Gene K03E5.3 (Nematode worm)

K03E5.3

Species: Nematode worm
Alias: aSWK160, CE18009, K03E5.3
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 3408034-3415071, WormBase Genetic Map location: I:-4.6,

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
K03E5.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 302 Kinase domain by global Sugen HMM Fasta, JSON
K03E5.3.AA Protein Genbank 384 None Fasta, JSON

Protein domain

Protein domains of K03E5.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase K03E5.3.AA CDC2 45-346 51 2e-204 634.88 In-house 1-301 (301) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-301/301
Sequence Identity: 51% (163 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEG--IPSTCLREISCIKDLQ-HDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFID
......|||||||||.|......|  .|||.||.....||  .|||..|||||.|.|. |.|||.|.|.|.                  .|||||||..|
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----------------NKLYMVFEYLD

RDLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYT--HEVVTLWYRPPEILLGSQRY
.|||....|..|.|...||..|||.|.|.|.....|| |||.||||||||||....|.||||||||||.|..|.|.||  |||||||||.||||||..||
MDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRY

STSLDMWSLGCIFSEI---ASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPV-NLKKLEET-------SCLTGNGLDVLREILR
||. ||||.||||.|.   ...||||.|..|| ||||||.|.|||| ..||||...|.||. ||.|.  .|.|. .        |||. .|.|.|...|.
STPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQ

YPPERRLTAKGALSHRYF
| |..|..|| ||.|.||
YDPQKRISAKEALQHPYF
Kinase K03E5.3.AA CDK 45-346 43 1.7e-165 533.58 In-house 1-284 (284) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-284/284
Sequence Identity: 43% (144 aa)

FCSLRRIGEGTYGVVFKAIHVRDN-----VKCALKMIRTDR-----DEEGIPSTCLREISCIKDLQHDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLY
.. | .|||||||||.||.. ...       .|||.||..      ..||.|.| .||||. |.| |.|||.|.|... ..  ..| ...  .  ..|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDK--H--ENKLY

MVFEFIDRDLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGV-----IKIADFGLARNFSF------PSRNYTHEVV
||||..| ||| ...             .|..|||||..|.||| ..|.||||||||||... |.     .||||||||| |.       |.| ||||||
MVFEYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVV

TLWYRPPEILLGSQRYS--TSLDMWSLGCIFSEIAS---NKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPVNLKKLEETSCLTGN
|||||.||.||||..||  |. ||||.||||.|..    .||||||..|| ||||||.| |||. ..|||| ..|.|                       
TLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------

GLDVLREILRYPPERRLTAKGALSHRYF
  | |   | | |..|..|. ||.| ||
--DLLNKMLCYDPKKRISAEQALQHPYF
Kinase K03E5.3.AA CDK5 45-346 44 9.3e-136 431.67 In-house 1-287 (287) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-287/287
Sequence Identity: 44% (137 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDRDL
.  . .|||||||.|.||      .  ||| .| | . ||.||| .|||. .| |.| ||| |.|.|                 |. || .||||.| ||
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIH----------------SEKKLTLVFEFCDQDL

KNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRYSTSLD
|  .. ..     . .. .||||.|||  |..|| ... |||||||| |..  |  | ||||||| |  | |.|.||||||||||| .|.||. |||| |
KKYMDSCNG---EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSID

MWSLGCIFSEIA-SNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYK---AVFPQWPVNLKKLEETSCLTGNGLDVLREILRYPPERRLTAKGA
||| |||| |.| . .|||||  .  ||..||.|.|||.  .||..   | ||     .| .|..    . .  | ..|.| | ..|.. |. |..|| |
MWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAA

LSHRYF
| | ||
LHHPYF
Kinase K03E5.3.AA CMGC 45-346 26 1.3e-128 425.07 In-house 1-513 (513) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-513/513
Sequence Identity: 26% (135 aa)

FCSLRRIGEGTYGVVFKAIH--------------VRDNVKCALKMIR---TDRD------EEGIPSTCLREISCIKDLQ-----------------HDNI
.  ...|||||||||.|...               ..| ..|.| |.    ...      ..|.|...||||.. | |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTLFDIIYASHFLNYNNIFFEK--FSSNSKLYMVFEFIDRDLKNLLEMLEP-----TNSVLPPNY------------VKSFM------WQLLSALS--YC
|.|.||.| ..  .... ....  . .. .||.|||..| ||......  .      .  |..              .|.||      .|.| .|   ||
VKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HLRR--IVHRDLKPQNILVSDS--------------------GVIKIADFGLARNFSFP---------------------SRNYTHEVVTLWYRPPEILL
| ..  |.||||||.|||...                     |..||.|||||| .. .                     .| |||.|||.|||.|||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GSQRYS---------TSLDMWSLGCIFSEIASN--------KPLFPGECE-----------ISQLFKIFEIVGTPN---------------IKSWPGVDS
|...|.         |. ||||.|||| |.  .        ||||||. |           | ||||||.. |||.                . ||.. .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

FPHY---------------KAV-----------FPQWP-VNLKKLEET---------------------------------SCLTGNGLDVLREILRYPP
 |.|               .             ||.||  ..|.|.                                   .|..  ..| |  .|.| |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

ERRLTAKGALSHRYF
..|.||. ||.| ||
DKRITAEQALQHPYF
Kinase K03E5.3.AA PFTAIRE 45-346 42 1.1e-100 340.76 In-house 1-287 (287) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-287/287
Sequence Identity: 42% (131 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDRDL
.  | . |||.|  |.|.|    .   ||| || . .||| | |  || |  |.|.| |||.| |||     |                 .|||....||
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLT----------------FVFEYVHTDL

KNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRYSTSLD
.  ..     .  . || |. |..|||  ||||| ||. |||||||| |.|. |  | |||||||  | ||. | ||||||||||| .||||  |||.||
CQYMDK---HPGGMHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLD

MWSLGCIFSEIASNKPLFPGE-CEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQ----WPVNLKKLEETSCLTGNGLDVLREILRYPPERRLTAKG
||  |||| |    .|.|||      || |||.. |||.   |||| ..|.|| .  .     | .|..  .   .  .. |.. ..|.. |. |. |. 
MWGVGCIFVEMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQE

ALSHRYF
|..| ||
AMQHPYF
Kinase K03E5.3.AA PCTAIRE 45-346 42 7.1e-96 324.83 In-house 1-291 (291) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-291/291
Sequence Identity: 42% (132 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDRDL
.  | . |||||  |.|     ..   ||| || .  ||| | |  ||.|  |||.| ||||| |||.  |                 | .|||..|.||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHH----------------QLTLVFEYMDMDL

KNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRYSTSLD
|  ..      ...  . || |..|||  | ||| |.| |||||||| |.   |. | |||||||  | |.. | |||||||||||..|.||  |||..|
KQYMDD---CGNIMNMHNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQID

MWSLGCIFSEIASNKPLFPGEC------EISQLFKIFEIVGTPNIKSWPGVDSFPHYKA-VFPQWPVNLKKLEETSCLT---GNGLDVLREILRYPPERR
||  |||| |... .|||||           ||  || | |||  |.|||| |.. ...  ||... ..  .     |.    .. | | ..|.| .. |
MWGVGCIFYEMCTGRPLFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYR-EQPLINHAPRLDKILKQCQDLLTMLLQYESKNR

LTAKGALSHRYF
. |  |..| ||
VSAEKAMKHPYF
Kinase K03E5.3.AA CRK7 45-346 34 5.5e-90 305.26 In-house 1-343 (343) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-343/343
Sequence Identity: 34% (124 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRD---EEGIPSTCLREISCIKDLQHDNIVTLFDIIYA-SHFLNYNNIFFEKFSSNSK--LYMVFE
.  .  ||||||| | ||   . .   ||| .|.| .   .|| | |  |||   . |.|.|||.| .|.      .  .         . |   |||||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFK---------KHKGSFYMVFE

FIDRDLKNLLEMLEPTNS--V-LPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPS--RNYTHEVVTLWYRPPEIL
 .| ||  |||     .   .   .. .|.|| |||  . ||| . . |||.|  |||.  .| .||||||||| .   .  | ||  |.|||||||| |
YMDHDLMGLLE-----SKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELL

LGSQRY--------------------------------------STSLDMWSLGCIFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHY
|| .||                                       .. |||| |||. | .. ||.|.|. |. || ||..| |.||. .|| |.  | .
LGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWW

KAVFPQWPVNLKKLEETS------CLTGNGLDVLREILRYPPERRLTAKGALSHRYF
..  |.   | . .|| .       ..   || | ..| . |. | ||. .| | .|
NTMKPKRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase K03E5.3.AA Pkinase 45-346 30 2.5e-88 304.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLR--EISCIKDLQHDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDR
.. .|.||.|..|.|.|..|. .. . |.| |. ...... . | .|  ||.  | |.|.|||.|.|. .                 ....|||.|. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----------------KDHIYMVMEYCEG

-----DLKNLLE-MLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVI----KIADFGLARNF-SFPSRNYTHEVVTLWYRPPE
     ||. ... . . . . .... .|..|.|.|..| ||| ..|.||||||.|||... |.|    ||.|||||. |   ... .|. ..|.||..||
GLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE

ILLGSQRYSTSLDMWSLGCIFSEIASNKPLFPGE----CEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPVNLKKLEETSCLTGNGLDVLREIL
...|.| |... ||||.|||. | .. .|.|||.      ..|...|..| |.|.  .||  .| . .. ... |    . ...   .. ...|... .|
VIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTFHNWSEECKDFIKWCL

RYPPERRLTAKGALSHRYF
.. |..|.||. .| | .|
CKDPKKRPTAEQILQHPWF
Kinase K03E5.3.AA S_TKc 45-346 28 1.3e-86 294.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-231/231
Sequence Identity: 28% (90 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDR--
.  || ||.|..|.|.|..|.... ..|.|.|.          . .|||.. |  .|.|||.|.|...                  ..||||.|..|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----------------DHLYMVMEYCDGDL

-DLKNLLEMLEP--TNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRY
 ||. ...   .  .....|.  ....|.|...|| ||| ..|.||||||.|||...  .|||.|||||| .       |. ..|.||..||.|     |
GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GY

ST-SLDMWSLGCIFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPVNLKKLEETSCLTGNGLDVLREILRYPPERRLTAK
.. . |.||.|||. | .. .|.||      |....|...|                                    .  ..| .| .|.. ||.|.|| 
GKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

GALS-------HRYF
 ||        | .|
EALQDEWDIKCHPWF
Kinase K03E5.3.AA CDK4 45-346 39 8.1e-86 291.42 In-house 1-290 (290) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-290/290
Sequence Identity: 39% (122 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEE--GIPSTCLREISCIKDLQ---HDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEF
.  .  |||| || |..|  . .    ||| .|    ||  |.|   .|||| .. |.   | ||| |.|.            . .   .  |. |||| 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCH----------VMDTDRAEMKITMVFEH

IDRDLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRY
.| ||. .|. . |  . .||  .|  | |||... . |  ||.|||||||||||. .| .|.||||||| .||     |  ||||||| ||.||  . |
CDWDLHTYLDKCPP--PGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSF-QMALTPVVVTLWYRAPEVLL-QSYY

STSLDMWSLGCIFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWP-----GVDSFPHYKAVFPQWPVNLKKLEETSCLTGNGLDVLREILRYPPERR
 |  ||||.||||.|.   .|||.|. |  || |||...|.|  . ||       |.|| ..      | ..|..     .   |.| | . |.| ...|
NTPVDMWSVGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRH------PRPFKDF--CPHMCKQGDDLLQKMLCYNHHKR

LTAKGALSHRYF
..| ..|.| ||
MSAYQCLQHPYF
Kinase K03E5.3.AA CDK7 127-346 38 9.8e-86 228.22 In-house 71-288 (288) Show / Hide 
Range on Protein: 127-346
Range on HMM: 71-288/288
Sequence Identity: 38% (85 aa)

FSSNSKLYMVFEFIDRDLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLW
|   | ...||.|.| ||    .  .    .| |  .|..| ..|  | |||.  | |||||| | |..  |..||||||||| .  | |.||| ||| |
FMHKSNIQLVFDFMDWDLE---VVIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRW

YRPPEILLGSQRYSTSLDMWSLGCIFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWP---VNLKKLEETSCLTGNGLDVL
|| || | |   | |. |||| |||| |     | .||. .| || .||.. |||. . ||.. ... |    .. .   . |...   .  .   || .
YRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHI--FTAASDDLLDLM

REILRYPPERRLTAKGALSHRYF
  ..   | .|.|.  .|.. ||
CGMWTMNPCKRWTCTQCLKMPYF
Kinase K03E5.3.AA PITSLRE 132-346 45 4.6e-84 285.6 In-house 77-295 (295) Show / Hide 
Range on Protein: 132-346
Range on HMM: 77-295/295
Sequence Identity: 45% (99 aa)

KLYMVFEFIDRDLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPE
| |||.|... ||| |.|     |    |  .|..| |||.. .. |   | |||||  |.| | .|. ||.|||||| .  | . ||  ||||||| ||
KIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPE

ILLGSQRYSTSLDMWSLGCIFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVF---PQWPVNLKKLEE-TSCLTGNGLDVLREIL
.|||.. ||| .|||| |||| |. . ||||.|. || |. .||   |||. |.|||. ..|| |..    .. . ||.|.      .. .|.| |   |
LLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQML

RYPPERRLTAKGALSHRYF
 | |..|.||  || | .|
TYNPKNRITASDALKHPWF
Kinase K03E5.3.AA CDK7 45-111 32 5.9e-21 52.16 In-house 1-71 (288) Show / Hide 
Range on Protein: 45-111
Range on HMM: 1-71/288
Sequence Identity: 32% (23 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIR----TDRDEEGIPSTCLREISCIKDLQHDNIVTLFDII
.  .. ||||....|.||     . . | | |.    ..  . ||  | .|||   . .||||.. | ||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIF
Kinase K03E5.3.AA Pkinase_Tyr 45-209 26 5.3e-20 68.37 Pfam 1-159 (270) Show / Hide 
Range on Protein: 45-209
Range on HMM: 1-159/270
Sequence Identity: 26% (46 aa)

FCSLRRIGEGTYGVVFKAIHV----RDNVKCALKMIRTDRDEEG-IPSTCLREISCIKDL-QHDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFE
   .. .||| .|.|.|..       .....| ||.. . ..|  .    .||..  | | .|.||| |  ...            ..  .| ..|.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT------------DQGEPN-QIYIVME

FIDR-DLKNLLEML-EPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLAR
.    ||.. |    |. ... ..    .. ||  ....| . ....||||   |.||....|.||.||||||
YMPHGDLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase K03E5.3.AA PITSLRE 45-107 45 6.5e-18 61.95 In-house 1-66 (295) Show / Hide 
Range on Protein: 45-107
Range on HMM: 1-66/295
Sequence Identity: 45% (30 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTD--RDEEGIPSTCLREIS-CIKDLQHDNIVTL
|  | ||.|||||||..|   | .   ||| .  .  .. ||.| | ||||.   . |||.|||..
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNV
Kinase K03E5.3.AA TyrKc 45-346 22 1.3e-13 -2.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-346
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDL--QHDNIVTLFDIIYAS--HFLNYNNIFFEKFSSNSKLYMVFEFI
   .. .||| .|.|.|..     ...| ||.. |          .||..  . |  .|.||| |. ..  .              | .   |..|.|. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----------FMYIEPLMIVMEYM

DR-DLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFP------SRNYT-----HEV--VTLW
.  |||. |   .|.   |..    ||.||  .  .| | ....||||   |.||.. ...||.||||.|.          .  |.     ..   . . 
PHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YRPPEILLGSQRYSTSLDMWSLGCIFSEIASN-KPLFPGECE--ISQLFKIFEIVGTPNIKSWPGVD---SFPHYKAVFPQWPVNLKKLEETSCLTGNGL
  .|| .    ...|  | || |    || .. ..  ||. .  .|  . ..| | . .    |  |   |                      | .    
WMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS-NQEVIEYVKQGYRMPQPPNDYPMS--------------------FVCCPDEMY

DVLREILRYPPERRLTAKGALSHRYF
.. ..  .. || | | .    |..|
QIMKQCWHEDPEDRPTFSEI--HECF