Gene akt-2 (Nematode worm)

akt-2

Species: Nematode worm
Alias: F28H6.1a, CE18646, akt-2, F28H6.1, F28H6.1A, aSWK002
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 14151426-14155798, WormBase Genetic Map location: n/a,

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
akt-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
akt-2.AA Protein Genbank 528 None Fasta, JSON

Protein domain

Protein domains of akt-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH akt-2.AA PH 13-115 25 1.4e-19 73.26 Pfam 1-92 (92) Show / Hide 
Range on Protein: 13-115
Range on HMM: 1-92/92
Sequence Identity: 25% (26 aa)

IVIESWLHKKGEHIRNWRPRYFILFRDGTLLGFRSKPKEDQPLPEPLNNFMIRDAATVCLDKPRPNMFIVRCLQWTTVIERTFYADSADFRQMWIEAIQA
...| ||||||  ...|..|.|.||. ..|. ..... ..     ||..  .... .     .||..| .|. ..    . .|.|.|.. .. |..|||.
VIKEGWLHKKG-KRKSWKKRWFVLFN-NCLYYYKDDK-YRPKGSIPLSDCQVTKVPDN----KRPHCFQIRT-DR---RTYYFQAESEEEMNDWMQAIQS

VSS
...
ACR
PH akt-2.AA PH 13-117 23 6.5e-19 70.08 SMART 1-82 (82) Show / Hide 
Range on Protein: 13-117
Range on HMM: 1-82/82
Sequence Identity: 23% (25 aa)

IVIESWLHKKGEHIRNWRPRYFILFRDGTLLGFRSKPKEDQPLPEPLNNFMIRDAATVCLDKPRPNMFIVRCLQWTTVIERTFYADSADFRQMWIEAIQA
...| ||.||.    .|..|.|.||. ..|. ...|        .|   . ..|. ||   .    .| ... ..    . .|...|.. .|.|..|||.
VIKEGWLYKKS--K-RWKKRWFVLFN-DCLYYYKDK--------KPKGSIPLSDC-TVRE-P----CFEIHH-DR----TYYFQCESEEEMQEWMQAIQK

VSSHN
....|
AIHNN
Kinase akt-2.AA Akt 180-437 54 4e-194 626.05 In-house 1-264 (264) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-264/264
Sequence Identity: 54% (144 aa)

FDFLKVLGQGTFGKVILCREKSSDKLY-AIKIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEA
||||||||.|.||||.|...|...|.| |.|...|.. ... .|.||.||...|  | |||.. |.|||| | ...|||...||||||.||||...||| 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RTRFYGSEIILALGYLHHRNIVYRD-MKLENLLLDRDGHIKITDFGLCKEE-IKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWG-VGVVMYEMMCGR
|.|||..|||||...||..||.||| .|.||.|.|.||||..||||||||. ||..||| ||||||||||||..........||||| .|.|||||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

LPFSAKENGKLFELITTCDLKFP--NRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFF
.|| .. . ..|..| ....|||  ...|||. .|.||||.. | ||||.||.||.|. | ..|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase akt-2.AA AGC 180-437 33 1.2e-182 477.23 In-house 1-395 (395) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-395/395
Sequence Identity: 33% (133 aa)

FDFLKVLGQGTFGKVILCREK------SSDKLYAIKIIRKEM-VVDRS--EVAHTLTE------------NRVLYACV----------HPFLTL-LKYSF
|.||||.|.|.||||.|.|.|      ...|.||.|...|.  .|..   .|.||.||             ..|  |           |||..  |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QAQYH--ICFVME----FAN-----GG-ELFTHLQ---RCKTFSEARTRFYGSE-------IILALGYLHH-RNIVYRD-MKLENLLLDRDGHIKITDFG
| . |  ..||||    ..|     || |||.|||   ....|.| |.||| .|       |.||| |||  ..|..|| .|.||.|||.|||||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEEIKYG--------------------------------------------------DKTSTFCG--TPEYLAPEVIEDIDYDRSVDWWG--VGVVMY
|||| ...|                                                  |.|.||||  ||||.|||..    |....|||.  .|..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMCGRLPFSAKENG----------KLFELIT------TCDLKFP----------NRLSPEAVTLLSGLLERVPAKRLGAGPDD-----AREVSRAEFF
||..|. ||......          ..|..|       ....|||            .||||. |...||.. |.||||.|..|     | |. . ..|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase akt-2.AA SGK 180-437 44 1.9e-133 414.67 In-house 1-283 (283) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-283/283
Sequence Identity: 44% (126 aa)

FDFLKVLGQGTFGKVILCREKSS------------------DKLYAIKIIRKEMVV-------DRSEVAHTLTEN-RVLYACVHPFLTLLKYSFQAQYHI
||||||.|.| |||| . . |.                   ||.||.|...|. ..        . |. |...|   .|    |||.  |.|.|| .   
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMEFANGGELFTHLQRCKTFSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDI
 |||...||||.| |||| | |.| | ||| .||..||.|||  .|.||| | ||.||| .||...||||||||.||  |.|.|||||||||||||.   
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

DYDRSVDWWGVGVVMYEMMCGRLPFSAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFF
 .||.||||  | |.|||| |  ||  .    ... |   .|..|   |..|  |. |||.. | ||||.  .|..|. .  ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase akt-2.AA PKC 180-437 48 1.5e-131 428.72 In-house 1-262 (262) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-262/262
Sequence Identity: 48% (127 aa)

FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLY-ACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEA
|.|||||| | ||||.| . | .|..||||...|.....   |  |.|| |||  |  ||||| |  .|| . .. ||||. ||| |  | |... |.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRLPF
..|||. |||.|| .|| ..|.||| ||.| |||..|||||.|||.|||.. .||.||||||||.|.|||...  .|  |||||  || |||||.|. ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

SAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGPDD---AREVSRAEFF
...    ||. |.. .  .|  || ||| ...|.... |.||||..|..   .... .  ||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase akt-2.AA RSK 183-437 42 8e-113 381.13 In-house 1-278 (278) Show / Hide 
Range on Protein: 183-437
Range on HMM: 1-278/278
Sequence Identity: 42% (117 aa)

LKVLGQGTFGKVILCREK---SSDKLYAIKIIRKEMVVDRSE-VAHTLTENRVLYACV-HPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKT---
||||||| .||| |||..    ....|| |...| ..| |   ..||.|| ..| .|  |||.  |.|.|| . ..  .||. .|||||||||. |.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDR---DGHIKITDFGLCKE-EIKYGDKTSTFCGTPEYLAPEVIE----DIDYDRSVDWWGVGV
||| . .|| .||.||. .|| . |..|| |.|| |.|    .||||.||||.||.  .... .| |||.| ||.|||..     .  .|...|||  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VMYEMMCGRLPFSA---KENGKLFELITTCD--LKFP--NRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFF
.||||  |..|| .   .   .... | ...  |..|  . ||.||  |....|.| |.||||.||.|| |. . ..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase akt-2.AA AktR 180-430 44 2.4e-108 366.23 In-house 1-264 (268) Show / Hide 
Range on Protein: 180-430
Range on HMM: 1-264/268
Sequence Identity: 44% (117 aa)

FDFLKVLGQGTFGKVILCREK-SSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACV-HPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSE
|...|.||.|.||||.|...|  ..|.||.|.|.|.  ..|    ||.||  .. .|. |||.  |.|.|| .... |.||.  |||||.||...|.|||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ARTRFYGSEIILALGYLHHR-NIVYRDMKLENLLLDRDGHIKITDFGLCK-EEIK-YGDKTSTFCGTPEYLAPEVIED-IDYDRSVDWWGVGVVMYEMMC
 ..||| ..|.||| ||| . ||.|||.| ||.||| |||.||||||| | . .. | .|. .|||||||.|||.|     ...||||| .|.. |||. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRLPFSAKENGKLFELITTCD-LKFPNR--LSPEAVTLLS-GLLERVPAKRLG---AGPDDARE
|  || .| .  .|..| ... .|||    .|...  |.  .|| . | ||||   .|... ..
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKS
Kinase akt-2.AA Eta 180-437 46 2.4e-106 359.62 In-house 1-261 (261) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-261/261
Sequence Identity: 46% (122 aa)

FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVL-YACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEA
|.|.||||.| ||||.| . |  | .||||...|....   .|  |.|| |.|  |  ||||| |  .|| .  . ||||. |||.|  ..|| . | |.
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRLPF
|.|||  |...|| .||.....|||.||.|.|||..|| |. |||.||| |  |  |.||||||.|.|||......|  ||||| .||.|||||||. ||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

SAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGP--DDAREVSRAEFF
 |     ||| |   |  .|  |. ||| .| . . . | ||||.    .. ... .  ||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase akt-2.AA PKN 180-437 47 7e-105 354.73 In-house 1-260 (260) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-260/260
Sequence Identity: 47% (125 aa)

FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACV---HPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFS
| .. ||| | ||||.| . |.....||||...|. .| | ||   ..| |.. .     ||||  |   || . |.|||||.| ||.|  |.     ||
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

EARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRL
|.|..||   ..| | |||...|.|||.||.|||||..|..|| ||||||| . |||.|||||||||.|||||. |  | | |||||.||..|||. |  
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFSAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFF
||.  .   .|. |   | ..|  || ||. ..  || ..| .|||||  || ..   .||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase akt-2.AA PKA 180-437 38 2.5e-103 349.57 In-house 1-263 (263) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-263/263
Sequence Identity: 38% (103 aa)

FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTL-LKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEA
|.....||.|.||.| |||.|.| . ||.|...|. .|..  | |...|...| .. |||.   ....||   .. .|||...|||.|..|.. . ||. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RTRFYGS-EIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDI-DYDRSVDWWGVGVVMYEMMCGRL
 ..||   .|.||| |||. ||.||| | ||.|.|..|||||||||  | ...    |.| ||||||||||.|     . .|||||  |.. |||. |  
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK-KVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFSAK--ENGKLFELITTCDLKFPNRLSPEA---VTLLSGLLERVPAKRLGAGPDDAREVSRAEFF
||...  .  ...| |  ...|||. ... |     |.. ||.. . ||.|   .... . . ..|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase akt-2.AA Delta 180-437 48 7e-103 348.1 In-house 1-259 (259) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-259/259
Sequence Identity: 48% (125 aa)

FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLY-ACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEA
| |.||||.| ||||.|   |  .| |||| ..|..|.   .|  |. | |||  |  ||||. |  .||.. |. ||||. |||.|  |.| |. |.|.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRLPF
|.|||..|||..| .||...|.|||.||.|.|||.|||||| |||.|||..    |.|||||||.|.|||.|.   | .|||||  ||.||||. |  ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

SAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFF
. ..  .||. |      .|  .. ||  .|..|.|| | ||||     . .. .  ||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase akt-2.AA S_TKc 180-437 34 3.9e-98 333.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTLLKYSFQAQYHICFVMEFANG--GELFTHLQRCKT---
...|...|.|.|||| .||.|......|||||.           |.. | ..|    ||..  |...||   |...|||...|  |.||........   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDR-SVDWWGVGVVMYE
   |.| ..|||  .|..|| |.| ..|..|| | ||.|||.  ||||.||||...        .||||||.|.||||.    |.. ..||| .|...||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MMCGRLPFSAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGPDDA--REVSRAEFF
|.||. ||.  .  ..|..|           ||||  .....|.. |.||..|    .  ...   ..|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase akt-2.AA Pkinase 180-437 30 1.3e-88 305.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTL-TENRVLYACVHPFLTLLKYSFQAQYHICFVMEFANGG----ELFTHLQ--RC
. .....|.|.||.| .|..|.. |..|.|||.|.   .  ...|.. .| ...  . ||.   |...|.   ||..|||...||    .||....  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KTF--SEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHI----KITDFGLCKE--EIKYGDKTSTFCGTPEYLAPEVIE-DIDYDRSVDWWG
..|  ||   .||  .|. .| |.| ..|..||.|.||.|.|..|||    ||.||||.|   . ...  ..||||||.|.|||||  . .|...||.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVVMYEMMCGRLPFSAK------ENGKLFELITTCDLKFPNRLS---------------------PEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEF
.|...|||.|||.||. .      .  .....|  ..|.|.   .                     .|.  .....|.. |.||..     |...   ..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase akt-2.AA TyrKc 180-437 19 5.8e-13 -13.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 180-437
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYAC--VHPF-LTLLKYSFQAQ------YHICFVMEFANGGELFTHLQ
  ..|.|| | ||.| ... |      |.| ....       ..  . | |..      ||  . |. .  | .        .. |||.. .| |  .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RCKT-FSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKY-------GDKTSTF--CGTP----EYLAPEVIEDIDYD
...  .. .    .   |     |||..|.. ||    | |.......||.||||...   .         ....   .|        .|||.| .  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RSVDWWGVGVVMYEMM-CGRLPFSA-----KENGKLFELITTC-DLKFPNR--------LSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFF
   | |  ||.|.|..  |  | .      ..|  ..|.. .   .. |           ..|  .. .   .. |..|        .|.   |.|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase akt-2.AA S_TK_X 438-491 30 3e-12 47.96 SMART 1-79 (79) Show / Hide 
Range on Protein: 438-491
Range on HMM: 1-79/79
Sequence Identity: 30% (24 aa)

KDVDWEATLR--KEVEPPFKPNVM----SETDTSFFDREFTSMPVQLTPPRR-------------------GEELPTVD
...||.. ..  ||.||||||..     |.|||| || |||.... |||. .                    ...  | 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase akt-2.AA Pkinase_C 457-503 36 8.9e-11 41.2 Pfam 1-40 (46) Show / Hide 
Range on Protein: 457-503
Range on HMM: 1-40/46
Sequence Identity: 36% (17 aa)

NVMSETDTSFFDREFTSMPVQLTPPRRGEELPTVDEEEELQANFIQF
.| |.|||| || |||..|...||       ..    .. |..|..|
QVKSPTDTSNFDPEFTDEPPMDTP------PDWR-MSSGDQEPFRGF
Kinase akt-2.AA Pkinase_Tyr 252-390 24 1.7e-05 19.25 Pfam 81-228 (270) Show / Hide 
Range on Protein: 252-390
Range on HMM: 81-228/270
Sequence Identity: 24% (37 aa)

HICFVMEFANGGELFTHLQRC----KTFSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIK---Y-GDKTSTFCGTPE
.|. |||.. .| | ..|..     . ..  .   .  .|  .. ||. .|.. ||    | |.......||.||||..   .   |   ....      
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIK

YLAPEVIEDIDYDRSVDWWGVGVVMYEMMC-GRLP-FSAKENGKLFELI
 .|||.| .  .    | |  ||.|.|..  |. | .    |  ..|.|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase akt-2.AA Pkinase_Tyr 180-214 33 0.002477 11.91 Pfam 1-38 (270) Show / Hide 
Range on Protein: 180-214
Range on HMM: 1-38/270
Sequence Identity: 33% (13 aa)

FDFLKVLGQGTFGKVILCREK----SSDKLYAIKIIRKE
  |.|.||.| ||.| ... |    . .   |.|.. ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE