Gene lit-1 (Nematode worm)

lit-1

Species: Nematode worm
Alias: lit-1, CE29476, aSWK198, W06F12.1a
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 13709045-13719073, WormBase Genetic Map location: III:21.52,

Classification

Group: CMGC
Family: MAPK
Subfamily: nmo

Sequence

Name Sequence Type Origin Length Description Download
lit-1.AA Protein Genbank 634 None Fasta, JSON
lit-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 292 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of lit-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase lit-1.AA nmo 240-531 78 4e-249 775.37 In-house 1-292 (292) Show / Hide 
Range on Protein: 240-531
Range on HMM: 1-292/292
Sequence Identity: 78% (228 aa)

SQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALT
.|||||||||||||||||||||.||||||||||||||||.||||||||.|||..|.||||||.||||||....||||.||.||||||||||||||||.|.
IQPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLS

PDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQR
.||||||.|||||||||||.|||||||||||||||||||.||||||||||.|.|.....||.|||||||||||.|||||.||.|||||||||||||||.|
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

KILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL
.|||||..||.|||||.|||||||.|.|||||||||.|.||.....|..|.||...|||...||||.||...||||||||||...||.|.||
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase lit-1.AA MAPK 240-531 46 4.7e-172 577.89 In-house 1-328 (328) Show / Hide 
Range on Protein: 240-531
Range on HMM: 1-328/328
Sequence Identity: 46% (153 aa)

SQPDRPIGYGAFGVVWSVTDPR------SGKRVALKKMPNVFQNLASCKRVFREIKMLSSF-RHDNVLSLLDILQP------ANPSFFQELYVLTELMQS
 |...|||.||.|||.|..| |      .||.||.||....|||. .|||..||||.|  | .|.|. .||||..|       ... |...|. .|||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHKIIVSPQALTPDHVKVFVYQILRG--LKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRD-------------RLNMTHEVVTQYYRAP
|||.|| |.| |. ||.. |.||||||  |||.| ||..|||.||.|.|||.|| ||||||||||..|. .             .  ||  |.|..||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLMG--ARRYTGAVDIWSVGCIFAELLQ-RKILFQAAGPIEQLQMIIDLLGTPSQEAMKYAC--EGAKNHVLRAG-LRAPDTQRLYKIASPDD--KNHE
|....  ...|| |||.|||||||||.|. ||.||.   .|.|...|...|||||.| ... |  | |.| . . | |. .. . ..|. . ..  .|..
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVDLLQKLLHFDPDKRISVEEALQHRYL
|.|||.|.|.|||||||.||||||| |.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase lit-1.AA ERK 245-531 46 2.5e-128 432.61 In-house 6-307 (307) Show / Hide 
Range on Protein: 245-531
Range on HMM: 6-307/307
Sequence Identity: 46% (142 aa)

PIGYGAFGVVWSVTDPR-----SGKRVALKKMPNVFQNLASCKRVFREIKMLSSFR-HDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQAL
.||.||.||| |..|       .|..|| || .|.| ..  |||  ||||.|  |. |.|. .|.||. |  |  . ..|. .|||..|||.|| |.|.|
QIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQEL

TPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLN-------MTHEVVTQYYRAPELLMGARRYTGAVDIWSVGC
..||.. |.||||.||||.| ||..|||.||.|.|||||| ||||||||||. |     |       ||  |.| .|||||..  .. || |.||||.||
SDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGC

IFAELLQRKILFQAAGPIEQLQMIIDLLGTP-SQEAMKYA-CEGAKNHVLRAGL--RAPDT-QRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEAL
||||.| || ||. .. ..|.. |....||| |.| ..|   |.|.. .   .   |.|   . ... |.    |..|.|||.|.|.|||||||.|||.|
IFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNAN---CNPQAIDLLEKMLVFDPDKRITVEECL

QHRYL
.| |.
EHPYF
Kinase lit-1.AA CMGC 240-531 25 1.2e-124 411.8 In-house 1-513 (513) Show / Hide 
Range on Protein: 240-531
Range on HMM: 1-513/513
Sequence Identity: 25% (129 aa)

SQPDRPIGYGAFGVVWSVTDPRSG--------------KRVALKKMPNVFQNLASCK----------RVFREIKMLSSFR-----------------HDN
 . ...|| |..|||.. .| |..              ..||.||. |.| .   .|          | .||||.|  ..                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VLSLLDILQPAN--PSF----------FQELYVLTELMQSDLHKIIVSPQ---------ALTPDH------------VKVFV------YQILRGLK--YL
...|.||... |  ..           |..||  .|.|. ||...| . |          |.. |            .| |.      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HTAN--ILHRDIKPGNLLVNSNCIL--------------------KICDFGLARTWDQRDRL--------------------NMTHEVVTQYYRAPELLM
| ..  |.|||.|| |.|.|.|| |                    |||||||||  .....                      .||.||| .|||||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GARRYT---------GAVDIWSVGCIFAELLQR--------KILFQ-----------AAGPIEQLQMIIDLLGTP----------------SQEAMKYAC
|...||          ..|.|||||||||....        |.||.            .  |.||..|...||||                ..| ... .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

---------------------EGAKNHVLR----AGLRAPDTQRLYKIASP------------------------------DDKNHEAVDLLQKLLHFDP
                     |.|.|.. .       . .. ..|.. ...                               . ...|.|||.|.|..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRISVEEALQHRYL
||||..|.|||| |.
DKRITAEQALQHPYF
Kinase lit-1.AA p38 241-531 43 2.1e-109 369.75 In-house 2-289 (289) Show / Hide 
Range on Protein: 241-531
Range on HMM: 2-289/289
Sequence Identity: 43% (131 aa)

QPDRPIGYGAFGVVWSVTDPRSGKR---VALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQP--ANPSFFQELYVLTELMQSDLHKIIVSP
|  .|.| ||.| | .. | |.|..   || ||.   ||     || .||.. |   ||.||..|||.  |   . . ||. |. |..|..||..|. . 
QNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC-

QALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAE
|.|. ||..  |||||||||| | |.| ||| ||.|. || .| |.| ||||||   . |   ||  |.|  ||||| .    .|| .||||||||| ||
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDD-EMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE

LLQRKILFQAAGPIEQLQMIIDLLGTPSQEAM-KYACEGAKNHVL-RAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL
|.....||    .|.||| |. ..|||..| . | . | |.| .  .. .   | ..... |.|      |.||| |.|. ||||||..|||.|| |.
LITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANP-----QAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase lit-1.AA ERK5 241-531 43 2.2e-104 353.11 In-house 2-295 (295) Show / Hide 
Range on Protein: 241-531
Range on HMM: 2-295/295
Sequence Identity: 43% (131 aa)

QPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANP-SFFQELYVLTELMQSDLHKIIVSPQALT
..   || ||.||| |    . |..||.||.|| |  .   || |||.|.|  |||||.. . |||.|  | | ... ||  .|| ||||.|| | | .|
KIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPFT

PDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQ----RDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAE
 .|.. |.|||||||||.| |...|||.|| ||||| || ||| |||.||        . .. ||  | | .||||||..    || |.|.||||||| |
LEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGE

LLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMK-YACEGAKNHVLR--AGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL
.. |. .|    .|.|||.|.. ||.|.   ..  . .  .|.. .  .  .  | ...|  | .      |.||| ..| |.| .||.| .|||| .|
MIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADR-----QALDLLARMLRFEPSERITVNKALQHPFL
Kinase lit-1.AA ERK7 243-531 36 2.9e-94 319.48 In-house 4-292 (292) Show / Hide 
Range on Protein: 243-531
Range on HMM: 4-292/292
Sequence Identity: 36% (107 aa)

DRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFR-HDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPD
 . .| ||.|.|| ..| |... |||||.   |.|     | |||| .|  |. |.|...|.....  |    . .|.  | | .||| .|   . |   
RKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADND---RDIYLVFEFMETDLHAVIRKGNILKDI

HVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQY-----YRAPELLMGARRYTGAVDIWSVGCIFAEL
|... .||.|| .||.| .|..|||.|| |.|..|.| .|.|||||||.  |.. ..  . ..| |     ||||| |.|..||| .|| ||.||| .|.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

LQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL
|. | .|.    ..|.  |..... |.|| ..         .| . .    .. | ..    .  ..|.|||..|| | |.||...|.||||.| 
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQ-MNQQKRKTLDQMMP--QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase lit-1.AA S_TKc 240-531 27 4.9e-93 316.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 240-531
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

SQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQS---DLHKIIVSPQ
 .  |.|| ||||.|. ... ..|..||.|...         ... |||..|.. .|.|.  |.|. |       ..||. .|..     ||...|.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

A------LTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTG-AVDIWSV
       ... |.. ..|||...|.|.|  .|.|||.|| |.|...   .|||||||||          |. ..| .|.|||.|     |.. ..|.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQ--
|||..|.| .. .|.      |.||.....|                                         .|| |...|.|..||.||... ||||  
GCILYEMLCGYPPFP------QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----HRYL
     | ..
WDIKCHPWF
Kinase lit-1.AA CDK 286-531 35 1.6e-87 280.11 In-house 57-284 (284) Show / Hide 
Range on Protein: 286-531
Range on HMM: 57-284/284
Sequence Identity: 35% (96 aa)

REIKMLSSFRHDNVLSLLDILQPANPS----FF--QELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCI
|||..|    |.|. .|.|.    |..    ..    ||   | |  || |..          .| . .|.|||| |.|  .|.|||.|| |.|.|.| .
REISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGE

-----LKICDFGLARTWDQR-----DRLNMTHEVVTQYYRAPELLMGARRYT--GAVDIWSVGCIFAELLQ---RKILFQAAGPIEQLQMIIDLLGTPSQ
     ||| |||||| .  .      .  .||||||  |||||||.|...|.   ..|.|||||||||...   || ||.    |.|| .|....|||. 
VKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTE

E------AMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL
.       . .                                    |||.|.| .||.|||| |.|||| |.
DNWPGVTKLPDY-----------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase lit-1.AA ERK1 244-531 42 2.2e-84 286.65 In-house 5-289 (289) Show / Hide 
Range on Protein: 244-531
Range on HMM: 5-289/289
Sequence Identity: 42% (124 aa)

RPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHV
. || ||.|.| |  | . ..|||.||.   |     |.|  ||||.|  |.|.|.. . ||..      ....|.  .||  || |.. . | |  ||.
QYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLSNDHI

KVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWD-QRDRLN-MTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKI
  |.|||||||||.| ||.||||.|| |||.|  | ||||||||||  | . |    .|  | | .|||||... .. || ..|||||||| ||.|  . 
CYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP

LFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL
.|     ..||  |. .|| |||. ..      |      .|     . . ..    |.   |.|||.|.| | |.||| ||||| | ||
IFPGKHYLDQLNHILGVLGSPSQDDLNCIIN-EKARNYLQSLPHKPKVPWARLFPKADS--KALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase lit-1.AA Pkinase 240-531 28 5.8e-81 280.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 240-531
Range on HMM: 1-293/293
Sequence Identity: 28% (90 aa)

SQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFR--EIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQS-----DLHKII
 .  |.|| |.||.|.  ..  .||.||.|... . ..   ... .|  ||... ...|.|.. |.|. .       ...|. .|...      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

V--SPQAL--TPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCIL----KICDFGLARTW-DQRDRLNMTHEVVTQYYRAPELLMGARRYTGA
   .  ..  .....| ..|||||||.|.|  .|.|||.|| |.|...|. .    ||||||||.     ...  ||. ..| .|.|||...|.. |. .
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPK

VDIWSVGCIFAELLQRKILFQAA----GPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKR
||.||.|||..|.| .. .|. .    . ..|.|||   .|.|  .   . |..   . .|    .. .... . .|.     |. |.. ..|..|| ||
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSE-----ECKDFIKWCLCKDPKKR

ISVEEALQHRYL
.. |..||| ..
PTAEQILQHPWF
Kinase lit-1.AA MAPK-Unclassified 241-389 42 1.2e-62 214.45 In-house 2-157 (575) Show / Hide 
Range on Protein: 241-389
Range on HMM: 2-157/575
Sequence Identity: 42% (67 aa)

QPDRPIGYGAFGVVWSVTDPRS-GKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSF--FQELYVLTELMQS---DLHKIIVS
 ..  || ||.|.|   .| .. .. || || . .|.|   |||| |||  |    | |.. . ||. .  ..   |. .|. ...||.   |||.|| |
EYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKS

PQ-ALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLAR
.|  .   |.. | ||||||||||| |.|.||| || |||.| .| ..|||||..|
NQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase lit-1.AA MAPK-Unclassified 399-531 32 3.6e-37 129.82 In-house 405-575 (575) Show / Hide 
Range on Protein: 399-531
Range on HMM: 405-575/575
Sequence Identity: 32% (55 aa)

MTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQR-----------KILFQAAG--------------------PIEQLQMIIDLLGTPSQEAM
||  ||| .|||||...    |. .|||||.||||||..|.           ..|| .                       . |..||.| ||.| .| .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

KY-ACEGAKNHVLRAGLRAPDTQR-LYKIASP-DDK----NHEAVDLLQKLLHFDPDKRISVEEALQHRYL
    |  |.  .   .  .|     |.  . | ||.    | |. |..||.| |.| |||. ..||.| | 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase lit-1.AA Pkinase_Tyr 243-390 29 2.4e-17 59.4 Pfam 4-160 (270) Show / Hide 
Range on Protein: 243-390
Range on HMM: 4-160/270
Sequence Identity: 29% (48 aa)

DRPIGYGAFGVVWSVTDP----RSGKRVALKKMPNVFQNLASCKR-----VFREIKMLSSF-RHDNVLSLLDILQ-PANPSFFQELYVLTELMQS-DLHK
.. .| ||||.|.  |        .  || |....     |. .       .||.|..... .|.|...|. .      |.   ..|. .|.|.  ||..
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLD

IIVS----PQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLART
   .    .|.||. .   . .|| .|. ||.  |. |||.   | ||..| . |||||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase lit-1.AA TyrKc 243-531 19 9.5e-14 -0.42 SMART 4-280 (280) Show / Hide 
Range on Protein: 243-531
Range on HMM: 4-280/280
Sequence Identity: 19% (63 aa)

DRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSF--RHDNVLSLLDILQPA--NPSFF---QELYVLTELMQS-DLHKIIVS
.. .| ||||.|.  |       || |.. .        .   ||.......  .|.|.. |. .      |   |   . |....|.|   ||.. . .
GKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKDYLRK

PQA-LTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQR-------DRLNM-----THEVVTQYYRAPELLMGARRYT
..  |....   | .|| .|  |||  |. |||.   | ||..| . ||.||||.| ..         |   .     .. ..     ||| .   ...|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

GAVDIWSVGCI------FAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKY----ACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKL
 . |.|| |        . .     . .|   ...  ..| ..      . ...    .                         .      |  .. .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F-VCCPDEMYQIMKQC

LHFDPDKRISVEEALQHRYL
 |.||..| . .|   |...
WHEDPEDRPTFSEI--HECF
Kinase lit-1.AA CDK 241-270 37 0.005192 5.29 In-house 2-36 (284) Show / Hide 
Range on Protein: 241-270
Range on HMM: 2-36/284
Sequence Identity: 37% (13 aa)

QPDRPIGYGAFGVVWSVTDPRSG-----KRVALKK
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EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKK