Gene R03D7.5 (Nematode worm)
R03D7.5
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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R03D7.5.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 325 | Kinase domain by global Sugen HMM | Fasta, JSON |
R03D7.5.AA | Protein | Genbank | 410 | None | Fasta, JSON |
Protein domains of R03D7.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | R03D7.5.AA | GSK | 27-351 | 32 | 1.1e-173 | 535.42 | In-house | 1-328 (328) | Show / Hide |
Range on Protein: 27-351 Range on HMM: 1-328/328 Sequence Identity: 32% (110 aa) ISAHKLCGSGRFSNVYCGQMISP--IEKEV-----AVKNVWSDTETRHLATSEYPEIQILSKLFHPAISNLLYFYSRNAND-----KVINCLVLDYLPQD .. .|..|.|.|..||...|.|| .||. |.|.|| |.... .. |.. ...|.||.|| | .|.||....... ...||||..|.||. YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYK--CNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQT LARLRDQ----GVKFDVLDAKLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETNE-KTGSAYQVTRFYRPPELLFGCEKFTA |...... . ...... |||..|.|.....|.|..|.|.||||||...|.. |.||..|||.|..||.|. .. .|...|.||.|||.|||...| LYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTC SIDIWSATCVAFELFANRVLFKGKDTKDQIVLITGVFGYPTDDDIKSIGVKRPRVARKDARGIETVKIKEKTNKTKKEAKQSTLVHEKYTRARAMSRSTE .||.||..|| .|.. ...||.|....||.|.|. ..|.||...|.|. ...|.. ......... ......|.||.|. |. ..|.||. ...| .... QIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEY-QT-YYHKKYR-TVYMFKWCH NKLAPFTSKMLDSEIYDFMKATLKIDPKKRKSAIDVLKMPLF .. . ...|.....|..||||| |.......| | TDMQ---------DWIDLISKCLVYDPKKRLSPLEACAHPFF |
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Kinase | R03D7.5.AA | CMGC | 27-351 | 17 | 7.1e-80 | 261.97 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 27-351 Range on HMM: 1-513/513 Sequence Identity: 17% (90 aa) ISAHKLCGSGRFSNVYCGQM-----------ISPIE--KEVAVKNVWSDTETRHLAT----------SEYPEIQILSKL-----------------FHPA | .|.| ...|| .. ...| ..||.| .... . | . . ||.|| .| |. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN ISNLLYFYSRNANDKV-------------INCLVLDYLPQDLARLRDQGVK----------------------------FDVLDAKLYTFQLFCAIS--H | .|.... .. .|. .|| .|...||... .. . | . . . |..|..... . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY LTSKN--IVHMDIKPQNVVMDRMA-------------------GRLKLADFGNARRLETN---------------------EKTGSAYQVTRFYRPPELL . |.. |.| |.||.|. .. ||||..|||.|| .... .. . | |||.||.||.| CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL FGC---------EKFTASIDIWSATCVAFELFAN--------RVLFK-----------GKDTKDQIVLITGVFGYP----------------TDDDIKSI .|. ..| .||.||. |. .|.. . . ||. ||.. ||. .| |.| | ...... | LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI G--------------------VKRPRVARKDARGIETVKIKEKTNKTKKEAKQSTLVHEKYTRARAMSRSTENKLAPFTS--------------KMLDSE . . | ... . ... | .|. .. .... .|. ||.. .. .. . |..|.. KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKK----AMVF-NW-IY----EEKFKSHKFNHQFKRKCCDPQ IYDFMKATLKIDPKKRKSAIDVLKMPLF |..| |..||.|| .| . |..| | AIDLLKKMLQYDPDKRITAEQALQHPYF |
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Kinase | R03D7.5.AA | S_TKc | 27-351 | 19 | 2.4e-55 | 191.11 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 27-351 Range on HMM: 1-231/231 Sequence Identity: 19% (67 aa) ISAHKLCGSGRFSNVYCGQMISPIEKEVAVKNVWSDTETRHLATSEYPEIQILSKLFHPAISNLLYFYSRNANDKVINCLVLDYLPQ---DLARLRDQGV ... |.| |. ||... .. ..||.| . . . |||||.| || | .|.... ..|..|... || .. .. YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG K------FDVLDAKLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETNEKTGSAYQVTRFYRPPELLFGCEKFTA-SIDIWSA . |. .|. |. |..||. .. |..|.| |.||.|. .|. ..|..||| ||.| . . .|..|..||.| ... ..|.|| RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSC TCVAFELFANRVLFKGKDTKDQIVLITGVFGYPTDDDIKSIGVKRPRVARKDARGIETVKIKEKTNKTKKEAKQSTLVHEKYTRARAMSRSTENKLAPFT |. .|... . .| . ... . | GCILYEMLCGYPPFP---QMQMMFKKIG------------------------------------------------------------------------ SKMLDSEIYDFMKATLKIDPKKRKSAIDVLK-------MPLF ..| ||.. |. ||.|| .| ..|. .| | ----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | R03D7.5.AA | CDK | 106-351 | 26 | 6.8e-43 | 134.96 | In-house | 95-284 (284) | Show / Hide |
Range on Protein: 106-351 Range on HMM: 95-284/284 Sequence Identity: 26% (68 aa) LVLDYLPQDLARLRDQGVKFDVLDAKLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMA----GRLKLADFGNARRLET------NEKTGSAYQVTRFY .| .|...||. . | | |..|| ..... |..|.| |.|||| ... ||||.|||| || . .| . ||. | MVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY RPPELLFGCEKFT--ASIDIWSATCVAFELFA---NRVLFKGKDTKDQIVLITGVFGYPTDDDIKSIGVKRPRVARKDARGIETVKIKEKTNKTKKEAKQ |.||||.|... . .||.||. |. |.| .. || |. ||. .| ..| ||.|. .. .| | RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGV-TKLPDY-------------------------- STLVHEKYTRARAMSRSTENKLAPFTSKMLDSEIYDFMKATLKIDPKKRKSAIDVLKMPLF |.. | ||||| || . |..| | -----------------------------------DLLNKMLCYDPKKRISAEQALQHPYF |
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Kinase | R03D7.5.AA | Pkinase | 27-351 | 22 | 5.7e-42 | 149.48 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 27-351 Range on HMM: 1-293/293 Sequence Identity: 22% (78 aa) ISAHKLCGSGRFSNVYCGQMISPIEKEVAVKNVWSDTETRHLATSEYP--EIQILSKLFHPAISNLLYFYSRNANDKVINCLVLDYLPQ-----DLA-RL . .. ||| |. || .. .. .|.|||| .. ..| . ||||. .| || | |.... . .. | .|..|.. ||. .. YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY-MVMEYCEGGLYVMDLFDYI R-DQGVKF--DVLDAKLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRL----KLADFGNARRL-ETNEKTGSAYQVTRFYRPPELLFGCEKFTAS . ... .| . ..| | |..... .. |..|.| |.||.|. .| | . |..||| |. . . | . . .|..|..||.. |... . . STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK IDIWSATCVAFELFANRVLFKGK----DTKDQIVLITGVFGYPTDDDIKSIGVKRPRVARKDARGIETVKIKEKTNKTKKEAKQSTLVHEKYTRARAMSR .|.||. |. .|.. | .|.|. . ||...| . | |.. |. .... ... . VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------------------------- STENKLAPFTSKMLDSEIYDFMKATLKIDPKKRKSAIDVLKMPLF . . . . ...| ||.| |. ||||| .| ..|. | | ----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | R03D7.5.AA | CDK5 | 106-252 | 35 | 1.3e-30 | 93.56 | In-house | 75-222 (287) | Show / Hide |
Range on Protein: 106-252 Range on HMM: 75-222/287 Sequence Identity: 35% (53 aa) LVLDYLPQDLAR-LRDQGVKFDVLDAKLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETNEKTGSAYQVTRFYRPPELLFGC || .. ||| . . . ... | .| . .|| .. .... | | |||| . | ||||||| || .. |. || |||| |.| LVFEFCDQDLKKYMDSCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKN-GELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGS EKFTASIDIWSATCVAFELF-ANRVLFKGKDTKDQIVLITGVFGYPTDD ... |||.||. |. |. | | || | |..|| .| . | |. | KHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCED |
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Kinase | R03D7.5.AA | Ciliate-E2 | 27-351 | 14 | 4.5e-28 | 93.45 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 27-351 Range on HMM: 1-365/365 Sequence Identity: 14% (65 aa) ISAHKLCGSGRFSNVYCGQMISPIE----------------------KEVAVKNV-WSDTETRHLATSEYPEIQ----------ILSKLFHPAISNLLYF . .|..|.| |. || .. .. . |..|.|.. .. | ... ||. ||..| || | .. .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YSRNANDKVINCLVLDYLPQD--LARLRDQGVK----------FDVLDAKLYTFQLFC---------------AISHLTSKN-IVHMDIKPQNVVMDRMA . . .... ||..|. . . ..... | |. .| .. |.. |. .| ||| |.| ||||.|... FQEKDDNNI--YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- GRLKLADFGNARRLETN-----------EKTGSA---------------------YQVTRFYRPPELLFGCEK--------FTASIDIWSATCVAFELFA .|..|||..... .. ... . | | .|| | | . . ..||||. .. .|. --IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF NRVLFKGKDTKDQIVLITGVFGYPTDDDIKSIGVKRPRVARKDARGIETVKIKEKTNKTKKEAKQSTLVHEKYTRARAMSRSTENKLAPFTSKM------ .. | . ..|. . .. GKPPF-------------------------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQC ----------LDSEIYDFMKA----TLKIDPKKRKS-AIDVLKMPLF .. | |..| |. ||.|| . . ..|. | | IQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | R03D7.5.AA | ERK7 | 135-258 | 34 | 9.5e-28 | 91.74 | In-house | 107-235 (292) | Show / Hide |
Range on Protein: 135-258 Range on HMM: 107-235/292 Sequence Identity: 34% (45 aa) FQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETNEKTGSAYQV------TRFYRPPELLFGCEKFTASIDIWSATCVAFELFANRV .||. || .. | |..| |.|| |. .| . ..|..||| || . |. . . .. || || || | | ...| .| || |. |. .. YQLLRAIKYMHSGNVIHRDLKPSNILLD-SECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKP LFKGKDTKDQIVLITGVFGYPTDDDIKSIG .| | | .|| .| . . || ||..|| MFPGTSTMNQIEKILETIPKPTQEDIEAIG |
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Kinase | R03D7.5.AA | DYRK | 133-351 | 25 | 9.7e-28 | 98.48 | In-house | 108-320 (320) | Show / Hide |
Range on Protein: 133-351 Range on HMM: 108-320/320 Sequence Identity: 25% (58 aa) YTFQLFCAISHLTSK-NIVHMDIKPQNVVMDR--MAGRLKLADFGNARRLETNEKTGSAYQVTRFYRPPELLFGCEKFTASIDIWSATCVAFELFANRVL ...|.. .. .| .. ||.| |.|| |... ..|..||| . . . . | . |||| || . || .. .||.|| |. ||| .| FAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ---RIYTYIQSRFYRAPEVILGC-PYCYAIDMWSLGCILAELFTGWPL FKGKDTKDQIVLITGVFGYPTDDDIKSI--GVKRPRVARKDARGIETVKIKEKTNKTKKEAKQSTLVHEKYTRARAMSRSTENK-LAPFTSKMLDSEIYD | |.. ||. .| |.|.|. . |.. |. . . ... |..|. ... . ..|.. . |. ... . |. |.. | FPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD FMKATLKIDPKKRKSAIDVLKMPLF | | |..||.|| .. . |. | | FIKKCLQWDPHKRITPSQALQHPWF |
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Kinase | R03D7.5.AA | MAPK | 134-263 | 28 | 8.6e-26 | 86.0 | In-house | 121-269 (328) | Show / Hide |
Range on Protein: 134-263 Range on HMM: 121-269/328 Sequence Identity: 28% (43 aa) TFQLFCA--ISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETN------EKTG--------SAYQVTRFYRPPELLFG--CEKFTASIDIWS ..|. .. . .. | |..| |.|| |.... . ||..||| || .... .... . | .||.|| ||.... . | ..|.|| MYQILRGLKLKYIHSANVIHRDLKPSNILVNE-NCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWS ATCVAFELFA-NRVLFKGKDTKDQIVLITGVFGYPTDDDIKSIG-VKRPR . | |. ...||.|||. ||. ||. | | |....|. |. ...| VGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHAR |
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Kinase | R03D7.5.AA | PRP4 | 133-233 | 42 | 3.1e-24 | 85.63 | In-house | 111-208 (320) | Show / Hide |
Range on Protein: 133-233 Range on HMM: 111-208/320 Sequence Identity: 42% (43 aa) YTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETNEKTGSAYQVTRFYRPPELLFGCEKFTASIDIWSATCVAFELFANRVLFKG |. ||| | || ||.| |||| |.. ||. ||| | . . || | | | |||| || . | .. ..||.||. | .||.. ..| | YAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEIT--PYLVSRFYRAPEIIIGH-PYDYQIDMWSVGCTLYELYTGKIMFPG K | K |
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Kinase | R03D7.5.AA | CDKL | 131-247 | 35 | 1.7e-20 | 66.79 | In-house | 101-217 (286) | Show / Hide |
Range on Protein: 131-247 Range on HMM: 101-217/286 Sequence Identity: 35% (42 aa) KLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETNEKTGSAYQVTRFYRPPELLFGCEKFTASIDIWSATCVAFELFANRVLF . |..|. ||... . |..| |||| | |..|| ||| || |. . | || || |||| | . ..|||.. || |.. |. RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW KGKDTKDQIVLITGVFG |. || .| ..| PGQSDIDQLYHIQKCLG |
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Kinase | R03D7.5.AA | TyrKc | 27-351 | 17 | 2.2e-08 | -86.96 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 27-351 Range on HMM: 1-280/280 Sequence Identity: 17% (61 aa) ISAHKLCGSGRFSNVYCGQMISPIEKEVAVKNVWSDTETRHLATSEYPEIQILSKL--FHPAISNLLYFYSRN----ANDKVINCLVLDYLPQD--LARL |. | |.| | || |... .|||| . .|. . |..|..|| || | .|. . .. . ..|. | | . .| ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL-MIVMEYMPHGDLKDYL RDQGVKFDVLDAKLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLADFGNARRLETN------EKTGSAYQ--VTR-----FYRPPELLFGCE |. . |. . | . .| | ..| |||..| |. |. .. . | .||| .| .. ... .. . .. .|| .. . RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG- KFTASIDIWSATCVAFELFANRVLFKGK-----DTKDQIVLITGVFGYPTDDDI----KSIGVKRPRVARKDARGIETVKIKEKTNKTKKEAKQSTLVHE ||| |.|| . .|.| . . .... ... . KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------------- KYTRARAMSRSTENKLAPFTSKMLDSEIYDFMKATLKIDPKKRKSAIDVLKMPLF | .|.|. || . ||..| . .. .| ------------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | R03D7.5.AA | CDKL | 326-351 | 38 | 3.5e-08 | 24.09 | In-house | 261-286 (286) | Show / Hide |
Range on Protein: 326-351 Range on HMM: 261-286/286 Sequence Identity: 38% (10 aa) DFMKATLKIDPKKRKSAIDVLKMPLF ||||. |..|| .| .. . ...|.| DFMKKCLHMDPDERMTCEQLMHHPYF |
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Kinase | R03D7.5.AA | CDK5 | 305-351 | 25 | 0.000387 | 8.44 | In-house | 242-287 (287) | Show / Hide |
Range on Protein: 305-351 Range on HMM: 242-287/287 Sequence Identity: 25% (12 aa) SRSTENKLAPFTSKMLDSEIYDFMKATLKIDPKKRKSAIDVLKMPLF .. . ... . | ||.. |... |...|..| || . |. | | MYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF |
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Kinase | R03D7.5.AA | MAPK | 326-351 | 34 | 0.004867 | 6.09 | In-house | 303-328 (328) | Show / Hide |
Range on Protein: 326-351 Range on HMM: 303-328/328 Sequence Identity: 34% (9 aa) DFMKATLKIDPKKRKSAIDVLKMPLF |... | .||.|| .. . | | | DLLEKMLVFDPDKRITVEEALQHPYF |
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Kinase | R03D7.5.AA | PRP4 | 326-351 | 38 | 0.02474 | 4.45 | In-house | 295-320 (320) | Show / Hide |
Range on Protein: 326-351 Range on HMM: 295-320/320 Sequence Identity: 38% (10 aa) DFMKATLKIDPKKRKSAIDVLKMPLF |.. | ||||| . ..|| | . DLLDKCLMLDPKKRITCNEALKHPFI |