Gene C38C3.4 (Nematode worm)
C38C3.4
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| C38C3.4.AA | Protein | Genbank | 307 | None | Fasta, JSON |
| C38C3.4.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 248 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of C38C3.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | C38C3.4.AA | Worm6 | 36-283 | 37 | 9.20000000001e-129 | 434.07 | In-house | 1-261 (279) | Show / Hide |
Range on Protein: 36-283 Range on HMM: 1-261/279 Sequence Identity: 37% (99 aa) YAVGKKVAQGRYGAVYEVLRRSDGK--PFACKLEI--CEAHSHGLDQDYSVMTKAAKRGAENLVRMIDRGKIEEH-FKFIIMPLLGENLMNLRFLFEDGR . |.||...|..||||.|...||.| .||.|.| ...... |.....|................||||.... |..|.|.|.|.||..||. ..|.. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSLSTGLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQMLHQNPEALKLCLIDYGICR--SFKDKSGELKTPR-TDIKFRGTNRYASLAAHYGDEQS ||..|||..|.. ...|. ||. |..|||.|..|||| ..|| ... | .....|.|.|| ...| .||.||| |...||||.|||.||.|.|.||. FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQM-KEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQC AKDDMESWFYMMIELISGNLPWSFMHRDQHKEVEFHR----IQAYLMGLKYQNTV--DYTFI .|||.|||||||.|.|.|.||| .|....|.|..... ..|..| . .... ....| RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDI |
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| Kinase | C38C3.4.AA | CK1 | 36-283 | 25 | 9.3e-90 | 304.5 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 36-283
Range on HMM: 1-339/339
Sequence Identity: 25% (86 aa)
YAVGKKVAQGRYG-AVYEV-----LRRSDG-----KPFACKLEIC-EAHSHGLDQDYSVMTKAAKRG-------------------AENLVRMIDRGKIE
. |.|| ..| .| ..|.| . ... . .|.|.| ....| . .. ..| |. ..| ..... |. .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED
EHFKFIIMPLLGENLMNLRF--LFEDGRFSLSTGLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQML------HQ-NPEALKLCLIDYGICR-SFK
.......|.|||.||. || . ...||..|.|..|. .. .. .| |..|||||..|||. ... |. |.|. .. .||.|..| ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR
DKSG------------ELKTPRT---DIKFRG-TNRYASLAAHYGDEQSAKDDMESWFYMMIELISGN--LPWSFMHR----------DQHKE---V---
||.| ....||. .||| | ||.|...| | ||. .||..|||||.||.. |. |||. | . ....|
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM
-----------------EFHRIQAYLMGLKYQNTVDYTFI
|| | |...|||. . || .|
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
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| Kinase | C38C3.4.AA | TTBKL | 36-250 | 28 | 8.3e-51 | 169.79 | In-house | 1-229 (288) | Show / Hide |
Range on Protein: 36-250
Range on HMM: 1-229/288
Sequence Identity: 28% (69 aa)
YAVGKKVAQGRYGAVYEVLRRSD-GKPFACKLEICEAHSHGLDQDY--S--------VMTKAAKRGAENLVRMIDRGKIEEHFKFIIMPLLGENLMNLRF
. . |....| .|.||.| ..| .. .|.| | ... . . |..| ...|. .... ||.. . |..| |.|.||. ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEE--------KNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKD-YNFMVMTLCGPNLQDLRK
LFEDGR-FSLSTGLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQMLHQ--NPEALKLCLIDYGICRSFKDKSGEL-----------KTPRT---DI
.. || .| .|.. . .. .| |..|||.| .|.|. .|. .... . |||.|..| ...|.||. ..||.
MMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWG----YHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKA
KFRGTNRYASLAAHYGDEQSAKDDMESWFYMMIELISGNLPWS
|||| ||.|...| . ||. .||. ||.||.||| | |||.
PFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWT
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| Kinase | C38C3.4.AA | TTBK | 105-249 | 42 | 4.2e-38 | 132.27 | In-house | 68-207 (257) | Show / Hide |
Range on Protein: 105-249 Range on HMM: 68-207/257 Sequence Identity: 42% (62 aa) EHFKFIIMPLLGENLMNLRFLFEDGRFSLSTGLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQMLHQNPEALKLC-LIDYGICRSFKDKSGELKTP ..| ...| |.|.|| .|| .| ||||| ||| . .| |.| |..|. ||||| ||| . .||. . | ..|.| | . .|| .| DKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMG------RNPSTCRKCYMLDFGLARQYTNACGEVRPP RTDIKFRGTNRYASLAAHYGDEQSAKDDMESWFYMMIELISGNLPW | |||| |||| || | .||. | |||..| . | ||| REVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPW |
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| Kinase | C38C3.4.AA | CK1-Unique | 36-283 | 25 | 1.7e-32 | 109.99 | In-house | 1-263 (337) | Show / Hide |
Range on Protein: 36-283 Range on HMM: 1-263/337 Sequence Identity: 25% (70 aa) YAVGKKVAQGRYGAVYEVLRRSDG------KPFACKLEICEAHSH--GLDQDYSVMTKAAKRG-----AENLVRMIDRGKIEEHFKFIIMPLLGENLMNL . | |. | || |..| .| . .. | | . | | .|| | . . .| . ..|.| ..| .. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFH-QHRDWWWIVMTMHGPSMEEC RFLFEDGRFSLS------TGLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQMLHQNPEALKLCLIDYGICRS--FKDKSGELKTPRTDIKFRGTNR ... | |. . ..... | |. |. ||..| |.| .| || . .||||||. | ....... || ..|||. . CMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQH----CYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKD YASLAAHYGDEQSAKDDMESWFYMMIELISGN--LPWSFMHRDQHKEVEFHRIQAYLMGLKYQNTVDYTFI |.. . | |....|||||||||.. |. . | | |. | || |||. ||| | YCPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWKL---DKIIPSGIDNIIVYLRGLKFEDPVDYRQI |
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| Kinase | C38C3.4.AA | Dual | 75-249 | 27 | 1.4e-30 | 100.01 | In-house | 46-225 (282) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 46-225/282 Sequence Identity: 27% (52 aa) GLDQDYSVMTKAAK-------RGAENLVRMIDRGKIEE-HFKFIIMPLLGENLMNLRFLFEDGRFSLSTGLRLALFAIQPIQSLHQLGYVHRDIKASNFC .|. || |.| | .. . ..|.||.|. . |...| . | | | . | .| .. |. .. || ||..||.||.|| .|| RLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFH IADPQMLHQNPEALKLCLIDYGICRSFKD-KSGELKTPRTDIKFRGTNRYASLAAHYGDEQSAKDDMESWFYMMIELI-SGN-LPW . . . .. . |..| |.. | . .. .|.|. .|. |. |||. | .| |||.|.| || |. .. ..| CG------LGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSW |
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| Kinase | C38C3.4.AA | CK1-A | 36-249 | 34 | 1.1e-29 | 101.96 | In-house | 1-205 (261) | Show / Hide |
Range on Protein: 36-249 Range on HMM: 1-205/261 Sequence Identity: 34% (75 aa) YAVGKKVAQGRYGAVYEVLRRSDGKPFACKLEICEAHSHGLDQDYSVMTKAAKRGAENLVRMIDRGKIEEHFKFIIMPLLGENLMNLRFLFEDGRFSLST | . .|. | .| .| . .|. | |.| .|. | . | . . |. . .| |. | . ..| ||| | .| | | . ||.. | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQ--GCVGIPHMRWYGC-EKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKT GLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQMLHQNPEALKLCLIDYGICRSFKDKSGELKTP-RTDIKFRGTNRYASLAAHYGDEQSAKDDMES | || | | .|. ...||||| || . | | || |||.|. . ..|. . | |.| . || ||||. || | ||| .||||| VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMG--IGRHCN----KLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMES WFYMMIELISGNLPW |.|. | ||| MGYVMMYFNRGKLPW |
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| Kinase | C38C3.4.AA | CK1-D | 36-249 | 30 | 7e-24 | 81.03 | In-house | 1-205 (261) | Show / Hide |
Range on Protein: 36-249 Range on HMM: 1-205/261 Sequence Identity: 30% (66 aa) YAVGKKVAQGRYGAVYEVLRRSDGKPFACKLEICEAHSHGLDQDYSVMTKAAKRGAENLVRMIDRGKIEEHFKFIIMPLLGENLMNLRFLFEDGRFSLST | .|.|. | .| .| . . | ||| .. |. . | . | . | . .| | . ..| ||| | | | . . .||| | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIE-SKFYKMMQGGIG--IPEIRWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLKT GLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQMLHQNPEALKLCLIDYGICRSFKDKSGELKTP-RTDIKFRGTNRYASLAAHYGDEQSAKDDMES | ||. |. |. .| ..||||| || . . . .||.|. . ..| . | | . || ||||. | | ||| .||.|| VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM------VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLES WFYMMIELISGNLPW |... | ||| LGYVLMYFNRGSLPW |
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| Kinase | C38C3.4.AA | CK1-Unclassified | 36-249 | 32 | 1.6e-23 | 66.34 | In-house | 1-216 (244) | Show / Hide |
Range on Protein: 36-249 Range on HMM: 1-216/244 Sequence Identity: 32% (73 aa) YAVGKKVAQGRYGAVYEVLRRSDGKPFACKLEICEAHSHGLDQDYSVMTKAAKRGA------ENLVRMIDRGKIEE-HFKFIIMPLLGENLMNLRFLFED | |..|. || | .|.. ... .|.||| . . |. .| .. ..|. .. .|. |. |. .. ...| |||..| | | . YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIM-QYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNMCN GRFSLSTGLRLALFAIQPIQSLHQLGYVHRDIKASNFCIA-DPQMLHQNPEALKLCLIDYGICRSFK--DKSGELKTPRTDIKFRGTNRYASLAAHYGDE ..||| | | .| || |. || ...||||| ||.. .. || . .||.|. .. || |. . | . .. || ||||. ||.| | RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQ------VYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIE QSAKDDMESWFYMMIELISGNLPW || .||.|| | .| .. | ||| QSRRDDLESLGYVLIYFLKGSLPW |
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| Kinase | C38C3.4.AA | CK1 | 36-249 | 31 | 1.1e-22 | 75.11 | In-house | 1-216 (271) | Show / Hide |
Range on Protein: 36-249 Range on HMM: 1-216/271 Sequence Identity: 31% (69 aa) YAVGKKVAQGRYGAVYEVLRRSDGKP--FACKLEICEAHSHGLDQDYSVMTKAAK---RG-AENLVRMIDRGKIEE-HFKFIIMPLLGENLMNLRFLFED | ||.|. || | .|.. . ..|. |.||| . |. . ... . . .... .|. |. |. .. ...| |||..| | | | . YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFCN GRFSLSTGLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQMLHQNPEALKLCLIDYGICRSFKD-KSGELKTPRTDIKFRGTNRYASLAAHYGDEQS ..||| | | .| || |. .| ...||||| ||.. .. .. .. .||.|. ..| |... |.. .. || ||||. .|.| ||| RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-----YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQS AKDDMESWFYMMIELISGNLPW .||||| |... .. | ||| RRDDMESLGYVLMYFLRGSLPW |
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| Kinase | C38C3.4.AA | S_TKc | 36-305 | 12 | 9.9e-11 | -19.55 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 36-305
Range on HMM: 1-231/231
Sequence Identity: 12% (37 aa)
YAVGKKVAQGRYGAVYEVLRRSDGKPFACKLEICEAHSHGLDQDYSVMTKAAKRGAENLVRMIDRGKIEEHFKFIIMPLLGENLMNLRFLFEDGR-----
| ...|. .| .| || . ...|. .|.| . . ... | . .|.|...| .. ...| ... .| .|. . .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
--FSLSTGLRLALFAIQPIQSLHQLGYVHRDIKASNFCIADPQMLHQNPEALKLCLIDYGICRSFKDKSGELKTPRTDIKFRGTNRYASLAAHYGDEQSA
|. . ... .. .. .|..| .|||.| .| . . . ..| |..| . | || | .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-------
KDDMESWFY----------MMIELISGNLPWSFMHRDQHKEVEFHRIQAYLMGLKYQNTVDYTFISEMVQLAMRNN-----GVRMNEK-------FDWQ
.. . ...|...| |.. . .. |..| . ... ... .. . .. . |
-----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | C38C3.4.AA | Pkinase | 36-65 | 36 | 1.1e-05 | 21.14 | Pfam | 1-30 (293) | Show / Hide |
Range on Protein: 36-65 Range on HMM: 1-30/293 Sequence Identity: 36% (11 aa) YAVGKKVAQGRYGAVYEVLRRSDGKPFACK | .|.|. .| .| ||. ....|| .|.| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK |
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| Kinase | C38C3.4.AA | Pkinase | 150-250 | 19 | 0.006953 | 11.28 | Pfam | 124-213 (293) | Show / Hide |
Range on Protein: 150-250 Range on HMM: 124-213/293 Sequence Identity: 19% (20 aa) LHQLGYVHRDIKASNFCIADPQMLHQNPEALKLCLIDYGICRSF-KDKSGELKTPRTDIKFRGTNRYASLAAHYGDEQSAKDDMESWFYMMIELISGNLP .|. | .|||.| .|. | . . .....| |... | ... ..|. . .. | . . | || | ...|...|..| CHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGRPP WS .. FP |
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