | LHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNE--LRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVG -LPWSEVVHPDRIEFLKLEKFDAA------MASNPLTK-SFEPIMDHLKTLRYPDRPNYLMI ||| . .|. | .| .. . | .| | |. ||| . ...| |||.| | CLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | T11F8.4.AA | Worm6 | 22-130 | 33 | 1.3e-17 | 59.95 | In-house | 1-117 (279) | Show / Hide |
Range on Protein: 22-130 Range on HMM: 1-117/279 Sequence Identity: 33% (39 aa) WHPVKVLGSGAFGKVVHVVNIVDGS--DGAMKMEKYQEG-NESVLKGEVEVLRALSGQK--NAIQLLDSGLEPD--YRFIVMTLCGMDLQKVYNLL-KGQ | .| .|.|.|| | | . |.. ||| || .|. ..|| |. || |. .| . .. | | . ...|||||.|..|. . .. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSDSTVLRVAIRSLHAV || .| |..|| .| |. FSMGTGLKIAIQCLEAI |
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Kinase | T11F8.4.AA | CK1-D | 22-294 | 25 | 2.5e-17 | 57.54 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 22-294 Range on HMM: 1-261/261 Sequence Identity: 25% (70 aa) WHPVKVLGSGAFGKVVHVVNIVDGSDGAMKMEKYQEGNESVLKGEVEVLRALSGQKNAIQLLDSGLEPDYRFIVMTLCGMDLQKVYNLLKGQFSDSTVLR . . .|||.|| . | || . . |.|.| . |. | . . ..| .. | | || .|| | | | ..| . .|| ||| YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKT-KHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLM VAIRSLHAVKAVWEYYFIGTELFRTKLHEACYIHRDLKPCNVTLDYNEYSPLIFLIDFGMGRKYAKIDEGEYVIRRPRDACRFRGTIRYCSPRMHLRREQ .| . . || .| .||||.|| | . ....||||. ..| . . |. || || | |. || LADQMICRI----EY-----------IHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPY--RENKNLTGTARYASINTHQGIEQ GRVDDLYAWLYMIVEL-KVELPWS---EVVHPDRIEFLKLEKFDAAMAS--NPLTKSFEPIMDHLKTLRYPDRPNYLMI | ||| . |... . ||| . .. | . | . . . . . |. |.. ..|.. |.|.|. . SRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | T11F8.4.AA | CK1-A | 22-139 | 33 | 2.9e-13 | 43.08 | In-house | 1-117 (261) | Show / Hide |
Range on Protein: 22-139 Range on HMM: 1-117/261 Sequence Identity: 33% (39 aa) WHPVKVLGSGAFGKVVHVVNIVDGSDGAMKMEKYQEGNESVLKGEVEVLRALSGQKNAIQLLDSGLEPDYRFIVMTLCGMDLQKVYNLLKGQFSDSTVLR .. |. .|||.|| . .|| .|.. |.|||. .. | | | | |.| ... | | || .|| | | | ..|. | .|. ||| YRLVRKIGSGSFGDIYLGINITNGEEVAIKMES-NKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLM VAIRSLHAVKAVWEYYFI .| . . | | || LADQMIMRIEYVHEKNFI |
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Kinase | T11F8.4.AA | Dual | 148-234 | 31 | 4.1e-13 | 40.31 | In-house | 129-213 (282) | Show / Hide |
Range on Protein: 148-234 Range on HMM: 129-213/282 Sequence Identity: 31% (28 aa) LHEACYIHRDLKPCNVTLDYNEYSPLIFLIDFGMGRKYAKID--EGEYVIRRPRDACRFRGTIRYCSPRMHLRREQGRVDDLYAWLYMI || . |.||. || | .. . ... ||...||| || .. .. .| . |. || . . ..||| ||| .| ||. LHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKY--IDPENKKHRT--ARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMV |
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Kinase | T11F8.4.AA | S_TKc | 22-302 | 16 | 7e-13 | 11.97 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 22-302 Range on HMM: 1-231/231 Sequence Identity: 16% (49 aa) WHPVKVLGSGAFGKVVHVVNIVDGSDGAMKMEKYQEGNESVLKGEVEVLRALSGQKNAIQLLDSGLEPDYRFIVMTLCGM---DLQKVYNLLKGQ----- .. ....|.|||||| .... .| |.|. | .. |...|. . .| ..|.|. . |. ..|| .|. || .. ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP FSDSTVLRVAIRSLHAVKAVWEYYFIGTELFRTKLHEACYIHRDLKPCNVTLDYNEYSPLIFLIDFGMGRKYAKIDEGEYVIRRPRDACRFRGTIRYCSP |. .. ... . |.. .|. ||||||| |. || | ..|||. |.. | || |..| FPE-HARFYMYQICCALEY---------------CHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------------TTFCGTPWYMAP RMHLRREQGRVDDLYAWLY----------MIVELKV-ELPWSEVVHPDRIEFLKLEKFDAAMASNPLTKSFEPIMDHLKTLRYPDRPNYLMIYE-----L . . . .. |. . . |.. ..... . . .... ..... . .|| . . EVL------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK LAKMM . . CHPWF |
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Kinase | T11F8.4.AA | CK1-Unique | 149-237 | 31 | 1.6e-12 | 39.74 | In-house | 134-223 (337) | Show / Hide |
Range on Protein: 149-237 Range on HMM: 134-223/337 Sequence Identity: 31% (29 aa) HEACYIHRDLKPCNVTLDYNE--YSPLIFLIDFGMGRKYAKIDEGEYVIRRPRDACRFRGTIRYCSPRMHLRREQGRVDDLYAWLYMIVEL |.. ..||..|| |. .. . .. .|.| |. ... .|| || |||. .||. |. ||.|| ||. |.||.. | HWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNH-QIRQPRPITPFRGCKDYCPCSCHQCREHGRRDDMESWFYMLYHL |
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Kinase | T11F8.4.AA | CK1-Unclassified | 25-120 | 26 | 2.7e-12 | 32.62 | In-house | 4-107 (244) | Show / Hide |
Range on Protein: 25-120 Range on HMM: 4-107/244 Sequence Identity: 26% (28 aa) VKVLGSGAFGKVVHVVNIVDGSDGAMKMEKYQEGNESVLKGEVEVLRALSGQKNAIQ--------LLDSGLE--PDYRFIVMTLCGMDLQKVYNLLKGQF .. .|.|.|| . ...|. .. |.|.|| . |. |. ....| . .| . . .| | || ..||.| | .| . |. ...| IEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNC-DNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRKF SDSTVL | ||| SLKTVL |
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Kinase | T11F8.4.AA | CK1-A | 148-243 | 35 | 4.8e-12 | 38.69 | In-house | 111-205 (261) | Show / Hide |
Range on Protein: 148-243 Range on HMM: 111-205/261 Sequence Identity: 35% (34 aa) LHEACYIHRDLKPCNVTLDYNEYSPLIFLIDFGMGRKYAKIDEGEYVIRRPRDACRFRGTIRYCSPRMHLRREQGRVDDLYAWLYMIVEL-KVELPW .|| ..||||.|| | . . .||||||. .|| . . . |. ||.|| | || || | ||. . |... . .||| VHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPY--REDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPW |
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Kinase | T11F8.4.AA | CK1 | 25-123 | 26 | 6.4e-10 | 30.53 | In-house | 4-111 (271) | Show / Hide |
Range on Protein: 25-123 Range on HMM: 4-111/271 Sequence Identity: 26% (29 aa) VKVLGSGAFGKVVHVVNIVDGSDG---AMKMEKYQEGNESVLKGEVEVLRALSG------QKNAIQLLDSGLE--PDYRFIVMTLCGMDLQKVYNLLKGQ .. .|.|.|| . .. |. . |.|.|| . |. |. ... | | .. .. .| | || ..||.| | .| . .|. ... GRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNRK FSDSTVLRVA || ||| .| FSLKTVLMIA |
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Kinase | T11F8.4.AA | Pkinase | 22-123 | 22 | 7.9e-10 | 35.84 | Pfam | 1-114 (293) | Show / Hide |
Range on Protein: 22-123 Range on HMM: 1-114/293 Sequence Identity: 22% (26 aa) WHPVKVLGSGAFGKVVHVVNIVDGSDGAMKMEKYQEGNESVLKG-----EVEVLRALSGQKNAIQLLDSGLEPDYRFIVMTLCGMDLQKVYNLL------ .| ....|||.||.| . ... .| |.| |... ...... |..... | . .| ..|.|. ..|. .|| .|...| | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW -KGQF--SDSTVLRVA .| | |. .. ... RHGCFYFSEWECKFYM |
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Kinase | T11F8.4.AA | CK1 | 148-227 | 33 | 5.7e-08 | 23.74 | In-house | 121-199 (271) | Show / Hide |
Range on Protein: 148-227 Range on HMM: 121-199/271 Sequence Identity: 33% (27 aa) LHEACYIHRDLKPCNVTLD-YNEYSPLIFLIDFGMGRKYAKIDEGEYVIRRPRDACRFRGTIRYCSPRMHLRREQGRVDDL .|. ..||||.|| | |. . ...||||. .| ...... . |. . || || | .|| .||.| ||. VHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPY--RENKNLTGTARYASINTHLGIEQSRRDDM |
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Kinase | T11F8.4.AA | CK1-Unclassified | 148-192 | 31 | 2e-07 | 17.97 | In-house | 120-166 (244) | Show / Hide |
Range on Protein: 148-192 Range on HMM: 120-166/244 Sequence Identity: 31% (15 aa) LHEACYIHRDLKPCNVTLD-YNEYSPLIFLIDFGMGRKYAKI-DEGE ||. ..||||.|| | .. .. ...|||| . .| .. .|. LHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGK |
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Kinase | T11F8.4.AA | CK1-Unique | 22-130 | 19 | 2e-06 | 18.28 | In-house | 1-130 (337) | Show / Hide |
Range on Protein: 22-130 Range on HMM: 1-130/337 Sequence Identity: 19% (25 aa) WHPVKVLGSGAFGKVVHVVNIVDG------SDGAMKMEKYQEGNE-SVLKGEVEVLRALSGQKNAIQ-------LLDSGLEPDYRFIVMTLCGMDLQKVY | | .|.| .| | | .| .|| | . |. | |. ... . . . |... .|. .||||. | . . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC NLLKG-QFSDS------TVLRVAIRSLHAV ..|. || . .... . | .. MMMKNFQFTLNEKKNQLCAIQCGYQCLNVI |
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Kinase | T11F8.4.AA | Dual | 22-39 | 55 | 0.000239 | 10.38 | In-house | 1-18 (282) | Show / Hide |
Range on Protein: 22-39 Range on HMM: 1-18/282 Sequence Identity: 55% (10 aa) WHPVKVLGSGAFGKVVHV | |. |||| |. |.|| WKVVNLLGSGGFRDVYHV |
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Kinase | T11F8.4.AA | TyrKc | 22-298 | 16 | 0.000288 | -153.65 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 22-298 Range on HMM: 1-280/280 Sequence Identity: 16% (51 aa) WHPVKVLGSGAFGKVVHVVNIVDGSDGAMKMEKYQEGNESVLKGEVEVLRAL-SGQKNAIQLLDSGLEP-------DYRFIVMTLCGM-DLQKVYNLLKG . |.||.||||.|.. . . . | || | . . | .... | .| ..|. ... . .||| .. ||.. .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP QFSDSTVLRVAI------RSLHAVKAVWEYYFIGTELFRTKLHEACYIHRDLKPCNVTLDYNEYSPLIFLIDFGMGRKYAKI----DEGEYVIRRPRDAC ... .. | .. . || ..||||| |. .. | . |||. |. ...| . .. . KLCMKDLLSFCWQIACGMEYLHSK---------------------NCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG RFRGTIRYCSPRMHLRREQGRVDDLYAW---LYMIVELKVELPWSE----VVHPDRIEFLKLEKFDAAMASN-------PLTKSFEPIMDHLKTLRYPDR .. || ..| .. | ... .. | . . .. . . . ||..| . .... .. .. || || KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDR PNYLMIYELL |. |.|.. PTFSEIHECF |
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Kinase | T11F8.4.AA | Pkinase | 154-229 | 25 | 0.000448 | 15.49 | Pfam | 130-197 (293) | Show / Hide |
Range on Protein: 154-229 Range on HMM: 130-197/293 Sequence Identity: 25% (20 aa) IHRDLKPCNVTLDYNEYSP--LIFLIDFGMGRKYAKIDEGEYVIRRPRDACRFRGTIRYCSPRMHL-RREQGRVDDLYA ||||||| |. .| |.. . . ..||| ... . . . . | ||..|..| .. ... |. | .. IHRDLKPENILID-NNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS |
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Kinase | T11F8.4.AA | CK1-Unclassified | 206-227 | 59 | 0.006888 | 4.38 | In-house | 178-199 (244) | Show / Hide |
Range on Protein: 206-227 Range on HMM: 178-199/244 Sequence Identity: 59% (13 aa) GTIRYCSPRMHLRREQGRVDDL || || | ..|| ||.| ||| GTARYASINAHLGIEQSRRDDL |