Gene PAK4 (Mouse)

PAK4

Species: Mouse
Alias: PAK4, Pak4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
PAK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
PAK4.AA Protein Sugen 593 None Fasta, JSON
PAK4.NA RNA Sugen 2898 None Fasta, JSON

Protein domain

Protein domains of PAK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK4.AA PBD 10-67 31 5.1e-19 68.94 Pfam 1-60 (60) Show / Hide 
Range on Protein: 10-67
Range on HMM: 1-60/60
Sequence Identity: 31% (19 aa)

EISAP-SNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES-ARRPKPLIDPACITSIQPGAP
.||.| .||.|..| |.|. ...|||.|..||.|   |  ..|..  .|........  .
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK4.AA PBD 11-46 50 1.7e-16 62.06 SMART 1-38 (38) Show / Hide 
Range on Protein: 11-46
Range on HMM: 1-38/38
Sequence Identity: 50% (19 aa)

ISAPS-NFEHRVHTG-FDQHEQKFTGLPRQWQSLIEES
||.|. ||.|.|| | .|.....||||| |||.|.  .
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK4.AA PAKB 323-574 86 1.3e-226 759.1 In-house 1-252 (252) Show / Hide 
Range on Protein: 323-574
Range on HMM: 1-252/252
Sequence Identity: 86% (217 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
|||..|||||||||||||| ...|..|||||||||||||||||||||||||||.|.|.||||.||||||||||||||.||||||||||||||||||||.|
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

CLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPP
|..||||||.||||||||||||||||||||||||||||||||||||||||.||||||||||||||.|||||||.||||||||.|||||||||||||||||
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

LKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
|.|||.|||..||||||.||.||.|..||||.|||||.||.||.|||.||||
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK4.AA STE20 323-574 46 1.1e-149 503.6 In-house 1-288 (288) Show / Hide 
Range on Protein: 323-574
Range on HMM: 1-288/288
Sequence Identity: 46% (134 aa)

LDNFIKIGEGSTGIVCIATVRSSGKL----VAVKKMDLRKQ----QRRELLFNEVVIMRDYRHENVVEMYNSYLVG----DELWVVMEFLEGGALTDIVT
 ... |||.||.| |. |. ...|..    ||.|||.|.|.    ...|....|..||....|.|.|..|.|||..    ||||.|||...|| ||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

HT----------RMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK-----EVPRRKSLVGTPYWMAPELISR----
|.          .|||||||..|  |||.|. ||....||||||.| ||||.||.|||.|||.|||..|     . ..|...||||||||||.|..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-LPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIR--DNLPPRLKN--LHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
  .|.  .|||||| . |||..||||||...|..|| ||   .| ||.||.   || ||... |.|. |..||..|.|| .||||||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK4.AA PAKA 324-574 50 1.1e-133 450.43 In-house 2-260 (260) Show / Hide 
Range on Protein: 324-574
Range on HMM: 2-260/260
Sequence Identity: 50% (132 aa)

DNFIKIGEGSTGIVCIATVRSSGKL--VAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR------MN
... |||.|..| | .|| .. ..   ||.|.|.. .| . ||. ||  .|....|.|.|  . |||| ||||||||..||| |||..|...      |.
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEP
|.|||.||  .||.|  .|....|||||||| |||  ||.||. ||||||| ..|  .|.. ||||||||||.|.|  |.. |||||||.|.|||..|||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
|| |||||.||  |  |  | .|. .| |.... |||. |  |. .||.| |||.||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK4.AA STE 323-574 30 2.2e-116 392.96 In-house 1-359 (359) Show / Hide 
Range on Protein: 323-574
Range on HMM: 1-359/359
Sequence Identity: 30% (110 aa)

LDNFIKIGEGSTGIVCIATVR------SSGKL---------VAVKKMDLRKQ-----------------QRRELLFNEVVIMRDYR--HENVVEMYNSYL
...  |||.|..| |. |  .      ..|..         .|.|.|.|...                 . .. . .|. ||....  |.|.|. | .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------DELWVVMEFLEGGALTDIVTH---------------TRMNEEQIAAVCLAVLQA-LAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA
..       ||||..||...|| |.||. |               .|..|.|||..| ..|.. |. || ...||||||.. |||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QVSKEVP----------------RRKSLVGTPYWMAPELISR------LPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDN-----------
|......                .|...|||| ||||| |..       .|.  .|||||| ..|||..|.||.....|..|| || .|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----LPPRLKN-----------------LHKASPSLKGFLDRLLVRDPAQRATAAELLK--HPFL
     ||.|..                  || ||..| |... |..|| .|.|| .|||  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK4.AA S_TKc 323-574 28 7.2e-93 315.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 323-574
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEG--GALTDIVTHTR-------
 .   |||.|. | |. .. ...|..||.|...       | . .|. |..  .|.|.| .| ..   |.|..|||...|  | | |.  . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP-EVDIWSLGVMVIEMVD
..| ... ..  ...||. .| .|.||||.| . |||..  ..|..|||...|.       ....|||..||||..   .||. ..|.||.|....||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLK-------HPFL
|.||.    . . .|.|.             ||..| |....|..||..| || |.|.       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK4.AA Pkinase 323-574 29 3.3e-86 297.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 323-574
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL--LFN--EVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGG----ALTDIVT---H
.    |||.|| | |.... ...||.||||....|..   ..  ...  |. ||.  .|.|.|..| ..  .|....|||..|||     | |...   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRM--NEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRV----KLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSL
...   |...  ... .|..|. .|..|.||||.|.. ||. ..| .    |..|||...|.     .  ....|||..||||.|  . .|||.||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVMVIEMVDGEPPYFNE----PPLKAMKMIRDNLPPRLKNLHKAS---------------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL
|....||. |.||. ..    . .  |.||. ...|.|.     .                     ...| |....| .||..| ||...|.||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK4.AA MST 324-574 39 2.2e-75 239.04 In-house 2-254 (254) Show / Hide 
Range on Protein: 324-574
Range on HMM: 2-254/254
Sequence Identity: 39% (101 aa)

DNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYL--VGDELWVVMEFLEGGALTDIVTHTR--MNEEQI
|   |.|.|| | |  |. ...||.||.|..        . . .|  || .   ...|  | ||.     ..| |||. ..| . ||.  |.   ||.||
DIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQI

AAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFN
|...  .|| |. ||    ||||||.  ||| |.|  ||.|||  .| .     | ...||||||||| |  . |   .||||||   |||  |.|||..
ACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSD

EPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
  |  ||.||  . || .|. .. |. .  |. . |...| ||.|| .||.||| 
IHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK4.AA YSK 328-574 37 1.1e-73 221.09 In-house 6-257 (257) Show / Hide 
Range on Protein: 328-574
Range on HMM: 6-257/257
Sequence Identity: 37% (95 aa)

KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTH---TRMNEEQIAAVC
.|| || | |  .  .  .. ||.|  || .     |..  |. .  .    ..   | ||| .  ||..||.. || . |         . |..|| . 
CIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIIL

LAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR--LPYGPEVDIWSLGVMVIEMVDGEPPYFNEP
  .|..|  || . .||||||.  .||. .| ||| |||  .|.   . .|   ||||||||||.|      |   .||||||.  .||  |||||    
REILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPYCDYH

PLKAMKMIRDNLPPRLKN-LHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
|...|  |  | ||.|.   .  | ..| | .  |. ||.|| .| ||||| | 
PMRVMFLIPKNNPPKLEGRSY--SKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK4.AA KHS 324-574 40 6.7e-72 241.09 In-house 2-258 (258) Show / Hide 
Range on Protein: 324-574
Range on HMM: 2-258/258
Sequence Identity: 40% (105 aa)

DNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAV
.   ..| |  | |  |    |..|.||| . .  ..  ...  |...|.| || |.|  . |||  | ||..||.  ||.| ||   |  ..| ||| |
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

CLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLPYGPEVDIWSLGVMVIEMVDGEPPYFN
|  .||.|. ||..| .|||||   ||||..| ||| |||  ||..  . .||| .|||||||||  .   .  |.   |||..|.  ||. .  || |.
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

EPPLKA-MKMIRDNL-PPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
  |..| . | . |  ||.||. || |..   |.   |...| .| ||  ||.|||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK4.AA CAMK 328-574 18 8.5e-68 217.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 328-574
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)

KIGEGSTGIVCIATVRSSG------------KLVAVKKMDLRKQQR----------------------------RELLFNEVVIMRD-------YRHENV
..|.|| |.|  .. ....            . ||.| .| .| .                             |. ...|. ||.         .|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEMYNSYL------------VGDE--------LWVVM---EFLEGG----A-LTDIVTH---------------TRMNEEQIAAVCLAVLQALAVLHAQG
. .|  |               .         .. ||   |. .||      .  || |                |..|.. . .   ...|.. .| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDIKSDSILLTHD-----------------GRVKLSDFGFCAQVSK-----------------------EVPRRKSLVGTPYWMA-PELISR-----
..|||.| . |||...                 . .|..|||| ... .                       | .  |  .|||. || ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------LPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMK-------------MIR----DNLPPRLKN------------------LHKASPSL
          .|||..|.||.||.   |. |.||.  .     ..             .|.    |  || ...                    . |.. 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

KGFLDRLLVRDPAQRATAAELLKHPFL
| .. ..|..|| .|.|... |.||..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PAK4.AA SLK 325-574 35 2.7e-67 226.05 In-house 2-259 (259) Show / Hide 
Range on Protein: 325-574
Range on HMM: 2-259/259
Sequence Identity: 35% (92 aa)

NFI-KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAA
. |  .|.|  | |  |  .  ... | | ......   |  . |. |. .  | |.|..|..| . ..||...|| .|||.  |.   .  . |.||. 
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

VCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-----SRLPYGPEVDIWSLGVMVIEMVDGEPP
||  ...||  || . |||||.|   ||.| || |.| |||  |.  ... .| . .|||||||||..        ||   .||||||. .||| ..|||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

YFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
. .  |.. .  |.   ||.|..  . | . | || . ||.|| .| |.|.|..|...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase PAK4.AA MSN 323-574 37 6.6e-67 219.89 In-house 1-265 (265) Show / Hide 
Range on Protein: 323-574
Range on HMM: 1-265/265
Sequence Identity: 37% (99 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDY-RHENVVEMYNSYL------VGDELWVVMEFLEGGALTDIVTHTR--
 .    .| |  | |        |.|.|.| ||.|.    |.   |. ... |  | |..  |  ..        . ||.||||   |..||.| .|.  
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQ-EINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

-MNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS-----RLPYGPEVDIWSLGVMV
 . |. || .|  .|. || ||.. |||||||   .||||.  ||| |||  ||... | || . .||||||||| |      .  |    |.||.|.  
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
||| .|.||  .  |..|. .|  | ||.||  .| |   . |... |...  || .....|||||.
IEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase PAK4.AA Pkinase_Tyr 323-532 25 4.4e-21 72.04 Pfam 1-232 (270) Show / Hide 
Range on Protein: 323-532
Range on HMM: 1-232/270
Sequence Identity: 25% (60 aa)

LDNFIKIGEGSTGIVCIATVR----SSGKLVAVKKM--DLRKQQ--RRELLFNEVVIMRDY-RHENVVEMYNSYL-VGDE--LWVVMEFLEGGALTDIVT
.    |.|||. | |. .| .    . .  ||||..  .  ..|  |....  |. ||. . .|.|.| .|   .  |.   ...|||. ..| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HT-----RMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVP-RRKSLVGTPY-WMAPELISRLPYGPEVDIWS
       . . ...   |. . .... |.... ||||.    .|.|... || .||| .  . ...   | ..    |  ||||| |.   .  . |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGVMVIEMVD-GEPP-YFNEPPLKAMKMI-RDN
 ||   |..  || | | . ..   ...| .|.
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
Kinase PAK4.AA TyrKc 323-574 23 1.4e-17 61.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 323-574
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDY--RHENVVEMYNSYLVG-------DELWVVMEFLEGGALTDIVTHTR
.    |.|||  |.|. .| .     ||||..   .   || . .|  ||. .  .|.|.| .|   . .       . |..|||. ..|.| |    .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKE--------VPRRKSLVGTP-----YWMAPELISRLPYGPEV
   . ..    |. . .  . || ...||||.    .|......|| |||| .  .  .        . | |.  |.       ||||| |    . .. 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGVMVIEMV-DGEPPYFN-----EPPLKAMKMIRDNLPPRLKNLHK--------ASPSLKGFLDRLLVRDPAQRATAAELLKHPFL
|.|| ||.  |.  .|..|| .      ..  ... ...    |..  .         ... .     .   .||..| | .|.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF