Gene R06C7.8 (Nematode worm)

R06C7.8

Species: Nematode worm
Alias: CE06251, aSWK209, R06C7.8
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 7260006-7263285, WormBase Genetic Map location: I:1.86,

Classification

Group: Other
Family: BUB

Sequence

Name Sequence Type Origin Length Description Download
R06C7.8.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON
R06C7.8.AA Protein Genbank 987 None Fasta, JSON

Protein domain

Protein domains of R06C7.8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase R06C7.8.AA BUB 690-956 37 7.4e-155 520.75 In-house 1-311 (311) Show / Hide 
Range on Protein: 690-956
Range on HMM: 1-311/311
Sequence Identity: 37% (116 aa)

LHIQTLIGQGGYAKVYRAVTDDQ--------------RTVAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKCCIMEVMDAYVYSTASLLVNQYH-EYG
..||..||.|.||.||.|...|.              ..||.|...|...||.||||||..|||.|. |.|..||.|.......|...|.....|| .||
FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERS-ETMMHCCFMHICSCHYYQDKSCMWMEYHIDYG

TLLEYANNMK---DPN-----WHITCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKIDDKWGKDALMSND----SFVIKIIDWGRAIDMMPLKN-QR
|||...|.||   ..|     .....|...||...|...|...||||||||||||....|.|.|.....||..    ....|.||.||.|||..... ||
TLLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQR

FKGRAGTEA--FDCPEMV----DGRSWTYQADYFGFAATMAVVVAGKYAQLTGASVGDYSLNVDIKRRNILRD-------ACYDVINRFLN----IPSCD
||....|..  |.|.||.    ....||||.||||.||||.....|||.|......|.|.......||.. .|       .......|.||    ||.|.
FKFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQ

SLPDWNILIKSF
.||.|..|...|
TLPMWHELRQQF
Kinase R06C7.8.AA Ciliate-E2 766-891 18 7.9e-17 54.28 In-house 111-282 (365) Show / Hide 
Range on Protein: 766-891
Range on HMM: 111-282/365
Sequence Identity: 18% (35 aa)

LVNQYHEYGTLLEYANNM-----------KDPNWHITCFLITQMAR---------------VVKEVHASK-IIHGDIKPDNFMITRKIDDKWGKDALMSN
||  | ..|.|..| .|.           | ...   .....| ..                ... |  . ||| ||||.| ..                
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------

DSFVIKIIDWGRAI----------------DMMPLKN---------------QRFKGRAGTEAFDCPEMVDGRS---------WTYQADYFGF
    |||||.| .                  .|  ||               . |.  .||  . .||.. | .         ..|..|.. .
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL
Kinase R06C7.8.AA Pkinase 690-902 19 1.1e-12 45.98 Pfam 1-209 (293) Show / Hide 
Range on Protein: 690-902
Range on HMM: 1-209/293
Sequence Identity: 19% (45 aa)

LHIQTLIGQGGYAKVYRAVTDDQRT-VAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKC---CIMEVMDAYVYSTASLLVNQYHEYG----TLL----
.||   ||.|....||...  . .  ||||    .   .   . ....|.  . ...|...   .| .  |.. ...   .|  |.| |     |     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR---HEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-EYANNMKDPNWHITCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKIDDKWGKDALMSNDSFVIKIIDWGRAIDMMPLKNQRFKGRAGTEAFDCPEM
 .. ...    ..  .| ..|..| ..  |. .||| |.||.|..| .. . .             .||.|.| |  .  . |.......||  .  || 
TWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----------CVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEV

VD-GRSWTYQADYFGFAATMAVVVAGK
.  |. ... .| ...  ... .. |.
IRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase R06C7.8.AA S_TKc 690-957 16 2e-12 5.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 690-957
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

LHIQTLIGQGGYAKVYRAVTDD-QRTVAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKCC---IMEVMDAYVYSTASLLVNQYHEY--GTLLEYANNM
 .|  .||.|...|||...  . .| ||.|                  .   | .... |     |    |...  .   .|  | .   |.|..|  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

KDP------NWHITCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKIDDKWGKDALMSNDSFVIKIIDWGRAIDMMPLKNQRFKGRAGTEAFDCPEMV
. .      .   ..|.. |... ..  |  .||| |.||.| ....                 .|||.| | |  .        .   ||  .  ||..
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------HIKICDFGLARQL--------TTFCGTPWYMAPEVL

DGRSWTY-QADYFGFAATMAVVVAGKYAQLTGASVGDYSLNVDIKRRNILRDACYDVINRFLNI-PS--CDSLPDWN----ILIKSFS
   ....  .|   .  ...  ..|.          .. .  .. .     . . | |.. |.  |.         .    | .  . 
---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase R06C7.8.AA CAMK 791-879 21 1.9e-11 32.39 In-house 181-294 (425) Show / Hide 
Range on Protein: 791-879
Range on HMM: 181-294/425
Sequence Identity: 21% (26 aa)

TCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKID-----------DKWGKDALMSNDSFVIKIIDWGRAIDMMPLK---------------------
..... |..  |.  |  .|.| |.||.| ... . |           |         .... |||||.| |. ..| .                     
ARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD---------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPT

-NQRFKGRAGTEAFDC-PEMVDG
 .| .| . || .. . ||.. |
EGQKMKTFCGTPEYMAAPEVLNG
Kinase R06C7.8.AA CK1-G 791-851 36 8.9e-10 29.23 In-house 98-148 (266) Show / Hide 
Range on Protein: 791-851
Range on HMM: 98-148/266
Sequence Identity: 36% (22 aa)

TCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKIDDKWGKDALMSNDSFVIKIIDWGRA
.| . .|| . ...||.   | .|.|||||.| |            ..|  || ||| | |
VCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGR----------PSNKDQHVIHIIDFGMA
Kinase R06C7.8.AA Worm8 797-825 37 1.4e-08 20.88 In-house 107-135 (261) Show / Hide 
Range on Protein: 797-825
Range on HMM: 107-135/261
Sequence Identity: 37% (11 aa)

QMARVVKEVHASKIIHGDIKPDNFMITRK
|. .. . .|.  |.|||||.|| |.  .
QLVKILQDIHSFGIVHGDIKADNLMVSHS
Kinase R06C7.8.AA Type2 690-718 36 2e-08 23.71 In-house 1-33 (315) Show / Hide 
Range on Protein: 690-718
Range on HMM: 1-33/315
Sequence Identity: 36% (12 aa)

LHIQTLIGQGGYAKVYRAVTDDQ----RTVAVK
.   .|||.|....|..|  ...    ||||||
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVK
Kinase R06C7.8.AA TKL 766-887 18 4.6e-08 25.15 In-house 115-271 (364) Show / Hide 
Range on Protein: 766-887
Range on HMM: 115-271/364
Sequence Identity: 18% (31 aa)

LVNQYHEYGTLLEYANNMKDPNWHITCFLITQMARVVKEVHASK--------IIHGDIKPDNFMITRK--------IDDKWGKDALMSNDSFVIKIIDWG
.| .|.. |.||.| .      || .| .. ..|| .   |...        ||| |.|..| .. ..        .         . |.  ..|| | |
IVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY---------NPNADWCCKICDFG

RAIDMMPLKNQRFKG------------------RAGTEAFDCPEMVDGR----------------SWTYQAD
 . .| . .|.   .                  . || ..  ||. .|                 . . ..|
LSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD
Kinase R06C7.8.AA Ciliate-E3 804-822 52 3.9e-07 18.63 In-house 118-136 (202) Show / Hide 
Range on Protein: 804-822
Range on HMM: 118-136/202
Sequence Identity: 52% (10 aa)

EVHASKIIHGDIKPDNFMI
..|. .|||.||||||. .
AIHEKNIIHSDIKPDNILV
Kinase R06C7.8.AA Ciliate-E2-Unclassified 803-891 21 3e-06 17.88 In-house 157-256 (352) Show / Hide 
Range on Protein: 803-891
Range on HMM: 157-256/352
Sequence Identity: 21% (24 aa)

KEVHASK-IIHGDIKPDNFMITRK-IDDKWGKDALMSNDSFVIKIIDWGRAIDMMPL--------------KNQRFKGRAGTEAFD----CPEMVDGRSW
.  | .. ||| ||||.| ... .                . |||||.| ..                   |.|... ..||  .      ||. .|   
EYLHHKNNIIHRDIKPENILFDNNGK-------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNY

T----YQADYFGF
     |..|....
DHSKAYKCDIWSL
Kinase R06C7.8.AA CMGC 792-849 19 1.7e-05 13.02 In-house 177-249 (513) Show / Hide 
Range on Protein: 792-849
Range on HMM: 177-249/513
Sequence Identity: 19% (16 aa)

CFLI------TQMARVVK--EVHASK--IIHGDIKPDNFMITRK----------------IDDKWGKDALMSNDSFVIKIIDWG
....       |. | .|    |  .  ||| |.|| | .|. .                            ......||.|.|
KYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC-----------QKNGRLKICDFG
Kinase R06C7.8.AA CAMK 695-718 18 7.8e-05 10.72 In-house 1-37 (425) Show / Hide 
Range on Protein: 695-718
Range on HMM: 1-37/425
Sequence Identity: 18% (7 aa)

LIGQGGYAKVYRAVT-DDQ------------RTVAVK
 .|.|...||....   ..            . ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK
Kinase R06C7.8.AA TKL 696-718 31 0.000121 12.66 In-house 1-32 (364) Show / Hide 
Range on Protein: 696-718
Range on HMM: 1-32/364
Sequence Identity: 31% (10 aa)

IGQGGYAKVYRAVTDDQR---------TVAVK
||.||...||...   ..         .||||
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVK
Kinase R06C7.8.AA CMGC 690-718 22 0.000183 9.56 In-house 1-44 (513) Show / Hide 
Range on Protein: 690-718
Range on HMM: 1-44/513
Sequence Identity: 22% (10 aa)

LHIQTLIGQGGYAKVYRAVT---------------DDQRTVAVK
 .|   ||.| |..||...                .... ||.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIK
Kinase R06C7.8.AA Ciliate-E2-Unclassified 691-712 45 0.0006 9.61 In-house 2-23 (352) Show / Hide 
Range on Protein: 691-712
Range on HMM: 2-23/352
Sequence Identity: 45% (10 aa)

HIQTLIGQGGYAKVYRAVTDDQ
.|.  |||||..|||... ..|
KIIKQIGQGGFGKVYKCQHKKQ
Kinase R06C7.8.AA Ciliate-E2 690-713 25 0.000612 9.39 In-house 1-24 (365) Show / Hide 
Range on Protein: 690-713
Range on HMM: 1-24/365
Sequence Identity: 25% (6 aa)

LHIQTLIGQGGYAKVYRAVTDDQR
  .. .||||....||..  . ..
YKFIKKIGQGNFGSVYKCKVWKVQ
Kinase R06C7.8.AA Ciliate-E3 690-707 33 0.009181 4.79 In-house 1-18 (202) Show / Hide 
Range on Protein: 690-707
Range on HMM: 1-18/202
Sequence Identity: 33% (6 aa)

LHIQTLIGQGGYAKVYRA
  .| ..|.|..  ||.|
YTVQQILGCGQFGRVYKA