Gene Obscn (Mouse)

Obscn

Species: Mouse
Alias: Obscn
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: CAMK, Secondary Family: Trio,

Classification

Group: CAMK
Family: Trio

Sequence

Name Sequence Type Origin Length Description Download
Obscn.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 254 Kinase domain by global Sugen HMM Fasta, JSON
Obscn.NA RNA Sugen 25569 None Fasta, JSON
Obscn.AA Protein Sugen 8523 None Fasta, JSON
Obscn.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Obscn.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set Obscn.AA I-set 5-94 40 7.5e-37 127.57 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5-94
Range on HMM: 1-92/92
Sequence Identity: 40% (37 aa)

PRFLTRPKAFVVSVGKDATLSCQIVGNPTPHVSWEKDRQPVEA-GARFRLAQDG-DVYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLRV
|.|...|| ..|..|..|...||. |.|.| ||| || ||.   . |..  .|| . |.|||..   .|.|.| |.|.|  ||| . . | |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 17-84 35 4e-14 54.15 SMART 1-56 (56) Show / Hide 
Range on Protein: 17-84
Range on HMM: 1-56/56
Sequence Identity: 35% (24 aa)

SVGKDATLSCQIVGNPTPHVSWEKDRQPVEAGARFRLAQDGDVYRLTILDLALGDSGQYVCRARNAIG
  | ..|| |   |||.| ..| |  ||..           .  .||| . ...||| |.|.|||..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 11-95 21 1.8e-11 45.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 11-95
Range on HMM: 1-58/58
Sequence Identity: 21% (19 aa)

PKAFVVSVGKDATLSCQIVGNPTPHVSWEKDRQPVEAGARFRLAQDGDVYRLTILDLALGDS---GQYVCRARNAIGEAFA--AVGLRVD
|.  .|..| ..||.| .      ...|                       ||| .. . ||   | |.|.|.   |....   . |.| 
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set Obscn.AA V-set 5-94 17 3e-06 23.21 Pfam 1-128 (128) Show / Hide 
Range on Protein: 5-94
Range on HMM: 1-128/128
Sequence Identity: 17% (23 aa)

PRFLTR--PK----AFVVSVGKDATLSCQIVGNP----TP-HVSWEKDRQPV--------------EAG-----------ARFRLAQDGD--VYRLTILD
. ..|   |.      .|..|...||.|.   ..    .. ...| .. ||                ..            |........   . ||| .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

LALGDSGQYVCRARNA-IGEAFAAVGLRV
| . ||| | | . |  ..   . . |.|
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGv Obscn.AA IGv 21-79 19 0.005941 0.52 SMART 1-76 (76) Show / Hide 
Range on Protein: 21-79
Range on HMM: 1-76/76
Sequence Identity: 19% (15 aa)

DATLSCQIVGNPTPHVSWEKDRQ-----------PVEAGARFRLAQDGDV--------YRLTILDLALGDSGQYVCRA
..||||.  |. . ...| . ..            .. . . |.   .|           ||. .|   |.| | |  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY-SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
I-set Obscn.AA I-set 105-196 36 4e-30 104.74 Pfam 1-92 (92) Show / Hide 
Range on Protein: 105-196
Range on HMM: 1-92/92
Sequence Identity: 36% (35 aa)

PHFLLRPTSIRVREGADATFRCRVGGSPQPAVSWSKDGRRLGPPDAP--HVRVEEHG-ESSALRIRSARPRDGGTYEVRAENPLGSASAAAALVV
|.|. .|... |.|| .|.| |.| |.|.| ||| |||. | |   .  .... . |   . |.|. . |.| |.|...|.|..|.|.. | | |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP---DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 111-197 20 1.3e-12 49.17 SMART 1-58 (58) Show / Hide 
Range on Protein: 111-197
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

PTSIRVREGADATFRCRVGGSPQPAVSWSKDGRRLGPPDAPHVRVEEHGESSALRIRSARPRDG---GTYEVRAENPLGSASA--AAALVVD
|  . |.|| ..|..| |       ..|.                        |.| ...| |    |||  .|.   |....   . | | 
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 117-186 30 4.3e-12 47.43 SMART 1-56 (56) Show / Hide 
Range on Protein: 117-186
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

REGADATFRCRVGGSPQPAVSWSKDGRRLGPPDAPHVRVEEHGESSALRIRSARPRDGGTYEVRAENPLG
.|| ..|..|.. |.| | ..| | | .|               .. |.|....| | |.|. .|.|| |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 103-196 14 5e-05 19.18 Pfam 1-128 (128) Show / Hide 
Range on Protein: 103-196
Range on HMM: 1-128/128
Sequence Identity: 14% (19 aa)

QAPHFLLRPT----SIRVREGADATFRCRVGGSP----QP-AVSWSKDGRRLGPPDAPHV--------------RVEEHGESSA-----------LRIRS
| .   . |.    ...| ||...|..| .  ..    ..  ..|... ...|...  ..                ... ..             |.|..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

ARPRDGGTYEVRAENP-LGSASAAAALVV
..| | |||   . |.  ..  .   |.|
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 242-322 36 1.2e-22 79.4 Pfam 11-92 (92) Show / Hide 
Range on Protein: 242-322
Range on HMM: 11-92/92
Sequence Identity: 36% (30 aa)

TVTEGKHARLSCFVTGEPKPETVWKKDGQLVTE-GRRHVVYEDEQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVV
.|.||. ||..| |||.|.|. .|.|||| ... ..||.. .|.  .  | |. ....| | |||.|.| .|.  ... . |
EVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 244-312 33 2.4e-10 41.6 SMART 1-56 (56) Show / Hide 
Range on Protein: 244-312
Range on HMM: 1-56/56
Sequence Identity: 33% (23 aa)

TEGKHARLSCFVTGEPKPETVWKKDGQLVTEGRRHVVYEDEQENFVLKILFCKQSDRGLYTCTASNLVG
 ||  ..| |..|| | |.  |.| || .              |  |.|   . .|.|.|||.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 238-323 20 2.8e-09 38.05 SMART 1-58 (58) Show / Hide 
Range on Protein: 238-323
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

TRTCTVTEGKHARLSCFVTGEPKPETVWKKDGQLVTEGRRHVVYEDEQENFVLKILFCKQSDR---GLYTCTASNLVGQTYS--SVLVVVR
 .  || ||  ..|.| |.     .  |.                       | |   . .|    | |.|.|.   ||..|  .. . |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set Obscn.AA V-set 226-322 16 0.015748 10.55 Pfam 1-128 (128) Show / Hide 
Range on Protein: 226-322
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

AEGIPP-SPPGAGTRTCTVTEGKHARLSCFVT-GEPKPETV----WKKDGQLVTEGRRHVV---------------YEDEQENFV-----------LKIL
.. . . .|.|.  .  || ||. ..|.|... .   .|..    | .. |   .. . ..               |.  ....            |.| 
QSQVTQHPPRGC-PWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTIS

FCKQSDRGLYTCTASNL-VGQTYSSVLVVV
  . || | |.| ..|   ..  ... ..|
NLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG Obscn.AA IG 333-413 20 1.4e-10 42.44 SMART 1-58 (58) Show / Hide 
Range on Protein: 333-413
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LQDLEVREKESATFQCEVAQPATEAAWFKEETRLWASAKYDIEEEGTERRLTVRNVSADDD---AVYICETT--EGSR-TVAELSVQ
 . ..|.| |..|..| |.    .  |.                      ||. ||...|    ..| |. |  ...    ..|.||
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 327-398 33 1.2e-09 35.22 Pfam 1-75 (92) Show / Hide 
Range on Protein: 327-398
Range on HMM: 1-75/92
Sequence Identity: 33% (25 aa)

VPFKKRLQDLEVREKESATFQCEV-AQPATEAAWFKEETRLWA-SAKYDIEEEG-TERRLTVRNVSADDDAVYIC
  | ....|.||.| |.|.|.|.|  .|  .  ||| .  |   | .. . ..|  . .||..|| .||  .| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
IGc2 Obscn.AA IGc2 339-405 22 0.000195 17.42 SMART 1-56 (56) Show / Hide 
Range on Protein: 339-405
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

REKESATFQCE-VAQPATEAAWFKEETRLWASAKYDIEEEGTERRLTVRNVSADDDAVYICETTEGSR
.| .|.|..|.  . |. .  |.| ...|            .. .||..||. .|. .| |. .    
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGv Obscn.AA IGv 343-400 14 0.004002 2.24 SMART 1-76 (76) Show / Hide 
Range on Protein: 343-400
Range on HMM: 1-76/76
Sequence Identity: 14% (11 aa)

SATFQCEVAQPATEAAWFKE---------ETRLWASAKYDIEEEGTERR----------LTVRNVSADDDAVYICET
|.| .|.. .  ..  |...         .  .... .|    ...             || .|. ..| ..|.|..
SVTLSCKFSGFTFYMHWYRQPPDSTPKGKGLEWMGY-SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
V-set Obscn.AA V-set 383-412 23 1.427046 3.8 Pfam 95-128 (128) Show / Hide 
Range on Protein: 383-412
Range on HMM: 95-128/128
Sequence Identity: 23% (8 aa)

LTVRNVSADDDAVYICETTE----GSRTVAELSV
|| .|.. .| ..| |  .     .  .  .| |
LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 447-485 26 0.000204 17.5 Pfam 32-72 (92) Show / Hide 
Range on Protein: 447-485
Range on HMM: 32-72/92
Sequence Identity: 26% (11 aa)

VRWLRNQEEMVA-GGRVAITAEG-TCHTLTIFQCTLEDMGE
| |... ...   . |. .|..|   .|||| ... .|.|.
VSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGK
IG Obscn.AA IG 423-504 13 0.396183 0.76 SMART 1-58 (58) Show / Hide 
Range on Protein: 423-504
Range on HMM: 1-58/58
Sequence Identity: 13% (12 aa)

PRKTAVRTGDTAIFWVELAVPEGPVRWLRNQEEMVAGGRVAITAEGTCHTLTIFQCTLEDM---GEVAFVSG-GCRTT-TQFCVSAP
|. . |. |.|. .    .     ..|.                      ||| . ..||    |.   .   |. .    . ..  
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
FN3 Obscn.AA FN3 508-594 24 1.1e-11 46.03 SMART 1-69 (69) Show / Hide 
Range on Protein: 508-594
Range on HMM: 1-69/69
Sequence Identity: 24% (25 aa)

PLYPPAD--PVVKAKTES------SVTLSWSAPPHGDRPVTIDGYVLEKRKLGAYAWSRCHEAGWLATTEFTITGVAEE----GDFQFRVSAINH--FGQ
|  || .  ..|.. |..      ||||||..|        | ||.                        .|.||  .        .|||.|.|.   |.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

G
|
G
I-set Obscn.AA I-set 622-634 38 11.633849 1.36 Pfam 80-92 (92) Show / Hide 
Range on Protein: 622-634
Range on HMM: 80-92/92
Sequence Identity: 38% (5 aa)

EGGEVTFSVDLTV
..||.. .. |||
SFGEAECTAELTV
V-set Obscn.AA V-set 608-629 25 14.85771 0.29 Pfam 1-27 (128) Show / Hide 
Range on Protein: 608-629
Range on HMM: 1-27/128
Sequence Identity: 25% (7 aa)

MLAVKT-PLK----AVEAVEGGEVTFS
.. |.. | .     |...||. ||..
QSQVTQHPPRGCPWWVTVQEGQSVTLP
I-set Obscn.AA I-set 639-669 33 0.004412 12.97 Pfam 33-65 (92) Show / Hide 
Range on Protein: 639-669
Range on HMM: 33-65/92
Sequence Identity: 33% (11 aa)

EWFLDGEALKA-SSIYVIRCDR-TRHMLTIREV
.|| ||. |.  |. .....|   .. |||..|
SWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNV
I-set Obscn.AA I-set 733-775 35 1.7e-07 27.96 Pfam 32-76 (92) Show / Hide 
Range on Protein: 733-775
Range on HMM: 32-76/92
Sequence Identity: 35% (16 aa)

VTWLKDGRELSL-GPKYEMQVSA-GRRALLVRDVAQDDAGLYECV
|.|.|||..|.  . .. |. .  |.  | ...| .||.| |.||
VSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCV
IGc2 Obscn.AA IGc2 717-781 19 0.000231 16.71 SMART 1-56 (56) Show / Hide 
Range on Protein: 717-781
Range on HMM: 1-56/56
Sequence Identity: 19% (13 aa)

HEEAQLLAELS---DQAAAVTWLKDGRELSLGPKYEMQVSAGRRALLVRDVAQDDAGLYECVSRGSRT
||  ..  .     . .. ..|.| | .|.           ..  | ...|. .|.|.|.|. |..  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 709-788 17 0.000631 20.29 SMART 1-58 (58) Show / Hide 
Range on Protein: 709-788
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

AREVLAQLHEEAQLLAELSDQAAAVTWLKDGRELSLGPKYEMQVSAGRRALLVRDVAQDDA---GLYECVSR-GSRTA---YQLLVQ
 . |.... | ..|    |     ..|.                      | . .|  .|.   | | |. . |. ..    .| ||
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
V-set Obscn.AA V-set 701-787 14 5.316036 1.83 Pfam 1-128 (128) Show / Hide 
Range on Protein: 701-787
Range on HMM: 1-128/128
Sequence Identity: 14% (18 aa)

SSKLPAAAAR----EVLAQLHEEAQLLAELS-----DQAA-AVTWLK-DGR--------------ELSLGPKYEMQVSAGRRA-----------LLVRDV
.| . .   |    .| .|. . . |   .|     ...   ..| .                    . | .| . .  ||.            |  ...
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

AQDDAGLYECVSRG-----SRTAYQLLV
  .| | | |.. .       . ..| |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 804-868 29 6.1e-14 49.82 Pfam 10-77 (92) Show / Hide 
Range on Protein: 804-868
Range on HMM: 10-77/92
Sequence Identity: 29% (20 aa)

VKAEAGASATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRVEASG-CSRRLVVQQAGKADAGEYSCEA
|..  | .|...|.|    . .|.|||||..|.. |..... ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 801-880 17 7.8e-10 39.92 SMART 1-58 (58) Show / Hide 
Range on Protein: 801-880
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

HSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--SFRLDVA
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 807-873 22 9.9e-08 32.93 SMART 1-56 (56) Show / Hide 
Range on Protein: 807-873
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGASATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. | |.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 793-879 16 0.002528 13.29 Pfam 1-128 (128) Show / Hide 
Range on Protein: 793-879
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

MFAKEQQAHS----EVKAEAGASATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRVEASGCSR----RLVVQQ
..  .|. ..    .| .. |.|.||.| .       .. . ..|...  ..                       ... | ||. ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCE-----AGGQKLSFRLDV
.  .| | | |       ..   . || |
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 896-960 30 2e-13 48.08 Pfam 10-77 (92) Show / Hide 
Range on Protein: 896-960
Range on HMM: 10-77/92
Sequence Identity: 30% (21 aa)

VKAEAGNSATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRMEASG-CSRRLVVQQAGKADAGEYSCEA
|..  | .|...|.|    . .|.|||||..|.. |....| ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 893-972 17 4.7e-10 40.64 SMART 1-58 (58) Show / Hide 
Range on Protein: 893-972
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

RSEVKAEAGNSATLSCEVAQAQTEVTWFKDGKKLSSSSKVRMEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--SFHLDVT
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| |.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 899-965 22 4e-08 34.23 SMART 1-56 (56) Show / Hide 
Range on Protein: 899-965
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGNSATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRMEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. |.|.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 889-978 13 0.542017 5.25 Pfam 1-128 (128) Show / Hide 
Range on Protein: 889-978
Range on HMM: 1-128/128
Sequence Identity: 13% (18 aa)

EQQARS--------EVKAEAGNSATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRMEASGCSR----RLVVQQ
 .|           .| .. | |.||.| .       .. . ..|...  ..                       ... | | . ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCEAGGQKLSFHLDVTEPKLVF
.  .| | | | . .   ...   .. .|. 
LQPSDSGTYYCAVWNC--NEDYFGHGTRLTV
I-set Obscn.AA I-set 988-1053 30 2.1e-14 51.36 Pfam 10-78 (92) Show / Hide 
Range on Protein: 988-1053
Range on HMM: 10-78/92
Sequence Identity: 30% (21 aa)

VKAEAGASATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRMEASG-CSRRLVVQQAGKADAGEYSCEAE
|..  | .|...|.|    . .|.|||||..|.. |....| ..|    .| .... ..|.|.|.| |.
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVAT
IG Obscn.AA IG 985-1064 17 5.6e-10 40.39 SMART 1-58 (58) Show / Hide 
Range on Protein: 985-1064
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

HSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRMEASGCSRRLVVQQAGKADA---GEYSCEAE--GQKL--SFRLDVA
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|.   ..   ...| | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 991-1057 22 2.6e-08 34.87 SMART 1-56 (56) Show / Hide 
Range on Protein: 991-1057
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGASATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRMEASGCSRRLVVQQAGKADAGEYSCEAEGQKL
. | |.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.|.. . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 981-1023 14 0.513826 5.33 Pfam 1-56 (128) Show / Hide 
Range on Protein: 981-1023
Range on HMM: 1-56/128
Sequence Identity: 14% (8 aa)

EQQAHS--------EVKAEAGASATLSCEVA------QAQTEVTWFKDGKKLSSSSK
 .| .         .| .. |.|.||.| .       .. . ..|...  .. ....
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQ
I-set Obscn.AA I-set 1080-1144 30 4.3e-14 50.34 Pfam 10-77 (92) Show / Hide 
Range on Protein: 1080-1144
Range on HMM: 10-77/92
Sequence Identity: 30% (21 aa)

VKAEAGASATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRMEASG-CSRRLVVQQAGKADAGEYSCEA
|..  | .|...|.|    . .|.|||||..|.. |....| ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 1077-1156 17 5.7e-10 40.37 SMART 1-58 (58) Show / Hide 
Range on Protein: 1077-1156
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

RSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRMEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--SFRLDVT
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| |.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1083-1149 22 1.3e-07 32.58 SMART 1-56 (56) Show / Hide 
Range on Protein: 1083-1149
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGASATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRMEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. | |.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 1073-1155 15 0.712677 4.84 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1073-1155
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

EQQARS--------EVKAEAGASATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRMEASGCSR----RLVVQQ
 .|           .| .. |.|.||.| .       .. . ..|...  ..                       ... | | . ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCE-----AGGQKLSFRLDV
.  .| | | |       ..   . || |
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 1172-1236 30 6.6e-14 49.7 Pfam 10-77 (92) Show / Hide 
Range on Protein: 1172-1236
Range on HMM: 10-77/92
Sequence Identity: 30% (21 aa)

VKAEVGNSATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRMEASG-CSRRLVVQQAGKADAGEYSCEA
|.. .| .|...|.|    . .|.|||||..|.. |....| ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 1169-1248 17 8.6e-10 39.77 SMART 1-58 (58) Show / Hide 
Range on Protein: 1169-1248
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

RSEVKAEVGNSATLSCEVAQAQTEVTWFKDGKKLSSSSKVRMEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--SFRLDVA
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1175-1241 22 2.3e-08 35.03 SMART 1-56 (56) Show / Hide 
Range on Protein: 1175-1241
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EVGNSATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRMEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. |.|.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 1165-1247 15 0.152439 7.15 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1165-1247
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

EQQARS--------EVKAEVGNSATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRMEASGCSR----RLVVQQ
 .|           .| ...| |.||.| .       .. . ..|...  ..                       ... | | . ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCE-----AGGQKLSFRLDV
.  .| | | |       ..   . || |
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 1264-1328 29 6.1e-14 49.82 Pfam 10-77 (92) Show / Hide 
Range on Protein: 1264-1328
Range on HMM: 10-77/92
Sequence Identity: 29% (20 aa)

VKAEAGASATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRVEASG-CSRRLVVQQAGKADAGEYSCEA
|..  | .|...|.|    . .|.|||||..|.. |..... ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 1261-1340 17 7.8e-10 39.92 SMART 1-58 (58) Show / Hide 
Range on Protein: 1261-1340
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

HSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--SFRLDVA
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1267-1333 22 9.9e-08 32.93 SMART 1-56 (56) Show / Hide 
Range on Protein: 1267-1333
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGASATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. | |.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 1253-1339 16 0.004995 12.27 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1253-1339
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

AFAKEQQAHS----EVKAEAGASATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRVEASGCSR----RLVVQQ
..  .|. ..    .| .. |.|.||.| .       .. . ..|...  ..                       ... | ||. ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCE-----AGGQKLSFRLDV
.  .| | | |       ..   . || |
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 1356-1420 29 6.1e-14 49.82 Pfam 10-77 (92) Show / Hide 
Range on Protein: 1356-1420
Range on HMM: 10-77/92
Sequence Identity: 29% (20 aa)

VKAEAGASATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRVEASG-CSRRLVVQQAGKADAGEYSCEA
|..  | .|...|.|    . .|.|||||..|.. |..... ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 1353-1432 17 1.1e-09 39.38 SMART 1-58 (58) Show / Hide 
Range on Protein: 1353-1432
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

HSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--FFRLDVA
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1359-1425 22 9.9e-08 32.93 SMART 1-56 (56) Show / Hide 
Range on Protein: 1359-1425
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGASATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. | |.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 1345-1420 15 0.011818 10.98 Pfam 1-112 (128) Show / Hide 
Range on Protein: 1345-1420
Range on HMM: 1-112/128
Sequence Identity: 15% (18 aa)

AFAKEQQAHS----EVKAEAGASATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRVEASGCSR----RLVVQQ
..  .|. ..    .| .. |.|.||.| .       .. . ..|...  ..                       ... | ||. ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCEA
.  .| | | | .
LQPSDSGTYYCAV
I-set Obscn.AA I-set 1448-1512 29 6.1e-14 49.82 Pfam 10-77 (92) Show / Hide 
Range on Protein: 1448-1512
Range on HMM: 10-77/92
Sequence Identity: 29% (20 aa)

VKAEAGASATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRVEASG-CSRRLVVQQAGKADAGEYSCEA
|..  | .|...|.|    . .|.|||||..|.. |..... ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 1445-1524 17 7.8e-10 39.92 SMART 1-58 (58) Show / Hide 
Range on Protein: 1445-1524
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

HSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--SFRLDVA
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1451-1517 22 9.9e-08 32.93 SMART 1-56 (56) Show / Hide 
Range on Protein: 1451-1517
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGASATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. | |.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 1437-1523 16 0.002528 13.29 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1437-1523
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

MFAKEQQAHS----EVKAEAGASATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRVEASGCSR----RLVVQQ
..  .|. ..    .| .. |.|.||.| .       .. . ..|...  ..                       ... | ||. ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCE-----AGGQKLSFRLDV
.  .| | | |       ..   . || |
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 1540-1604 29 6.1e-14 49.82 Pfam 10-77 (92) Show / Hide 
Range on Protein: 1540-1604
Range on HMM: 10-77/92
Sequence Identity: 29% (20 aa)

VKAEAGASATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRVEASG-CSRRLVVQQAGKADAGEYSCEA
|..  | .|...|.|    . .|.|||||..|.. |..... ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 1537-1616 17 7.8e-10 39.92 SMART 1-58 (58) Show / Hide 
Range on Protein: 1537-1616
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

HSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--SFRLDVA
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1543-1609 22 9.9e-08 32.93 SMART 1-56 (56) Show / Hide 
Range on Protein: 1543-1609
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGASATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. | |.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 1533-1615 16 0.007021 11.76 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1533-1615
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

EQQAHS--------EVKAEAGASATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRVEASGCSR----RLVVQQ
 .| .         .| .. |.|.||.| .       .. . ..|...  ..                       ... | ||. ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCE-----AGGQKLSFRLDV
.  .| | | |       ..   . || |
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 1632-1696 29 6.1e-14 49.82 Pfam 10-77 (92) Show / Hide 
Range on Protein: 1632-1696
Range on HMM: 10-77/92
Sequence Identity: 29% (20 aa)

VKAEAGASATLSCEVAQAQT-EVTWFKDGKKLSS-SSKVRVEASG-CSRRLVVQQAGKADAGEYSCEA
|..  | .|...|.|    . .|.|||||..|.. |..... ..|    .| .... ..|.|.|.| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
I-set Obscn.AA I-set 1725-1791 33 6.4e-11 39.58 Pfam 9-77 (92) Show / Hide 
Range on Protein: 1725-1791
Range on HMM: 9-77/92
Sequence Identity: 33% (23 aa)

PLVVKEHETIILTATIAAPSVAAVTWLKDGVEIRR-SKRHEATSLG-DTHTLTVRGAQVLDSAIYSCRV
...|.| ||. .. ..       |.|.||| ..|  |.||  |  | .|.|||....|  |. .|.|..
DVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
I-set Obscn.AA I-set 1807-1891 31 9.5e-11 38.99 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1807-1891
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

AKFSKPLEPVEGELGGTVMLVCELSPEQA-EVVWRCGNTQLRP-GKRFQMTSEG-PRRTLTVSGLREDDAEEYVC----ESRDDRTSARLTV
 ||.... .||   | |. . |. . .   .|.| ... .||| ..|.||| .|  . |||.|.   ||. .| |    ..  . ..|.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 1813-1892 18 2.7e-10 41.46 SMART 1-58 (58) Show / Hide 
Range on Protein: 1813-1892
Range on HMM: 1-58/58
Sequence Identity: 18% (16 aa)

LEPVEGELGGTVMLVCELSPEQAEVVWRCGNTQLRPGKRFQMTSEGPRRTLTVSGLREDDA---EEYVCESR--DDRT--SARLTVK
 . |.. .|.|| | |  |    .. |.                      ||. .....|.    .|.|. .  ..    ...|||.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IG Obscn.AA IG 1629-1708 17 7.8e-10 39.92 SMART 1-58 (58) Show / Hide 
Range on Protein: 1629-1708
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

HSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADA---GEYSCEAG--GQKL--SFRLDVA
 . | . .| ..||.| |.    ...|.                      |.. .. ..|.   |.| |.|    ..   ...| | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1635-1701 22 9.9e-08 32.93 SMART 1-56 (56) Show / Hide 
Range on Protein: 1635-1701
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EAGASATLSCEVAQAQT-EVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKL
. | |.|| |... . . ...|.| |..|.            . .| .. . ..|.|.|.|.| . . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 1723-1803 19 1e-06 29.14 SMART 1-58 (58) Show / Hide 
Range on Protein: 1723-1803
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

REPLVVKEHETIILTATIAAPSVAAVTWLKDGVEIRRSKRHEATSLGDTHTLTVRGAQVLDS---AIYSCRVG---KEG-QDFPVQVE
 . ..||| ||. ||  ..      ..|.                      ||. ..|. ||   ..| |..    ... | . ..|.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1819-1885 19 0.000319 15.37 SMART 1-56 (56) Show / Hide 
Range on Protein: 1819-1885
Range on HMM: 1-56/56
Sequence Identity: 19% (13 aa)

ELGGTVMLVCE-LSPEQAEVVWRCGNTQLRPGKRFQMTSEGPRRTLTVSGLREDDAEEYVCESRDDRT
. |..| | |.    . ... |.  ...|             . |||..  ...|. .|.|. |    
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGc2 Obscn.AA IGc2 1729-1796 19 0.000369 14.76 SMART 1-56 (56) Show / Hide 
Range on Protein: 1729-1796
Range on HMM: 1-56/56
Sequence Identity: 19% (13 aa)

KEHETIILTATIAAPSVAAVTWLKDGVEIRRSKRHEATSLGDTHTLTVRGAQVLDSAIYSCRVGKEGQ
.| ....||   ..  .. ..|.| | ..            .  |||.. ... || .|.|..  .  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGv Obscn.AA IGv 1639-1791 9 0.002279 4.69 SMART 1-76 (76) Show / Hide 
Range on Protein: 1639-1791
Range on HMM: 1-76/76
Sequence Identity: 9% (15 aa)

SATLSCEVAQAQTEVTWFKD-------GKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKLSFRLDVAEPEAESQIPERPSRREPLVVKEH
|.||||.. . .....|..        || |.                                                                    
SVTLSCKFSGFTFYMHWYRQPPDSTPKGKGLEWMGY----------------------------------------------------------------

ETIILTATIAAPSVAAVTWLKDGVEIRRSKRHEATSLGDTHTLTVRGAQVLDSAIYSCRV
                   .|. ... ..   .  . . . .|| .. .. |...| | .
------------------SYKGRFTWSKDNI-TR-WSKNQFYLTMSNLRPEDTGTYYCAR
V-set Obscn.AA V-set 1621-1707 16 0.004995 12.27 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1621-1707
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

AFAKEQQAHS----EVKAEAGASATLSCEVA------QAQTEVTWFKDGKKL-----------------------SSSSKVRVEASGCSR----RLVVQQ
..  .|. ..    .| .. |.|.||.| .       .. . ..|...  ..                       ... | ||. ||. .     |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AGKADAGEYSCE-----AGGQKLSFRLDV
.  .| | | |       ..   . || |
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
V-set Obscn.AA V-set 1760-1805 22 0.106296 7.69 Pfam 79-128 (128) Show / Hide 
Range on Protein: 1760-1805
Range on HMM: 79-128/128
Sequence Identity: 22% (11 aa)

SKRHEATSLGD--THTLTVRGAQVLDSAIYSCRVGK--EGQDFPVQVEEV
..| . .. ..  . .|| . .|. ||..| | |    |..  .     |
KGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
V-set Obscn.AA V-set 1806-1891 17 0.136083 7.32 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1806-1891
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

AAKFSK-PLE----PVEGELGGTVMLVCELS-----PEQA-EVVWRC-GNT-----------------------QLRPGKRFQMTSEGP--RRTLTVSGL
.   .  | .    .|....|..| | | .|     .|.   . |   ...                       . |  .|..... ..  . .|| | |
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

REDDAEEYVCESRD-----DRTSARLTV
...|   | | . .       .. ||||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 1897-1981 31 2.2e-14 51.31 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1897-1981
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

VKFTSGLSAMVAEEGQEATFQCVVSPSDA-GVTWYKDGMQLQP-SEKFVMVESG-ASRSLTILGLTLEDAG----QVTVEAEGASSSAALRV
 |||  .. ... ||. |.|.| |. .    |.|.||| .|.| |....|...|    .|||.. . .|.|    ..| ..  |...| | |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 1903-1982 20 6.4e-11 43.53 SMART 1-58 (58) Show / Hide 
Range on Protein: 1903-1982
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LSAMVAEEGQEATFQCVVSPSDAGVTWYKDGMQLQPSEKFVMVESGASRSLTILGLTLEDA---GQVTVEAE--GASS--SAALRVR
 . ... ||. .|..| ||     ..||                      ||| ....||.   |  . .|.   ..|  .. |.|.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 1909-1975 29 5.2e-05 22.88 SMART 1-56 (56) Show / Hide 
Range on Protein: 1909-1975
Range on HMM: 1-56/56
Sequence Identity: 29% (20 aa)

EEGQEATFQCV-VSPSDAGVTWYKDGMQLQPSEKFVMVESGASRSLTILGLTLEDAGQVTVEAEGASS
.||| .|..|      |. ..||| | .|.            . .|||   |.||.|  | .|... .
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 1907-1964 17 0.000745 15.12 Pfam 17-106 (128) Show / Hide 
Range on Protein: 1907-1964
Range on HMM: 17-106/128
Sequence Identity: 17% (16 aa)

VAEEGQEATFQCVVS-----PSDA-GVTWYKDGMQLQPSEKFVM-----------------VESGASR----------SLTILGLTLEDAG
...||| .|..| .|     ...   ..||..  .. .. ....                 . .|  .          ||||  |...| |
TVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSG
IG Obscn.AA IG 1992-2071 17 0.028067 10.73 SMART 1-58 (58) Show / Hide 
Range on Protein: 1992-2071
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

LEPQTVEERTSVTLEVELTRPWPEVKWTRNAAVLTPXENVEIRAEGARHCLVLRSVGFADR---GFFGCETP--DDKT--XAPLTVR
 . .|| |  .|||.   .    ...|.                      |.. .| ..|    | . |.    ...    . |||.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 1986-2053 23 0.830984 5.25 Pfam 1-71 (92) Show / Hide 
Range on Protein: 1986-2053
Range on HMM: 1-71/92
Sequence Identity: 23% (17 aa)

VLFKKKLEPQTVEERTSVTLEVELT-RPWPEVKWTRNAAVLTP-XENVEIRAEG-ARHCLVLRSVGFADRG
  | .|. ...| |  ....|.. |  | |.| |... . |.|  . . ....|  .. |  . |  .| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEG
IG Obscn.AA IG 2079-2158 18 0.005062 17.18 SMART 1-58 (58) Show / Hide 
Range on Protein: 2079-2158
Range on HMM: 1-58/58
Sequence Identity: 18% (16 aa)

LQEVEAKEQGTASMDVELSHAEVEGSWTRDGLRLQPGPKCHLAVQGPVHILTLSALQPQDS---GLVAFRAE--GVHT--SARLIVT
 . |..|| .|...    |    . .|.                      ||.  .||.||   |    .|.   ..   ...|.|.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 2104-2140 35 0.572164 5.8 Pfam 33-71 (92) Show / Hide 
Range on Protein: 2104-2140
Range on HMM: 33-71/92
Sequence Identity: 35% (14 aa)

SWTRDGLRLQP-GPKCHLAVQG-PVHILTLSALQPQDSG
||..||  |.| . ...    |   . || |  || |.|
SWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEG
IG Obscn.AA IG 2168-2246 20 1.7e-09 38.8 SMART 1-58 (58) Show / Hide 
Range on Protein: 2168-2246
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LQDVVATQKEKVTLECELSRPVDVRWLKDGVELRAGKAIGIVAQGTCRSLVIYRCETGDQ---GVYVCDAL--DAQT--SASLRVQ
 . |..   | |||.|  |    ..|.                      |.| . .  |.   |.|.| |   ...   .. |.||
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 2162-2245 29 2.4e-08 30.83 Pfam 1-92 (92) Show / Hide 
Range on Protein: 2162-2245
Range on HMM: 1-92/92
Sequence Identity: 29% (27 aa)

VSFTRVLQDVVATQKEKVTLECELS-RPV-DVRWLKDGVELRA-GKAIGIVAQG-TCRSLVIYRCETGDQGVYVCDAL----DAQTSASLRV
 .||....||...  | ...||. .  |  .| |.||| .||  .. . ... |    .| |.... .| |.| | |      |...|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 2174-2239 22 7.1e-05 21.64 SMART 1-56 (56) Show / Hide 
Range on Protein: 2174-2239
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TQKEKVTLECE--LSRPVDVRWLKDGVELRAGKAIGIVAQGTCRSLVIYRCETGDQGVYVCDALDAQT
 . . |||.|.   .   ...|.| | .|            .  .| | . . .| |.|.| |  .  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 2164-2195 19 0.426215 5.61 Pfam 1-47 (128) Show / Hide 
Range on Protein: 2164-2195
Range on HMM: 1-47/128
Sequence Identity: 19% (9 aa)

FTRVLQ--------DVVATQKEKVTLECELS-------RPVDVRWLK
   | |         |.. . ..|||.| .|       .. .. | .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYR
I-set Obscn.AA I-set 2250-2334 39 1.8e-12 44.82 Pfam 1-92 (92) Show / Hide 
Range on Protein: 2250-2334
Range on HMM: 1-92/92
Sequence Identity: 39% (36 aa)

VQITKPLEDVEVMEKEGATFSCEVSHDEVPGL-WFRESSKLRP-SDNVRIRQEG-RTYTLIFRRVLAEDAGEVKFVAEN----AESRAHLRV
 ..|... ||||.| | |.|.|.|. |  |   ||.  ..||| || ......|  ||||....| ..|.|. . ||.|    ||..|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 2256-2335 20 3.7e-07 31.03 SMART 1-58 (58) Show / Hide 
Range on Protein: 2256-2335
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LEDVEVMEKEGATFSCEVSHDEVPGLWFRESSKLRPSDNVRIRQEGRTYTLIFRRVLAEDA---GEVKFVAE--NAES--RAHLRVK
 . |.|.| | .|..| ||       |.                      |.. .| .||.   |.   .|.  ...|   ..|.|.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 2339-2414 34 2.7e-12 44.24 Pfam 1-79 (92) Show / Hide 
Range on Protein: 2339-2414
Range on HMM: 1-79/92
Sequence Identity: 34% (27 aa)

VTLLRPLRDKIAMEKHRGVLECQVSRASA-QVRWFKGGVELQS-GPKYEVVSDG-LYRKLVINDVQPEDEDTYTCDAGN
 . .....|  ..|  .  .||||.     || |||.| .|.. . .. .. ||    .| | .|||.|| .||| | |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATN
IG Obscn.AA IG 2345-2424 21 3.2e-10 41.22 SMART 1-58 (58) Show / Hide 
Range on Protein: 2345-2424
Range on HMM: 1-58/58
Sequence Identity: 21% (19 aa)

LRDKIAMEKHRGVLECQVSRASAQVRWFKGGVELQSGPKYEVVSDGLYRKLVINDVQPEDE---DTYTCDAG--NVKT--SAQFFVE
 .   ..|  . .|.| ||    |..|.                      |.| .|||||.    ||.| |   ...   ...  |.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 2354-2417 27 0.001476 9.0 SMART 1-56 (56) Show / Hide 
Range on Protein: 2354-2417
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

HRG---VLECQVSRA-SAQVRWFKGGVELQSGPKYEVVSDGLYRKLVINDVQPEDEDTYTCDAGNVKT
| |   .|.| .. .  ....|.| | .|.               | | .|.|||. .||| | | . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 2395-2433 25 0.00272 13.18 Pfam 95-128 (128) Show / Hide 
Range on Protein: 2395-2433
Range on HMM: 95-128/128
Sequence Identity: 25% (10 aa)

LVINDVQPEDEDTYTCDAGNVKTSAQFFVEEQSITIVRG
| |...||.|. ||.| . |       ..  .. | .. 
LTISNLQPSDSGTYYCAVWNC-----NEDYFGHGTRLTV
IGv Obscn.AA IGv 2355-2412 19 0.006528 0.11 SMART 1-76 (76) Show / Hide 
Range on Protein: 2355-2412
Range on HMM: 1-76/76
Sequence Identity: 19% (15 aa)

RGVLECQVSRASAQVRWFKG-------GVEL-----QSGPKYEVVSDG--------LYRKLVINDVQPEDEDTYTCDA
   | |..|  . .. |..        |..|     ..  ..... |          |  |......|||..||.|. 
SVTLSCKFSGFTFYMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFY--LTMSNLRPEDTGTYYCAR
I-set Obscn.AA I-set 2428-2452 32 24.861653 0.24 Pfam 1-25 (92) Show / Hide 
Range on Protein: 2428-2452
Range on HMM: 1-25/92
Sequence Identity: 32% (8 aa)

ITIVRGLKDMTVMEPAPAWFECETS
 .... .||..|.|   | |||. .
PKFTQKPKDVEVQEGETARFECQVT
I-set Obscn.AA I-set 2517-2602 31 9.8e-20 69.48 Pfam 1-92 (92) Show / Hide 
Range on Protein: 2517-2602
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

PVVLTRPLEPKAGRELQSVVLSCDFRPAPK-AVQWYKDDTPLSP-SEKFKMALEG-QMAELRILRLTPADAGVYRCQA----GSAQSSAEVTV
|.....|  .   .| ... ..|. .  |.  |.|.||. ||.| |....|  .| . . |.|.. .|.|.|.|.|.|    |.|...||.||
PKFTQKP-KDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 2524-2603 20 9.9e-13 49.54 SMART 1-58 (58) Show / Hide 
Range on Protein: 2524-2603
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LEPKAGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMALEGQMAELRILRLTPADA---GVYRCQAG--SAQS--SAEVTVE
 .   ..| ..|.|.| .      ..||                      |.| ...|.|.   |.|.|||   ...|  ....||.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 2530-2596 29 5.1e-10 40.53 SMART 1-56 (56) Show / Hide 
Range on Protein: 2530-2596
Range on HMM: 1-56/56
Sequence Identity: 29% (20 aa)

RELQSVVLSCD-FRPAPKAVQWYKDDTPLSPSEKFKMALEGQMAELRILRLTPADAGVYRCQAGSAQS
.| |||.| |.        ..||| ..||.              .|.| . ||.|.|.|.|.| .. .
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 2533-2602 15 7e-06 22.15 Pfam 22-128 (128) Show / Hide 
Range on Protein: 2533-2602
Range on HMM: 22-128/128
Sequence Identity: 15% (17 aa)

QSVVLSCDFR-PA----PK-AVQWYK-DDT-----------------------PLSPSEKFKMALEGQ--MAELRILRLTPADAGVYRCQAGS-----AQ
||| |.| .. .     .   ..||.  ..                       . . .... ..  ..   . |.|  |.|.| |.| |.. .      .
QSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFG

SSAEVTV
.. ..||
HGTRLTV
IGv Obscn.AA IGv 2534-2591 22 0.000839 9.04 SMART 1-76 (76) Show / Hide 
Range on Protein: 2534-2591
Range on HMM: 1-76/76
Sequence Identity: 22% (17 aa)

SVVLSCDFRPAPKAVQWYKD-----------DTPLSPSEKFKMALEGQM--------AELRILRLTPADAGVYRCQA
|| ||| | .    . ||.               .. | | .  . ...        . |.. .|.|.| |.| |. 
SVTLSCKFSGFTFYMHWYRQPPDSTPKGKGLEWMGY-SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
I-set Obscn.AA I-set 2607-2675 23 2e-06 24.61 Pfam 1-72 (92) Show / Hide 
Range on Protein: 2607-2675
Range on HMM: 1-72/92
Sequence Identity: 23% (17 aa)

VTVIQPLQDAEAMEEGRVCFSCELSHKDE-DIEWSLNGTPLYN-DSFHEISHEG-CLHTLVLKSVRQADTGT
 ...|...|.|..|  .. |.|. . . . ...|  .| || . .. | .. .|   .||  . | ..|.|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGK
IG Obscn.AA IG 2613-2692 16 0.006344 16.33 SMART 1-58 (58) Show / Hide 
Range on Protein: 2613-2692
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

LQDAEAMEEGRVCFSCELSHKDEDIEWSLNGTPLYNDSFHEISHEGCLHTLVLKSVRQADT---GT-VCATS-PKVSV--SARLVVK
 .  ...| ..| ..|  |     | |.                      |.. .|. .|.   || .|. .  ...   ...| |.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 2696-2769 33 2.3e-12 44.5 Pfam 1-77 (92) Show / Hide 
Range on Protein: 2696-2769
Range on HMM: 1-77/92
Sequence Identity: 33% (26 aa)

VVFLKALDDVSAEERGTLTLQCEVS-DPEARVVWRKDGVELGP-SDKYDFLHKA-GARGLTVHDLSHEDAGLYTCQV
 .|.. . || . |  |....|.|. ||.  |.| ||| .| | ||.. .  .  |   ||. .   .|.| |||..
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IG Obscn.AA IG 2702-2781 20 2.9e-12 47.99 SMART 1-58 (58) Show / Hide 
Range on Protein: 2702-2781
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LDDVSAEERGTLTLQCEVSDPEARVVWRKDGVELGPSDKYDFLHKAGARGLTVHDLSHEDA---GLYTCQVG--SKET--QSKVSVH
   |.. | .|.||.| ||    .. |.                      ||. ... ||.   | |.||.   ...     ...|.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 2708-2774 25 1e-08 36.18 SMART 1-56 (56) Show / Hide 
Range on Protein: 2708-2774
Range on HMM: 1-56/56
Sequence Identity: 25% (17 aa)

EERGTLTLQCE-VSDPEARVVWRKDGVELGPSDKYDFLHKAGARGLTVHDLSHEDAGLYTCQVGSKET
.| ...||.|.   .|.. . |.| | .|            .   ||. . . ||.|.|||.. ..  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set Obscn.AA I-set 2818-2855 25 0.00025 17.2 Pfam 33-72 (92) Show / Hide 
Range on Protein: 2818-2855
Range on HMM: 33-72/92
Sequence Identity: 25% (10 aa)

VWTVGGKTVGG-SGHFHAVRQG-RKYTLTVKDAALSDAGE
.|. .|. .   | ... .. |   ||||....  .|.|.
SWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGK
V-set Obscn.AA V-set 2695-2785 15 0.000398 16.06 Pfam 1-128 (128) Show / Hide 
Range on Protein: 2695-2785
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

PVVFLK-ALD----DVSAEERGTLTLQCEVS-DP----EA-RVVWRKDGVEL-----------------GPSDKYDFLHKAGAR-----G-----LTVHD
...            |...| ...||.| .| |.       .. | ..   .                 .....|   .|   .     .     || ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

LSHEDAGLYTCQVGSKETQSKVSVHDLHV
|. .| | |.|.| .  ...  .   |.|
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGv Obscn.AA IGv 2712-2769 20 0.004854 1.4 SMART 1-76 (76) Show / Hide 
Range on Protein: 2712-2769
Range on HMM: 1-76/76
Sequence Identity: 20% (16 aa)

TLTLQCEVSDPEARVVWRKD---------GVELGPSDKYDFLHKAGARG----------LTVHDLSHEDAGLYTCQV
..||.|..|     . | .          |.|.  . .|                    || ..|  || | |.|..
SVTLSCKFSGFTFYMHWYRQPPDSTPKGKGLEWMGY-SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
IG Obscn.AA IG 2791-2872 15 0.00752 15.69 SMART 1-58 (58) Show / Hide 
Range on Protein: 2791-2872
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

LKTVEVLEGESCSFECVLSHESPSDPAVWTVGGKTVGGSGHFHAVRQGRKYTLTVKDAALSDA---GEVVFSVL--GLTS--KASLIIR
 . |.| |||. ...|  |         |.                      ||. .. ..|.   |. .  .     .|   . |...
PP-VTVKEGETVTLTC-VS------QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 2785-2806 50 0.008126 12.07 Pfam 1-22 (92) Show / Hide 
Range on Protein: 2785-2806
Range on HMM: 1-22/92
Sequence Identity: 50% (11 aa)

VGITKRLKTVEVLEGESCSFEC
  .|...| ||| |||.. |||
PKFTQKPKDVEVQEGETARFEC
I-set Obscn.AA I-set 2876-2947 25 3.6e-12 43.8 Pfam 1-75 (92) Show / Hide 
Range on Protein: 2876-2947
Range on HMM: 1-75/92
Sequence Identity: 25% (19 aa)

VDITKPLEDQRTTLGEDVMLSCELSRAGT-SVRWLKDGKAIRK-SQKYDLLSEG-TRAVLVVRKASLKDSGEYTC
  .|... |.  . ||.. ..|. .   . .| |.|||. .|  |...    .|  .. | ....   |.|.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
IG Obscn.AA IG 2882-2961 18 1.2e-08 35.99 SMART 1-58 (58) Show / Hide 
Range on Protein: 2882-2961
Range on HMM: 1-58/58
Sequence Identity: 18% (16 aa)

LEDQRTTLGEDVMLSCELSRAGTSVRWLKDGKAIRKSQKYDLLSEGTRAVLVVRKASLKDS---GEYTCETE--ASKS--TAKLCVE
 . .   .||.| |.|  |    ...|.                      |.. .... ||   |.|.|. .    .|  ...| |.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 2888-2954 20 4.2e-08 34.15 SMART 1-56 (56) Show / Hide 
Range on Protein: 2888-2954
Range on HMM: 1-56/56
Sequence Identity: 20% (14 aa)

TLGEDVMLSCE-LSRAGTSVRWLKDGKAIRKSQKYDLLSEGTRAVLVVRKASLKDSGEYTCETEASKS
  |..| | |.   . . ...|.| |. .            ..  | .. ... |||.|||. . ...
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 2875-2947 13 9.5e-05 18.21 Pfam 1-110 (128) Show / Hide 
Range on Protein: 2875-2947
Range on HMM: 1-110/128
Sequence Identity: 13% (15 aa)

PVDITK-PLE----DQRTTLGEDVMLSCELS-RA----GT-SVRWLKDGKAI-------------------------RKSQKYDLLSEGT--RAVLVVRK
....|  | .      .  .|..| |.| .|       .. .. | ..                             |.. .. . . ..  .. |  ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

ASLKDSGEYTC
... ||| |.|
LQPSDSGTYYC
IG Obscn.AA IG 2971-3050 18 3.2e-09 37.87 SMART 1-58 (58) Show / Hide 
Range on Protein: 2971-3050
Range on HMM: 1-58/58
Sequence Identity: 18% (16 aa)

LADLQVEEKGRAVFTCKTEHPASVVTWRKGLLELRASGKHVPSQEGLTLKLTINALERTDS---DTYTCDIG--QART--QARLLVH
   . | | .....||  .     ..|.                      |||  ... ||    ||.|     |.     ..| |.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IG Obscn.AA IG 3060-3141 16 4e-06 27.72 SMART 1-58 (58) Show / Hide 
Range on Protein: 3060-3141
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

LEDTAVQEGSSAKFCCRIAPADYGPVHWFLDKTPLHSNELNEITVQPGGYHVLTLRQLALKDS---GTVYFEAG--DQRT--SAALRVT
 . . |.||..... | ..      ..|.                       ||. .. . ||   || | .|   ..    .. |.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 2965-3049 33 5e-05 19.58 Pfam 1-92 (92) Show / Hide 
Range on Protein: 2965-3049
Range on HMM: 1-92/92
Sequence Identity: 33% (31 aa)

NRFTEELADLQVEEKGRAVFTCK-TEHPASVVTWRKGLLELRA-SGKHVPSQEG-LTLKLTINALERTDSDTYTC----DIGQARTQARLLV
 .||  . |..| |  .| |.|. | .|  .|.| |.  .||  | .|. ...|  | .|||   .. |. .|||      |.| . |.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set Obscn.AA V-set 2964-3056 15 0.002461 13.33 Pfam 1-128 (128) Show / Hide 
Range on Protein: 2964-3056
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

ANRFTE-ELA----DLQVEEKGRAVFTCKTE--H----PASVVTWRK-GLL-----------------------ELRASGKHVPSQEGL--TLKLTINAL
.   |    .     . |.| ... ..|.    .    . . ..| . . .                       . | .|.   |. .   .. |||. |
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

ERTDSDTYTCDIGQARTQARLLVHGQKVRV
.. || ||.| .           || ...|
QPSDSGTYYCAVWNC--NEDYFGHGTRLTV
IGc2 Obscn.AA IGc2 2977-3043 23 0.003384 5.55 SMART 1-56 (56) Show / Hide 
Range on Protein: 2977-3043
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

EEKGRAVFTCK-TEHPASVVTWRKGLLELRASGKHVPSQEGLTLKLTINALERTDSDTYTCDIGQART
.| . ...||. |  |.  ..|.|   .|                |||   .. || .|||    .  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set Obscn.AA I-set 3054-3077 33 0.568295 5.81 Pfam 1-24 (92) Show / Hide 
Range on Protein: 3054-3077
Range on HMM: 1-24/92
Sequence Identity: 33% (8 aa)

VRVIEDLEDTAVQEGSSAKFCCRI
 ...  . |  ||||..|.| |..
PKFTQKPKDVEVQEGETARFECQV
I-set Obscn.AA I-set 3145-3229 33 6e-11 39.66 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3145-3229
Range on HMM: 1-92/92
Sequence Identity: 33% (31 aa)

SIFSRPLTDVTVTEGEDLTLVCETTTVDS-SVRWTKDGKTLRP-SARCQLSHEG-CQAQLLITATTPQDGGRYKC----EIGGASSSSIVRV
  |.....||.|.|||.... |. |     .| |.|||. ||| | |.| . .|   . | |.  .| | | |.|    . | |...  . |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 3151-3230 21 5.4e-10 40.45 SMART 1-58 (58) Show / Hide 
Range on Protein: 3151-3230
Range on HMM: 1-58/58
Sequence Identity: 21% (19 aa)

LTDVTVTEGEDLTLVCETTTVDSSVRWTKDGKTLRPSARCQLSHEGCQAQLLITATTPQDG---GRYKCEIG--GASS--SSIVRVH
   ||| |||..|| |  .    ...|.                      | |   .|.|    | | |.     ..|  .  ..|.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 3157-3223 27 1.9e-07 31.98 SMART 1-56 (56) Show / Hide 
Range on Protein: 3157-3223
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

TEGEDLTLVCE-TTTVDSSVRWTKDGKTLRPSARCQLSHEGCQAQLLITATTPQDGGRYKCEIGGASS
 ||...|| |. |   | ...|.| |. |                | |.  || | |.| |.  .. .
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3145-3231 13 2.9e-05 19.98 Pfam 1-128 (128) Show / Hide 
Range on Protein: 3145-3231
Range on HMM: 1-128/128
Sequence Identity: 13% (18 aa)

SIFSRP--LT----DVTVTEGEDLTLVCETT-----TVDS-SVRWTKDGKTL---------------------RPSARCQLSHE------GCQAQLLITA
...  .   .     ||| ||...|| |  .       .. .. | ..  ..                     ... |.. . .      .. ..| |. 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

TTPQDGGRYKCEIGGA---SSSSIVRVHA
 .| | | | | . .    .  . .|.. 
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG Obscn.AA IG 3240-3319 25 2.7e-13 51.39 SMART 1-58 (58) Show / Hide 
Range on Protein: 3240-3319
Range on HMM: 1-58/58
Sequence Identity: 25% (22 aa)

LKDVEVPEGKAATLRCVLSSVAAPVEWRHGDDVLKSSNKYSLRQEGAVLELVIRDLQPQDS---GQYSCSFG--DQTT--SATLTVK
 . |.| ||  .||.|  |     . |.                      |.| ..||.||   | | |     ...   ..||||.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 3264-3318 32 6.2e-12 43.01 Pfam 32-92 (92) Show / Hide 
Range on Protein: 3264-3318
Range on HMM: 32-92/92
Sequence Identity: 32% (20 aa)

VEWRHGDDVLKS-SNKYSLRQEG-AVLELVIRDLQPQDSGQYSC----SFGDQTTSATLTV
|.| ...  |.. |.... ...|     | |.. || |.|.|.|    ||| ....|.|||
VSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 3246-3312 22 1.6e-07 32.2 SMART 1-56 (56) Show / Hide 
Range on Protein: 3246-3312
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

PEGKAATLRCV-LSSVAAPVEWRHGDDVLKSSNKYSLRQEGAVLELVIRDLQPQDSGQYSCSFGDQTT
 || ..||.|    . .. . |.. .  |               .| |.. .| ||| |.|.      
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3233-3318 17 6e-06 22.27 Pfam 1-128 (128) Show / Hide 
Range on Protein: 3233-3318
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

PVRFRE-SLK----DVEVPEGKAATLRCVLS-----SVAA-PVEWRH-GDD-------------VLKS----------SNKYSLRQEGA--VLELVIRDL
..     . .     |.|.||. .||.| .|     . .   . |   ..              .  .          ...... . .    . | |..|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

QPQDSGQYSCSFGD-----QTTSATLTV
|| ||| | |   .       .. .|||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 3234-3255 45 0.010952 11.63 Pfam 1-22 (92) Show / Hide 
Range on Protein: 3234-3255
Range on HMM: 1-22/92
Sequence Identity: 45% (10 aa)

VRFRESLKDVEVPEGKAATLRC
 .|   .||||| ||..|.. |
PKFTQKPKDVEVQEGETARFEC
IG Obscn.AA IG 3329-3407 22 1.7e-11 45.45 SMART 1-58 (58) Show / Hide 
Range on Protein: 3329-3407
Range on HMM: 1-58/58
Sequence Identity: 22% (19 aa)

LRNKEATEGTTVTLRCELTKEAPVEWKKGTETLRNGDKYSLKQDGAVCELQICSLLVADA---GEYSCVCG--QEKT--SATLTVK
 .  .. || ||||.|  .    . |.                      |.| .. ..|.   |.| |.    | .   ..||||.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 3323-3406 31 2.2e-10 37.75 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3323-3406
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

AQFVGKLRNKEATEGTTVTLRCELTKEAP--VEWKKGTETLRN-GDKYSLKQDG-AVCELQICSLLVADAGEYSCV----CGQEKTSATLTV
 .|. |... |..|| |... |. | . |  |.|.|. . ||. .|... ..||   . | |     .|.|.|.||     |. ...|.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 3335-3400 22 2e-06 28.81 SMART 1-56 (56) Show / Hide 
Range on Protein: 3335-3400
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TEGTTVTLRCE--LTKEAPVEWKKGTETLRNGDKYSLKQDGAVCELQICSLLVADAGEYSCVCGQEKT
 ||..|||.|.     .. . |.|  . |               .|.| .  ..|.|.|.|.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3323-3406 15 0.002001 13.64 Pfam 1-128 (128) Show / Hide 
Range on Protein: 3323-3406
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

AQFVGK--LR----NKEATEGTTVTLRCELT-------KEAPVEWKK-GTE-----------------------TLRNGDKYSLKQDGA--VCELQICSL
...|     |      .. ||..|||.| ..        .  . | . ..                        . |  ..... ...    . |.| .|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

LVADAGEYSCV-----CGQEKTSATLTV
 ..| | | |.      ..  .. .|||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 3411-3494 29 8.7e-13 45.91 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3411-3494
Range on HMM: 1-92/92
Sequence Identity: 29% (27 aa)

VHFVRRLRSKEATEGDTTTLQCELSKAAP--VEWRKGTETLRD-GDRYSLKQDG-AVCELQIRSLTIADAGEYLCT----CGQEKTSATLTV
 .|...... |..||.| ...|. .   |  |.| |. . ||  .||.. ..||   . | |.  ...|.|.| |.     |. ...|.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 3417-3495 22 1.7e-11 45.4 SMART 1-58 (58) Show / Hide 
Range on Protein: 3417-3495
Range on HMM: 1-58/58
Sequence Identity: 22% (19 aa)

LRSKEATEGDTTTLQCELSKAAPVEWRKGTETLRDGDRYSLKQDGAVCELQIRSLTIADA---GEYLCTCG--QEKT--SATLTVR
 .  .. ||.| ||.|  |    . |.                      |.| ... .|.   |.| |.    | .   ..||||.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 3423-3488 22 3e-07 31.35 SMART 1-56 (56) Show / Hide 
Range on Protein: 3423-3488
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TEGDTTTLQCE--LSKAAPVEWRKGTETLRDGDRYSLKQDGAVCELQIRSLTIADAGEYLCTCGQEKT
 ||.. ||.|.   . .. . |.|  . |               .|.|.. | .|.|.| |.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3418-3494 16 6.3e-05 18.82 Pfam 10-128 (128) Show / Hide 
Range on Protein: 3418-3494
Range on HMM: 10-128/128
Sequence Identity: 16% (20 aa)

R----SKEATEGDTTTLQCELS-------KAAPVEWRK-GTE-----------------------TLRDGDRYSLKQDGA--VCELQIRSLTIADAGEYL
|    . .. ||.. ||.| .|           . | . ..                        . |  .|... ...    . |.|..|. .| | | 
RGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYY

CT-----CGQEKTSATLTV
|       ..  .. .|||
CAVWNCNEDYFGHGTRLTV
IG Obscn.AA IG 3505-3583 22 6.5e-13 50.14 SMART 1-58 (58) Show / Hide 
Range on Protein: 3505-3583
Range on HMM: 1-58/58
Sequence Identity: 22% (19 aa)

LKNEEATEGTTATLSCELSKAAPVTWKKGPKTLQSGDKYVLRQDGAVCGLQIHGLTMADA---GEYSCVCG--QEKT--SATLTVR
 .  .. || |.||.|  |    ..|.                      |.| .....|.   |.| |.    | .   ..||||.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 3499-3582 31 5.8e-10 36.32 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3499-3582
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

AKFKDSLKNEEATEGTTATLSCELSKAAP--VTWKKGPKTLQS-GDKYVLRQDG-AVCGLQIHGLTMADAGEYSCV----CGQEKTSATLTV
 ||   .|. |..|| ||...|. .   |  |.|.|. . |.. .|... ..||   . | | . . .|.|.|.||     |. ...|.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 3511-3576 22 6.4e-09 36.88 SMART 1-56 (56) Show / Hide 
Range on Protein: 3511-3576
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TEGTTATLSCE--LSKAAPVTWKKGPKTLQSGDKYVLRQDGAVCGLQIHGLTMADAGEYSCVCGQEKT
 ||...|| |.   . .. ..|.|  . |.               |.|   |..|.|.|.|.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3498-3582 14 0.001822 13.78 Pfam 1-128 (128) Show / Hide 
Range on Protein: 3498-3582
Range on HMM: 1-128/128
Sequence Identity: 14% (18 aa)

PAKFKD-SLK----NEEATEGTTATLSCELS-------KAAPVTWKK-GPK-----------------------TLQSGDKYVLRQDGA--VCGLQIHGL
.   .  . .      .. ||...||.| .|           ..| . .|                        . .  ... . ...    . |.|. |
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TMADAGEYSCV-----CGQEKTSATLTV
...| | | |.      ..  .. .|||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 3587-3655 30 4.5e-05 19.72 Pfam 1-73 (92) Show / Hide 
Range on Protein: 3587-3655
Range on HMM: 1-73/92
Sequence Identity: 30% (22 aa)

AKFIEDLRSQEATEGATAILRCELSKAAP--VEWRKGSETLKD-GDRYTLRQDG-AVCELQIRGLAVVDTGTY
 ||.  ....|..|| || . |. .   |  |.| |. . |.  .||.  ..||   . | |..    |.|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKY
IG Obscn.AA IG 3593-3672 19 0.000194 21.99 SMART 1-58 (58) Show / Hide 
Range on Protein: 3593-3672
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

LRSQEATEGATAILRCELSKAAPVEWRKGSETLKDGDRYTLRQDGAVCELQIRGLAVVDT---GTYXXCVC-GQERT--SATLNIN
 . ... || |. |.|  |    . |.                      |.| .. . |.   |||   .  ||     ..|| . 
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 3599-3664 17 0.000309 15.5 SMART 1-56 (56) Show / Hide 
Range on Protein: 3599-3664
Range on HMM: 1-56/56
Sequence Identity: 17% (12 aa)

TEGATAILRCE--LSKAAPVEWRKGSETLKDGDRYTLRQDGAVCELQIRGLAVVDTGTYXXCVCGQER
 || ...|.|.   . .. . |.| .. |               .|.|.  .. | |.|   ...   
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3586-3655 14 0.011507 11.02 Pfam 1-108 (128) Show / Hide 
Range on Protein: 3586-3655
Range on HMM: 1-108/128
Sequence Identity: 14% (16 aa)

PAKFIE-DLR----SQEATEGATAILRCELS-------KAAPVEWRK-GSE-----------------------TLKDGDRYTLRQDGA--VCELQIRGL
.      . |    . .. ||... |.| .|           . | . ..                        .    .|.|. ...    . |.|. |
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

AVVDTGTY
 . |.|||
QPSDSGTY
IG Obscn.AA IG 3682-3760 22 5.2e-11 43.83 SMART 1-58 (58) Show / Hide 
Range on Protein: 3682-3760
Range on HMM: 1-58/58
Sequence Identity: 22% (19 aa)

LRNEEATEGTMATLRCQMSKAAPVEWRKGSETLRDGDRYSLRQDGAMCELQIRGLTIEDS---GEYTCVCG--QEKT--SATLSVK
 .  .. ||  .||.|  |    . |.                      |.| ... |||   |.|.|.    | .   ..||.|.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 3676-3759 33 1.7e-09 34.71 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3676-3759
Range on HMM: 1-92/92
Sequence Identity: 33% (31 aa)

TKFTEGLRNEEATEGTMATLRCQMSKAAP--VEWRKGSETLRD-GDRYSLRQDG-AMCELQIRGLTIEDSGEYTCV----CGQEKTSATLSV
 |||  ... |..||  |.. || .   |  |.| |. . ||  .||.. ..||   . | |.. ...|.|.||||     |. ...|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 3688-3753 26 7.4e-08 33.34 SMART 1-56 (56) Show / Hide 
Range on Protein: 3688-3753
Range on HMM: 1-56/56
Sequence Identity: 26% (18 aa)

TEGTMATLRCQ--MSKAAPVEWRKGSETLRDGDRYSLRQDGAMCELQIRGLTIEDSGEYTCVCGQEKT
 ||. .||.|    . .. . |.| .. |               .|.|.  | ||||.|||.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3675-3747 17 1.4e-05 21.05 Pfam 1-111 (128) Show / Hide 
Range on Protein: 3675-3747
Range on HMM: 1-111/128
Sequence Identity: 17% (19 aa)

PTKFTE-GLR----NEEATEGTMATLRCQMS-------KAAPVEWRK-GSE-----------------------TLRDGDRYSLRQDGA--MCELQIRGL
.   |    |      .. ||...||.|. |           . | . ..                        . |  .|... ...    . |.|. |
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TIEDSGEYTCV
. .||| |.|.
QPSDSGTYYCA
IG Obscn.AA IG 3770-3848 19 1.3e-09 39.23 SMART 1-58 (58) Show / Hide 
Range on Protein: 3770-3848
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

LRSQEATEGTMATLRCQMSKTAPVEWKKGSETLRDGGRYSLRQDGPVCELQICDLAVEDA---GEYSCVCG--QEKT--SATLSIK
 . ... ||  .||.|  |    . |.                      |.| .. .||.   |.| |.    | .   ..||...
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 3764-3847 28 3.7e-07 26.81 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3764-3847
Range on HMM: 1-92/92
Sequence Identity: 28% (26 aa)

SRFIEDLRSQEATEGTMATLRCQMSKTAP--VEWKKGSETLRD-GGRYSLRQDG-PVCELQICDLAVEDAGEYSCV----CGQEKTSATLSI
 .|.  ....|..||  |.. || . . |  |.|.|. . ||  . |.. ..||   . | | .   .|.|.|.||     |. ...|.| .
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 3776-3841 22 6.6e-07 30.2 SMART 1-56 (56) Show / Hide 
Range on Protein: 3776-3841
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TEGTMATLRCQ--MSKTAPVEWKKGSETLRDGGRYSLRQDGPVCELQICDLAVEDAGEYSCVCGQEKT
 ||. .||.|    . .. . |.| .. |               .|.| . ..||.|.|.|.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3763-3835 17 0.000321 16.38 Pfam 1-111 (128) Show / Hide 
Range on Protein: 3763-3835
Range on HMM: 1-111/128
Sequence Identity: 17% (19 aa)

PSRFIE-DLR----SQEATEGTMATLRCQMS-------KTAPVEWKK-GSE-----------------------TLRDGGRYSLRQDGP--VCELQICDL
.|     . |    . .. ||...||.|. |        .  . | . ..                        . |  ||... ....   . |.| .|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

AVEDAGEYSCV
 ..| | | |.
QPSDSGTYYCA
I-set Obscn.AA I-set 3940-4023 31 5.7e-11 39.75 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3940-4023
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

PRFIEDLRSQEATEGTMATLRCQMSKAAP--VEWRKGSETLRD-GGRYSLRQDG-AVCELQIHDLDVEDAGQYSCV----CGQEKTSAVLTV
|.|.  ....|..||  |.. || .   |  |.| |. . ||  . |.. ..||   . | | . . .|.|.|.||     |. ...| |||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 3858-3936 20 2.2e-10 41.77 SMART 1-58 (58) Show / Hide 
Range on Protein: 3858-3936
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LRSQEATEGTMATLRCQMSKAAPVEWRKGSETLGDGGRYSLRQNGAVCELQIHDLAVEDT---GEYSCVCG--QEKT--SATLNVK
 . ... ||  .||.|  |    . |.                      |.| .. .||.   |.| |.    | .   ..|| |.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 3852-3935 28 9.1e-10 35.65 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3852-3935
Range on HMM: 1-92/92
Sequence Identity: 28% (26 aa)

PRFIEDLRSQEATEGTMATLRCQMSKAAP--VEWRKGSETLGD-GGRYSLRQNG-AVCELQIHDLAVEDTGEYSCV----CGQEKTSATLNV
|.|.  ....|..||  |.. || .   |  |.| |. . |   . |.. ...|   . | | .   .|.|.|.||     |. ...|.|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 3946-4024 20 1e-09 39.55 SMART 1-58 (58) Show / Hide 
Range on Protein: 3946-4024
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LRSQEATEGTMATLRCQMSKAAPVEWRKGSETLRDGGRYSLRQDGAVCELQIHDLDVEDA---GQYSCVCG--QEKT--SAVLTVD
 . ... ||  .||.|  |    . |.                      |.| .. .||.   | | |.    | .   .. ||| 
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 3952-4017 22 6e-08 33.66 SMART 1-56 (56) Show / Hide 
Range on Protein: 3952-4017
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TEGTMATLRCQ--MSKAAPVEWRKGSETLRDGGRYSLRQDGAVCELQIHDLDVEDAGQYSCVCGQEKT
 ||. .||.|    . .. . |.| .. |               .|.| .  .||.| |.|.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGc2 Obscn.AA IGc2 3864-3929 22 8.2e-08 33.2 SMART 1-56 (56) Show / Hide 
Range on Protein: 3864-3929
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TEGTMATLRCQ--MSKAAPVEWRKGSETLGDGGRYSLRQNGAVCELQIHDLAVEDTGEYSCVCGQEKT
 ||. .||.|    . .. . |.| .. |               .|.| . ..|| |.|.|.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 3932-4023 18 4.6e-05 19.28 Pfam 1-128 (128) Show / Hide 
Range on Protein: 3932-4023
Range on HMM: 1-128/128
Sequence Identity: 18% (24 aa)

TLNVKALPPRFIEDLRSQEATEGTMATLRCQMS-------KAAPVEWRK-GSE-----------------------TLRDGGRYSLRQDGA--VCELQIH
 . |...|||.   ... .. ||...||.|. |           . | . ..                        . |  ||... ...    . |.|.
QSQVTQHPPRGC--PWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTIS

DLDVEDAGQYSCV-----CGQEKTSAVLTV
.| ..| | | |.      ..  ..  |||
NLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
V-set Obscn.AA V-set 3852-3923 16 9.7e-05 18.18 Pfam 1-111 (128) Show / Hide 
Range on Protein: 3852-3923
Range on HMM: 1-111/128
Sequence Identity: 16% (18 aa)

PRFIED--LR----SQEATEGTMATLRCQMS-------KAAPVEWRK-GSE-----------------------TLGDGGRYSLRQNGA--VCELQIHDL
. ...    |    . .. ||...||.|. |           . | . ..                        .    ||... .|.    . |.|..|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

AVEDTGEYSCV
 ..|.| | |.
QPSDSGTYYCA
I-set Obscn.AA I-set 4116-4199 31 2.2e-11 41.16 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4116-4199
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

PRFIEDLRSQEATEGTMATLRCQMSKAAP--VEWRKGSETLRD-GDRYSLRQDG-AVCELQIRDLAVEDAGEYLCV----CGQEKTSATLSV
|.|.  ....|..||  |.. || .   |  |.| |. . ||  .||.. ..||   . | |..   .|.|.| ||     |. ...|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 4034-4112 22 1.6e-10 42.22 SMART 1-58 (58) Show / Hide 
Range on Protein: 4034-4112
Range on HMM: 1-58/58
Sequence Identity: 22% (19 aa)

LKKEEATEGTMVTLRCQMSKEATVEWRKGAKTLSDGGRYSLRQDGAMCELQICGLAVEDA---GEYSCVCG--QEKT--SATLSVK
 .  .. ||  |||.|  |   .. |.                      |.| .. .||.   |.| |.    | .   ..||.|.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 4292-4375 27 1.9e-10 37.96 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4292-4375
Range on HMM: 1-92/92
Sequence Identity: 27% (25 aa)

PRFIEDLRSQEAREGTVATLRCRMSKAAP--VEWRKGSETLKD-GDRYSLRQEG-NLCELQIRDLAVEDTEEYSCV----CGQEKTSATLSV
|.|.  ....|..||  |.. |. .   |  |.| |. . |.  .||.. ...| . . | |..   .|. .|.||     |. ...|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 4122-4200 20 3.2e-10 41.18 SMART 1-58 (58) Show / Hide 
Range on Protein: 4122-4200
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LRSQEATEGTMATLRCQMSKAAPVEWRKGSETLRDGDRYSLRQDGAVCELQIRDLAVEDA---GEYLCVCG--QEKT--SATLSVK
 . ... ||  .||.|  |    . |.                      |.| .. .||.   |.| |.    | .   ..||.|.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IG Obscn.AA IG 4210-4288 20 4.9e-10 40.59 SMART 1-58 (58) Show / Hide 
Range on Protein: 4210-4288
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LRSQEATEGTMATLRCQMSKAAPVEWRKGSKTLRDGDRYSLRQDGAMCELQICDLAVEDT---GDYSCVCG--QEKT--SATLSVK
 . ... ||  .||.|  |    . |.                      |.| .. .||.   |.| |.    | .   ..||.|.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 4204-4287 31 1.3e-08 31.7 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4204-4287
Range on HMM: 1-92/92
Sequence Identity: 31% (29 aa)

PRFIEDLRSQEATEGTMATLRCQMSKAAP--VEWRKGSKTLRD-GDRYSLRQDG-AMCELQICDLAVEDTGDYSCV----CGQEKTSATLSV
|.|.  ....|..||  |.. || .   |  |.| |. . ||  .||.. ..||   . | | .   .|.| |.||     |. ...|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 4128-4193 22 1.9e-08 35.29 SMART 1-56 (56) Show / Hide 
Range on Protein: 4128-4193
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TEGTMATLRCQ--MSKAAPVEWRKGSETLRDGDRYSLRQDGAVCELQIRDLAVEDAGEYLCVCGQEKT
 ||. .||.|    . .. . |.| .. |               .|.|.. ..||.|.| |.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 4298-4376 19 2.7e-08 34.8 SMART 1-58 (58) Show / Hide 
Range on Protein: 4298-4376
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

LRSQEAREGTVATLRCRMSKAAPVEWRKGSETLKDGDRYSLRQEGNLCELQIRDLAVEDT---EEYSCVCG--QEKT--SATLSVK
 . ....||  .||.|  |    . |.                      |.| .. .||.    .| |.    | .   ..||.|.
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 4040-4105 23 9.5e-08 32.99 SMART 1-56 (56) Show / Hide 
Range on Protein: 4040-4105
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

TEGTMVTLRCQ--MSKEATVEWRKGAKTLSDGGRYSLRQDGAMCELQICGLAVEDAGEYSCVCGQEKT
 ||. |||.|    . .... |.|  . |.              .|.|   ..||.|.|.|.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set Obscn.AA I-set 4028-4111 30 9.9e-08 28.74 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4028-4111
Range on HMM: 1-92/92
Sequence Identity: 30% (28 aa)

PKFTEGLKKEEATEGTMVTLRCQMSKE-A-TVEWRKGAKTLSD-GGRYSLRQDG-AMCELQICGLAVEDAGEYSCV----CGQEKTSATLSV
||||  .|  |..||  ... || . .   .|.| |. . |.  . |.. ..||   . | | .   .|.|.|.||     |. ...|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set Obscn.AA V-set 4108-4187 17 5.4e-05 19.06 Pfam 1-111 (128) Show / Hide 
Range on Protein: 4108-4187
Range on HMM: 1-111/128
Sequence Identity: 17% (20 aa)

TLSVKALPPRFIEDLRSQEATEGTMATLRCQMS-------KAAPVEWRK-GSE-----------------------TLRDGDRYSLRQDGA--VCELQIR
 ..|...|||.   ... .. ||...||.|. |           . | . ..                        . |  .|... ...    . |.|.
QSQVTQHPPRGC--PWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTIS

DLAVEDAGEYLCV
.| ..| | | |.
NLQPSDSGTYYCA
IGc2 Obscn.AA IGc2 4216-4281 22 6.2e-05 22.21 SMART 1-56 (56) Show / Hide 
Range on Protein: 4216-4281
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

TEGTMATLRCQ--MSKAAPVEWRKGSKTLRDGDRYSLRQDGAMCELQICDLAVEDTGDYSCVCGQEKT
 ||. .||.|    . .. . |.| .. |               .|.| . ..|| | |.|.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGc2 Obscn.AA IGc2 4304-4369 20 6.3e-05 22.12 SMART 1-56 (56) Show / Hide 
Range on Protein: 4304-4369
Range on HMM: 1-56/56
Sequence Identity: 20% (14 aa)

REGTVATLRCR--MSKAAPVEWRKGSETLKDGDRYSLRQEGNLCELQIRDLAVEDTEEYSCVCGQEKT
.||. .||.|.   . .. . |.| .. |            .  .|.|.. ..||  .|.|.   .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 4196-4275 17 0.003649 12.74 Pfam 1-111 (128) Show / Hide 
Range on Protein: 4196-4275
Range on HMM: 1-111/128
Sequence Identity: 17% (20 aa)

TLSVKALPPRFIEDLRSQEATEGTMATLRCQMS-------KAAPVEWRK-GSK-----------------------TLRDGDRYSLRQDGA--MCELQIC
 ..|...|||.   ... .. ||...||.|. |           . | . ..                        . |  .|... ...    . |.| 
QSQVTQHPPRGC--PWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTIS

DLAVEDTGDYSCV
.| ..|.| | |.
NLQPSDSGTYYCA
V-set Obscn.AA V-set 4038-4099 17 0.072168 8.27 Pfam 17-111 (128) Show / Hide 
Range on Protein: 4038-4099
Range on HMM: 17-111/128
Sequence Identity: 17% (17 aa)

EATEGTMVTLRCQMS-------KEATVEWRK-GAK-----------------------TLSDGGRYSLRQDGA--MCELQICGLAVEDAGEYSCV
.. ||..|||.|. |        . .. | . .                         . .  ||... ...    . |.|  | ..| | | |.
TVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCA
V-set Obscn.AA V-set 4284-4363 15 0.853453 4.57 Pfam 1-111 (128) Show / Hide 
Range on Protein: 4284-4363
Range on HMM: 1-111/128
Sequence Identity: 15% (18 aa)

TLSVKALPPRFIEDLRSQEAREGTVATLRCRMS-------KAAPVEWRK-GSE-----------------------TLKDGDRYSLRQEGN--LCELQIR
 ..|...|||.   ... .. ||. .||.|  |           . | . ..                        .    .|... . ..   . |.|.
QSQVTQHPPRGC--PWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTIS

DLAVEDTEEYSCV
.| ..|.  | |.
NLQPSDSGTYYCA
IG Obscn.AA IG 4386-4464 20 3.1e-11 44.55 SMART 1-58 (58) Show / Hide 
Range on Protein: 4386-4464
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LRSQEAPESSTVTLRCKLSKKASVVWKKGSETLRNGARYSLRQDGAVCELEIRDLTVEDT---GEYSCTCG--QERT--SATLSIM
 . ... | .||||.|  |   .. |.                      |.| ....||.   |.| |.    |     ..||.. 
PP-VTVKEGETVTLTC-VS---QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 4380-4463 25 4.1e-09 33.43 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4380-4463
Range on HMM: 1-92/92
Sequence Identity: 25% (23 aa)

AKFIEDLRSQEAPESSTVTLRCKLSKK-A-SVVWKKGSETLRN-GARYSLRQDG-AVCELEIRDLTVEDTGEYSCT----CGQERTSATLSI
 ||.  ....|. | .|... |. . .   .|.|.|. . ||. . |.. ..||   . |.|.. . .|.|.|.|.     |.  ..|.| .
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 4392-4457 23 2.6e-07 31.53 SMART 1-56 (56) Show / Hide 
Range on Protein: 4392-4457
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

PESSTVTLRCK--LSKKASVVWKKGSETLRNGARYSLRQDGAVCELEIRDLTVEDTGEYSCTCGQERT
 |  .|||.|.   .  ... |.| .. |               .|.|.. |.|| |.|.|.   .  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 4379-4450 15 1.3e-05 21.18 Pfam 1-110 (128) Show / Hide 
Range on Protein: 4379-4450
Range on HMM: 1-110/128
Sequence Identity: 15% (17 aa)

PAKFIE-DLR----SQEAPESSTVTLRCKLS-------KKASVVWKK-GSE-----------------------TLRNGARYSLRQDGA--VCELEIRDL
.      . |    . ...|  .|||.|..|          .. | . ..                        . |   |... ...    . | |..|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TVEDTGEYSC
...|.| | |
QPSDSGTYYC
IG Obscn.AA IG 4474-4553 17 1.2e-09 39.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 4474-4553
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

LQNLQAEEGSMASLRCELSVPNAAMVWSKGGLELQGDTRREARQQGCVAELLLRDLRREDA---GEYSCTCG--SQTT--SATLMVT
 . . . ||. ..|.|  |     . |.                      | . ....||.   |.| |.    ...   ..|| |.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 4480-4546 22 2.6e-07 31.56 SMART 1-56 (56) Show / Hide 
Range on Protein: 4480-4546
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

EEGSMASLRCE-LSVPNAAMVWSKGGLELQGDTRREARQQGCVAELLLRDLRREDAGEYSCTCGSQTT
.||  ..|.|.    |..   | | | .|.              .| ... ..||.|.|.|.  .   
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 4467-4539 15 3e-07 26.84 Pfam 1-110 (128) Show / Hide 
Range on Protein: 4467-4539
Range on HMM: 1-110/128
Sequence Identity: 15% (17 aa)

QVVFQQ-PLQ----NLQAEEGSMASLRCELS------VPNAAMVWSK-GGL-------------------------ELQGDTRREARQQGCVAELLLRDL
|.. .| |       . ..|| ...|.| .|       .|  . |.. . .                         . .| ..  .  ... . | ...|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

RREDAGEYSC
...| | | |
QPSDSGTYYC
I-set Obscn.AA I-set 4499-4552 25 0.001789 14.3 Pfam 33-92 (92) Show / Hide 
Range on Protein: 4499-4552
Range on HMM: 33-92/92
Sequence Identity: 25% (15 aa)

VWSKGGLELQG-DTRREARQQG-CVAELLLRDLRREDAGEYSCT----CGSQTTSATLMV
.| |.| .|.  . |   .. |   . |  ..  ..|.|.|.|.     |.....|.| |
SWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
I-set Obscn.AA I-set 4468-4490 26 0.024227 10.46 Pfam 1-23 (92) Show / Hide 
Range on Protein: 4468-4490
Range on HMM: 1-23/92
Sequence Identity: 26% (6 aa)

VVFQQPLQNLQAEEGSMASLRCE
 .|.|....... ||. | . |.
PKFTQKPKDVEVQEGETARFECQ
IG Obscn.AA IG 4563-4642 21 4.8e-10 40.62 SMART 1-58 (58) Show / Hide 
Range on Protein: 4563-4642
Range on HMM: 1-58/58
Sequence Identity: 21% (19 aa)

LQAQDVDEGATARLRCELSREAVSVEWRKGSLQLFPCAKYQMVQEGTTAELLVHGVEQEDA---GEYTCDAG--HTQS--IARLSVR
 . . | || |..|.|  |    .. |.                      | . .|. ||.   |.|.| |    ..|   ..|.|.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 4557-4630 32 1.5e-08 31.55 Pfam 1-77 (92) Show / Hide 
Range on Protein: 4557-4630
Range on HMM: 1-77/92
Sequence Identity: 32% (25 aa)

VRFLRELQAQDVDEGATARLRCELSRE-AVSVEWRKGSLQLFP-CAKYQMVQEG-TTAELLVHGVEQEDAGEYTCDA
 .|.. .. . | || |||. |. . .   .|.| |.  .| |   ..||...|  |. | . .|...|.|.||| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVA
IGc2 Obscn.AA IGc2 4569-4635 25 5.6e-08 33.76 SMART 1-56 (56) Show / Hide 
Range on Protein: 4569-4635
Range on HMM: 1-56/56
Sequence Identity: 25% (17 aa)

DEGATARLRCE-LSREAVSVEWRKGSLQLFPCAKYQMVQEGTTAELLVHGVEQEDAGEYTCDAGHTQS
 || ...|.|.   ... .. |.|   |  |          .  .| .  |. ||.|.||| | .  .
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 4568-4641 13 0.001638 13.94 Pfam 18-128 (128) Show / Hide 
Range on Protein: 4568-4641
Range on HMM: 18-128/128
Sequence Identity: 13% (15 aa)

VDEGATARLRCELS--R----EAVSVEWRK-GSL------------QLFPC-----------AKYQMVQEGT--TAELLVHGVEQEDAGEYTCDAGH---
| ||....|.| .|  .       .. | . ...            ....             .... . ..  .. |  . .. .| | |.| . .   
VQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNE

--TQSIARLSV
   ..  || |
DYFGHGTRLTV
IG Obscn.AA IG 4743-4825 20 5.6e-08 33.75 SMART 1-58 (58) Show / Hide 
Range on Protein: 4743-4825
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LVDMEVQADEDVEFTCKVSQAGATDVQWHLQGLPLQSNEVTEVAVLADGCTHVLQLKGVTLEDA---GTVSFHVG--GLSS--SAQLTVR
   ..|.. |.|..|| ||      ..|.                        |.. .|..||.   ||    .     .|  ...|||.
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 4646-4719 31 2.6e-07 27.3 Pfam 1-75 (92) Show / Hide 
Range on Protein: 4646-4719
Range on HMM: 1-75/92
Sequence Identity: 31% (24 aa)

PKFKTDLQSTEQEAGGTARLCCQLSEAEPGTPVQWLKEGVELHV-GSKYEMRRQG-AVCELLIHGLEAKDTGEYAC
||| . ... |   | |||. || .   |   |.|.| | .|.. .... |.. |   . | | . .. |.|.| |
PKFTQKPKDVEVQEGETARFECQVTGD-PPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
IGc2 Obscn.AA IGc2 4658-4726 20 3.4e-07 31.13 SMART 1-56 (56) Show / Hide 
Range on Protein: 4658-4726
Range on HMM: 1-56/56
Sequence Identity: 20% (14 aa)

EAGGTARLCCQLSEAEPGTPVQWLKEGVELHVGSKYEMRRQGAVCELLIHGLEAKDTGEYACLVGGQKT
. |....| |   .. |.  ..|.| | .|               .| |   .  | |.|.|.. . . 
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 4652-4733 15 4e-06 27.56 SMART 1-58 (58) Show / Hide 
Range on Protein: 4652-4733
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

LQSTEQEAGGTARLCCQLSEAEPGTPVQWLKEGVELHVGSKYEMRRQGAVCELLIHGLEAKDT---GEYACLVG--GQKT--LASLRVK
 . ..  .|.|..| |  |       ..|.                      | | .... |.   |.| | .    ..    . |.|.
PP-VTVKEGETVTLTC-VS------QIWWY----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 4737-4808 26 8e-06 22.26 Pfam 1-72 (92) Show / Hide 
Range on Protein: 4737-4808
Range on HMM: 1-72/92
Sequence Identity: 26% (20 aa)

VTIVRGLVDMEVQADEDVEFTCKVSQAGATDVQWHLQGLPLQSNEVT--EVAVLADG-CTHVLQLKGVTLEDAGT
 .... . |.|||  |...|.|.|.     .|.|.  | ||..       . . .||  |. |  ..|. .|.|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP---DSDRHQMTYDGDGTYTLTISNVQPDDEGK
IGv Obscn.AA IGv 4662-4721 18 0.000265 14.06 SMART 1-76 (76) Show / Hide 
Range on Protein: 4662-4721
Range on HMM: 1-76/76
Sequence Identity: 18% (15 aa)

TARLCCQLSEAEPGTPVQWLKE---------GVELHVGSKYEMRRQGAV----------CELLIHGLEAKDTGEYACLV
...| |..|       . |...         |.|. .. .|  | ..              | ...|...||| | | .
SVTLSCKFSGFTF--YMHWYRQPPDSTPKGKGLEWMGY-SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
IGc2 Obscn.AA IGc2 4749-4814 21 0.000778 11.66 SMART 1-56 (56) Show / Hide 
Range on Protein: 4749-4814
Range on HMM: 1-56/56
Sequence Identity: 21% (15 aa)

QADEDVEFTCKVSQAGATDVQWHLQGLPLQSNEVTEVAVLADGCTHVLQLKGVTLEDAG----TVSFHVG
. ...|..||... . . ...|   | ||.                 |..| ||.||.|    ... ..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 4660-4739 14 0.819941 4.63 Pfam 21-128 (128) Show / Hide 
Range on Protein: 4660-4739
Range on HMM: 21-128/128
Sequence Identity: 14% (16 aa)

GGTARLCCQLS----EAEPGTPVQWLKEGVEL---------------------HVGSKYEMRRQ------GAVCELLIHGLEAKDTGEYACLVGGQKTLA
|....| |..|    . |. . ..| .    .                     .... .  |..      .  . | |. |.  |.| | | | .     
GQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNC--NE

SLRVKEPEVTI
    .. ..|.
DYFGHGTRLTV
V-set Obscn.AA V-set 4747-4808 12 6.670364 1.49 Pfam 17-107 (128) Show / Hide 
Range on Protein: 4747-4808
Range on HMM: 17-107/128
Sequence Identity: 12% (11 aa)

EVQADEDVEFTCKVS----QAGAT-DVQWHL-QGL-----------------------PLQSNEVTEVAVLADGCTHVLQLKGVTLEDAGT
.||  ..|...|..|    . ... ...|   | .                       . . .. .....  ....  |... ....| ||
TVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGT
IG Obscn.AA IG 4835-4916 19 1e-06 29.2 SMART 1-58 (58) Show / Hide 
Range on Protein: 4835-4916
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

LKDVQLSEGQDAHFRCRLSRASGQEARWALGGVPLQCNEMNDITVEQGTLYLLTLHKVTLEDA---GTITLQVG--SCSS--EAQLKVT
 . |  .||... ..|  |     . .|                        ||. .|..||.   || . |.   . .|  ...|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 4829-4915 26 5e-06 22.86 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4829-4915
Range on HMM: 1-92/92
Sequence Identity: 26% (25 aa)

VTVLEPLKDVQLSEGQDAHFRCRLSRASGQ---EARWALGGVPLQC-NEMNDITVEQGTLYLLTLHKVTLEDAGTITLQ----VGSCSSEAQLKV
 ... ..|||. .||..| | |   ...|.   .  |  .| ||.  ..   .| ...  | ||  .|. .|.|. | .    .|.....|.|.|
PKFTQKPKDVEVQEGETARFEC---QVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 4841-4905 23 0.010763 0.74 SMART 1-56 (56) Show / Hide 
Range on Protein: 4841-4905
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

SEGQDAHFRCRLSRASGQEARWALGGVPLQCNEMNDITVEQGTLYLLTLHKVTLEDAG----TITLQVG
 |||.. ..|. . . . . .|   | ||.            .   ||.  ||.||.|    . .  .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 4828-4915 15 0.030095 9.58 Pfam 1-128 (128) Show / Hide 
Range on Protein: 4828-4915
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

EVTVLE-PLK----DVQLSEGQDAHFRCRLS-----------------RASGQEARWAL------------GGVPLQCNEMNDITVEQG-TLYLLTLHKV
 ..|   | .     |  .|||.....| .|                 . .||  .|              |... ....   ...  . . . ||....
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TLEDAGTITLQVGS-----CSSEAQLKV
...| || . .| .       .. .| |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG Obscn.AA IG 4925-5007 18 0.000275 21.49 SMART 1-58 (58) Show / Hide 
Range on Protein: 4925-5007
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

LENVDALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSEKVEVVYFENGLRHLLLLKNLKPQDS-------CRVTFLAGDVVT--SAFLTVR
 . | . ||. . ..|  |       .|.                        | . |..|.||       |..|  .|..    .. |||.
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 4919-5006 27 0.002977 13.55 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4919-5006
Range on HMM: 1-92/92
Sequence Identity: 27% (26 aa)

NTVLRGLENVDALEGGEALFECQLS---QPEVAAHTWLLDDEPVHT-SEKVEVVYFENGLRHLLLLKNLKPQDS----CRVTFLAGDVVTSAFLTV
 .... . .| . ||  | |||| .   .|.|   .|. |..|... |... ..| . . .. |  .| .| |.    |..|  .| . ..|.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQV---SWFKDGQPLRPDSDRHQMTYDG-DGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 5017-5099 21 2.4e-09 38.29 SMART 1-58 (58) Show / Hide 
Range on Protein: 5017-5099
Range on HMM: 1-58/58
Sequence Identity: 21% (19 aa)

PHDASVKAGMQVRFTCILSEAVPVGEATWYINGAAIQPDDTDWTVTTDGSHHALTLSNAQPQHA---GEVTFAAR--DAVA--SARLSVL
|   .||.|  |..||  |      . .||                       ||. |.||...   |. . .|.  .. .  ...|.|.
PP-VTVKEGETVTLTC-VS------QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 5011-5082 30 0.000102 18.52 Pfam 1-72 (92) Show / Hide 
Range on Protein: 5011-5082
Range on HMM: 1-72/92
Sequence Identity: 30% (22 aa)

LEVLEPPHDASVKAGMQVRFTCILSEAVPVGEATWYINGAAIQPDDTDWTVTTDG-SHHALTLSNAQPQHAGE
 ... .|.|. |. |  .||.|  .   |  . .|. .|. ..||.    .| ||  .. || ||.||  .|.
PKFTQKPKDVEVQEGETARFECQVTGD-PPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGK
IGc2 Obscn.AA IGc2 5023-5092 22 0.004202 4.65 SMART 1-56 (56) Show / Hide 
Range on Protein: 5023-5092
Range on HMM: 1-56/56
Sequence Identity: 22% (16 aa)

KAGMQVRFTCILSEAVPVGEATWYINGAAIQPDDTDWTVTTDGSHHALTLSNAQPQHAGEVTFAARDAVA
. | .|..||.  .. |. . .||  |  ..            .   ||..|..| ..|. |  || .. 
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 5010-5081 16 0.03604 9.31 Pfam 1-106 (128) Show / Hide 
Range on Protein: 5010-5081
Range on HMM: 1-106/128
Sequence Identity: 16% (17 aa)

RLEVLE-PPH----DASVKAGMQVRFTCILS----EAVPVGEATWYI-NGA--------------AIQ----------PDDTDWTVTTDGSHHALTLSNA
 ..|   ||.      .|. |  |...| .|    .  ...  .||    .                .          .. . .........  ||.||.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

QPQHAG
|| . |
QPSDSG
FN3 Obscn.AA FN3 5102-5184 27 1.3e-16 62.43 SMART 1-69 (69) Show / Hide 
Range on Protein: 5102-5184
Range on HMM: 1-69/69
Sequence Identity: 27% (27 aa)

PDPPED---AEVVGRSDH------SVTLSWVAPMSDGGGGLCGYRVEMKEASTGQWQLCHDLVPGPECVVDDLVPG----KTYRFRVAAV--GPAGAG
|.||..    .|.  ...      |||||| .|         |||                      ..|..|.||    ..|.|||.||  . || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
IG Obscn.AA IG 5209-5291 17 9.7e-05 22.99 SMART 1-58 (58) Show / Hide 
Range on Protein: 5209-5291
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

PETRQAVVGEDICLELEVAADGGEVVWHKGTERIQPGGHFEVLSRGQRQMLVIKGFRTEDQ---GEYRCGPIQGLPSSG--AATFNVV
|.   ...||.. |.  |.    .. |.                      |.| . . ||.   |.|.|    .   ..   .|  | 
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 5232-5274 24 0.000215 17.42 Pfam 31-75 (92) Show / Hide 
Range on Protein: 5232-5274
Range on HMM: 31-75/92
Sequence Identity: 24% (11 aa)

EVVWHKGTERIQP-GGHFEVLSRG-QRQMLVIKGFRTEDQGEYRC
.|.|.|. . ..| . .. .  .| ... | |..   .| |.|.|
QVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
I-set Obscn.AA I-set 5474-5564 29 1.1e-16 59.1 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5474-5564
Range on HMM: 1-92/92
Sequence Identity: 29% (27 aa)

PVFSRTFGDTEAQVGDVLRLECVLATKTDMRACWLKDGIELTD-GRHYHIDQLKDGTCSLLVTGLAPTDSGRYTCQVSTKSGRVSHSACVVV
|.|...  | |.|.|. .|.||    . ..   |.||| .|.  ........ .|||..| ...  | |.| |||... ..| .. .| . |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IQ Obscn.AA IQ 5449-5469 47 2.1e-07 27.82 Pfam 1-21 (21) Show / Hide 
Range on Protein: 5449-5469
Range on HMM: 1-21/21
Sequence Identity: 47% (10 aa)

DKAAVKIQAAFKGYKVRKEMK
 .||.||||...||..||...
HRAAIKIQAWWRGYLARKHYR
IG Obscn.AA IG 5480-5565 15 2.5e-07 31.62 SMART 1-58 (58) Show / Hide 
Range on Protein: 5480-5565
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

FGDTEAQVGDVLRLECVLATKTDMRACWLKDGIELTDGRHYHIDQLKDGTCSLLVTGLAPTDS---GRYTCQVSTKSGRVSH--SACVVVS
 . .....|. ..|.|  .     .  |.                       | . .. | ||   | |.||..  .| ..   .. . |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IQ Obscn.AA IQ 5447-5469 43 2e-06 28.47 SMART 1-23 (23) Show / Hide 
Range on Protein: 5447-5469
Range on HMM: 1-23/23
Sequence Identity: 43% (10 aa)

SLDKAAVKIQAAFKGYKVRKEMK
 . .||..|||.. ||..||..|
RMHRAAIIIQAWWRGYLARKRYK
IGc2 Obscn.AA IGc2 5486-5554 24 5e-06 27.41 SMART 1-56 (56) Show / Hide 
Range on Protein: 5486-5554
Range on HMM: 1-56/56
Sequence Identity: 24% (17 aa)

QVGDVLRLECVLATKTDMRACWLKDGIELTDGRHYHIDQLKDGTCSLLVTGLAPTDSGRYTCQVSTKSG
. |. ..|.|  . . |    |.| | .|             .  .| ..  .| |||.|||... . |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 5339-5565 6 0.013597 10.77 Pfam 1-128 (128) Show / Hide 
Range on Protein: 5339-5565
Range on HMM: 1-128/128
Sequence Identity: 6% (17 aa)

SELPEE-DSRVQHLRQEAEETAPDLSEGYSTADELARTGEADLSHTSSDDESRAGTPSLVTYLKKAGGPGISPLASKVTTSVKPQKQQEPVVPTCPPPGD
..  .  ..| . ..                                                                                     
QSQVTQHPPRGC-PW-------------------------------------------------------------------------------------

LSAADLMDPSLDKAAVKIQAAFKGYKVRKEMKQQEGPVFSRTFGDTEAQVGDVLRLECVLATKT----DM-RACWLK-DGI-------------ELTDGR
                                              ..|.|. ..|.| . . .    .. .  | .                   ....
--------------------------------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFG

HYHIDQLKDGTCS-----------LLVTGLAPTDSGRYTCQVSTKSGRVSHSACVVVS
| .    . |...           |  . | | ||| |.|.|.. .  . ..   .. 
HGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 5704-5794 41 1.8e-32 112.71 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5704-5794
Range on HMM: 1-92/92
Sequence Identity: 41% (38 aa)

PVFLTELQNQDVQDGYPMSFDCVVTGQPVPSVRWFKDGKLLEE-DDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRV
|.|.. .... || |    |.| |||.| |.| |||||. | . .|.... .|. | . |.|. | |.|.|.|.| |.|| | ....||| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 5716-5784 30 1.7e-14 55.41 SMART 1-56 (56) Show / Hide 
Range on Protein: 5716-5784
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

QDGYPMSFDCVVTGQPVPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMG
. | . .. | .|| |.|...|.| |. |.            ..  | |. | |.| |.|.|.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 5710-5795 18 1.3e-10 42.48 SMART 1-58 (58) Show / Hide 
Range on Protein: 5710-5795
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

LQNQDVQDGYPMSFDCVVTGQPVPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADM---GVYRCLAENSMGVSS-TKAELRVE
 . . |. | . .. | |.     ...|.                       |.|  | |.|    |.|.| |. .. ..|   ..|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set Obscn.AA V-set 5704-5794 13 0.00059 15.47 Pfam 1-128 (128) Show / Hide 
Range on Protein: 5704-5794
Range on HMM: 1-128/128
Sequence Identity: 13% (18 aa)

PVFLTE--LQ----NQDVQDGYPMSFDCVVT-GQ----PVPSVRWFKDGKLLEEDDHYMI---------------NEDQQGGHQ-----------LIITA
....|            || |   .. | .. .     .. .. |...   . . ....|                .  .|  .           | |. 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

VVPADMGVYRCLAENS-MGVSSTKAELRV
. |.| |.| | . |. ...  .  .|.|
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Obscn.AA I-set 5836-5926 38 4.7e-23 80.75 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5836-5926
Range on HMM: 1-92/92
Sequence Identity: 38% (36 aa)

PQVLEELKDLQVAPGTRLAKFQLKVKGYPAPKLYWFKDGQPLTT-SDHIRMTDKK-TLHTLEIVSVTREDSGQYAAYISNAVGAAYSSARLLV
|...  .||..|  | . |.|. .|.|.| |.  ||||||||.. ||...|| ..   .||.|  |...|.|.|  . .| .| | ..|.| |
PKFTQKPKDVEVQEGET-ARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Obscn.AA IGc2 5851-5916 33 0.000109 19.82 SMART 1-56 (56) Show / Hide 
Range on Protein: 5851-5916
Range on HMM: 1-56/56
Sequence Identity: 33% (23 aa)

TRLAKFQLK--VKGYPAPKLYWFKDGQPLTTSDHIRMTDKKTLHTLEIVSVTREDSGQYAAYISNAVG
     ..|.  . |.|.|   |.| ||||            .  ||.| .||.|||| |. | .|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 5843-5927 15 0.004072 17.6 SMART 1-58 (58) Show / Hide 
Range on Protein: 5843-5927
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

KDLQVAPGTRLAKFQLKVKGYPAPKLYWFKDGQPLTTSDHIRMTDKKTLHTLEIVSVTREDS---GQYAAYISNAVGAAYS--SARLLVR
   ...     ....  |.      ..|.                      |.| .|..|||   | |    .   | ..|  ...| |.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set Obscn.AA I-set 5947-6042 28 8.3e-20 69.73 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5947-6042
Range on HMM: 1-92/92
Sequence Identity: 28% (28 aa)

PRILEKFTPKKVKRGSSITFSVKVEGHPAPSVHWLKEEAEKGVLWIGPDTPGYTMASSS-KQHSLVLLDVGRQHQGTYTCIATNPAGQALCSASLHI
|... | .. .|. |....|...|.|.| |.| |.| ...  .     |.  . |  .    ..|  ..| .   |.|||.|||..|.| |.|.| .
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP-----DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 5953-6043 17 9.1e-11 43.01 SMART 1-58 (58) Show / Hide 
Range on Protein: 5953-6043
Range on HMM: 1-58/58
Sequence Identity: 17% (17 aa)

FTPKKVKRGSSITFSVKVEGHPAPSVHWLKEEAEKGVLWIGPDTPGYTMASSSKQHSLVLLDVGRQHQ---GTYTCIATNPAGQALC--SASLHIS
     ||.|...|..  |.     ...|.                            |.. .| ....   |||.| ||  .||. .  .. |...
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 5959-6032 25 9.8e-09 36.27 SMART 1-56 (56) Show / Hide 
Range on Protein: 5959-6032
Range on HMM: 1-56/56
Sequence Identity: 25% (19 aa)

KRGSSITFSVKVEGHPAPSVHWLKEEAEKGVLWIGPDTPGYTMASSSKQHSLVLLDVGRQHQGTYTCIATNPAG
. | |.|.  ...| |.|..||.| . .                   .  .| . .| . . |.|||.|.||.|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 5937-6042 14 0.365544 5.84 Pfam 1-128 (128) Show / Hide 
Range on Protein: 5937-6042
Range on HMM: 1-128/128
Sequence Identity: 14% (20 aa)

ASDVHE---RLVPPRILEKFTPKKVKRGSSITFSVKVE-GH----PAPSVHWLK--EEAEKGVLWI-------GPDTPGYTMASSSKQHS----------
.|.|.    |   |.      .  |..| |.|.. ..  ..    .  ...| .    ..| .. |        ... ||.. . ..  .          
QSQVTQHPPRGC-PW------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDF

-LVLLDVGRQHQGTYTCIATNP-AGQALCSASLHI
 | . .. . . |||.| ..|.  ..   .  |..
SLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
RhoGEF Obscn.AA RhoGEF 6273-6452 24 3.6e-27 94.99 Pfam 1-196 (196) Show / Hide 
Range on Protein: 6273-6452
Range on HMM: 1-196/196
Sequence Identity: 24% (50 aa)

VIQELLSSEQAFVGELQFLESHHMKHLERSPRVPAAVA-SQKTVIFRNVQDISHFHSSFLKELQG-----CG---TDDD--VAMCF--IK-NQEAFEKYL
||||....|...|  |. .  | ||.|...  .|  .  ..   || |...| .||..||..|.      |.   ....  .. ||  .|  .. |. | 
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA-NPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMYS

EFLVGRVQAESVV----VSTP-VQEFYKKYAEETLSAKDPTQPPPPP-LQHYLEQPVERVQKYQALLKELIRNKAR-NRQ-NCALLEQAYAVVSALPQRA
|.     .|....     . | .|.|.|.  .|    .||      . ||..| .|| |. .|. |||||... .. .       |..|  ... . ...
EYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE----NDPCC-RRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHI

EN
  
NE
RhoGEF Obscn.AA RhoGEF 6273-6452 21 9.4e-17 62.9 SMART 1-211 (211) Show / Hide 
Range on Protein: 6273-6452
Range on HMM: 1-211/211
Sequence Identity: 21% (47 aa)

VIQELLSSEQAFVGELQFLESHHMKHLERSPR---VPAAVASQKTVIFR-NVQDISHFHSSFLKELQGC-------------------GTDDDVAMCFIK
|||||. .|...| .|. .  | || .... .   .|    .... ||  |...|  ||..||.||  .                      |... ||.|
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK

N---QEAFEKYLEFLVGRVQAESVVVS---TPVQEFYKKYAEETLSAKDPTQPPPP---------PLQHYLEQPVERVQKYQALLKELIRNKARNRQNCA
.   .| |. | |.     .|...      .  .....|. .|        .  |.         .|...| .|. |. ||. ||||....  ..     
WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKEC-------ESHPNCRSNSEHRLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYE

LLEQAYAVVSALPQRAEN
 |..|....  ..|. . 
DLQKALDCMKDVAQHCNE
PH Obscn.AA PH 6472-6582 14 7.9e-14 53.19 SMART 1-82 (82) Show / Hide 
Range on Protein: 6472-6582
Range on HMM: 1-82/82
Sequence Identity: 14% (16 aa)

PIRQGHFIVWEGAPGARMPWKGHNRHVFLFRNYLVICKPRRDSRTDTFSYVFRNMMKLSSIDLNDQVEGDDRAFEVWHEREDSVRKYLLQARTVIIKNSW
.|..|.  ...         . . |...||...|...|..            . .. ||.. ... .     .||..|  .     |..|...   ...|
VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK----------KPKGSIPLSDCTVRE-P-----CFEIHH-DR----TYYFQCESEEEMQEW

VKEICGIQQRL
.. |.  ....
MQAIQKAIHNN
PH Obscn.AA PH 6472-6580 17 4.1e-11 42.74 Pfam 1-92 (92) Show / Hide 
Range on Protein: 6472-6580
Range on HMM: 1-92/92
Sequence Identity: 17% (19 aa)

PIRQGHFIVWEGAPGARMPWKGHNRHVFLFRNYLVICKPRRDSRTDTFSYVFRNMMKLSSIDLNDQVEG-DDRAFEVWHEREDSVRKYLLQARTVIIKNS
.|..|.. ...         . . |...||.|.|...|..         |  . .  ||.... . ... ..  |....  .   |.|..|| .   .|.
VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK--------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR---RTYYFQAESEEEMND

WVKEICGIQQ
|.. |. .. 
WMQAIQSACR
I-set Obscn.AA I-set 6590-6663 40 2e-23 82.01 Pfam 1-75 (92) Show / Hide 
Range on Protein: 6590-6663
Range on HMM: 1-75/92
Sequence Identity: 40% (30 aa)

PEFEEELADCTAELGETVKLACRVTGTPKPIVSWYKDGKPVEV-DPHHILIEDPDGSCTLILDNLTGIDSGQYMC
|.|.  . | ..  |||... |.|||.|.| |||.|||.|. . . .|   .| || .||. .| .  |.|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
I-set Obscn.AA I-set 6684-6766 35 1.1e-17 62.53 Pfam 1-83 (92) Show / Hide 
Range on Protein: 6684-6766
Range on HMM: 1-83/92
Sequence Identity: 35% (30 aa)

PRFVNKVRATPFVEGEDAQITCTVEGAPYPQIRWYKDGTLLAP-GNRYRMLNEPRSGVLVLVIQAASKEDLGHYECELVNRLGS
|.|. | .     |||.|  .|.|.| | ||. |.|||  |.| ..|..| ..  .|   | |. . ..| | |.|  .|..|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDG-DGTYTLTISNVQPDDEGKYTCVATNSFGE
IGc2 Obscn.AA IGc2 6696-6765 31 6e-17 63.54 SMART 1-56 (56) Show / Hide 
Range on Protein: 6696-6765
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

VEGEDAQITCTVEGAPYPQIRWYKDGTLLAPGNRYRMLNEPRSGVLVLVIQAASKEDLGHYECELVNRLG
 ||.....|| ..|.| |.|.||| |. |.             .   | |. ...|| |.|.|.  |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGc2 Obscn.AA IGc2 6602-6670 34 2e-14 55.18 SMART 1-56 (56) Show / Hide 
Range on Protein: 6602-6670
Range on HMM: 1-56/56
Sequence Identity: 34% (24 aa)

ELGETVKLACRVTGTPKPIVSWYKDGKPVEVDPHHILIEDPDGSCTLILDNLTGIDSGQYMCFAASAAG
. |..| | |..|| | | ..||| |.|..            .. || . | |  ||| | |.| ...|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 6690-6776 22 9.1e-10 39.69 SMART 1-58 (58) Show / Hide 
Range on Protein: 6690-6776
Range on HMM: 1-58/58
Sequence Identity: 22% (21 aa)

VRATPFVEGEDAQITCTVEGAPYPQIRWYKDGTLLAPGNRYRMLNEPRSGVLVLVIQAASKEDL---GHYECELVNRLGSTRG--GGELYMQ
 . .  .|||....|| |.     ||.||                        |.|  ...||    | | |.     |.. .  | .|. |
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG Obscn.AA IG 6596-6681 23 1.7e-09 38.83 SMART 1-58 (58) Show / Hide 
Range on Protein: 6596-6681
Range on HMM: 1-58/58
Sequence Identity: 23% (21 aa)

LADCTAELGETVKLACRVTGTPKPIVSWYKDGKPVEVDPHHILIEDPDGSCTLILDNLTGIDS---GQYMCFAASAAGNAST--LGKILVQ
    |. .||||.| | |.      ..||                       |.. |..  ||   | | | |   .|...     .. ||
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set Obscn.AA V-set 6677-6771 16 4.8e-05 19.22 Pfam 1-123 (128) Show / Hide 
Range on Protein: 6677-6771
Range on HMM: 1-123/128
Sequence Identity: 16% (21 aa)

KILVQV-PPR---FVNKVRATPFVEGEDAQITCTVE-GA----PYPQIRWYK-DGT------------LLAPG-----------NRYRMLNEPRSGVLVL
 . |.. |||   .         .||... ..|..  .     .  .| ||.   .             . ..           .|... . |... . |
QSQVTQHPPRGCPW-----WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSL

VIQAASKEDLGHYECELVNRLGSTRGGG
 |. .. .| | | |   |    . |.|
TISNLQPSDSGTYYCAVWNCNEDYFGHG
IGv Obscn.AA IGv 6606-6665 22 7.8e-05 19.4 SMART 1-76 (76) Show / Hide 
Range on Protein: 6606-6665
Range on HMM: 1-76/76
Sequence Identity: 22% (17 aa)

TVKLACRVTGTPKPIVSWYKD-------GKPVE-----VDPHHILIED-----PDGSCTLILDNLTGIDSGQYMCFA
.|.| |...|     ..||.        ||..|     .     .  |      ... .| . ||.  |.| | |. 
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
IGv Obscn.AA IGv 6700-6760 16 0.004733 1.51 SMART 1-76 (76) Show / Hide 
Range on Protein: 6700-6760
Range on HMM: 1-76/76
Sequence Identity: 16% (13 aa)

DAQITCTVEGAPYPQIRWYKD-------GTLLA-----PGNRYRMLNEP----RSGVLVLVIQAASKEDLGHYECEL
.. ..|.. |  . .. ||.        |  |        .|. .   .     ..   |...    || | | |. 
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
V-set Obscn.AA V-set 6600-6632 21 1.901569 3.37 Pfam 17-58 (128) Show / Hide 
Range on Protein: 6600-6632
Range on HMM: 17-58/128
Sequence Identity: 21% (9 aa)

TAELGETVKLACRVTGTP----KP-IVSWYK----DGKPVEV
|...|..|.| | .. ..     .  ..||.    ..||...
TVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWI
I-set Obscn.AA I-set 6937-7026 42 1.4e-29 102.9 Pfam 1-92 (92) Show / Hide 
Range on Protein: 6937-7026
Range on HMM: 1-92/92
Sequence Identity: 42% (39 aa)

PSMQVTIEDVQVQVGDMAQFDAVIEGHPPPIVTWYKGSTQLTS-SARLSQRQDG-TTYSLVLTDVAPHDAGVYTCVANNAGGQVLCKAELLV
|... .. ||.||.|. | |.  ..|.||| |.|.|.  .|.. | | . ..||  ||.|  ..| | |.|.||||| | .|.. |.||| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Obscn.AA IG 6943-7027 18 1.3e-11 45.84 SMART 1-58 (58) Show / Hide 
Range on Protein: 6943-7027
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

IEDVQVQVGDMAQFDAVIEGHPPPIVTWYKGSTQLTSSARLSQRQDGTTYSLVLTDVAPHDA---GVYTCVANNAGGQVLC--KAELLVH
 . | |..|. ...   ..      ..||                      |.. .| | |.   |.|.|.|.  .||. .   ..| |.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 Obscn.AA IGc2 6949-7016 27 9e-09 36.38 SMART 1-56 (56) Show / Hide 
Range on Protein: 6949-7016
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

QVGDMAQFDAVIEGHPPPIVTWYKGSTQLTSSARLSQRQDGTTYSLVLTDVAPHDAGVYTCVANNAGG
. |. ...    .| | | ..||| ...|            .  .| ...|.| |.|.|||.| |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Obscn.AA V-set 6938-7026 15 8.9e-05 18.31 Pfam 1-128 (128) Show / Hide 
Range on Protein: 6938-7026
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

SMQVTI---E----DVQVQVGDMAQFDAVIE-GH----PPPIVTWYK-GST-------------------------QLTSSARLSQRQDGTTYSLVLTDV
. |||    .     | ||.|... .      ..    ..  ..||. ...                         .   . ..|.  .....|| ....
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

APHDAGVYTCVANNA-GGQVLCKAELLV
 | | |.|.|.. |   ..     .| |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
Kinase Obscn.AA Trio 7047-7300 50 7.6e-236 612.81 In-house 1-258 (258) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-258/258
Sequence Identity: 50% (130 aa)

YDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPLRSKTRAQAYQERDILATLGHPLVTGLLDQFETRKTLILILELCSSEELLDRLFKKGVVTEAEVKVY
|..|||||||.|..|.|..||.....|||||||.|.....|.|.|...|..| ||.|..|.|..||....|||||||...|||..|...|...|.|||.|
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

IQQLVEGLHYLHSHGILHLDIKPPNILMVHPAR--EDIKICDFGFAQKITPS--EPQYSKYGSPEFVSPEIIEQNPVSEGSDIWAMGVISYLSLTCSSPF
..|..|..||||...||||||||.|..|.|...  ..|||||||.||...|.  |||...||.|||..||||..||||.|.|||..||..|..|...|||
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

AGESDRATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPSTSQCLAHPWF
..||||.|..|...|..|.......|.|..||.||...||..|..||..|.||.||||
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase Obscn.AA MLCK 7047-7300 38 2.9e-105 278.23 In-house 1-257 (257) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-257/257
Sequence Identity: 38% (98 aa)

YDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPL-RSKTRAQAYQERDILATLGHPLVTGLLDQFETRKTLILILELCSSEELLDRLFKKG-VVTEAEVK
|.. ||.||| || | |.. | ..  .|||||.  ..| ..   .| .|. .| || .  . | ||| .  ..|.|. | .||..|    . . ||.|| 
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

VYIQQLVEGLHYLHSHGILHLDIKPPNILMVHPAREDIKICDFGFAQKITPSEP-QYSKYGSPEFVSPEIIEQNPVSEGSDIWAMGVISYLSLTCSSPFA
.|. |. ||.|..|...|.|||.|| ||... .   .||| ||| |.|. | |.    ..|.||||.||..   ||. ..|.|..|||.|. |.  |||.
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM

GESDRATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPSTSQCLAHPWF
|..|| |. ||....      .  . |..|||||.  | . .. |.....||.|||.
GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase Obscn.AA CAMK 7052-7300 21 1.1e-95 308.83 In-house 1-425 (425) Show / Hide 
Range on Protein: 7052-7300
Range on HMM: 1-425/425
Sequence Identity: 21% (90 aa)

EIGRGVFGFVKRVQHK-GNKMF-----------CAAKFIPLR-----------------------------SKTRAQAYQERDILATLG-------HPLV
..||| || ||...||  ...            .|.|.|. .                              |.|.. ..| .|. .|        || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

TGLLDQFE------------TRKT--------LILIL---ELCSSEEL----LDRLFKK---------------GVVTEAEVKVYIQQLVEGLHYLHSHG
  |.. .|            | ..        .....   |.||  ||    .|.. ..               | .||.|.. |..|.....||.|||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHLDIKPPNILMVHPARED---------------IKICDFGFAQKITPSE------------------------PQYSKYGSPEFVS-PEIIEQ-----
| |.|.|| |||...  ...               |||.|||||.|..|.|                        . .   |.||... ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------NPVSEGSDIWAMGVISYLSLTCSSPFAGE-------------SDRATLLNVLEGRVSWSSPT---------------------AAHLSEDA
          .... .|.|..||| |  |.  .|| |.             .|. .. ....|. .. .|                        ..|...
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

KDFIKATLQRTPRARPSTSQCLAHPWF
||.|.  ||. |  |.. .|||.|||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Obscn.AA S_TKc 7047-7300 29 9.8e-82 278.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

YDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPLRSKTRAQAYQERDILATLGHPLVTGLLDQFETRKTLILILELCSS--EELLDRLFKKGV------V
|.. ..||.| || |....||. .  .| | |.       ....|..||   .|| .  |.| |.. . | ...|.|.    .|.|.. |.|        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TEAEVKVYIQQLVEGLHYLHSHGILHLDIKPPNILMVHPAREDIKICDFGFAQKITPSEPQYSKYGSPEFVSPEIIEQNPVSE-GSDIWAMGVISYLSLT
.| ... |..|....| |.|||||.| |.|| |||. .     |||||||.| ..      ..  |.|....||..   . .   .|.|. |.| |  |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

CSSPFAGESDRATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPSTSQCLA-------HPWF
   ||    . .......              |..|||||.  ||. |. ||.  ..|.       ||||
GYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Obscn.AA DAPK 7049-7300 37 9.9e-76 207.96 In-house 1-264 (264) Show / Hide 
Range on Protein: 7049-7300
Range on HMM: 1-264/264
Sequence Identity: 37% (100 aa)

VQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPLRSKTRA-------QAYQERDILATLG-HPLVTGLLDQFETRKTLILILELCSSEELLDRLFK--KGVV
  ||.||| |  |....||   .  |||||  | ...            |  ||  .  || | .| . .|||.  |||||. |  || | .    .  .
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

TEAEVKVYIQQLVEGLHYLHSHGILHLDIKPPNILMVH-PARE-DIKICDFGFAQKITPSEPQYSKYGSPEFVSPEIIEQNPVSEGSDIWAMGVISYLSL
.|...   ..|  ||.|||||  | |||.|| ||.       . ||||.||| . || ..|      | ||.| |||.   | |   |.|. ||| |  |
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML

TCSSPFAGESDRATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPSTSQCLAHPWF
.  |||.|.    |.||.   ... |  .   .|| |||||.  | . |. |..  .|| ||| 
SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase Obscn.AA Pkinase 7047-7300 29 3.2e-70 244.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPLRSKTRAQAYQ-----ERDILATLGHPLVTGLLDQFETRKTLILILELCSSE----ELLDRLF--KK
| . . ||.| || |.. .|||.    | | |..|..   . ..     |  |.. |.|| .  |.| ||... . ...|.|       .| |..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GVV--TEAEVKVYIQQLVEGLHYLHSHGILHLDIKPPNILMVHPAREDI----KICDFGFAQK--ITPSEPQYSKYGSPEFVSPEIIE-QNPVSEGSDIW
|..  .| |.| |. |...|| |.||.||.| |.|| |||..   . .|    ||||||.| .  . ...  ..  |.|....||.|  ... .  .|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AMGVISYLSLTCSSPFAGE------SDRATLLNVLEGRVSWSSPTAAHLS-----------------EDAKDFIKATLQRTPRARPSTSQCLAHPWF
..|.| |  |.   || |.      .... . ...........|.    |                 |..|||||  |.. |  ||.  |.| ||||
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Obscn.AA DRAK 7049-7300 34 4e-61 188.47 In-house 1-259 (259) Show / Hide 
Range on Protein: 7049-7300
Range on HMM: 1-259/259
Sequence Identity: 34% (90 aa)

VQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPLRSK---TRAQAYQERDILA-TLGHPLVTGLLDQFETRKTLILILELCSSEELLD--RLFKKGVVTEAE
   | ||| |  | .  ||      ||||.  | .    |.   .|  .|    . | | .| . .|||  .||.||. .  |. .   . |   ..|..
TAKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKD

VKVYIQQLVEGLHYLHSHGILHLDIKPPNILMV-HPAREDIKICDFGFAQKITPSEPQYSKYGSPEFVSPEIIEQNPVSEGSDIWAMGVISYLSLTCSSP
|.  ..|  ||.||||.  | ||| || |||.      .|||||||| . .|  .|      | |..| ||| . .|..   |.|  ||. |. ||  ||
VQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP

FAGESDRATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPSTSQCLAHPWF
|.|.    | ||.    ...|  .   .|. | |||.  .   |  |..  .|| ||| 
FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase Obscn.AA Ciliate-E2 7047-7300 20 8.7e-60 203.9 In-house 1-365 (365) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-365/365
Sequence Identity: 20% (79 aa)

YDVQEEIGRGVFGFVKRVQHKGN------------------------KMFCAAKFIPLRSKTRAQ---AY----------QERDILATLGHPLVTGLLDQ
|.... ||.| || |...... .                        |..    ...   .   |    .          .|. || .| || .  . . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--TRKTLILILELCSSEELLDRLFKK-----------GVVTEAEVKVYIQQLVE---------------GLHYLHSHG-ILHLDIKPPNILMVHPARE
|.  ..... |..|.|.  .|.|.. ..           .  || |.| ...|...               .|.|||| . |.| |||| |||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

DIKICDFGFAQKITPSEPQYSK--------------------------------YGSPEFVSPEIIE---------QNPVSEGSDIWAMGVISYLSLTCS
 |||.|||...|..... ....                                .|.|....|||..         |.. .. .|||..||| |  |.  
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

SPFAGESDRATLLNVLEGRVSWSSP--------------TAAHLSEDAKDFIKA----TLQRTPRARPS-TSQCLAHPWF
 ||        . . ... .. ..|                 ..|...||.||      ||. |  |..  .|.| ||||
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Obscn.AA CAMKL 7047-7300 28 2.2e-57 181.59 In-house 1-297 (297) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-297/297
Sequence Identity: 28% (87 aa)

YDVQEEIGRGVFGFVKRVQHKGN-KMFCAAKFIPLRSKTRAQAYQ----------------ERDILATLG---HPLVTGLLDQFETRKT------LILIL
|.. ...|.| || ||  .|. . .   | |.|  . ..  .  .                |  |.  |    || .  |.. .||...      . |..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCSSEE--LLDRLFKK----GVVTEAEVKVYIQQLVEGLHYLHSHGILHLDIKPPNILMVHPAREDIKICDFGFAQKITP-----SEPQYSKYGSPEFV
|.||. |  |.|.. |.    |  .| | . | .|.|....|.||||| | |||| |||  .  .. |||.||||. ...|      .      |||.. 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEIIEQ-NP--VSEGSDIWAMGVISYLSLTCSSPFAGESD------RATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPSTSQCLAHPWF
.|||..  |        |||..||| |  ..   || ....         .|   . .     |   |.| |..|.|.  ||. |  ||.  | . |||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase Obscn.AA RSK 7049-7300 27 3.4e-56 193.02 In-house 1-278 (278) Show / Hide 
Range on Protein: 7049-7300
Range on HMM: 1-278/278
Sequence Identity: 27% (76 aa)

VQEE--IGRGVFGFVKRVQHKGNKMFCAAKFIPLRSKTRAQ-----AYQERDILATLG-HPLVTGLLDQFETRKTLILILELCSSEELLDRLFKKGV---
...   .| | .  .....|. ...  | | .  .   ..|     . .||.||.. . || .  | . |.| . | ||.|.|.  ||...| |..    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

VTEAEVKVYIQQLVEGLHYLHSHGILHLDIKPPNILMVHPA-REDIKICDFGFAQKITPS--EPQYSKYGSPEFVSPEIIE---QNP-VSEGSDIWAMGV
 .| |...|. ..|  . .||..|| | |.|| |||  .   .. ||..||||. .  ..  .. ..  .. |.. ||..    |.   ..  |.|  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

ISYLSLTCSSPFAG---ESDRATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPS-----TSQCLAHPWF
. |  ||  .||.|   ..   .. ....|. | ..|  . ||..|||.|.. |.| |  |..     ... ..||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Obscn.AA RSK 7047-7300 30 5.6e-52 179.0 In-house 1-271 (271) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-271/271
Sequence Identity: 30% (82 aa)

YDVQEEIGRGVFG---FVKRVQHKGNKMFCAAKFI---PLRSKTRAQAYQERDILATLGHPLVTGLLDQFETRKTLILILELCSSEELLDRLFKKGVVTE
|...|.||.| |.    .|..||| ...  | | |    .  |.| ..  ||.||.   || .  | . |.. . . .|....   .|.||| |... .|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

AEVKVYIQQLVEGLHYLHSHGILHLDIKPPNILMVHP--AREDIKICDFGFAQKITPSEP-QYSKYGSPEFVSPEIIEQNPVSEGSDIWAMGVISYLSLT
 ||| |   .   . ||||.|| | | || ||| .      . ||||||||| .    .   ..  .. ... ||.. .   .. .|.|  ||. |  ||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

CSSPFAGESDRAT---LLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPST-----SQCLAHPWF
   ||..  .  .   .... .|. | ...  . .|. ||| . . | | |  |...      | . ||||
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase Obscn.AA MSK 7047-7300 25 1.6e-43 144.99 In-house 1-277 (277) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-277/277
Sequence Identity: 25% (70 aa)

YDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIP-----LRSKTRAQAYQERDIL-ATLGHPLVTGLLDQFETRKTLILILELCSSEELLDRLFKKGVVTE
  |   .| | |. .... |.      |.| ..     .. || ... .|| .| .. .|| .  | . | .   . |..|.|.  ||. .. |..  .|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

AEVKVYIQQLVEGLHYLHSHGILHLDIKPPNILMVHPAR-EDIKICDFGFAQKITPS--EPQYSKYGSPEFVSPEIIEQ---NPV--SEGSDIWAMGVIS
.|. ... .||  . ..|. || | |.|| |||         .|. |||||   ...  .. .|  .. .. .||....   ...  .|  |.| .|||.
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YLSLTCSSPFA--GESDR---ATLLNV----LEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPSTSQCLAHPWF
|  ||  .||.  ... .   ..   .    ..|..|  .      |.||||.|.  |.. |  |....  .|| | 
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase Obscn.AA TyrKc 7047-7300 20 1.2e-11 -34.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 7047-7300
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPLRSKTRAQAYQERDILATL--GHPLVTGLLDQFETR-------KTLILILELCSSEELLDRL-FKKG
    ...|.| || | . . |   . .| | .   .  |.  ..|  |.  |   || .  |.    .        . | ...|...   |.|.|  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

VVTEAEVKVYIQQLVEGLHYLHSHGILHLDIKPPNILMVHPAREDIKICDFGFAQKITPS------EPQYSKYG--SPEFV------SPEIIEQNPVSEG
 .. ..   .  |  .|  ||||... | |.   |.|  ..    .||.||| . .|.        .  |.| .  .  ..      .|| |  .  .. 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDIWAMGVISY--LSLTCSSPFAG-----ESDRATLLNVLEGRVSWSSPT-----AAHLSEDAKDFIKATLQRTPRARPSTSQCLAHPWF
||.|. ||  .  ... . .|  |      |..  . .| .|.     |        . ...  . .|   .. |  ||. |..  |  |
SDVWSFGVCMWEIFTY-GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Obscn.AA Pkinase_Tyr 7116-7164 26 7.549835 0.11 Pfam 82-134 (270) Show / Hide 
Range on Protein: 7116-7164
Range on HMM: 82-134/270
Sequence Identity: 26% (14 aa)

LILILELCSSEELLDRLFK----KGVVTEAEVKVYIQQLVEGLHYLHSHGILH
.....|..    ||| | |    |. .|  .   . .|  .|. ||.|... |
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
I-set Obscn.AA I-set 8017-8099 33 2.2e-17 61.53 Pfam 1-84 (92) Show / Hide 
Range on Protein: 8017-8099
Range on HMM: 1-84/92
Sequence Identity: 33% (28 aa)

PSFLRELSDEAVVLGQSVTLACQVLAQPTAQATWSKDGVLLES-SGHLLISSTLKNFQLLTILVVKEEDLGTYTCCVSNPLGTA
|.|.. ..|  |  |..... |||  .|. | .| |||  | . | .  .. . .. . |||. |. .| |.||| ..|..|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEA
IGc2 Obscn.AA IGc2 8029-8097 36 3.2e-12 47.85 SMART 1-56 (56) Show / Hide 
Range on Protein: 8029-8097
Range on HMM: 1-56/56
Sequence Identity: 36% (25 aa)

VLGQSVTLACQVLAQPTAQATWSKDGVLLESSGHLLISSTLKNFQLLTILVVKEEDLGTYTCCVSNPLG
  |||||| | . . |... .| | |  |.            . . |||  |..|| |.||| ..|| |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Obscn.AA IG 8023-8109 23 1.6e-07 32.22 SMART 1-58 (58) Show / Hide 
Range on Protein: 8023-8109
Range on HMM: 1-58/58
Sequence Identity: 23% (21 aa)

LSDEAVVLGQSVTLACQVLAQPTAQATWSKDGVLLESSGHLLISSTLKNFQLLTILVVKEEDL---GTYTCCVSNPLGTAVT-TGVLRKAE
 .   |..|..||| | |      | .|.                       |||  |..||    |||.| ..   |..    |.  . .
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set Obscn.AA V-set 8017-8095 18 0.006267 11.93 Pfam 1-115 (128) Show / Hide 
Range on Protein: 8017-8095
Range on HMM: 1-115/128
Sequence Identity: 18% (22 aa)

PSFLRE--LS----DEAVVLGQSVTLACQVL-----AQPTAQATWSKDGVLLESSGHLLI---------------------SSTLKNFQL-----LTILV
.|..     .       |..|||||| |..       ... . .|...   . .. ...|                     . |. .        |||  
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

VKEEDLGTYTCCVSNP
....| |||.| |.|.
LQPSDSGTYYCAVWNC
FN3 Obscn.AA FN3 8111-8189 21 0.000513 20.59 SMART 1-69 (69) Show / Hide 
Range on Protein: 8111-8189
Range on HMM: 1-69/69
Sequence Identity: 21% (20 aa)

PSSSPR---PEVGELYKD------AVLLVWKPVESCGPVTYIVQCCIEGGSWTTLASDISDCCYLTGKLSRG----GMYIFRTACVSK--AGMG
|.. |.   ..| .  ..       | | |||         ||..                  |    |. |      | || ..|..  || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR-----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase Obscn.AA Trio 8227-8479 46 1.5e-220 572.78 In-house 1-258 (258) Show / Hide 
Range on Protein: 8227-8479
Range on HMM: 1-258/258
Sequence Identity: 46% (120 aa)

FAFQMQIRRGRFSVVRQCREKASGRALAAKIVPYQPEDKTAVLREYEALKRLHHPHLAQLHAAYLSPRHLVLILELCSGPELLPSLAERESYSESDVKDY
..||..|.||||||||.|..||.||..|||..||...||..|..|||.|..|.||....||..|..|||..||||||...|||..|....||.||.||.|
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

LWQMLSATQYLHAQHILHLDLRSENMMVTEYNL----LKVIDLGNAQSLDQEKVPAPENFKDYLETMAPELLEGQGAVPQTDIWAIGVTAFIMLSGEYPE
.||||.|..|||..||||||...||||...||.    .|..|.|.||.|...||..........|.||||...|......||||.|||....||||..|.
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

SSEGTRDLQKGLRKGLIRLSRCYAG-LSGGAVAFLQSSLCAQPWGRPCASTCLQCGWL
..|..|........|......||.. .|..|..|... |...||.|||||.|||..|.
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase Obscn.AA CAMK 8232-8479 18 5.2e-63 201.59 In-house 1-425 (425) Show / Hide 
Range on Protein: 8232-8479
Range on HMM: 1-425/425
Sequence Identity: 18% (79 aa)

QIRRGRFSVVRQCREKASG------------RALAAKIVPYQ-----------------------------PEDKTAVLREYEALKR-------LHHPHL
.. ||.|..|. |..| ..            .  |.||.. .                             |.|.  |.||.| .|.       |.||..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

AQLHAAYLSPRH-------------------LVLIL---ELCSGPEL----------LPS----------LAERESYSESDVKDYLWQMLSATQYLHAQH
 .|. .| .|..                   .....   |.||| ||           ..          . ||  ..|.... | .|..|| .|.| ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

ILHLDLRSENMMVTEY-----------------NLLKVIDLGNAQSLDQEK----------------------VPAPENFKDYLETMA-PELLEG-----
| |.||  || ....                  | .|.|| | |. .|. .                       .  . |   .| || ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QGAVPQTDIWAIGVTAFIMLSGEYPESSE-------------GTRDLQKGLRKGLIRLSRCYAG---------------------LSGGAV
         ..  |..|.|..||  .|||.|..|  ..               ..| .  .||  .    |                       .|  . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

AFLQSSLCAQPWGRPCASTCLQCGWL
 .... |.  |. |. .. ||.  |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Obscn.AA MLCK 8227-8418 33 3.4e-58 151.62 In-house 1-195 (257) Show / Hide 
Range on Protein: 8227-8418
Range on HMM: 1-195/257
Sequence Identity: 33% (68 aa)

FAFQMQIRRGRFSVVRQCREKASGRALAAKIVPY-QPEDKTAVLREYEALKRLHHPHLAQLHAAYLSPRHLVLILELCSGPELLPSLAERE-SYSESDVK
. .   . ||.|..|. |.||..|...|||...   |.||  |..|.| .. |||| | |.|.|. ...  |.|.|. || ||.    ...  ..|..| 
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

DYLWQMLSATQYLHAQHILHLDLRSEN-MMVT-EYNLLKVIDLGNAQSLDQEKVP------APENFKDYLETMAPELLEGQGAVPQTDIWAIGVTAFIML
.|. | . . ...| |.|.||||. || |..| . . .|.|| | |. .|  . .       || |       |||    .   .|||.|..|| ....|
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPE-F------VAPEVVNYDPVGFQTDMWSVGVICYMLL

SG
||
SG
Kinase Obscn.AA S_TKc 8227-8479 26 5.1e-43 150.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 8227-8479
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

FAFQMQIRRGRFSVVRQCREKASGRALAAKIVPYQPEDKTAVLREYEALKRLHHPHLAQLHAAYLSPRHLVLILELCSG--PELLPSLAERES------Y
. .  .| .| |..|..||.| .||  | ||..        ..|| . ||. |||.. .|. .. .  || ...|.|.|   .|.  . .| .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SESDVKDYLWQMLSATQYLHAQHILHLDLRSENMMVTEYNLLKVIDLGNAQSLDQEKVPAPENFKDY---LETMAPELLEGQGAVP-QTDIWAIGVTAFI
.| ... |..|...| .|.| ..|.| ||  || ...|   .|..| | |  |           . .   .. ||||.|   |  .   |.|..|.. ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLSGEYPESSEGTRDLQKGLRKGLIRLSRCYAGLSGGAVAFLQSSLCAQPWGRPCASTCLQ-------CGWL
||.|. | .     ..|. ..| .          |  |  |..  |.  |  || |  .||         |.
MLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Obscn.AA Pkinase 8227-8421 26 3.3e-37 132.63 Pfam 1-211 (293) Show / Hide 
Range on Protein: 8227-8421
Range on HMM: 1-211/293
Sequence Identity: 26% (57 aa)

FAFQMQIRRGRFSVVRQCREKASGRALAAKIVPYQPEDKTA---VLR--EYEALKRLHHPHLAQLHAAYLSPRHLVLILELCSGP----ELLPSLA--ER
. .  .| .| |..|..|..| .|.  | ||.... |..      .|  | . .|||.||.  .|. .. ...|. ...|.| |     .|   .   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ESY--SESDVKDYLWQMLSATQYLHAQHILHLDLRSENMMVT-EYNL---LKVIDLGNAQSLDQEKVPAPENFKDY---LETMAPELLE-GQGAVPQTDI
 ..  || ..|.|..|.|.. .|.|.. |.| || .|| ..  ....   .|..| | |  .|       . ....   .. ||||..  ||.  |  |.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAIGVTAFIMLSGEYP
|..|.. ..||.|. |
WSCGCILYEMLCGRPP
Kinase Obscn.AA DAPK 8229-8418 32 4.4e-37 99.47 In-house 1-202 (264) Show / Hide 
Range on Protein: 8229-8418
Range on HMM: 1-202/264
Sequence Identity: 32% (67 aa)

FQMQIRRGRFSVVRQCREKASGRALAAKIVP--YQPED-----KTAVLREYEALKRLH-HPHLAQLHAAYLSPRHLVLILELCSGPELLPSLAE--RESY
    . ||.|.|||.||.| .|.  ||| .       .         ..|   |. .  ||..  ||..|      .||||. || ||   ..|   |. 
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

SESDVKDYLWQMLSATQYLHAQHILHLDLRSENMMVTE--YNL--LKVIDLGNAQSLDQEKVPAPENFKDYLET---MAPELLEGQGAVPQTDIWAIGVT
.| |.   . | | .  ||| ..| ||||  .| | |   . .  .| || | .  ...      |.|.|   |    ||| .      . ||.|.||| 
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICN-----GEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVI

AFIMLSG
. |||||
TYIMLSG
Kinase Obscn.AA MSK 8236-8421 27 2.6e-34 113.39 In-house 10-209 (277) Show / Hide 
Range on Protein: 8236-8421
Range on HMM: 10-209/277
Sequence Identity: 27% (54 aa)

GRFSVVRQCREKASGRALAAKIVP-----YQPEDKTAVLREYEALKRL-HHPHLAQLHAAYLSPRHLVLILELCSGPELLPSLAERESYSESDVKDYLWQ
|.|...| |. . .| . |.||..      .   .  . .|  .|...  || . .|| |. .. |. |..|.|.|.||. ..  ||  .|| . ... .
GKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESECRMIMRE

MLSATQYLHAQHILHLDLRSENMMVTEY---NLLKVIDLGNAQSLDQEKVPAPENFKDYLETMAPELLEG--QGAV---PQTDIWAIGVTAFIMLSGEYP
  .| ...|  .| | ||  || . ..      .|.|| | |  . |..      .   |. ||||.|..  .. .   .. |.|  ||. . ||.|  |
LVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVP
Kinase Obscn.AA Ciliate-E2 8227-8421 16 2.4e-32 108.36 In-house 1-295 (365) Show / Hide 
Range on Protein: 8227-8421
Range on HMM: 1-295/365
Sequence Identity: 16% (51 aa)

FAFQMQIRRGRFSVVRQCREKASGRALAAK---------------------IVPYQPEDKTAVLREYEALKRLH----------------HPHLAQLHAA
. |. .| .| |..|..|. .  ..  | |                     .  ... .. ....|   .....                ||.. ... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YL--SPRHLVLILELCSGPELLP--------SLAERE---SYSESDVKDYLWQMLS---------------ATQYLHAQH-ILHLDLRSENMMVTEYNLL
.   .  .. |..|.|.| .|.         .. |.|   ...|  .|.. .| |.               | .||| .. |.| |.  || ..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVIDLGNAQSLDQEKV-----PAPENFKDYL--------------------------ETMAPELLEGQGAV---------PQTDIWAIGVTAFIMLSGEY
|.||.|... .|..       .  .....                            . |||| |.|..            . |||..||. ..||.|..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

P
|
P
Kinase Obscn.AA RSK 8229-8421 25 8.2e-29 102.05 In-house 1-211 (278) Show / Hide 
Range on Protein: 8229-8421
Range on HMM: 1-211/278
Sequence Identity: 25% (55 aa)

FQMQ--IRRGRFSVVRQCREKASGRALAAKIVPYQPEDKTAV-----LREYEALKRLH-HPHLAQLHAAYLSPRHLVLILELCSGPELLPSLAERES---
 ..   .  | ....| |. ...|.  | |..     .....     ..| . |.|   || . .|| |.  . .| ||.|.|.|.||.  | ....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YSESDVKDYLWQMLSATQYLHAQHILHLDLRSENMMVTE---YNLLKVIDLGNAQSLDQEKVPAPENFKDY-----LETMAPELLE----GQGAVPQTDI
 ||.....|. .  .| ..|| |.| | ||  ||.. ..      .|..| | .  .     .. .|.. .     .| ||||.|     . |   . |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-----RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDW

WAIGVTAFIMLSGEYP
|  ||  . ||.|  |
WSLGVLMYEMLTGCPP
Kinase Obscn.AA DRAK 8230-8418 29 8.1e-25 73.57 In-house 2-197 (259) Show / Hide 
Range on Protein: 8230-8418
Range on HMM: 2-197/259
Sequence Identity: 29% (60 aa)

QMQIRRGRFSVVRQCREKASGRALAAKIVPYQPEDKTA---VLREYEALKR-LHHPHLAQLHAAYLSPRHLVLILELCSGPELLP-SLAER-ESYSESDV
  .  ||.| |||.| .| .|.  ||| .      .     .|.|   |      |..  ||. |     ..|.||. .| |.    .|.. |  .| ||
AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDV

KDYLWQMLSATQYLHAQHILHLDLRSENMMVT-EYNL--LKVIDLGNAQSLDQEKVPAPENFKDYLET---MAPELLEGQGAVPQTDIWAIGVTAFIMLS
.  . | | . .||| . | ||||.  | . | || .  .|..| | .  . .      |.  .   |   .||| |.       ||.| ||| ...||.
QRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNG-----EEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLT

G
.
H
Kinase Obscn.AA RSK 8227-8366 27 2.6e-22 76.56 In-house 1-150 (271) Show / Hide 
Range on Protein: 8227-8366
Range on HMM: 1-150/271
Sequence Identity: 27% (41 aa)

FAFQMQIRRGRFS---VVRQCREKASGRALAAKIVPYQPEDKT---AVLREYEALKRLHHPHLAQLHAAYLSPRHLVLILELCSGPELLPSLAERESYSE
. ..  | .| ||   |.. |. |....  | ||.     | .       |   |   |||   .|| .. . ... .|.... | .|.  |    . ||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

SDVKDYLWQMLSATQYLHAQHILHLDLRSENMMVTEY----NLLKVIDLG
..||.|.   ..| .||| | | | ||  ||. . .       .|. |.|
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFG
Kinase Obscn.AA CAMKL 8235-8366 24 4.2e-21 63.96 In-house 9-174 (297) Show / Hide 
Range on Protein: 8235-8366
Range on HMM: 9-174/297
Sequence Identity: 24% (40 aa)

RGRFSVVRQCRE-KASGRALAAKIVPYQ----PEDKTA------------VLREYEALKRLH---HPHLAQLHAAYLSPRH------LVLILELCSGPE-
.| |..|. ..  .  |.  | ||.  .     . ...            . ||.. .|.|.   ||.  .|.  .  |.|      ..|..|.||| | 
KGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEM

-LLPSLAER----ESYSESDVKDYLWQMLSATQYLHAQHILHLDLRSENMMVTEYN--LLKVIDLG
 |.  . ..    .. .|.. . | .|..|| .|.| ..| | |.  || ...| .   .|.|| |
DLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFG
Kinase Obscn.AA CAMKL 8389-8421 38 1.4e-08 23.33 In-house 200-235 (297) Show / Hide 
Range on Protein: 8389-8421
Range on HMM: 200-235/297
Sequence Identity: 38% (14 aa)

MAPELLEG--QGAV-PQTDIWAIGVTAFIMLSGEYP
||||...|  .    |..|||..||. . |. |..|
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLP
Kinase Obscn.AA Pkinase_Tyr 8235-8362 22 1.2e-05 19.71 Pfam 9-152 (270) Show / Hide 
Range on Protein: 8235-8362
Range on HMM: 9-152/270
Sequence Identity: 22% (33 aa)

RGRFSVVRQCREK----ASGRALAAKIV--PYQPED--KTAVLREYEALKRL-HHPHLAQLHAAYL-SPRH--LVLILELCSGPELLPSLAE----RESY
.| | .|.... |      .   | |..   . .|.  . . .|| . .| | |||.. .|... .   ..  . ...|.. .  ||  | .    ... 
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPL

SESDVKDYLWQMLSATQYLHAQHILHLDLRSENMMVTEYNLLKV
. .|  .. ||  .. .||..... | ||.  | .||| |  |.
TMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKI
Kinase Obscn.AA DRAK 8445-8479 34 1.6e-05 12.55 In-house 225-259 (259) Show / Hide 
Range on Protein: 8445-8479
Range on HMM: 225-259/259
Sequence Identity: 34% (12 aa)

YAGLSGGAVAFLQSSLCAQPWGRPCASTCLQCGWL
. ..|  |. | || .  .|  |. |  ||.  ||
FSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase Obscn.AA RSK 8389-8421 45 0.004547 7.08 In-house 172-204 (271) Show / Hide 
Range on Protein: 8389-8421
Range on HMM: 172-204/271
Sequence Identity: 45% (15 aa)

MAPELLEGQGAVPQTDIWAIGVTAFIMLSGEYP
|||| |  ||     |.|  ||  ..||.|  |
MAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTP
Kinase Obscn.AA DAPK 8447-8479 33 0.030317 1.65 In-house 232-264 (264) Show / Hide 
Range on Protein: 8447-8479
Range on HMM: 232-264/264
Sequence Identity: 33% (11 aa)

GLSGGAVAFLQSSLCAQPWGRPCASTCLQCGWL
..|  |. | .. |   |  |. |  |||  |.
CTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI