Gene NEK4 (Mouse)

NEK4

Species: Mouse
Alias: NEK4, Nek4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK4

Sequence

Name Sequence Type Origin Length Description Download
NEK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 256 Kinase domain by global Sugen HMM Fasta, JSON
NEK4.AA Protein Sugen 792 None Fasta, JSON
NEK4.NA RNA Sugen 2714 None Fasta, JSON

Protein domain

Protein domains of NEK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK4.AA NEK4 6-261 73 4.3e-218 730.82 In-house 1-257 (257) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-257/257
Sequence Identity: 73% (189 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDG-LLYIVMGFCEGGDLYRKLKEQKGQLLP
||.|.|||.||||||.||.||||.||||.||..|.|||.|||.|||.||||||||||||||.||||||...| .||||||||||||||||||.||.|.|.
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

ESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKH
|.|||||||||||||||.||||||||||||||.|||..||||.||.||.|||.||.|||.|.||||||||||.|.|.||.||||.|.||||||||.||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTMLSRRPEERPSVRSILRQPYI
||.|||||||.|.||.|..||||..||..|..|...||...|..|||...|...|||
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK4.AA NEK 6-261 46 5.2e-159 534.56 In-house 1-286 (286) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-286/286
Sequence Identity: 46% (133 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQ-----YVIKKLNLRNASSRERRAAE-QEAQLLSQLKHPNIVTYKESWEGGD-GLLYIVMGFCE-GGDLYRK---
| . ...|.||.|.|..|....|||.     ||.|| |. | |..|...|  .|...|.||||||||.|..|..  . . |.||| .|| |||||.|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LKEQK--GQLLPESQVVEWFVQIAMALQYLHEK-----HILHRDLKTQNVFLTRTNI----IKVGDLGIARVLENHGDMAST-LIGTPYYMSPELFSNKP
.|.||  |....|.|...||.|...||.|.|..     .|||||.|.||.|||. |.    .|.||.||..||..  |||.| ..|||||||||...|||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNYKSDVWALGCCVYEMATL--KHAFNAK--DMNSLVYRIIEG-KLPPMPKV--YSTELAELIRTMLSRRPEERPSVRSILRQPYI
||.|||.|.|||..|||.||  ||.|.|.  .|.||...|..| . || |.   ||..| .||. || . ||.|||...|| .|.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK4.AA NEK1 6-261 47 1.5e-131 443.36 In-house 1-276 (276) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-276/276
Sequence Identity: 47% (131 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKES-WEGGDGLLYIVMGFCEGGDLYRKLKEQ--KGQL
| | ...| ||.| . ||||. ||..||||  |. . .. || ..  |. .|. .||||||.||||  |.| |.||||| .|.||||..| ..|  ||.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLT--RTN---------------IIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNY
 .| |   ||.|| .||.. | . |||||.|.||.|||  .                 ..|.|| ||||.| .  . |.| |||||| |||.  ||||| 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTMLSRRPEERPSVRSILRQPYI
|||.|.|||  ||  ||||.|.|. .  || .|..|  || |. ||.|| .|.  |..| |. |||| .|| .| |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK4.AA NEK8 6-261 37 2.6e-116 333.58 In-house 1-278 (278) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

YCYMRVVGRGSYGEVTLVKHRRDG--KQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKG-QL
|   ||||||. |...|   . |.  .. ..|  |.   |..||..|  | |.|| | ||||. | .. .  |. | |.|  ..|| ||... .|..  .
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFM-EDNTLMIEMEYADGGTLYQMIQHQQNKLF

LPES----------------QVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRT-NIIKVGDLGIARVLENHGDMA-S-TLIGTPYYMSPELFSNKPY
..|                 ...  |.|.  |. ..|.. ||||||||||.|.||  ...|.|| ||. ..     |. . |..|||||||||. . |||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

NYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEG-KLPPMPKVYSTELAELIRTMLSRRPEERPSVRSILRQPYI
| |||.|||||  |||..|| || |     ||  |. . .  | .  || |.  |..  |.  || |||.  |. .| .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK4.AA S_TKc 6-261 30 4.3e-93 316.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEG--GDLYRKLKEQKG---
|  .|..|.|..|.| ...|...|... ||...         . ...| |.|.. .|||||.......   . ||.|| .|.|  |||.. .|....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-QLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNY-KSDVWALGCCVYE
 . .|| ..  .. ||. ||.|.|...|.||||| .|..|..   ||..| |.||.|       .|..|||.||.||..   .|.. |.|.|..||..||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTMLSRRPEERPSVRSILR-------QPYI
|.. .  |       .....|           | |. ..|| .| . ||.||..  .|.        |..
MLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK4.AA Pkinase 6-261 28 6.4e-83 286.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQ--EAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGG----DLYRKLK-EQ
|.  |..|.||.|.| . .|. .||....|....|...| .....    |.|..  |.|||||......|  .. .|.|| .||||    ||.. .. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

KGQL-LPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNII----KVGDLGIARVL-ENHGDMASTLIGTPYYMSPELFS-NKPYNYKSDVWA
.| . ..| ..  .. ||. .|.|.|.. |.||||| .|... ... |    |..| |.|... . ..  ..|. |||.||.||.   ...| .|.|.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCCVYEMATLKHAFNAK------DMNSLVYRIIEGKLPPM-PKVYS-------------------TELAELIRTMLSRRPEERPSVRSILRQPYI
.|| .|||.. .  |  .      |.. ...|| ...|.   |. .|                    |. ..|. .| . |..||. . ||  |..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK4.AA NEK-Unclassified 6-261 36 7e-81 267.48 In-house 1-258 (258) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-258/258
Sequence Identity: 36% (96 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQ--LL
|  .  .| |  | | ||.|    |  .....  |    . ..       .||||.|| |||| .|.     | |    .|.||.| |... . .    .
YDKITTLGQGGGGAVYLVRHQI-SKRHLVQQISKR----KKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFY-TQDYCDGGNLDRRIQKHRKKNEPF

PESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLK
 |  .  |..|. ||.|| | . |.|||||.||.|||   ..  || ||.|...   | | | .||. .||||    .||| .||||.||| .|||.|  
DEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCE

HAFNAKDMNSLVYRIIEGKL------PPMPKVYSTELAELIRTMLSRRPEERPSVRSILRQPYI
 .| .. | .. . |  .         |  | ||| | ..||.|| | .. |||   |. |.||
PFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK4.AA NEK11 6-261 41 1.9e-73 250.35 In-house 1-259 (259) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-259/259
Sequence Identity: 41% (108 aa)

YCYMRVVGRGSYGEVTLV---KHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQK--G
|     .| ||.| | ||   | .|     |.| .        |   |  ||||||.|.|| || .  |.   |    |.  .||| ||  ...| |  |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFC-IITEYCEGRDLDYRIQEYKQAG

QLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMA
.. || |..|||.|. .   |.||. ||||||| .|.|| . |..|.|| |..|.|    |.| || ||| |||||    . |  |||.|.| | .||| 
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMC

TLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTMLSRRPEERPSVRSILRQPYI
 . |||   .  |.| .|.||. | .|  |  ||  ..  || . |  |||   ||. ||.
CMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK4.AA CAMK 11-261 19 1e-68 220.3 In-house 1-425 (425) Show / Hide 
Range on Protein: 11-261
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

VVGRGSYGEVTLVKHRRDG------------KQYVIKKLNLRNAS--------------------------SRERRAAEQEAQLLSQ-------LKHPNI
. ||||.|.| |..|....            ... || .. . ..                           . |.  ..| .....       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTYKESWE------------GGDG-------LLYIVM---GFCEGG----DLYRKLKEQKG-------------QLLPESQVVEWFVQIAMALQYLHEKH
.   | .|              .         .|.||    .|.||    ||. ...|...               ..|...  .| ||. |..|.|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKTQNVFLTRT-----------------NIIKVGDLGIARVLENH-----------------------GDMASTLIGTPYYMS-PELFSN-----
| |||||  |. |.                   | ||. | | |....                         |.. .|  |||.||. ||...      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVY-------------RIIEGKLPPMPKVYST-----------------------ELA
         ..|..|.|.|..|.  | | . .  |.... |. .              .|..||    |.  |.                       |  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELIRTMLSRRPEERPSVRSILRQPYI
 ||| || . ||.|...  .|. | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK4.AA NEK2 6-261 31 1.6e-67 226.37 In-house 1-319 (319) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-319/319
Sequence Identity: 31% (100 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVT-YKESWEGGDGLLYIVMGFCEGGDL---YRKLKEQKGQ
|    . |.||.| .  |..  |||  | | ..  .  . |. .   |  .|.||||||||  |          ||||| .||||||     | . .. |
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKER-Q

LLPESQVVEWFVQIAMALQYLHE------------------KH---ILHRDLKTQNVFLTRTNI------------------------------------
 ..|. .   . |.  |||  |                   .    |||||.|  |.||                                         
YMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYS

---IKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTM
   .| || | ||.|.     | | .|||||||||. .  .|| |||.|..|| .|||..|.  | |.    |   | .|.  . |  ||..| |.|  |
QVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

LSRRPEERPSVRSILRQPYI
.   .. |||.  ||..| |
INVDHYHRPSIEEILQHPQI
Kinase NEK4.AA Ciliate-E2 6-261 22 8.8e-65 221.3 In-house 1-365 (365) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQY------------------VIKKLNLRNASSRERRAAEQEAQLL----------------SQLKHPNIVTYKES
|   .. |.|..| | ..|.....||.                   ||. .. . . .. .. .|| ...                .||.||||. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WEG-GDGLLYIVMGFCEGGDLYRKLKEQ---KGQLLP------ESQVVEWFVQIA---------------MALQYLHEKH-ILHRDLKTQNVFLTRTNII
..   |  .|.|| .|.||||.  .|..   ... ..      | .. . . ||.                ||.|||.|. |.|||.| .|...     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVGDLGIAR----------------VLENHG----------------DMASTLIGTPYYMSPELFSNKP---------YNYKSDVWALGCCVYEMATLKH
|. |.|...                 . . .                .|. |..|||.||.|| ...|.         |.||.|.|.||.. ||| . |.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

AFNAKDMNSLVYRIIEG---KLPPM---------------PKVYSTELAELIRT----MLSRRPEERPS-VRSILRQPYI
 |         ...|.    ..|.                .|  | |   ||.     || . ||.|..    ||  |..
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK4.AA STE 6-261 23 1.3e-64 221.02 In-house 1-359 (359) Show / Hide 
Range on Protein: 6-261
Range on HMM: 1-359/359
Sequence Identity: 23% (84 aa)

YCYMRVVGRGSYGEVTLVKHRR---------------DGKQYVIKKLNLRNASS---------------RERRAAEQEAQLLSQLK--HPNIVTYKESWE
.  ....|.|..|.| . ...                 |. . ||..||.| ..                |.   ..| .......  |||||.|  . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GG------DGLLYIVMGFCEGGDLYRKLKE--QKGQLLP----------ESQVVEWFVQIAMA-LQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIAR
 .      |. |.|.| ...|| |   .|.   .|. |.          |||.    .||  . |.|||..|| |||.| .|..|     .|  | |.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLENHGD----------------MASTLIGTPYYMSPELFSN------KPYNYKSDVWALGCCVYEMATLKHAFNA-KDMNSLVYRIIE-----------
 |.....                .  |..||| .|.||  ..      |.|..|.|.| |||.. |||| |. .   ..|  . . ...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GKLPPMPK-------------------VYSTELAELIRTMLSRRPEERPSVRSILR--QPYI
   |. || |                     .| |. . |.  | . |..||..   |.   | |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK4.AA Pkinase_Tyr 6-202 28 3.5e-37 126.55 Pfam 1-210 (270) Show / Hide 
Range on Protein: 6-202
Range on HMM: 1-210/270
Sequence Identity: 28% (60 aa)

YCYMRVVGRGSYGEVTLVKHR----RDGKQYVIKKLNLRNASSRE--RRAAEQEAQLLSQL-KHPNIVTYKESWEGGDGL--LYIVMGFCEGGDLYRKLK
   ... |.|..||| . . .     .. .  .|.|   .|....  |..  .||....|| .||||| .       ..   .|||| ....|||.  |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EQ--KGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTLIG---TPY-YMSPELFSNKPYNYKSDVW
..   .| |. .. ... .|||....||..|.. |||| . |. .|..|..|..| | || ..| .   ..  |    |   |.|| .... .. |||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

ALGCCVYEMATL
. | . .|. |.
SFGVLMWEIFTY
Kinase NEK4.AA TyrKc 6-259 22 1.5e-29 105.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YCYMRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL--KHPNIVTYKESWEGG------DGLLYIVMGFCEGGDLYRKLKE
    .. |.| .||| . . .    |  .|.|.        |..  .||.....|  .|||||        .      .. |.||| ....|||   |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QKGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENH------GDMASTL--IGTP-----YYMSPELFSNKPYN
 ... |. .. ... .|||   .|||.|.. |||| . |. ... ...|..| | .| ....      .|. ..    |.        |.|| .  . ..
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

YKSDVWALGCCVYEMATLKHAFNA------KDMNSLVYRIIEGKLPPMPKV--------YSTELAELIRTMLSRRPEERPSVRSILRQP
 |||||. | | .|. |.            ..   .. .. .|. .| |.          ..|. .....   . ||.||. . | .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF