Gene K08F8.1 (Nematode worm)

K08F8.1

Species: Nematode worm
Alias: aSWK053, K08F8.1, CE03467
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 8743640-8747148, WormBase Genetic Map location: II:0.89,

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MK2

Sequence

Name Sequence Type Origin Length Description Download
K08F8.1.AA Protein Genbank 521 None Fasta, JSON
K08F8.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of K08F8.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase K08F8.1.AA MAPKAPK 144-405 56 3.3e-190 638.2 In-house 1-268 (268) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-268/268
Sequence Identity: 56% (151 aa)

TISAEIIGIGESGKVMACYQKVTGEKFALKVLRDSQKARREVELHWLTNAHENVVSILDIYENTFDN------VKCLLMVVEFLEGGDLLSQFESQGSIP
.|.....|||..||||.||.|.|..||||||||||.||||||||||....|...|.|.|.|||....      .||||.|.|..|||.|.......|...
QIWKQVLGIGINGKVMQCYHKRTQQKFALKVLRDSPKARREVELHWMCSGHPHIVQIIDVYENMYQFPHEPSPRKCLLIVMECMEGGELFHRIQERGDQH

YTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYKLGDYGFAKRPERNVLMESPCCTPFYAPPEVLGRERYDKSCDMWSLGVAMYILL
.||.....|..||..||...|.|||||||.|.||.|...|..|||.||.|.||||...|.. ...||.||.|..|||||.|.||||||||||||.|||.|
FTEREAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIML

CGYPPFYSMKGVALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELMATPLV
||||||||..|.|.||||..||.|..|.|||.||.|||.|.||.||.||||.|..||||.|.|..|..
CGYPPFYSNHGQAISPGMKHRIMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTERLTIEEFMNHPWI
Kinase K08F8.1.AA MAPKAPK 144-405 44 1.4e-181 567.46 In-house 1-292 (292) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-292/292
Sequence Identity: 44% (131 aa)

TISAEIIGIGESGKVMACYQKVTGEKFALKVLRDS-----QKARREVELHWLTNAHENVVSILDIYENTFDNVKCLLMVVEFLEGGDLLSQFESQGSIPY
....|..|.|..|||..|..|.||...|.|.|.|.     ||||||||||| ...|.|.|.|.|..||.....||...|.|..|||.|.......|....
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF

TEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYKLGDYGFAKR-------PER--NVLMESPCCTPFYAPPEVLGRER----YDKSCD
||.....|...|..||..||.|||||||.|.|||||. | .||..||.|.||||.       ...  .. ...||.||.|..|||.|...    ||||||
TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKSCD

MWSLGVAMYILLCGYPPFYSMKG-VALSPG-----------MRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELMATPLV
||||||.|||.|||||||||..|  ..|..           |..||....|.||.|||...|...||.||.|||..|..||||...|..|..
MWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase K08F8.1.AA CAMK 149-405 23 3e-91 294.25 In-house 1-425 (425) Show / Hide 
Range on Protein: 149-405
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

IIGIGESGKVMACYQKVTG------------EKFALKVLR---------------------------------DSQKARREVELHWLTNA------HENV
..| |  |||  |..| |.            .|.| |..                                  | .. |||.|.... ..      |.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSILDIYEN-----------TFDN-----VKCLLMVV---EFLEGG----DLLSQFESQGS-------------IPYTEKKVGEIIRQIGNAVMYLHDMN
......||.           | ..      |.. ||    |. .||    ||..   ..|.               .||. .  ..|||  || |.|..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IAHRDIKLENILCSGTGDN--------------CVYKLGDYGFAKRPER------------------------NVLMESPCCTPFYAP-PEVLGR-----
|.|||.|.||||..  .|.              .  |. | |||.. ..                        . .|. .| || |.. |||| .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------ERYDKSCDMWSLGVAMYILLCGYPPFYSMKGVALS---------PGMRSRIANAYYAFPHEE------------WDCVSKD--------TK
         . |...|||||.|| .||.||||||||. ..             . .  .| .. | ||...            ||..|..         |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DDIRCLLRTNPSDRLTIHELMATPLV
| ||..|...|..|.||.. .. | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase K08F8.1.AA S_TKc 144-405 29 6.5e-78 266.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-231/231
Sequence Identity: 29% (82 aa)

TISAEIIGIGESGKVMACYQKVTGEKFALKVLRDSQKARREVELHWLTNAHENVVSILDIYENTFDNVKCLLMVVEFLEG--GDLLSQFESQGS----IP
    ..|| |  |||. |. | ||...|.|...  ...|||....     |.|.| ..|....     ..| || |...|  |||..  ...|.     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

YTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYKLGDYGFAKRPERNVLMESPCCTPFYAPPEVLGRERYDK-SCDMWSLGVAMYIL
..|  .  ...|| .|. |.|...| |||.| ||||..      . |..| |.|..        . | ||.| .||||    |.| .||.||.|. .|..
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LCGYPPFYSMKGVALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELMA-------TPLV
|||||||.    . .   .                   |.. || || .|. .|..|.|. |...        | .
LCGYPPFP-QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase K08F8.1.AA CAMK1 143-405 32 1.3e-68 198.52 In-house 1-276 (276) Show / Hide 
Range on Protein: 143-405
Range on HMM: 1-276/276
Sequence Identity: 32% (93 aa)

YTISAEIIGIGESGKVMACYQKVT---GEKFALKVL--RD-SQKARR------EVELHWLTN----AHENVVSILDIYENTFDNVKCLLMVVEFLEGGDL
| .  ..|| |  ..|  | .| |   |...|.|..  ..  .| ..      | |.  ...     |.|.... ..|| .    . . .|.| . ||.|
YEF-GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESD----NHFYLVMELVTGGEL

LSQFESQGSIPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYK--LGDYGFAKRPERNV-LMESPCCTPFYAPPEVLGR---ERY
. .    |   ||||.  .|..||  || |.|...|.|||.| ||.|...  ..   |  . | | .|. . .. ||. .| || |  |||| .   . |
FDRIVEKG--NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPY

DKSCDMWSLGVAMYILLCGYPPFYSMKGVALSPGMRSRIANAYYAFPHEEWDCVSKD-TKDDIRCLLRTNPSDRLTIHELMATPLV
||.||||| ||  |||||||||||.  . .    . . | .. | ||  .|| .|.   || |...|  .|. |.|. .  . | .
DKACDMWSIGVITYILLCGYPPFYDENVDNE---LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Pkinase K08F8.1.AA Pkinase 143-405 28 7.4e-59 206.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 143-405
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

YTISAEIIGIGESGKVMACYQKVTGEKFALKVLRDSQKAR---------REVELHWLTNAHENVVSILDIYENTFDNVKCLLMVVEFLEGG----DLL--
|.|  ..|| | .|.|  |. | ||...|.|... . .           .|....   | |.|.| ..|..|.   . ..  || |..|||    ||   
YHIG-RKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED---KDHIY-MVMEYCEGGLYVMDLFDY

--SQFESQGSIPY--TEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDN--CVYKLGDYGFAKR--PERNVLMESPCCTPFYAPPEVLG-RE
       . . ..  .|. .  ...||  .. |.|.|.| |||.|.||||.. .|..  || |..| |.||     .|. | ..|.||.|..|||.  ..
IST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV-KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

RYDKSCDMWSLGVAMYILLCGYPPFYSM---KGVALSPGMRSRIANAYYAFPHEEWDCVS-----------------KDTKDDIRCLLRTNPSDRLTIHE
 |....||||.|. .|..|||.|||..    .. .    |  ||  . . |. ..|...|                 .. || |...|. .|..|.|...
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LMATPLV
..  | .
ILQHPWF
Kinase K08F8.1.AA RAD53 194-405 31 1.6e-56 166.6 In-house 63-305 (305) Show / Hide 
Range on Protein: 194-405
Range on HMM: 63-305/305
Sequence Identity: 31% (77 aa)

HENVVSILDIYENTFDNVKCLLMVVEFLEGGDLLSQFESQGS--IPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNC----------
|.....|.||....    | . ||.|. .||.|..   |..   . ..| .  .. .|. .|| ||||..|.|||.| |||||. ....|          
HPCIIRIYDIFDTP---QKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDE

-----VYKLGDYGFAKRPERNVLMESPCCTPFYAPPEVLG---R------------ERYDKSCDMWSLGVAMYILLCGYPPFYSMKG-VALSPGMRSRIA
     . |. | | .|  .   .|   | || |  |||.    .            . | |..|.||.|.  ||.|||||||   ..     . .   | 
DEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIK

N-AYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELMATPLV
| ..|.|||..|| .|  .|| |. .|  .|  |.|| |.. .|  
NQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM
Kinase K08F8.1.AA CAMK-Unique 144-405 23 1e-48 158.82 In-house 1-363 (363) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-363/363
Sequence Identity: 23% (85 aa)

TISAEIIGIGESGKVMACYQKVTGEKFALKVLRD------SQKA-------------------RREVELHWLTNAHENVVSILDIYENTFDNVK------
 .  .||| |. |.|  |  ..|| |.| |...       .||.                   .||... |..  |.| . ..|.    |   |      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQI-WKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------CLLMVVEFLEGGDLLSQFES------------------QGSIPYTE--KKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGD----
          . .| |...||||.. . .                  .  ....|    .  |....  || |.|. .| |||.|||||. .  ..    
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

---------NCVYKLGDYGFAKRPERNVLME---SPCCTPFYAPP--------------EVLGRERYDKSC----DMWSLGVAMYILLCGYPPFYSMKGV
         |   || |.| ..  . |   .   . | || |. |              ||... .||  |    | ||||| ||..|||.|||..    
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDC----

ALSP--------GMRSRIANAYY-AFPHEEWDC---VSKDTKDDIRCLLRTNPSDRLTIHELMATPLV
. ..        . ...|  . |  |. . |.    .|.  || . |.. . |. |... ||   . .
ECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase K08F8.1.AA Ciliate-E2 144-405 21 1.5e-48 164.76 In-house 1-365 (365) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-365/365
Sequence Identity: 21% (85 aa)

TISAEIIGIGESGKVMACYQ-----------------------KVTGEKFALKVLRDSQKARREVELHWL-----------------TNAHENVVSILDI
 .  ..|| |  |.|  | .                       ||.. ..|.|... .|.   . |.| .                 .. | |.. . . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YEN-TFDNVKCLLMVVEFLEGGDLLS-----QFESQGSIP----YTEKKVGEIIRQIGN---------------AVMYLHDMN-IAHRDIKLENILCSGT
... . .|.    .| |...||||..     .  ..  |.    .|||....|..|| .               |. |||  | | |||||.||||    
FQEKDDNNIY---LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

GDNCVYKLGDYGFAKR-----------PERNVLMESP----------------------CCTPFYAPPEVLG---------RERYDKSCDMWSLGVAMYI
      |. | |..|.           .... .|.                        |.|| | .||.|.         ...||..||.||||| .|.
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

LLCGYPPFYSMKGVALSPGMRSRIANAYYAFPHEE--------------WDCVSKDTKDDIRC----LLRTNPSDRLT-IHELMATPLV
.|.|.|||               | .  . || .|              |. .|...|| |.     .|  .|. |.| . ...  |  
MLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase K08F8.1.AA CAMKL 143-405 29 3.8e-48 151.67 In-house 1-297 (297) Show / Hide 
Range on Protein: 143-405
Range on HMM: 1-297/297
Sequence Identity: 29% (90 aa)

YTISAEIIGIGESGKVMACYQ-KVTGEKFALKVLR------DSQKA--------------RREVELHWLTN--AHENVVSILDIYE-NTF--DNVKCLLM
|.|    .| |  |||  .   . |||| | |..       | ..               |||.... . |   |.|........|  ..  .. |.. .
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYL

VVEFLEGGD--LLSQFESQGS--IPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYKLGDYGFAKRPER-----NVLMESPCCTP
| |  .||.  |.   ...|    . .|.    . |||  || |.|...|.|||||.|||| .  |.| . |. | ||.   ..     . ...  | .|
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

FYAPPEVLGR--ERYD-KSCDMWSLGVAMYILLCGYPPFY--SMK--GVALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELM
 |..||.. .  ..|| .  |.||.|| .| ..||| ||   ...  |.     .. .|    | .|.  |  || | .| || .| .||..| |||..|
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPI--WYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

ATPLV
  | .
NHPWM
Kinase K08F8.1.AA ULK 144-405 24 6.5e-46 158.28 In-house 1-329 (329) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-329/329
Sequence Identity: 24% (82 aa)

TISAEIIGIGESGKVMACYQKVT----GEKFALKVLR---DSQKA------------RREVELHWLTN-------AHENVVSILDIYENTFDNVKCLLMV
 .  ...| |  |||   . | |    .||.| |..     .||             ..|...    .        |.|.|  .|..|.. .  ... ..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYII

VEFLEGGDLLSQFESQGSIP--------YTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGT----------GDNCVYKLGDYGFAKR---P-E
.|. .|||| .  . ..  |         .|... ....|| |. ..||..|| |||||..||| .              | |.|..| ||||    . .
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNM

RNVLMESPC------CTPFYAPPEVLG----RERYD-KSCDMWSLGVAMYILLCGYPPFYSMKGVALS-PGMRSRIANA--------YYAFPHE---EWD
 . .| .        .|| |  |..|     .. |. . ||.||||. .| .| |.||||..    .   .... | |            .  .   . .
EQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDP

CVSKDTKDDIRCLLRTNPSDRLTIHELMATPLV
 .|...|| ||..|  ...|| ...|| . |..
QISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase K08F8.1.AA ULK 144-405 23 1.9e-43 150.69 In-house 1-324 (324) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-324/324
Sequence Identity: 23% (76 aa)

TISAEIIGIGESG-KVMACYQKVT---GEKFALKVLR-----DSQKA----------RREVELHWLTN--AHEN--VVSILDIYENTFDNVKCLLMVVEF
 .  ...| |  | ||   . | |   ....| |.       ....           ..|...    .   |.|  .|  .|..|.. .  . . ...|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIMEY

LEGGDLLSQFESQGSIP-------YTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGT----------GDNCVYKLGDYGFAKRPERN----VL
 .|||| .  . ..  |        .|... ....|| |. ..||..|| |||||..||| .              | |.|..| ||||  . |     .
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQM

MESPC------CTPFYAPPEVLG----RERYD-KSCDMWSLGVAMYILLCGYPPFYSM-KGVALSPGMRS-------RIANAYYAFPHE---EWDCVSKD
. . .      .|| |  |..|     .. |. . ||.||||. .| .| |..||.|.     |   ..         |   .  ...    . . .|..
CQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPE

TKDDIRCLLRTNPSDRLTIHELMATPLV
.|| ||..|  ...|| ...|. . |..
CKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase K08F8.1.AA TyrKc 144-403 18 5.3e-10 -60.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 144-403
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

TISAEIIGIGESGKVMACYQKVTGEKFALKVLRDSQKARREV--ELHWLTNA---HENVVSILDIYENT---FDNVKCLLMVVEFLEGGDLLSQFESQGS
    ...| |. |.|. .  |   .. | |.|...   |..   |.  ...    |.|.| .. .       |  .. |..|.|. ..|||..   . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

IPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYKLGDYGFAKRPERN--------VLME----SPC--CTPFYAPPEVLGRERYD
   . |.  ..  || .   |||..|. |||.   |.| .  .   . | .| | ..  .          . .     .          .||..   .. 
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSCDMWSLGVAMY-ILLCGYPPFYS-----MKGVALSPGMRSRIANAYYAFPHEE-----WDCVSKDTKDDIRCLLRTNPSDRLTIHELMATP
   | || || |. |.  | .| .      |.       .. .. . |.  . ..       | ...  . ...  . .|.|| |  |.    
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE----VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase K08F8.1.AA RAD53 143-173 38 0.017726 2.61 In-house 1-30 (305) Show / Hide 
Range on Protein: 143-173
Range on HMM: 1-30/305
Sequence Identity: 38% (12 aa)

YTISAEIIGIGESGKVMACYQKVTGEKFALK
| .| ...| |  |.|  .| | |..|.| |
YYMS-KELGSGNFGTVKLAYEKKTCQKVAIK