Gene PCTAIRE3 (Mouse)

PCTAIRE3

Species: Mouse
Alias: Pctk3, PCTAIRE3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PCTAIRE

Sequence

Name Sequence Type Origin Length Description Download
PCTAIRE3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 282 Kinase domain by global Sugen HMM Fasta, JSON
PCTAIRE3.NA RNA Sugen 3061 None Fasta, JSON
PCTAIRE3.AA Protein Sugen 451 None Fasta, JSON

Protein domain

Protein domains of PCTAIRE3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PCTAIRE3.AA PCTAIRE 121-402 79 5.70000000001e-243 813.46 In-house 1-291 (291) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-291/291
Sequence Identity: 79% (231 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNVK
|.|||||||||||||.|.|||||.||||||||||||||||||||||||||||||||||||||||.|||...|||||||.|.|||||.|.|||.|||||||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

IFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPG
.|.|||||||||||.||||||||||||||||||||||||||||||||||||||||.|||||||||||||.|||.|||.|||||||||.|||.||.|||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

ST------VKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLD---TEGINLLSSLLLYESKSRMSAEAALNHPYF
||      ||..||.|||.||||.|..||||.|..|||.||||||..|||..||||||   .....||..||.||||.|.|||.|..||||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase PCTAIRE3.AA PFTAIRE 121-402 60 3.2e-192 644.89 In-house 1-287 (287) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-287/287
Sequence Identity: 60% (173 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNVK
|.||.|||||.||||.||.|.... .||||||||. |||.|.|||||.||||.|||||||.||| |||.. ||.||||.. ||.||.| . . |...||.
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

IFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPG
 |.|||||||.|||.|..|||||||||||| . |||||||||||||||||..|||.||||||||||||||||||||| .||||||||. || .|.|.|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

S-TVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFP--RYLPQPLLSHAPRLD--TEGINLLSSLLLYESKSRMSAEAALNHPYF
  .. . | .||..||||||. ||||... ... . |.   | |..|    ||..   .. .|.. .| .| . |.||..|. ||||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase PCTAIRE3.AA CDK5 121-402 56 2.4e-183 584.69 In-house 1-287 (287) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-287/287
Sequence Identity: 56% (163 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNV
| |..|.|||||.||.|.| | |. .||||..||. | || |.|||||..||| ||| ||| ||| ||... ||||||..| ||| |.| |.  |.|| .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMA-TGKPLF
| ||.|||.|||.||....||||||||||||| .|||||||||||||  .| ..|| |||||||||||||.||  |||.|||| .|||. ||| .|.|||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSTVKEELHLIFRLLGTPTEESWPGVTSISEFR--AYNFPRYLPQP-LLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALNHPYF
||. |...| .||...|||.|..||..|  ....  . ..| | ... . .. |.|| .| .||. .| .. . |.||.|||.||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PCTAIRE3.AA CDK 121-402 48 1.3e-178 576.28 In-house 1-284 (284) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-284/284
Sequence Identity: 48% (156 aa)

YVKLDKLGEGTYATVFKGRSKLTE-----NLVALKEIRLEH-----E-EGAPCTAIREVSLLKDLKHANIVTLHDLIHTD-----------RSLTLVFEY
| ||.|.|||||..|.|.|.|.|      ..||||.||.|.     | || |.|||||.||||.| |.|||.||| .||.           ..|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGE-----LKLADFGLARAKSV------PTKTYSNEVVTLWYRPPD
.| |||.|.|          .| .|.||||||.|||...|.||||||||.|||..||     ||.||||||||...      |..||..||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLGSTEYS--TPIDMWGVGCILYEMAT---GKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSL
.||||..||  ||||||.||||..||.|   .||||||..  . |..|||..|||||..|||||.  ..                         .||...
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LLYESKSRMSAEAALNHPYF
| |. | |.|||.||.||||
LCYDPKKRISAEQALQHPYF
Kinase PCTAIRE3.AA CDC2 121-402 51 2.5e-158 490.61 In-house 1-301 (301) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-301/301
Sequence Identity: 51% (155 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGA---PCTAIREVSLLKDLK-HANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD-HCG--NL
| |. |.|||||  |.|.. . |  .|||| ||||.|.     | ||||| |.||.|| | |||.||| ||  ..| .|||||| |||.|.|   .    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYS--NEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEM
|  ..|| .|.|.|.|...||.|.|.||||||||.||.. |..|.|||||||| ..| .||    ||||||||.| .|||.  ||||.||| .|||..||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPR---------LDTEGINLLSSLLLYESKSRMSAEAALNH
   .| ||||.|    ..|  ||| ||||.|..|||||.  .. .  |||. || | .. |.         || ||| ||...| |.   | ||..||.|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PYF
|||
PYF
Kinase PCTAIRE3.AA CMGC 121-402 27 2e-140 464.66 In-house 1-513 (513) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-513/513
Sequence Identity: 27% (139 aa)

YVKLDKLGEGTYATVFKGRSKLTE--------------NLVALKEIRLE----------HEEGAPCTAIREVSLLKDLK-----------------HANI
| ...|.|||||..|.|.| |.|.              ..||.| |...          ...| |..|.||...|| |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTLHDLIHTDR-----------------SLTLVFEYLDSDLKQYLDHCG---------NLMNMH-----------NVKIFM------FQLLRGLA--YCH
|.|.| ....                  .| |||||.| ||.||....          .|   |           |.| ||      .|.||||.  |||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

HRK--ILHRDLKPQNLLINERGEL--------------------KLADFGLARAKSVP---------------------TKTYSNEVVTLWYRPPDVLLG
 ..  |.||||||.|.|||...||                    |..||||||. ...                     ...|...|||.|||.| .|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

STEYS---------TPIDMWGVGCILYEMATG--------KPLFPGSTV-----------KEELHLIFRLLGTPT---------------EESWPGVTSI
...|.         ||||||.||||..|| ||        ||||||..             . |..||..|||||               || ||.... 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

SEFRA-------------YN------------FPRYLPQPLLSHAPR-----------------------------------LDTEGINLLSSLLLYESK
 ..               ..            ||.. |.|. .  |.                                   .| ..|.||. .| |. .
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

SRMSAEAALNHPYF
 |..|| ||.||||
KRITAEQALQHPYF
Kinase PCTAIRE3.AA CDK7 121-402 38 4.1e-112 299.93 In-house 1-288 (288) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-288/288
Sequence Identity: 38% (110 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIR-----LEHEEGAPCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMN
| |....|||..|||.|.. . |.  || |.|.      | . |   |||||. .|. ..| |.. | | .    .. |||...| ||         .. 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

MHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGK
  ..| .| ..|.|| |||   |||||||| |||.|| |.||.|||||||.   | . |.  ||| ||| |  | |   | | .||| ||||. |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAY-NFPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALNHPYF
| .||      |  ||. ||||||| ||..... ..    .|| |   ||         . . |.. ... .   |...  .|..|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PCTAIRE3.AA PITSLRE 121-402 40 1.6e-102 346.9 In-house 1-295 (295) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-295/295
Sequence Identity: 40% (119 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE---HEEGAPCTAIREVS-LLKDLKHANIVTLHDLI--HTDRSLTLVFEYLDSDLKQYLDHCG---
...|.. .||||  |.... |.|.  |||| . .|     || | |..||.. .|. |.| |||..   .   .  .  .|.||.. |||  ..      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

NLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEM
       .| .| ||||| .. |  .|.|||||  |||..  | ||..||||||    | | |.  ||||||| | .|||. .||||.||| ||||. |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYN-FPRYLPQPLLSHAP---RLDTEGINLLSSLLLYESKSRMSAEAALNHPYF
 |.||||.|.   .... || ..||||| .|||.|.   ... | || | .  | .. |   ..   |  ||  .| |  | |..|..|| ||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase PCTAIRE3.AA S_TKc 121-402 29 6.8e-98 332.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-231/231
Sequence Identity: 29% (87 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDS---DLKQYLDHCGNL----
| .|.|.|.|....|.|.| | |  .||.|.|.        ....||...||  .| |||.|.| ...  .| .|.||.|    ||..|....|      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST-PIDMWGVGCILYEM
 ..   .. .| |....|.||| ..|.||||||.|.|..|  ..|..||||||         .  ..|.||..| ||     |.. ..|.| .|||||||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALN-------HPYF
..|.|.||      .....|...|                                    . |...... .| .. . |..|  ||.       ||.|
LCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PCTAIRE3.AA CDK4 121-402 44 4.3e-96 325.54 In-house 1-290 (290) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-290/290
Sequence Identity: 44% (132 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEE--GAPCTAIREVSLLKDLK---HANIVTLHDLIH---TDR---SLTLVFEYLDSDLKQYLD
|...  .||| | ||.. |.  | . |||| .|    ||  | |   |||.|... |.   |.||| | |  |   |||    .|.|||  | ||..|||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

HCGN-LMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI
 |    |    .|  |.|||||. . |   | ||||||||.|..  |..|||||||||  |  ..  .  ||||||| | ||| |. | ||.||| ||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLLQSY-YNTPVDMWSVGCI

LYEMATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALNHPYF
  ||   .|||.|.  |. || || . |.|.|. ||   |.       || . |.|...  | ..  |. ||   | |. . ||||...|.||||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP---WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase PCTAIRE3.AA CRK7 121-402 34 1e-94 320.98 In-house 1-343 (343) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-343/343
Sequence Identity: 34% (117 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE----EGAPCTAIREVSLLKDLKHANIVTLHDLIHTD---------R-SLTLVFEYLDSDLKQY
| ...  |||||  | | . | |. .|||| .|...|    || | |||||. .|. |.|.|||.|.. .  .         . |  .|||| | ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDHC-GNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPT--KTYSNEVVTLWYRPPDVLLGSTEY--------
|.       .  ..| || ||| |..||| ...||||.|  |.|.| .||.|.|||||||        . | | |.|||||||  ||| ..|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAY----NFPRYLP
                               . ||||..|||| | .|.||.|.|.   . | .|... |.|. ..|| |.    . .     .. | | 
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

QPLLSHAP--RLDTEGINLLSSLLLYESKSRMSAEAALNHPYF
     |     .. |  .||  .| .  | |..|| .|.|..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase PCTAIRE3.AA Pkinase 121-402 33 4.5e-92 317.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEG-APCTAIR--EVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDS-----DLKQYLD---H
|... |.|.|....|.|.. | |. .||.|.|...||.   . |..|  |....| |.| |||.|.|  ...... .|.||..      ||. |.    |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

CGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGEL----KLADFGLARAK-SVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGV
.. .. .. .| .| |.||||.||| ..|.||||||.|.||...|..    |..|||||. .   .   ..  ..|.||..| |..|...|....|||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYEMATGKPLFPGS----TVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALNHP
|||||||..|.|.|||.    .  .....|.| .|.|....||   ||| |   .. .   . .    .... |.. .....| .  |.| .|| .|.||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase PCTAIRE3.AA Pkinase_Tyr 121-266 30 7.8e-16 54.25 Pfam 1-160 (270) Show / Hide 
Range on Protein: 121-266
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

YVKLDKLGEGTYATVFKGRSK----LTENLVALKEIRLEHEEGAPCTA------IREVSLLKDL-KHANIVTLHDLIH-TDRS--LTLVFEYLDS-DLKQ
 ... ||||| . .|.||. |     |.  || | ..    |||   .      .||....| | .| ||| |.  .   ...  . .|.||    ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YLDHC---GNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARA
||      ..  .|.    . .|  .|..| . ... ||||   | |..| .  | .||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase PCTAIRE3.AA TyrKc 121-402 21 2.4e-13 -6.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 121-402
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAI-REVSLLKDL--KHANIVTLHDLIHTD-------RSLTLVFEYLDS-DLKQYLDH
 ....||||| . .|.||. |     || | .. ..       .. || .... |  .| ||| |.  . ..         | .|.|| .  |||.||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVP------TKTYS-----NEV--VTLWYRPPDVLLGSTEYS
...  .|     |..|  .| .| |.... ||||   | |..|..  | .||||.|.          ...|.     ..   . .   .| ..    ...
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TPIDMWGVGCILYEMAT-GKPLFPG--------STVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSLLLYES
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TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS-------------------F--VCCPDEMYQIMKQCWHEDP

KSRMSAEAALNHPYF
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EDRPTFSEI--HECF