Gene HIPK4 (Mouse)

HIPK4

Species: Mouse
Alias: HIPK4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: HIPK

Sequence

Name Sequence Type Origin Length Description Download
HIPK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 337 Kinase domain by global Sugen HMM Fasta, JSON
HIPK4.NA RNA Sugen 2154 None Fasta, JSON
HIPK4.AA Protein Sugen 616 None Fasta, JSON

Protein domain

Protein domains of HIPK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HIPK4.AA HIPK 11-347 55 6.00000000001e-210 668.09 In-house 1-329 (329) Show / Hide 
Range on Protein: 11-347
Range on HMM: 1-329/329
Sequence Identity: 55% (186 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPDEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPA
|...|.||.||||.|.|.|.|.|.||||||||||..|..|....|...|.|......||.|..|..|.||......||||.|||||..|||.|.|.|||.
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

RHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHL
.|||....|||.||..||||..||||||||||||||.||||.|||||||||||..|.|  |...|.|||.||||||.|||||||..|.||||||.|||.|
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKV--VCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFL

GWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVSRLSFPDREA
|||||||..||||.||||.||.||..||||||.|.|.||.|  .     ||.||   .....| |. .| ||| . .|| .  ||      |      . 
GWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRD-KQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPER-----QDY

LAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV
..|..| ...|.. |.|.||..|.||.|..||.||||
RVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase HIPK4.AA DYRK 11-347 35 2.1e-149 502.66 In-house 1-320 (320) Show / Hide 
Range on Protein: 11-347
Range on HMM: 1-320/320
Sequence Identity: 35% (123 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGL-DPDEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPL-
| |.|..|||.|| |.|.| . |.|||||||..|  .  | ...|.|.|.. .   . |..|.......|.    ...|||||..||.|| |.|.| .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PARHIRTVTLQVLRALARLKEL-AIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAE
. ...|... |.| .|  |...  |||.|||||||||... |.. ..|||||||..  ..   .  .|||||||||||..||.|.|...|.|||||..||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQ---RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAE

LHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAA--RKAHHFFKRNPHPDATNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVSRLSF
|..||||.||.||||| ..|.|..|.|........  |..|.||..                  .  . ..  . ...  .  .......  .  .|.. 
LFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC------------------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPP

PDR--EALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV
  |  ... . .| .  . .||..|.|. |.||.|| ||.||..
GRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase HIPK4.AA CMGC 11-347 19 3e-101 333.52 In-house 1-513 (513) Show / Hide 
Range on Protein: 11-347
Range on HMM: 1-513/513
Sequence Identity: 19% (101 aa)

YDIIEVLGKGTFGEVAKGWR--------------RSTGEMVAIKILKNDAYRSR------------IIKNELKLLRCVR------------GLDPDEAHV
|.||...|.||.|.| |..               . |.|.||||..||. |               ..  |.|.|....              .... ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IRFLEFFHDAL-----------------KFYLVFELLEQNLFEFQKENNF-------APLPARH------------IRTVT------LQVLRALA--RLK
.. ...|..                   ..|||||.....|... |.|.|        ||.  |            |.  .       |.||.|.   . 
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ELA--IIHADLKPENIMLVDQTRCP----------------FRVKVIDFGSASIFSEV---------------------RYVKEPYIQSRFYRAPEILLG
     ||| |||||||.. ......                .|.|..|||.| ....                      .    .|...|.|||||||||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

LP----------FCEKVDVWSLGCVMAELHLG--------WPLYPGNNE-----------YDQVRYICETQGLPKPHLLHAAR-------KAHHFFKRNP
 .          .....|.||.||..||. .|        .|| ||..|           .||   |... | |  .......       .   ......
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIK

HPDA-----------------TNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVSRLSFPDR---EALAEH---------ADLKSMVELI
 |.                     .. ..|   . . . .|... .  .. .|  .  .        .|  .   |  ..|          . .  ..|.
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKK-----AMVF-NWIYEEKFKSHKFNHQFKRKCCDPQAIDLL

KRMLTWESHERISPSAALRHPFV
|.||... ..||... ||.||. 
KKMLQYDPDKRITAEQALQHPYF
Kinase HIPK4.AA S_TKc 11-347 20 5.6e-76 259.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-347
Range on HMM: 1-231/231
Sequence Identity: 20% (73 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPDEAHVIRFLEFFHDALKFYLVFELLEQ---NLFEFQKENNFAP
|.|....|||.||.| |.. ..||. |||||.|      . |..|...|.       .  ........|.|  ..|.|.|....   .||.. |...  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCE-KVDVWSLG
    .|  |.| .. |...||. . .. ||| |||||||.| .      ..|..|||.| ..         .. ...|.|||.|   ..   |.|.||.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVSR
|...|.  | |..|  ...   . |.                                                                          
CILYEMLCGYPPFP--QMQMMFKKIG--------------------------------------------------------------------------

LSFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALR-------HPFV
               ... ..|...|...  .|..   ||.       ||..
--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HIPK4.AA DYRK2 11-251 37 1.2e-75 245.38 In-house 1-243 (318) Show / Hide 
Range on Protein: 11-251
Range on HMM: 1-243/318
Sequence Identity: 37% (94 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPDEAH-VIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLP
| | ||.||| || |.|.    |...||||.. |     . .  |.. |   |  |.|... ... |..|.    ....||||  || |. |.|.|  . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

ARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSE-VRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAEL
 . .|  . ..| .|  |..  |||.|||||||.|  ..|    .|||||||     .   |.   |||||||||||. ||...   .| ||.||.||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRS--GIKVIDFGSSCFEHQYRIYT---YIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAEL

HLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAA-----RKAHHFFKR
  | || || || ||  .. |  |.| ....  .     ...  ||..
YTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNS
Kinase HIPK4.AA DYRK1 11-347 36 6e-72 245.33 In-house 1-321 (321) Show / Hide 
Range on Protein: 11-347
Range on HMM: 1-321/321
Sequence Identity: 36% (123 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPDEA-HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLP
|.|.  .||| || |.| . . . |.|||||.||        . |..||  .   |...  ....  . |       ||||||  ||..  .  .|    
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

ARHIRTVTLQVLRALARLK--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAE
   .|    |...||  .   || ||| |||||||.|.   |    .|.|||||.    .  |    ||||||||.||.|||...  ..|.|||||.. |
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS--AIKIIDFGSSCQLGQRIYQ---YIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVE

LHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVSRLSFPD
.| | ||. | || ||.  | |  |.|  |..  | ||| .|...|.    | |..| . | . .  . | .|.      |..|  |. ||  .|     
MHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPD----NTWYCKKTRDKKKH-YKEPCTRK------LHEILGVETGGPGGRRK---

REALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV
 |.    .| .   .|||||| .. ..||.|  ||.|.|.
GEPGHSVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase HIPK4.AA YAK 11-251 39 5.7e-67 226.45 In-house 1-241 (347) Show / Hide 
Range on Protein: 11-251
Range on HMM: 1-241/347
Sequence Identity: 39% (96 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCV-RGLDPDEAH----VIRFLEFFHDALKFYLVFELLEQNLFEFQKENNF
| .  .||.|||| |.|     | |..|.|..||        ||| ..||      ||.. .    ..| . ||     | ||||.|. ||.|. | |.|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

APLPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVM
  .    ||. | |.| ..  |..  ||| |||||||||    .    .|.|||||.    | . |   |||.|.||.|||... ..|  .| |||||..
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKP--EIKIIDFGSSC--QEKKMVYT-YIQQRHYRSPEIIVWMIYCTSIDMWSLGCIV

AELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKR
||| || |..||| ||.|.  | .. | |   ..   |    .|..
AELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHC
Kinase HIPK4.AA Pkinase 11-347 22 7.7e-54 189.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-347
Range on HMM: 1-293/293
Sequence Identity: 22% (81 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKN-----ELKLLRCVRGLDPDEAHVIRFLEFFHDALKFYLVFELLEQ-----NLFEFQ
| |....|.|.||.| |. ...||..||.||.| .  .|   ..     |..... ..       ...|....|.|  . |.|.|..|       ||.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

K---ENNFAPLPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIF-SEVRYVKEPYIQSRFYRAPEILL-GLPFCEK
.   ...|  .. .... . .|.||.|. . .  ||| |||||||.....  .. .||..|||.|  |          .  ...|.|||... | .   |
STWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDVWSLGCVMAELHLGWPLYPGN----NEYDQVRYICETQG--LPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSSADYLAETKVRPLERRKYMLKSLD
||.||.||...|. .| |..||     | .||   ||.. |  |. .      .   . |.. . .                                  
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------------------------------

QIETVNGGGAVSRLSFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV
                 . . .  |.  ... ..||..|..  ..|...  .| ||..
-----------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HIPK4.AA CDK 70-347 21 1.4e-38 120.93 In-house 67-284 (284) Show / Hide 
Range on Protein: 70-347
Range on HMM: 67-284/284
Sequence Identity: 21% (64 aa)

AHVIRFLEFFHDA-----------LKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRC--PFRVKV
..... .. .|.             |.|.||| ... | .. .           |.. ..| ||.|. . .  |.| |||| || |.. . .  . |.|.
PNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNI-LINNNGEVKCGRLKI

IDFGSASIFSE------VRYVKEPYIQSRFYRAPEILLGLPFC---EKVDVWSLGCVMAELHL---GWPLYPGNNEYDQVRYICETQGLPKPHLLHAARK
 ||| | .|.        . .  . .  . |||||.|||         .|.||.||..||. .   . || ||..| ||   |... | | .       |
ADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTK

AHHFFKRNPHPDATNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVSRLSFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRH
  ..                                                                         .|. .||. . . ||| ..|| |
LPDY-------------------------------------------------------------------------DLLNKMLCYDPKKRISAEQALQH

PFV
|. 
PYF
Kinase HIPK4.AA Ciliate-E2 11-205 20 1.1e-36 123.49 In-house 1-286 (365) Show / Hide 
Range on Protein: 11-205
Range on HMM: 1-286/365
Sequence Identity: 20% (60 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIK---------------------ILKNDAYRSRIIKNELKLLRCVRGLD------------PDEAHVIRFLE
|..|...|.|.|| | |. ........|||                     .  .  .  ..||.|....|...  .             .  ..|.. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

FFH--DALKFYLVFELLEQ-NLFEFQKENNFAPLPA---------RHIRTVTLQVLR---------------ALARLKELA-IIHADLKPENIMLVDQTR
.|   |  ..|||.|.... .||.. |.|.   .           ..|.... |.|.               ||  |..   ||| |.|||||..     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

CPFRVKVIDFGSASIFSEV----------RYVKEPY----------------------IQSRFYRAPEILLGLP---------FCEKVDVWSLGCVM
    .|.|||| . ....              ..                        . .  | ||||| | .           .|.|.||||...
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase HIPK4.AA RCK 86-236 35 3.3e-34 105.71 In-house 76-235 (298) Show / Hide 
Range on Protein: 86-236
Range on HMM: 76-235/298
Sequence Identity: 35% (57 aa)

YLVFELLEQNLFEFQKE--NNFAPLPARH--IRTVTLQVLRALARLKELAIIHADLKPENIMLVD-----QTRCPFRVKVIDFGSA-SIFSEVRYVKEPY
|.|||....||... |.      .|| .   |.    |.| .|| . .  . | ||||||||. .     . . ....|..|||.. .| |.  |    |
YFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTD--Y

IQSRFYRAPEILLGL-PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKP
. .| |||||.||      ...|.|..||.|.||   .||.||..| ||   ||.  | |..
VSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNK
Kinase HIPK4.AA CLK 11-146 32 1.6e-32 94.25 In-house 1-149 (350) Show / Hide 
Range on Protein: 11-146
Range on HMM: 1-149/350
Sequence Identity: 32% (48 aa)

YDIIEVLGKGTFGEVAKGWRRSTG-EMVAIKILKN-DAYRSRIIKNELK-LLRCVRGL-DPDEAHV---IRFLEFFHD-ALKFYLVFELLEQNLFEFQKE
| |. .|| |||| | . | .. |   ||.|| .| . ||    . |..  .. .    ||.  .    .. .. |    ... .||||.  ....| |.
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREA-AWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKS

NN------FAPLPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVD
||      ..|.| .|||  . | ..|.  | .. ..| ||||||| .||
NNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVD
Kinase HIPK4.AA CLK 154-222 38 3.3e-22 62.75 In-house 186-254 (350) Show / Hide 
Range on Protein: 154-222
Range on HMM: 186-254/350
Sequence Identity: 38% (27 aa)

VKVIDFGSAS-IFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYD
..|||||||  |  .  . . . ...| |||||. |||.. .. |||| ||.  || .|  |...... .
ICVIDFGSATKIRFDHEH-HSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNRE
Kinase HIPK4.AA RCK 11-44 52 2.9e-13 38.16 In-house 1-34 (298) Show / Hide 
Range on Protein: 11-44
Range on HMM: 1-34/298
Sequence Identity: 52% (18 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKN
| ||. ||.||.|.| |. .  ||| |||| .|.
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQ
Kinase HIPK4.AA CDK 11-45 32 2e-10 29.37 In-house 1-40 (284) Show / Hide 
Range on Protein: 11-45
Range on HMM: 1-40/284
Sequence Identity: 32% (13 aa)

YDIIEVLGKGTFGEVAKGWRRSTG-----EMVAIKILKND
|...| .| ||.|.| |.  . ||     ..||.| .. .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRME
Kinase HIPK4.AA TyrKc 11-249 20 7.8e-10 -63.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-249
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCV--RGLDPDEAHVIRFLEFFHDA-------LKFYLVFELLEQ-NLFEFQ
   ...|| | |||| ||  .   ..||.| ||.||   . . .|..... .  .       ...|..    .           ..|.|. .  .| .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KENNFAPLPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFG-SASIFSE-------VRYVKEPYIQSR-----FYRAPEIL
...    |. ..     .|. .  . | .  .|| ||   |... ..     .||. ||| |  | ..         |.|    ...        ||| .
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LGLPFCEKVDVWSLGCVMAEL-HLGWPLYPG-----NNEYDQVRYICETQGLPKPHL--------------------LHA-------ARKAHHFF
    | .| |||| | .| |.  .| . |||      . .. ..|. .   .|.|.                      |.        .  |..|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HIPK4.AA RCK 320-347 39 2.2e-09 25.6 In-house 271-298 (298) Show / Hide 
Range on Protein: 320-347
Range on HMM: 271-298/298
Sequence Identity: 39% (11 aa)

MVELIKRMLTWESHERISPSAALRHPFV
..||.. ||.|   .||....||.||. 
CIELMEKMLQWDPQKRITAQQALQHPYF
Kinase HIPK4.AA DYRK2 324-347 50 3.1e-09 25.85 In-house 295-318 (318) Show / Hide 
Range on Protein: 324-347
Range on HMM: 295-318/318
Sequence Identity: 50% (12 aa)

IKRMLTWESHERISPSAALRHPFV
||| ..|. .||..|| ||.||. 
IKRCFEWDPSERMTPSQALKHPWI
Kinase HIPK4.AA Pkinase_Tyr 11-46 40 6.8e-08 27.36 Pfam 1-40 (270) Show / Hide 
Range on Protein: 11-46
Range on HMM: 1-40/270
Sequence Identity: 40% (16 aa)

YDIIEVLGKGTFGEVAKGWRR----STGEMVAIKILKNDA
  ....||.| |||| ||  .    .|.  ||.|.||..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGA
Kinase HIPK4.AA CLK 322-347 42 0.000225 8.23 In-house 325-350 (350) Show / Hide 
Range on Protein: 322-347
Range on HMM: 325-350/350
Sequence Identity: 42% (11 aa)

ELIKRMLTWESHERISPSAALRHPFV
.||..||  .   ||. . || ||| 
DLIRKMLEYDPSKRITCKDALQHPFF
Kinase HIPK4.AA Ciliate-E2 318-347 28 0.000335 10.3 In-house 331-365 (365) Show / Hide 
Range on Protein: 318-347
Range on HMM: 331-365/365
Sequence Identity: 28% (10 aa)

KSMVELIKR----MLTWESHERIS-PSAALRHPFV
...  |||.    ||  .  .||. .. .| ||. 
QECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase HIPK4.AA YAK 334-347 50 0.001134 7.91 In-house 334-347 (347) Show / Hide 
Range on Protein: 334-347
Range on HMM: 334-347/347
Sequence Identity: 50% (7 aa)

ERISPSAALRHPFV
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ERWKPMQAMQHPFI
Kinase HIPK4.AA Pkinase_Tyr 183-208 46 3.673033 1.17 Pfam 182-207 (270) Show / Hide 
Range on Protein: 183-208
Range on HMM: 182-207/270
Sequence Identity: 46% (12 aa)

APEILLGLPFCEKVDVWSLGCVMAEL
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APECINYGKFTTKSDVWSFGVLMWEI