Gene ULK2 (Mouse)

ULK2

Species: Mouse
Alias: ULK2, Ulk2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
ULK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
ULK2.AA Protein Sugen 1037 None Fasta, JSON
ULK2.NA RNA Sugen 5813 None Fasta, JSON

Protein domain

Protein domains of ULK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ULK2.AA ULK 9-271 33 1.6e-123 416.64 In-house 1-324 (324) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-324/324
Sequence Identity: 33% (109 aa)

YCKRDLVGHGAFA-VVFRGR-HRQKT-DWEVAIKSINKKNLSKSQI---------LLGKEIKILKELQ---HEN--IVALYDVQELP--NSVFLVMEYCN
||...  |.|.|. .|..|| ....| .  ||.| |.||...|..          || .||.|.|.|    |.|  || |||..| .  | ....|||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLADYLQAKGTLSEDT----------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK----SNVSGIRIKIADFGFARYLHSNTMAATLC
|||| .|.. ...|.| |          .. |..||..... ||...|||||.||||||..  .  .    ...  ...||||||||. . .|.|....|
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMC

----------GSPMYMAPEVIMSQ-----HYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLR-------------MFYEKNRSLMPSIPR---ETSPYL
          |.|.||||.....|     .||.|.|.||.|...|..| ||.||... ..|.              ..|.||. . . .|.     || .
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

ANLLLGLLQRNQKDRMDFEAFFSHPFL
 .|. ..||...|||...| .|.||..
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase ULK2.AA ULK 9-271 32 4.1e-119 402.03 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-329/329
Sequence Identity: 32% (108 aa)

YCKRDLVGHGAFAVVFRGR-HRQK--TDWEVAIKSINKKNLSKSQIL---------LGKEIKILKEL--------QHENIVALYDVQELP--NSVFLVME
||...  |.|.|..|..|| ...|  ..  ||.| | |. ..... .         | .||||.|.|        .|.||| |||..| .  | ....||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGGDLADYLQAKGTLSEDT----------IRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK----SNVSGIRIKIADFGFARYLHSN----
||||||| .|.. ...|.|||          .. |..||..... ||...|||||.||||||..  .  .    ...  ...||||||||. . ..    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ

--TMAAT----LCGSPMYMAPEVIMSQ-----HYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLR-MFYEKNRSL-------MPSIPRE---------T
  .|...    |||.|.||||.....|     .||.|.|.||.|...|..|.|||||.|. ..|.  ....|.. .       . ..| .          
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SPYLANLLLGLLQRNQKDRMDFEAFFSHPFL
|| . .|. ..||...|||...| .|.||..
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase ULK2.AA S_TKc 9-271 35 6.8e-96 325.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-231/231
Sequence Identity: 35% (99 aa)

YCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNG--GDLADYLQAKGT----
| . ...|.|||..|...||.  |. .|||| |.        . . .||.|||. .|.||| |||| .  .....|||||.|  ||| ||.. .|.    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYLHSNTMAATLCGSPMYMAPEVIMSQHYDA-KADLWS
  ..| ..| ...||. |.  .||.|||||||||.||||.            .|||.|||.|| |       |.||.| ||||||.   .|.  |.| ||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

IGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFS-------HPFL
.| ..| .|.|.|||.     .. | ..| .          || . ... ..||.. ..|.     .        ||..
CGCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ULK2.AA CAMK 14-271 23 7.4e-85 273.26 In-house 1-425 (425) Show / Hide 
Range on Protein: 14-271
Range on HMM: 1-425/425
Sequence Identity: 23% (102 aa)

LVGHGAFAVVFRGRHRQKTD-----------WEVAIKSINKKNLSK---------------------------SQILLGKEIKILKELQ-------HENI
  |.|.|..|....|.. |             .|||| |.|| |..                           ..  . .||.|.| ||       |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VALYDVQELPNS-------------------VFLVM---EYCNGG----DLADYLQAK---------------GTLSEDTIRVFLHQIAAAMRILHSKGI
. ||.| | |.                    ...||   ||| ||    || ||....               | ..|.  | . .||. |.. .||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPQNILLSYANRRKSNVSGIR-----------IKIADFGFARYLHS------------------------NTMAATLCGSPMYMA-PEVIMS---
.|||||| ||||.. |. ... .  .           |||.|||||... .                        . .  | ||.| ||| |||. .   
VHRDLKPENILLDDNNDDSDP-V--EHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQ----------DLRMFYEKNRSLMPS-IPRETSP-----------------------Y
           . |. |.| ||.| . | .|.|.|||.. . .          ...  .|| ..   . .| . ||                        
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

LANLLLGLLQRNQKDRMDFEAFFSHPFL
  .|. ..||.. ..||  |   .||..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase ULK2.AA AGC 11-271 21 1e-83 215.53 In-house 1-395 (395) Show / Hide 
Range on Protein: 11-271
Range on HMM: 1-395/395
Sequence Identity: 21% (87 aa)

KRDL--VGHGAFAVVFRGRHRQ-----KTDWEVAIKSINKKN---------LSKSQIL--------LGKEIKILKELQ----------HENIVA-LYDVQ
 . |  .| |.|  |.  |..       |.   |.| ..||          . . ..         . .| .||....          | .||  |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ELPNS--VFLVMEYCN---------GG-DLADYLQ---AKGTLSEDTIRVFLHQ-------IAAAMRILHS-KGIIHRD-LKPQNILLSYANRRKSNVSG
. ..   ...||||..         || .|  .||    .|...|...| .. .       |. |.  ||| .|||||| ||| ||||            
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---------

IRIKIADFGFARYLHSN---------------------------------------------------TMAATLCG--SPMYMAPEVIMSQHYDAKADLW
  ||..|||..  . ..                                                    .. |.||  .| |||||..    |.  .| |
GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWW

S--IGTVIYQCLVGKPPFQANSPQ-------DLRMFYEKNR------SLMPSIP----------RETSPYLANLLLGLLQRNQKDRMD----------FE
|   | ..|. |.|.|||....||       .    ..| .      .  . .|          |. || . .|. .||... ..|            .|
SFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAE

AFFSHPFL
   .||. 
EIKNHPWF
Kinase ULK2.AA CAMKL 9-271 31 2.1e-83 266.02 In-house 1-297 (297) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-297/297
Sequence Identity: 31% (95 aa)

YCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK--------------EIKILKELQ---HENIVALYDVQELPNS------VFLVM
|   .  |.|.|..|  ..|.. |  .|||| |.|| ... .. . .              ||.|.| |.   |.||. ||.| | |.       ..|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCNGGD--LADYLQAK----GTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYLHS-----NTMAATL
||| ||.  | ||....    | ..|.  | .  || .|.  .||.||.|||.|| ||||.. ...        |||.||||. .        . .  | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-------NIKIIDFGFSNMYRPCIFGPGQKLKTF

CGSPMYMAPEVIMS--QHYD-AKADLWSIGTVIYQCLVGKPPFQANSPQ-----DLRMFYEKNRSLMPSIPRETSP-YLANLLLGLLQRNQKDRMDFEAF
|||| |||||.. .  ..||  |.| ||.| . |  ..|. || . . .     .   .|.|....   .|   ..  . .|. ..||.| ..|.  .  
CGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQI

FSHPFL
 .||..
MNHPWM
Kinase ULK2.AA Pkinase 9-271 30 4.5e-83 287.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

YCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ----ILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGG----DLADYLQ--
|..   .| |.|..|....|.   . .||.| |.|.. ....    ..|  ||.|.|.|.|.||| |||. | .... .|||||.||    ||.||..  
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

AKGTL--SEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARY--LHSNTMAATLCGSPMYMAPEVIM-SQHYDA
..|..  ||.... .. ||. ..  .||.|||||||||.|||..  .  ..     ..||.|||.|.   . .|. . |.||.| |||||||. .|.|. 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KADLWSIGTVIYQCLVGKPPFQAN----SPQDLRMFYEKNRSLMPSIPRETS---------------------PYLANLLLGLLQRNQKDRMDFEAFFSH
|.| ||.| ..|. | |.|||.      .  | .  ......  .. .....                     . .  .. ..|... |.|  .|  . |
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFL
|..
PWF
Kinase ULK2.AA Ciliate-E2 9-271 23 1.3e-76 260.86 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

YCKRDLVGHGAFAVVFRGRHRQKTDWE-----------------VAIKSINKKNLSKSQ-ILLGKEIKILKELQ----------------HENIVALYDV
| .  . | |.|..|........   .                 |.|| ...|...|.| . . .||.|..|..                | ||. .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

QE--LPNSVFLVMEYCNGGDLADYLQ------------AKGTLSEDTIRVFLHQIAA---------------AMRILHSKG-IIHRDLKPQNILLSYANR
 .    |...||||||.|||| ||..            . . ..|  |. .  ||.                |.. ||||. |||||.||.|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

RKSNVSGIRIKIADFGFARYLHSN--------------------------------TMAATLCGSPMYMAPEVIMSQH---------YDAKADLWSIGTV
         |||.|||...... .                                 |. |.||.|.|||||.....          || |.|.||.| .
---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

IYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRE------------------TSPYLANLLLG----LLQRNQKDRMD-FEAFFSHPFL
.|..| |||||           ....     ..| .                   |.   .|.      .||.... |.. .|  . ||..
LYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase ULK2.AA Ciliate-E2-Unclassified 9-271 24 4.2e-68 232.56 In-house 1-352 (352) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

YCKRDLVGHGAFAVVFRGRHRQKTDWEV-----AIKSINKKNLSKSQ----ILLGKEIK----------------ILKELQHENIVALYDVQELPNSVFL
| .    |.|.|..|.. .|. |.. ..     ..|....| ... .    ..  ||..                ||. ..|..|| .... .  . ...
YKIIKQIGQGGFGKVYKCQHK-KQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYCNGGDLADYLQAKGT-----------------LSEDTIR-----VFLHQIAAAMRILHSKG-IIHRDLKPQNILLSYANRRKSNVSGIRIKIADFG
|||||.|||| .|.. ...                 ..|  ..      .. ||  .   ||.|. |||||.||.|||..  ..        .|||.|||
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK------NYYIKIIDFG

FARYLHSN----------------TMAATLCGSPMYM----APEVIMSQHYD----AKADLWSIGTVIYQCLVGKPPFQANSPQD---------------
..... .|                 |. | ||.|.||    ||||...|.||     |.| || | ..|..| |..||..|.  .               
ISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRK

-LRMFYEKNRSLMPS-----IPRETSPYLANLLL----GLLQRNQKDRMDFEAFFSHPFL
 |.    ..    |.     ||   ||  ....      .|. |.. |..||  . ||..
QLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase ULK2.AA STE 9-271 22 3.2e-66 226.31 In-house 1-359 (359) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-359/359
Sequence Identity: 22% (84 aa)

YCKRDLVGHGAFAVVFRGRHRQKTDWE--------------VAIKSINKKNLS----------------KSQILLGKEIKILKELQ--HENIVALYDVQE
. . . .|.||| .|...... ... .              .||| .|..| .                . .  . |||||.|...  |.|||  |.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LP-------NSVFLVMEYCNGGDLADYLQAK--------------GTLSEDTIRVFLHQIAAA-MRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRI
         ......|||..|| | | .. |              ....|. |.....||  . .  |||..|||||.||.||||              .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------------V

KIADFGFARYLHSN-----------------TMAATLCGSPMYMAPEVIMS------QHYDAKADLWSIGTVIYQCLVGKPPFQA-NSPQDLRMFYEKNR
|..|||..  | ..                  .  |..|.| .||||||.       ..||.|.| ||.| .|   . ||||.   . .. . |.  ...
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

SLM------------PSIPRETS-------------------PYLANLLLGLLQRNQKDRMDFEAFFS--HPFL
. .            |..| ..|                   | . . .   ||.. ..| . .   .  |||.
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase ULK2.AA MARK 16-271 36 1.3e-65 213.51 In-house 8-262 (262) Show / Hide 
Range on Protein: 16-271
Range on HMM: 8-262/262
Sequence Identity: 36% (97 aa)

GHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSK-SQ-ILLGKEIKILKELQHENIVALYDVQE--LPNS-VFLVMEYCNGGDLADYLQAK--GTLSEDTI
|||..|.|  ..|. .|. .|||| ..|..|..  .   .  ||.|.| |.|.||. |..| |   ..  ..|.|||. ||.| ||..|.  | |.|.  
GHGSYAKVKLACHK-HTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEA

RVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYLHSNTMAATLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQC
|.. .||  |.  .|||.|.|||.||.|||.   ...        |||.||||..   ....  | ||.| |||||.. .. ||  |.| || | | |  
RRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNH-------NIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL
..|. || . . ||.   |.| .. ...||   |. . ||.  ||. | ..|.. |   .||..
VCGYFPFDGDT-QDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase ULK2.AA CAMK-Unique 9-229 26 2.8e-65 214.39 In-house 1-308 (363) Show / Hide 
Range on Protein: 9-229
Range on HMM: 1-308/363
Sequence Identity: 26% (83 aa)

YCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLS-KSQIL------------------LGKEIKILKELQHENIVALYDV----QELPN------
| .  ..|||.| .|... . ..|  . |.|...|.  . |.|..                  | .|. |.| . |.||. |||.     . ..      
YKMHRIIGHGNFGHVYEC-MDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------SVFLVMEYCNGGDLADYLQA--------------------KGTLSE---DTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRR--
           ..|||||.|||| |..|.                    .| .||   ||..... ... |   .||..|.|||||. ||...|      
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQ-CLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN

-----KSNVSGIRIKIADFGFARYLHSNTMAA---TLCGSPMYMAP--------------EVIMSQHYDAKA----DLWSIGTVIYQCLVGKPPFQANSP
     ... |  .||..||| ......| | .   | ||.|.||||              |||. | || .     |.||.| . |  |.|.||| ... 
HHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECE

QDLRMFYEKN
 ...   .|.
DRDYENHDKE
Kinase ULK2.AA Pkinase_Tyr 9-205 31 2.4e-35 120.32 Pfam 1-205 (270) Show / Hide 
Range on Protein: 9-205
Range on HMM: 1-205/270
Sequence Identity: 31% (68 aa)

YCKRDLVGHGAFAVVFRGRHR---QKTDWEVAIKSINKKNLSKSQ---ILLGKEIKILKEL-QHENIVALYDVQE-LPNS--VFLVMEYCNGGDLADYLQ
  .    |.||| .|..|. .   ..|. .||.|.. | . ...|     . .|.||.|.| .|.||| || |      .  ...||||. .||| |||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

A----KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYL--HSNT-MAATLCGSPM-YMAPEVIMSQH
.    |. |.  ..  . .|||..|  |.||..|||||   |.|..         ..  .||.||| ||..   ..   ... .  |   ||||.|.   
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT---------ENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

YDAKADLWSIGTVIY
.  | | || | ...
FTTKSDVWSFGVLMW
Kinase ULK2.AA TyrKc 9-271 23 7.9e-25 89.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

YCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKEL--QHENIVALYDVQELP-------NSVFLVMEYCNGGDLADYLQA
  . .  |.||| .|..|. .     .||.|....      .  . .|..|...|  .|.|||.|| |   .         ...||||. .||| |||..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KGT-LSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYLHSN--------TMAATLCGSPM------YMAPE
..  |. ..   | .|||. |. ||||..|||||   |.|..  .         ..||.||| .|....         .  ..  ..         ||||
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VIMSQHYDAKADLWSIGTVIY-QCLVGKPPFQA-----NSPQDLRMFYEKNRSLMPSIPRE------TSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL
.|.   .  | | || | ...  .  |..|         |.|... . .. . ...    .       .. . .. .   ... .||  |..   | ..
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
DUF3543 ULK2.AA DUF3543 817-1035 25 4.9e-84 290.28 Pfam 1-275 (275) Show / Hide 
Range on Protein: 817-1035
Range on HMM: 1-275/275
Sequence Identity: 25% (71 aa)

ETLMEREHTDTLRHLNMMLMFTECVLDLTAVRGGNPELCTSAVSLYQIQESVV----------VDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQ
.|.|..|||.|...|....... ||... .|.. . . ....|| |......|           ........ |.. |.||||.|| .|||.|...|.|.
QTSMDDEHTRTVQKLEECATRSDCVYGFAEVKYKQLIPLMPSVSTYGLGDANVQGRDDSMHQDDGLTPDAIVTWKSEEALVLYVKALSLLAKSMDIASAW

VKS--------------GKLSP-SMAVKQVVKNLNERYKFCITMCKKLTEKL---NRFFSDKQRFIDE-----------------INSVTAEKLIYNCAV
...              ..|.| |....|||. ..||.. |...|... .||   ......... ...                 .. ||||||.|..|.
WYRKNRGEDFNMTRDSSNQLCPTSNRINQVVQWIRERFNECLEKCEFVRLKLQEAQKRLPEDHPSHPKNHSNESSSSGSSNDVVVSSGVTAEKLMYDRAL

EMVQSAALDEMFQ-QTEDIVYRYHKAALLLEGLSKIL----------QDPTDVENVHKYKCSIERRLSALCCSTA
||...||..|.|. .... ...||.|. .||.|               |. | ..|.||..||..|||.|..  .
EMSRTAAINELFGEDLPGCEIAYHTAIWMLEALLENDEDEDKDENDGLDDEDKQMVEKYIVSIRKRLSVLRKKMY