Gene PKR (Mouse)

PKR

Species: Mouse
Alias: PKR, Prkr
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PKR

Sequence

Name Sequence Type Origin Length Description Download
PKR.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
PKR.AA Protein Sugen 515 None Fasta, JSON
PKR.NA RNA Sugen 4312 None Fasta, JSON

Protein domain

Protein domains of PKR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Dsrm PKR.AA dsrm 9-74 29 1.8e-18 69.92 Pfam 1-67 (67) Show / Hide 
Range on Protein: 9-74
Range on HMM: 1-67/67
Sequence Identity: 29% (20 aa)

YMDKLNK-YRQMHGVAITYKELSTSGPPHD-RRFTFQVLIDEKEFPEAKGRSKQEARNAAAKLAVDIL
.. .|.  | | .|  . |..... ||||. ..|| .. ...|.. ...|..|.||...||..|...|
PKSQLQEYYCQKNGWKPPYYYIEQ-GPPHHCPTFTCTCTVNGKKYGTGWGSNKKEAKQQAAMKALQKL
Dsrm PKR.AA dsrm 96-160 36 1.7e-14 55.54 Pfam 1-67 (67) Show / Hide 
Range on Protein: 96-160
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

YIGLVNS-FAQKKKLSVNYE---QCEPNSELPQRFICKCKIGQTMYGTGSGVTKQEAKQLAAKEAYQKL
.... .  ..||... ..|.   | .|  . | .|.| |... . ||||.| .|.||||.||..|.|||
PKSQLQEYYCQKNGWKPPYYYIEQ-GPPHHCP-TFTCTCTVNGKKYGTGWGSNKKEAKQQAAMKALQKL
Kinase PKR.AA PKR 242-500 83 5.4e-213 713.88 In-house 1-272 (272) Show / Hide 
Range on Protein: 242-500
Range on HMM: 1-272/272
Sequence Identity: 83% (226 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEHEVQALAELNHVNIVQYHSCWEGVDYDPEHS-------------MSDTSRYKTRCLFIQM
|.||||||.||||||||||||||||||.|||||||.|||||||||||.|.|||||.|||||.|.|||||||             |.||||||||||||||
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNNEKAEHEVQALAKLDHVNIVHYHSCWDGFDYDPEHSDDSLESSDYDPENMKDTSRYKTRCLFIQM

EFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLFLKHY
|||||||||||||||.|.||||.||||||||||.||.|||||.||||||||.|||||||||||||||||.|||.|||||||||.||||||||||.|..||
EFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVTALKNDGKSRTRRKGTLQYMSPEQIFSQHY

GKEVDIFALGLILAELLHTCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLKKLLSEKPKDRPETSEILKTL
||||||.|||||||||||.||||.|||||||.||.|||||||||||||.||.||||.||||||.|||||.||
GKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDNKEKTLLQKLLSKKPKDRPNTSEILRTL
Kinase PKR.AA PEK 310-502 25 2.7e-87 296.34 In-house 331-655 (655) Show / Hide 
Range on Protein: 310-502
Range on HMM: 331-655/655
Sequence Identity: 25% (84 aa)

EHSMSDTSRYKT-------------RCLFIQMEFCDKGTLEQWMRNR------------------------------------------NQSKVDKALIL
| ....|...|.             ..|.||||.|.|.||..|..|.                                          |....|| ...
EEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCW

DLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERH-----IKIGDFGLATALE--------------------NDGKSRTRRT-----------------
.. .||..|..||||.|.|||||||.|||| .. .     .||||||||| .|                    .........|                 
RIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNN

--------------------GTLQYMSPEQLFLK-----HYGKEVDIFALGLILAELLHTCFTES-EKIKFFESLRK------GDFSNDIFDNK---EKS
                    ||. |||||||  .     ||.. ||...||.|..|.... ||.. |..|.. .||.      |||....||||   ...
YHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQAD

LLKKLLSEKPKDRPETSEILKTLAE
.....|| .|..||....||...  
FIQWMLSHDPQQRPSAQQILQHEFF
Kinase PKR.AA S_TKc 242-501 30 9.7e-66 225.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 242-501
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEHEVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDK--GTLEQW
.| ...|| |.||.|.|..|. .|...|||..|   |... |.| | . .| |||... ...                   .|.. ||.||   |.| . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-----------------DHLYMVMEYCDGDLGDLFDY

MRNRNQ----SKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLFLKHYGK-EVDI
...|.     .. .   .  .  ||. ..||.||.| ||||||| ||.| .  ||||.|||||. |       |   ||. ||.|| |   .||| ..|.
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDW

FALGLILAELLH--TCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLKKLLSEKPKDRPETSEILK--------TLA
 ..| ||.|.|   . |   .  . |. ..         .   |....|.|   |..||   |.|.           
WSCGCILYEMLCGYPPFP--QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKR.AA Pkinase 242-500 26 1.4e-61 215.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 242-500
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEH--------EVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDK
.. .. || |.||.|.|..|. .||..|.|..|. .|| .         |.| ...||| |||... ..|                |...  . ||.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------------KDHIY-MVMEYCEG

G----TLEQWMRNRNQSKV--DKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHI----KIGDFGLATAL-ENDGKSRTRRTGTLQYMSPEQ
|     |  ... ... ..  .   . .   ||. |.||.||.| ||||||| ||..... ||    ||.|||||  . .  .   | ..||. ||.|| 
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

LF-LKHYGKEVDIFALGLILAELLH--TCFTES------EKIKFFESLRKGDFSNDIF----------------------DNKEKSLLKKLLSEKPKDRP
.   ..||..||....|.||.|.|   . | ..      .... ..  ...... |..                      .   |...|..|  .||.||
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

ETSEILKT--L
   .||.   .
TAEQILQHPWF
Kinase PKR.AA CAMK 247-498 17 2.5e-47 150.14 In-house 1-421 (425) Show / Hide 
Range on Protein: 247-498
Range on HMM: 1-421/425
Sequence Identity: 17% (73 aa)

EIGLGGFGQVFKAKHRIDG------------KRYAIKRVKY--------------------------------NTEKAEHEVQALAE-------LNHVNI
..| |.||.|....|. ..            ...||| ..                                 . .. ..|.. .         |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYHSCWEGVDYDPEHSMSD--TSRY----KTRCLFIQM---EFCDKGTLEQWMRNRNQSK-----------------VDKALILDLYEQIVTGVEYIHS
.. .  .|  .| .   ..|  | ..    |...... |   |.|. | | . . .. ...                 .. .    .  ||. .|.|.||
IKLYEVYEDPHYFK-N-TNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

KGLIHRDLKPGNIFLVDE-----------------RHIKIGDFGLATALEN-----------------------DGKSRTRRTGTLQYMS-PEQLF----
.. .|||||| || |.|                    ||| |||.|. ..                        .|.  . . ||. ||. || |     
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------LKHYGKEVDIFALGLILAELLHTCFTESEK---------------IKFFESLRKGDFSNDIFDNKE------------------------
           . ||...|. ..| ||  .|  ..   ..                . ||  .||... . .  ..                        
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

-KSLLKKLLSEKPKDRPETSEILK
 |.|..|.|   |..|.  ...|.
CKDLIRKMLQVDPEKRMTIEQCLN
Kinase PKR.AA STE 242-445 23 4.9e-44 152.61 In-house 1-262 (359) Show / Hide 
Range on Protein: 242-445
Range on HMM: 1-262/359
Sequence Identity: 23% (65 aa)

FEDIEEIGLGGFGQVFKAKHRI---------------DGKRYAIKRVKYNT------------------EKAE---HEVQALAELN--HVNIVQYHSCWE
.|.||.|| |.||.|.||...                 |...|||......                  |. .   .|.. . ..|  | |||.|. | .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GVDYDPEHSMSDTSRYKTR--CLFIQMEFCDKGTLEQWMR---NRNQ---------SKVDKALILDLYEQIVTG-VEYIHSKGLIHRDLKPGNIFLVDER
  . .           .     |.| ||..| |.|.. ..    ...         ....  .|     ||. |  .|.||.. ||||.||.||.|    
KEGHN-----------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----

HIKIGDFGLATALEND----------------GKSRTRRTGTLQYMSPEQLFL------KHYGKEVDIFALGLILAELL
 .|. |||... |...                .. |.  .||  .|.|| .        |.|.  .||  ||. . |..
-VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase PKR.AA TKL 248-500 19 2.2e-41 143.81 In-house 1-364 (364) Show / Hide 
Range on Protein: 248-500
Range on HMM: 1-364/364
Sequence Identity: 19% (76 aa)

IGLGGFGQVFKAKHRI--------DGKRYAIKRVKYNT-------------------------------EKAEHEVQALAELNHVNIVQYHS-CWEG---
|| ||||.|.|.|.|         .||  |.|. | .                                .. | |.  .  |.| ||||.   | ..   
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHS--------KGLIHRDLKPGNIFLVDERH------
 | ..|           .  |.| ||.|..|.|.  .           .....  .|  |..| ||        ...||||||. ||.. .  .      
CVCMHPV--------GPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYM

--------IKIGDFGLATALENDGK-------------------SRTRRTGTLQYMSPEQLFLK----------------HYGKEVDIFALGLILAELLH
        .||.||||.. ....|.                    . .. ||...|.|| |  .                 | . .|... |..| |.| 
YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT

TCFTESEKIKFFESLRKGDFSNDIFDNKEK----------------------------SLLKKLLSEKPKDRPETSEILKTL
 |  ...   . . ... . . ..|    .                            .|...  ...|..||  .||||.|
RCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase PKR.AA GCN2 320-502 27 8.7e-40 136.84 In-house 278-511 (511) Show / Hide 
Range on Protein: 320-502
Range on HMM: 278-511/511
Sequence Identity: 27% (67 aa)

KTRCLFIQMEFCDKGTLEQWMRNR--NQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATA-----------------
... |.||||.|...|| |   |   .. ..    .  .  ||. |. ||||.| ||||||| ||||  ....|||||||||                  
EVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQ

---------------LENDGKSRT-------------RRTGTLQYMSPEQLFLKHYGKEVDIFAL-GLILAELLHT-CFTESEKIKFFESLRKGDFSNDI
               ..|. .|..             ...||  ||.|||.  .||.. ||...| |.|. |...    |..|...    ||    |. .
ASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR----SCEF

---FD-------NKEKSLLKKLLSEKPKDRPETSEILKTLAE
   ||        .........|. .|. || ....|..   
PQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase PKR.AA PEK 324-399 42 1.7e-39 128.79 In-house 414-514 (758) Show / Hide 
Range on Protein: 324-399
Range on HMM: 414-514/758
Sequence Identity: 42% (43 aa)

LFIQMEFCDKGTLEQWMRNR-NQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDE-RH-----------------------IKIGDFGLA
..|||. | | ||..||||| . . ......|..  ||..||.||||||.|||||||.|||.. .  |                       ||||||||.
MYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLV

T
|
T
Kinase PKR.AA Ciliate-E2 323-498 22 1.7e-35 119.32 In-house 108-361 (365) Show / Hide 
Range on Protein: 323-498
Range on HMM: 108-361/365
Sequence Identity: 22% (59 aa)

CLFIQMEFCDKGTLEQWMRNRNQS---------KVDKALILDLYEQIVT---------------GVEYIHSKG-LIHRDLKPGNIFLVDERHIKIGDFGL
.... ||.|. |.|.....|....         . .   |... .||.                ..||.|||.  ||||.|| ||..     ||| ||||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGL

AT----------------ALENDGKSRTRRTG----------------TLQYMSPEQLFLKH---------YGKEVDIFALGLILAELLHTCF---TESE
..                 . . .  ..| .|                |. ||.|| |  |          |....||..|| || |.|   .    . .
SKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQIK

--KIKFFESLRKGDFSN-------DIFDNKEK--SLLKK----LLSEKPKDRPE-TSEILK
  ||.|..     | ..       . ..  ..   |.||    .|  .|. |.   ..||.
QCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase PKR.AA PEK 242-306 40 6.4e-31 104.41 In-house 1-87 (655) Show / Hide 
Range on Protein: 242-306
Range on HMM: 1-87/655
Sequence Identity: 40% (35 aa)

FEDIEEIGLGGF-GQVFKAKHRIDGKRYAIKRVKYNT---------------------EKAEHEVQALAELNHVNIVQYHSCWEGVD
||.|...| ||| |||.|.....||..|||||.|.|                      ||...||..|| ||| ||| ||..| ...
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKP
Kinase PKR.AA WEE 324-444 30 8.2e-29 93.82 In-house 80-229 (297) Show / Hide 
Range on Protein: 324-444
Range on HMM: 80-229/297
Sequence Identity: 30% (45 aa)

LFIQMEFCDKGT--LEQWM--RNRNQSKVDKALILDLYEQIVTGVEYIHSK-GLIHRDLKPGNIFLVDER--------------------HIKIGDFGLA
..||||.|..|   | .|     ... .   ..| ..  .|..|. .|||. |..| |.||.|||.  .                      .||||||..
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV

TALE-NDGKSRTRRTGTLQYMSPEQLF-LKHYGKE--VDIFALGLILAEL
| .. |. ..     |   ||.|| |   .||..    |||.||. . ||
TDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYEL
Kinase PKR.AA PEK 409-502 28 1.3e-26 84.91 In-house 646-758 (758) Show / Hide 
Range on Protein: 409-502
Range on HMM: 646-758/758
Sequence Identity: 28% (33 aa)

TRRTGTLQYMSPEQLFLK----------------HYGKEVDIFALGLILAELLHT-CFTESEKIKFFESLRKGDFSNDIFDN---KEKSLLKKLLSEKPK
| ..||. ||||||.  .                .|   |||..||||..||.|    |..|.|. . .||.|..   .|..   .|  ... ..|  | 
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPK-WFTQKYPQEYEFIQQMMSMNPD

DRPETSEILKTLAE
 ||....|.. .  
ERPTADQISMHDFF
Kinase PKR.AA NEK 323-423 33 2.8e-26 89.81 In-house 80-196 (286) Show / Hide 
Range on Protein: 323-423
Range on HMM: 80-196/286
Sequence Identity: 33% (39 aa)

CLFIQMEFCD-KGTLEQWMRN-RNQS----KVDKALILDLYEQIVTGVEYIHSK-----GLIHRDLKPGNIFLVDERH----IKIGDFGLATALENDG-K
||.| ||.|. .|.|.|  ..  .|       .   |.|   |.. .. |.|..       .|||.|| |||| ...     .||||||..  |...  .
CLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDM

SRTRRTGTLQYMSPEQL
 .|  .||  |||||..
AYTTQVGTPYYMSPEVC
Kinase PKR.AA PEK 242-303 38 2.5e-20 63.51 In-house 1-75 (758) Show / Hide 
Range on Protein: 242-303
Range on HMM: 1-75/758
Sequence Identity: 38% (29 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNT--------EKAEH-----EVQALAELNHVNIVQYHSCWE
|| |. .| |||| ||.||   |. .|||||.             .        || .|| |.| ||| |.. |.
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWL
Kinase PKR.AA WEE 242-303 40 2.6e-20 64.92 In-house 1-75 (297) Show / Hide 
Range on Protein: 242-303
Range on HMM: 1-75/297
Sequence Identity: 40% (30 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVK-----YN-TEKAEHEVQALAELN-------HVNIVQYHSCWE
|. .. || | ||.|.|...||||. ||||. |     |.  . | .||.|...|        | .||.|.| ||
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWE
Kinase PKR.AA NEK 242-299 34 1e-17 59.3 In-house 1-70 (286) Show / Hide 
Range on Protein: 242-299
Range on HMM: 1-70/286
Sequence Identity: 34% (24 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKR-----YAIKRVKYN------TEKAE-HEVQALAELNHVNIVQYH
.| |..|| | ||.|.|.....|||      |..|.....      ...|  .||. |..|.| ||| |.
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYY
Kinase PKR.AA TyrKc 242-500 21 3.1e-15 23.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 242-500
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAE--HEVQALAEL--NHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLE
 . ....| | ||.|.|.. .      |.| .| .. ...  .| . . .|  .| |||. . .           |..        |.| ||....| | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYI------EPLMIVMEYMPHGDLK

QWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALEND---------GKSRT---RRT-GTLQYMSPEQLF
.  |..    .  .  |.   ||  | ||.|||..|||||   |. . .....||.||||. ....|          ....   ..|   .  |.|| ..
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

LKHYGKEVDIFALGLILAELLHTCFTESEK--------IKFFESLRKG---DFSND--------IFDNKEKSLLKKLLSEKPKDRPETSEILKTL
 . .  . |... |  . |..  . .  .         .  .| ...|   .   .          |   . . |.   |.|.|||  ||| . .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase PKR.AA GCN2 242-302 37 1.2e-13 43.77 In-house 1-70 (511) Show / Hide 
Range on Protein: 242-302
Range on HMM: 1-70/511
Sequence Identity: 37% (26 aa)

FEDIEEIGLGGFGQVFK-AKHRIDGKRYAIKRVKYNTEKAEH--------EVQALAELNHVNIVQYHSCW
|| |...| |||||| | .. . ||. ||||. . |  . ..        ||  |. |.| ..|.|.  |
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAW
Kinase PKR.AA Ciliate-E2 242-303 22 8.5e-12 36.75 In-house 1-102 (365) Show / Hide 
Range on Protein: 242-303
Range on HMM: 1-102/365
Sequence Identity: 22% (23 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKR-----------------------YAIKRVKYN----TEKAEHEVQ-------------ALAELNHVNIVQYHSC
.. |. || |.||.|.|.|.. ..|.                       ||.|..| |    ... .|. .              | .||| ||.... |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WE
..
FQ
Kinase PKR.AA Pkinase_Tyr 328-413 34 1.1e-10 36.79 Pfam 86-174 (270) Show / Hide 
Range on Protein: 328-413
Range on HMM: 86-174/270
Sequence Identity: 34% (31 aa)

MEFCDKGTLEQWMRNR--NQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKS-RTRRTG
||.. .| |    |..  .. ...   .|.   ||  | || .||..|||||   |. . .....||.||||| ...||.   |.|  |
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGG
Kinase PKR.AA NEK 476-502 25 0.022918 4.61 In-house 260-286 (286) Show / Hide 
Range on Protein: 476-502
Range on HMM: 260-286/286
Sequence Identity: 25% (7 aa)

KSLLKKLLSEKPKDRPETSEILKTLAE
..|. ..|   |..|| ...||..   
QNLISQMLQKDPEQRPSCNQILEMPFI
Kinase PKR.AA Pkinase_Tyr 242-299 22 0.053887 7.38 Pfam 1-70 (270) Show / Hide 
Range on Protein: 242-299
Range on HMM: 1-70/270
Sequence Identity: 22% (16 aa)

FEDIEEIGLGGFGQVFKAKHR--IDGKRY--AIKRVKYNTEKAE-------HEVQALAEL-NHVNIVQYH
 . ....| | ||.|.|.. .   |....  |.| .| .. . .       .|.. . .| .| |||...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY