Gene C09B9.4 (Nematode worm)
C09B9.4
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| C09B9.4.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 267 | Kinase domain by global Sugen HMM | Fasta, JSON |
| C09B9.4.AA | Protein | Genbank | 359 | None | Fasta, JSON |
Protein domains of C09B9.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | C09B9.4.AA | Worm6 | 29-289 | 34 | 3.5e-133 | 448.74 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 29-289 Range on HMM: 1-279/279 Sequence Identity: 34% (95 aa) YKMCDSIATGPFSSVFLVEK--DGI--PYAMKVESQ-SKCLRPVLKLDHAVLRALGHQS--GFPSLTSAGRTEN--FKYVVMQLVGPDLSMLLEFAPQQR .|.. |..|.|..|..||. |. ..|||.|.| .. |..||....|| |..|. .|.... .|...| |.|.||.|||..|..| ...|... WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FTSSTVYKIALQTLDRLRVLHEAGWLNRDVKAQNFAVGL-----GEESSIVYMLDFGLTR--KYLEHNGSRSLLR-PHGPSVGTFPYAPLASLGFCDQSP |. .| .|||.|.|.....|| .|...||||..||..| .|....||||||..| ||....... | .. ...||..|||||. ...|.. FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR IDDIEGWLYMIVHLLKGGLPWHNSKRALNLPKVREWKMYCRRPGGKHYLFAGIPK-GWADIFDVIVNTAPHETPDYNKI ||.|.|.||.|....|.|||...|. . |...|.....|.......|...|| .. ||.|.| ... ...|||..| KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | C09B9.4.AA | CK1 | 29-289 | 22 | 2.6e-83 | 283.06 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 29-289 Range on HMM: 1-339/339 Sequence Identity: 22% (76 aa) YKMCDSIATGPFS-SVFLV------EKDG------IPYAMKVESQSKCLRPVLKLDHAVLRALGHQS-----------GFPS----------LTSAGRTE .| |..| | ...| ... ||||||. . .. .... ... .. .. .|.. . .|... WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED N-FKYVVMQLVGPDLSMLLE--FAPQQRFTSSTVYKIALQTLDRLRVLHEAGWLNRDVKAQNFAVGL-------------GEESSIVYMLDFGLTR-KYL . ..|.||.|.||.|. |.. . ....|. .|...||.|.|..|...|..|.. ||.|..||..|. ..|. .|||.|||. | ||. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR EHNGSR------------SLLRP---HGPSVG-TFPYAPLASLGFCDQSPIDDIEGWLYMIVHLLKGG--LPWHNSKRALNLPK---VREWKMYCRRPGG . .|.. |. . . .| |. |..... ..|.. ||.. |.||....|||. |||.| |. . | |...|. ... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKP-KDHQVEKMKYEFIDEKK KHYLF--------AGIPKGWADIFDVIVNTAPHETPDYNKI ....| ...|. . .|...| . ....||| .| MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | C09B9.4.AA | TTBKL | 29-182 | 28 | 1.5e-38 | 127.78 | In-house | 1-165 (288) | Show / Hide |
Range on Protein: 29-182 Range on HMM: 1-165/288 Sequence Identity: 28% (47 aa) YKMCDSIATGPFSSVF--LVEKD-GIPYAMKVESQS-KCLRPVLKLDHAVLRALG--HQSGFPSLTSAGRTENFKYVVMQLVGPDLSMLLEFAPQQR-FT .. .|. | | .|. . || . .|||.|... ..|. . || .| ... || . .|..... ..||.|.||.|. | |... |. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS SSTVYKIALQTLDRLRVLHEAGWLNRDVKAQNFAVGLGEE----SSIVYMLDFGLTRKYLEHNGS .|.. |. |.|. |. .|..|.. |||| .|...|. .. . .|| .|||..|.|....|. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGE |
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| Kinase | C09B9.4.AA | Dual | 97-293 | 28 | 7.9e-33 | 107.63 | In-house | 87-282 (282) | Show / Hide |
Range on Protein: 97-293 Range on HMM: 87-282/282 Sequence Identity: 28% (56 aa) KYVVMQLVGPDLSMLLEFAPQQRFTSSTVYKIALQTLDRLRVLHEAGWLNRDVKAQNFAVGLGEESSIVYMLDFGLTRKYLE-HNGSRSLLRPHGPSVGT ||.|| ..|| | . . .. .. . .|.|.|. .. || .|.|.|..| ||..|||.. . |||.||.. |||.. |. | |. KYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGC FPYAPLASLGFCDQSPIDDIEGWLYMIVHLL--KGGLPWHNSKRALNLPKVREWKMYCRRPGGKHYLFAGIPKGWADIFDVIVNTAPHETPDYNKIANMV || | .. || ||.| | ||. |. . |..| .. . . | . || . . .. ||.. ... ... . |||| . |. GRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMY----HFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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| Kinase | C09B9.4.AA | TTBK | 54-232 | 35 | 1e-27 | 95.03 | In-house | 29-207 (257) | Show / Hide |
Range on Protein: 54-232 Range on HMM: 29-207/257 Sequence Identity: 35% (63 aa) AMKVESQSKCLRPVLKLDHAVLRALGHQSGFPSLTSAGRTENFKYVVMQLVGPDLSMLLEFAPQQRFTSSTVYKIALQTLDRLRVLHEAGWLNRDVKAQN |.|||| .. . |||. |||. | . || ..| |.|||| | |. | .|.. |. || .. .| |. .. |. |.| ||.| | AIKVES-AQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSN FAVG-LGEESSIVYMLDFGLTRKYLEHNGSRSLLRPHGPSVGTFPYAPLASLGFCDQSPIDDIEGWLYMIVHLLKGGLPW ||.| . .. ..||||||| |.|. | |. || || . . || || | ..| ||| FAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPW |
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| Kinase | C09B9.4.AA | CK1-A | 29-289 | 28 | 2.8e-27 | 93.36 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 29-289 Range on HMM: 1-261/261 Sequence Identity: 28% (77 aa) YKMCDSIATGPFSSVFLV--EKDGIPYAMKVESQSKCLRPVLKLDHAVLRALGHQSGFPSLTSAGRTENFKYVVMQLVGPDLSMLLEFAPQQRFTSSTVY |.. | | | ..| ..| |.|.||. | | | . | | | |.| . |. .. .||.|.|| | | | . ||| || YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESN-KARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTVL KIALQTLDRLRVLHEAGWLNRDVKAQNFAVGLGEESSIVYMLDFGLTRKYLEHNGSRSLL-RPHGPSVGTFPYAPLASLGFCDQSPIDDIEGWLYMIVHL .| | . |. .|| ... ||.| || .|.| ....||||..|| ... . . | .|| || . .|| ||.| |... MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF LKGGLPW---HNSKRALNLPKVREWKMYCRRPGGKHYLFAGIPKGWADIFDVIVNTAPHETPDYNKI .| ||| . . |. | || | | | .. .. . | .|.||| . NRGKLPWQGMKAMTKKQKYEKISEKKMSTPI----EQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | C09B9.4.AA | CK1-D | 29-289 | 26 | 2.1e-26 | 90.08 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 29-289 Range on HMM: 1-261/261 Sequence Identity: 26% (70 aa) YKMCDSIATGPFSSVFLVE--KDGIPYAMKVESQSKCLRPVLKLDHAVLRALGHQSGFPSLTSAGRTENFKYVVMQLVGPDLSMLLEFAPQQRFTSSTVY |.. | | | ... . . . |.|.|. | | |... . . . | |.. |. .. .||.|.|| | | . . .| || YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECI-KTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVL KIALQTLDRLRVLHEAGWLNRDVKAQNFAVGLGEESSIVYMLDFGLTRKYLEHNGSRSL-LRPHGPSVGTFPYAPLASLGFCDQSPIDDIEGWLYMIVHL .|.| . |. .| .. ||.| || .||| ..||..||||...| . . . . | . || || . .|| ||.| |... MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF LKGGLPWHNSKRALNLPK---VREWKMYCRRPGGKHYLFAGIPKGWADIFDVIVNTAPHETPDYNKI .| ||| | | | . | || . . | .| |. ... .. | . ||| . NRGSLPWQGLKAATKRQKYERICEKKMSTKI----DTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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| Kinase | C09B9.4.AA | CK1-Unique | 29-232 | 20 | 5.3e-22 | 73.09 | In-house | 1-232 (337) | Show / Hide |
Range on Protein: 29-232 Range on HMM: 1-232/337 Sequence Identity: 20% (49 aa) YKMCDSIATGPFSSVFLVEKDGIP--------YAMKVESQSKCLRP--VLKLDHAVLRALGHQS-------GFPSLTSAGRTENFKYVVMQLVGPDLSML .. | | . | | . . |.|| | |. .. |. .|. .. . |. . . . .. ||...|| . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTE-QHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEE- LEFAPQQ-RFTSS------TVYKIALQTLDRLRVLHEAGWLNRDVKAQNFAVGLGE--ESSIVYMLDFGLTRK--YLEHNGSRSLLRPHGPSVGTFPYAP . ... || . .. . ..|.|. ... |..| ..|. | |. . . ||||.| |. .. |.. || | |. .|.| CCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCP LASLGFCDQSPIDDIEGWLYMIVHLLKG--GLPW .. . ... || | |.||..||. . || | CSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSW |
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| Kinase | C09B9.4.AA | CK1 | 29-177 | 26 | 4.7e-18 | 58.9 | In-house | 1-160 (271) | Show / Hide |
Range on Protein: 29-177 Range on HMM: 1-160/271 Sequence Identity: 26% (44 aa) YKMCDSIATGPFSSVFLVEKDGI-----PYAMKVESQSKCLRPVLKLDHAVLRALGH------QSGFPSLTSAGRT--ENFKYVVMQLVGPDLSMLLEFA |. | .| | ..|.. ..|.|.|.. . | |. ... | . |.| . |. ... ..|| | ||.| |. | YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK-HPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC PQQRFTSSTVYKIALQTLDRLRVLHEAGWLNRDVKAQNFAVGL-GEESSIVYMLDFGLTRKYL ...|. || || | ..|. ..|. . . ||.| || .|. | .. .||. |||| .|. -NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYR |
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| Kinase | C09B9.4.AA | CK1-Unclassified | 29-182 | 26 | 1.3e-16 | 45.58 | In-house | 1-166 (244) | Show / Hide |
Range on Protein: 29-182 Range on HMM: 1-166/244 Sequence Identity: 26% (45 aa) YKMCDSIATGPFSSVFLVE--KDGIPYAMKVESQSKCLRPVLKLDHAVLRALGHQS-------GFPSLTSAGRT--ENFKYVVMQLVGPDLSMLLEFAPQ |. . | .| | .... ... .|.|.|. . | |. ....| . . |.| . |. ... ..|| | ||.| |. . . YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-N QRFTSSTVYKIALQTLDRLRVLHEAGWLNRDVKAQNFAVG-LGEESSIVYMLDFGLTRKYL--EHNGS ..|. || || | ..|. .||. . . || | || .| || .. .||. |||| .|. .|. RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGK |
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| Kinase | C09B9.4.AA | S_TKc | 29-316 | 13 | 7.4e-10 | -32.36 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 29-316
Range on HMM: 1-231/231
Sequence Identity: 13% (41 aa)
YKMCDSIATGPFSSVFLVEK--DGIPYAMKVESQSKCLRPVLKLDHAVLRALGHQSGFPSLTSAGRTENFKYVVMQLVGP---DLSMLLEFAPQQR----
|.. . | | |..|... . .| .|.|. . .. ..|. | | . .. .. |.|| ... || ... . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP
FTSSTVYKIALQTLDRLRVLHEAGWLNRDVKAQNFAVGLGEESSIVYMLDFGLTRKYLEHNGSRSLLRPHGPSVGTFPYAPLASLGFCDQSPIDDIEGWL
|. .. ... |... | .|. | . ||.| .| . . |||| |.. .|| | . | |.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------GYG
Y----------MIVHLLKGGLPWHNSKRALNLPKVREWKMYCRRPGGKHYLFAGIPKGWADIFDVIVNTAPHETPDYNKIANMVLSIARNELIDLTAPFD
. .. .| | |.. .. .. . . .|. . . | .. . .
KCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
----WQVNPVL
. | .
DEWDIKCHPWF
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| Kinase | C09B9.4.AA | TTBKL | 207-293 | 21 | 6.8e-08 | 22.81 | In-house | 204-288 (288) | Show / Hide |
Range on Protein: 207-293 Range on HMM: 204-288/288 Sequence Identity: 21% (19 aa) CDQSPIDDIEGWLYMIVHLLKGGLPWHNSK-RALNLPKVREWKMYCRRPGGKHYLF--AGIPKGWADIFDVIVNTAPHETPDYNKIANMV ..|.. ||. |.|||. |..| |||.|.. . .. . |. . ... ...|. .... . . ....||| .| . KEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKM----EIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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