Gene M7.7 (Nematode worm)

M7.7

Species: Nematode worm
Alias: M7.7, aSWK080, CE03487
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 11089940-11091813, WormBase Genetic Map location: IV:4.84,

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
M7.7.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
M7.7.AA Protein Genbank 364 None Fasta, JSON

Protein domain

Protein domains of M7.7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase M7.7.AA TTBKL 20-284 30 7.50000000001e-114 384.53 In-house 1-285 (288) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-285/288
Sequence Identity: 30% (89 aa)

FVLQKMLSGGGFGQIFEASIYGSSNEKSVVKVEGQNAMFQLLYNECSCLKSLNTAFNPNNLPGASPFLRFHGYGGIDGFRWLAMERCGENLSDLRKDTPL
.. .||. .|||||..... ....... ..|.|     .. |....|..|  .  .. .. .|.. |...|..| ........|. ||.||.||||. | 
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEE-----KNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPN

GR-FSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDLKS-----RRHLYLLDFGMSKIYVEKDG-----------TLKARRT---SAPFRGTLRY
.. ||..|...|......||..||..|..||||||.|.|.....     .||.||.||||.. |..|||           .....|.   .||||||.||
KKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRY

VSVNIHRRQDASRWDDIWSAFYIATENMVGHLPWRRMGDAMKVEEKKVSSDLSRLIYGSD------RSRPKCMEYIENELNNSQSDPSYFY
.|.|.|.|.. .|.||.||..|.. | ..| |||..| |.|..|..|... . .| ....      ..  |.|.....  .... | ...|
CSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIY
Kinase M7.7.AA CK1 20-283 25 3.3e-81 276.1 In-house 1-339 (339) Show / Hide 
Range on Protein: 20-283
Range on HMM: 1-339/339
Sequence Identity: 25% (87 aa)

FVLQKMLSGGGFG-QIFEA------SIYGS---SNEKSVVKVEGQNAMFQ-LLYNECSCLKSLNTAFN------------PNNLPGASPFLRFHGYGGID
. . |.. .|||| ||...      .. ..   ..|. ..|||  ..| |  .  |.. .. . .. .            .... |   . ... .|. |
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

GFR-WLAMERCGENLSDLRK--DTPLGRFSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDL--------------KSRRHLYLLDFGMSK-IYV
..  .. |...|.||.||||    . ..||..|.| | .  .|||. ||..|..|||.||.|.|...              . .|..|..||||..  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

EKDGTL------------KARRT---SAPFRG-TLRYVSVNIHRRQDASRWDDIWSAFYIATENMVGH--LPWRRMGDAMK-----VEEKKVSSDLSRLI
.|||.             . .|.    ..||| |.||.|.| |.... .|.||.|| ||   | ..|.  |||. | | ||     ||..|  .    . 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

YGSDR------------SRPKCMEYIENELNNSQSDPSYF
. ..             .  |.|.||..    .  |  ..
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase M7.7.AA Worm6 20-268 32 3.9e-53 182.84 In-house 1-258 (279) Show / Hide 
Range on Protein: 20-268
Range on HMM: 1-258/279
Sequence Identity: 32% (85 aa)

FVLQKMLSGGGFGQIFEASIYGSSNE-KSVVKVEG--QNAMFQLLYNECSCLKSLNTAFNPNNLPGASPFLRFHGYGGIDG--FRWLAMERCGENLSDLR
. . | .  |||| .....     .  . ..|.|.   |.  | |. ||. || ..   ...       |...  .| .|   |... |. .|.||.|||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRH-------FCKIEDRGKVDNRGFNYIVMTLVGKNLWDLR

KDTPLGRFSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDL------KSRRHLYLLDFGMSK--IYVEKDGTLKARR-TSAPFRGTLRYVSVNIH
|..| ..||..|.| |    .||.. .|..|..||||||.| |.        . .. .|.|||||..   | .|...|. .| | ..||||.|| ... |
KNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACH

RRQDASRWDDIWSAFYIATENMVGHLPWRRMGDAMKVE-EKKVSSDLSRLIYGSDRSRPKCM-EY
..|. .| ||. | ||   |  || |||| | |   || .||   .  |  . ... .| .. |.
KGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEF
Kinase M7.7.AA TTBK 20-255 36 1.2e-49 171.23 In-house 1-229 (257) Show / Hide 
Range on Protein: 20-255
Range on HMM: 1-229/257
Sequence Identity: 36% (88 aa)

FVLQKMLSGGGFGQIFEASIYGSSNEKSVVKVEGQNAMFQLLYNECSCLKSLNTAFNPNNLPGASPFLRFHGYGGIDGFRWLAMERCGENLSDLRKDTPL
    |   ||||| |.||       |.  .|||  ..  | |  |   || |          |     || | |  | | .. |.  |.||.|||   | 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQ---------GCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPR

GRFSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDLKS--RRHLYLLDFGMSKIYVEKDGTLKARRTSAPFRGTLRYVSVNIHRRQDASRWDDIW
| ||. | | .    .....  ||.|.||||.|| |  . . .  .|  |.||||.   |.   |   . | .| |||| || |.| || ..  | || |
GCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLW

SAFYIATENMVGHLPWRRMGDAMKVEEKKVSSDLSRLI
| ||. .| ..| ||||.. |  .| | |   |.  |.
SLFYMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLL
Kinase M7.7.AA CK1-A 20-283 27 3.2e-18 60.86 In-house 1-261 (261) Show / Hide 
Range on Protein: 20-283
Range on HMM: 1-261/261
Sequence Identity: 27% (74 aa)

FVLQKMLSGGGFGQIFEASIYGSSNEKSVVKVEGQNAMFQLLYNECSCLKSLNTAFNPNNLPGASPFLRFHGYGGIDGFRWLAMERCGENLSDLRKDTPL
. | . .  | || |.  .|   . |   .|.| ..| .  |  |    . |.         |.  . . . ||    .  . |.  |  | ||      
YRLVRKIGSGSFGDIY-LGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQ---------GCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLF-NFCK

GRFSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDLKSRRH---LYLLDFGMSKIYVEKDGTLKAR-RTSAPFRGTLRYVSVNIHRRQDASRWDD
 ||.. | | .  ..|  . ..|  ...|||.|| |  . .   ||   |.|.|||..| | ..        |.     || || |.| |   . || ||
RRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIG--RHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDD

IWSAFYIATENMVGHLPWRRMGDAMK------VEEKKVSSDLSRLIYGSDRSRPKCMEYIENELNNSQSDPSYF
. |  |.      |.|||  |  . |      . |||.|  . .|  |.    .  |.|. |   . | |  | 
MESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase M7.7.AA CK1-Unique 136-223 30 1.5e-17 57.39 In-house 128-220 (337) Show / Hide 
Range on Protein: 136-223
Range on HMM: 128-220/337
Sequence Identity: 30% (28 aa)

EALQMMHSIGWLHRDVKPANVCVDLKS---RRHLYLLDFGMSKI--YVEKDGTLKARRTSAPFRGTLRYVSVNIHRRQDASRWDDIWSAFYIA
... .||  | .||. ||.|.| .  |    ...| ||.| ..    |.. . ..  |  .||||...| .   |. .. .| ||  | || .
NVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCSCHQCREHGRRDDMESWFYML
Kinase M7.7.AA Dual 107-199 29 1.6e-17 55.34 In-house 95-189 (282) Show / Hide 
Range on Protein: 107-199
Range on HMM: 95-189/282
Sequence Identity: 29% (28 aa)

GENLSDLRKDTPLGRFSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDLKSR-RHLYLLDFGMSKIYVE-KDGTLKARRTSAPFRGTLRY
|  | . |. . .| .|. .|  .    ..|.|  ||||.|||..||||  . |  .   .|..||.. . |.. . .  .. |.   . |..||
GPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRY
Kinase M7.7.AA CK1-D 20-283 26 2.9e-17 57.31 In-house 1-261 (261) Show / Hide 
Range on Protein: 20-283
Range on HMM: 1-261/261
Sequence Identity: 26% (71 aa)

FVLQKMLSGGGFGQIFEASIYGSSNEKSVVKVEGQNAMFQLLYNECSCLKSLNTAFNPNNLPGASPFLRFHGYGGIDGFRWLAMERCGENLSDLRKDTPL
. . . . .| ||.|.      ..||   .|.|   .    |  |    | ..            |..|. |  |   .  . |.  |  | ||      
YRIGRKIGSGSFGDIYHGTNI-QTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGI-------GIPEIRWCGQEG--DYNVMVMDLLGPSLEDLF-NYCH

GRFSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDLKSRRHL-YLLDFGMSKIYVEKD-GTLKARRTSAPFRGTLRYVSVNIHRRQDASRWDDIW
 .||. | |..  ..|  .. .|.  ..|||.|| |  . |  | .. |..|||..| | .       . |      || || |.| |.  . || ||. 
RKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLE

SAFYIATENMVGHLPWRRMGDAMK------VEEKKVSSDLSRLIYGSDRSRPKCMEYIENELNNSQSDPSYF
|  |.      | |||  .  | |      . |||.|  .  |  |      . |.|  |   . . | .|.
SLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase M7.7.AA CK2 129-177 38 2.9e-13 35.19 In-house 99-146 (288) Show / Hide 
Range on Protein: 129-177
Range on HMM: 99-146/288
Sequence Identity: 38% (19 aa)

FIFYKFIEALQMMHSIGWLHRDVKPANVCVDLKSRRHLYLLDFGMSKIY
. ...   ||   ||.| .||||||.|. .| . .|.|.| | |.. .|
YYMFELLKALDYCHSMGIMHRDVKPHNIMIDHE-KRKLRLIDWGLAEFY
Kinase M7.7.AA S_TKc 20-315 16 4.8e-12 -0.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-315
Range on HMM: 1-231/231
Sequence Identity: 16% (51 aa)

FVLQKMLSGGGFGQIFEASIYGSSNEKSVVKVEGQNAMFQLLYNECSCLKSLNTAFNPNNLPGASPFLRFHGYGGIDGFRWLAMERCGE---NLSDLRKD
. . . .  |.||. . .   . ....  .|.       . ...| ..||.     .  |.     . .        .. .. || |.    .| |. |.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKK

TPLGR----FSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDLKSRRHLYLLDFGMSKIYVEKDGTLKARRTSAPFRGTLRYVSVNIHRRQDASR
 . ..    |.  .  |..|  ..||. .|| | .|||.||.|. .|     |. . |||.....               | ||. |..  .      ..
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGK

-WDDIWSAFYIATENMVGHLPWRRMGDAMKVEEKKVSSDLSRLIYGSDRSRPKCMEYIENELNNSQSDPSYFYVPPAYDKMLQQIAG---DLRLRNLSMD
   |.||   |  | ..|  |..   . ... .| .                                      |.| | .....     . |.      
CKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EAL

T-----VCLDWM
.      |  |.
QDEWDIKCHPWF
Kinase M7.7.AA Pkinase 96-234 24 3.4e-11 40.65 Pfam 72-213 (293) Show / Hide 
Range on Protein: 96-234
Range on HMM: 72-213/293
Sequence Identity: 24% (37 aa)

DGFRWLAMERCGENL---SDLRKDT--PLGRF--SVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDLKSRR--HLYLLDFGMSKIYVEKDGTLKA
..  .. || |.  |   .  .  .    |.|  |  .  |..|  ...|. .|| | .|||.||.|. .| .     .. . ||| .| .      .  
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-N

RRTSAPFRGTLRYVSVNIHR-RQDASRWDDIWSAFYIATENMVGHLPWR
 .    | ||..|..  ..| .|. ..  |.||.  |  | . |..|..
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP
Kinase M7.7.AA VRK 98-174 29 9.4e-09 24.62 In-house 103-180 (284) Show / Hide 
Range on Protein: 98-174
Range on HMM: 103-180/284
Sequence Identity: 29% (23 aa)

FRWLAMERCGENLSDLRKDTPLGRFSVTTSLFIFYKFIEALQMMHSIGWLHRDVKPANVCVDL-KSRRHLYLLDFGMS
.| . |.| |. |  ...|.. .|||  |.|      . .|. .|. .  | |.| ||. ... |   . || |.| .
YRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLA
Kinase M7.7.AA VRK 20-52 32 5.4e-07 18.91 In-house 1-37 (284) Show / Hide 
Range on Protein: 20-52
Range on HMM: 1-37/284
Sequence Identity: 32% (12 aa)

FVLQKMLSGGGFGQIFEA----SIYGSSNEKSVVKVE
..| |.   |||| |..|    .  .... . |||.|
WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIE