Gene FGFR4 (Mouse)

FGFR4

Species: Mouse
Alias: FGFR4, Fgfr4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
FGFR4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 277 Kinase domain by global Sugen HMM Fasta, JSON
FGFR4.AA Protein Sugen 799 None Fasta, JSON
FGFR4.NA RNA Sugen 3069 None Fasta, JSON

Protein domain

Protein domains of FGFR4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 FGFR4.AA IGc2 45-105 34 6.8e-14 53.4 SMART 1-56 (56) Show / Hide 
Range on Protein: 45-105
Range on HMM: 1-56/56
Sequence Identity: 34% (22 aa)

ALGQPVRLCCG---RTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMT
  ||.|.| |.   . .   |||| |..|.       |...|.| .. |||.|.| |.||... 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR4.AA IG 39-115 23 4.9e-08 33.94 SMART 1-58 (58) Show / Hide 
Range on Protein: 39-115
Range on HMM: 1-58/58
Sequence Identity: 23% (19 aa)

EQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDA---GRYLCLARGSMTVVH--NLTLLMD
 . .|| .|..|.| |  .    .||                  |.| .  |||.   | | | |. ....    . ||   
PP-VTVKEGETVTLTC-VS--QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set FGFR4.AA V-set 22-98 17 0.218612 6.61 Pfam 1-110 (128) Show / Hide 
Range on Protein: 22-98
Range on HMM: 1-110/128
Sequence Identity: 17% (21 aa)

SEEMEQ--EPCLAPILEQQEQVLTVALGQPVRLCC-GR-------TERGRHWYK-EGS------------RLASA-----------GRVR------GWRG
.....|  .. . |.      ..||..|| |.| |  .       ..   .||.   .            .. .            |||.      . . 
QSQVTQHPPRGC-PW------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDF

RLEIASFLPEDAGRYLC
 | | .  |.| | | |
SLTISNLQPSDSGTYYC
I-set FGFR4.AA I-set 63-103 29 18.956734 0.64 Pfam 34-80 (92) Show / Hide 
Range on Protein: 63-103
Range on HMM: 34-80/92
Sequence Identity: 29% (14 aa)

WYKEGSRLAS---AGRVRGWRG----RLEIASFLPEDAGRYLCLARGS
|.| |. |..     ... ..|    .|.|    |.|.| | | |. |
WFKDGQPLRPDSDRHQMT-YDGDGTYTLTISNVQPDDEGKYTCVATNS
IGc2 FGFR4.AA IGc2 160-228 37 1.6e-20 75.38 SMART 1-56 (56) Show / Hide 
Range on Protein: 160-228
Range on HMM: 1-56/56
Sequence Identity: 37% (26 aa)

PAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLG
  |..| ..|||.||| |.|||.| ||                 |.|  ..| |.|.|.|||...|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FGFR4.AA I-set 159-238 32 2.1e-13 47.97 Pfam 12-92 (92) Show / Hide 
Range on Protein: 159-238
Range on HMM: 12-92/92
Sequence Identity: 32% (26 aa)

VPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRH-QHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDV
|  | |..| | . |.| |.. |.||||  .  ..   .. .. .. .| .. | |.| |.||| ..||.|.   .  | |
VQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG FGFR4.AA IG 154-239 19 1.5e-12 48.97 SMART 1-58 (58) Show / Hide 
Range on Protein: 154-239
Range on HMM: 1-58/58
Sequence Identity: 19% (18 aa)

KKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDR---GTYTCLVENSLGSIRY--SYLLDVL
 . . | .| ||...| ..     .|.|.                       |.. .| |.|    |||.| ..   |..    .  | |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGv FGFR4.AA IGv 164-223 19 0.000608 10.44 SMART 1-76 (76) Show / Hide 
Range on Protein: 164-223
Range on HMM: 1-76/76
Sequence Identity: 19% (15 aa)

TVKFRCPAAGNPMPTIHWLKD-------GQAFHG-----ENRIGGIRL-----RHQHWSLVMESVVPSDRGTYTCLV
.|.  | . |. . ..||..        |.. .       .|. . .          ..|.| .. |.| |||.| .
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
V-set FGFR4.AA V-set 159-226 20 0.013688 10.76 Pfam 18-115 (128) Show / Hide 
Range on Protein: 159-226
Range on HMM: 18-115/128
Sequence Identity: 20% (20 aa)

VPAGNTVKFRCPAAGNP----MP-TIHWLKDGQAF------------HGENR------IGGIRLRHQ--------HWSLVMESVVPSDRGTYTCLVENS
|. | .|...|    ..    .. .|.| .. |              |  ..       .  . | .        ..|| . .. ||| |||.| | |.
VQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNC
IG FGFR4.AA IG 253-348 21 2.1e-16 61.75 SMART 1-58 (58) Show / Hide 
Range on Protein: 253-348
Range on HMM: 1-58/58
Sequence Identity: 21% (22 aa)

PANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDA---GEYTCLAGNSIGLSYQ--SAWLTV
|  .|...|..|.| | |      .|.|.                                 | . ||..||.   |.|.| |    |  ..  ...|||
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTV

L
.
Q
IGc2 FGFR4.AA IGc2 259-337 26 8.3e-09 36.51 SMART 1-56 (56) Show / Hide 
Range on Protein: 259-337
Range on HMM: 1-56/56
Sequence Identity: 26% (21 aa)

VVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIG
  | .|.| |..  .  | |.|.|     |..                        | ..||. ||.|.|||.| |..|
HEGQSVTLTCPATGNPDPNIHWYK-----GQPLP------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set FGFR4.AA V-set 246-347 17 1.3e-05 21.23 Pfam 1-128 (128) Show / Hide 
Range on Protein: 246-347
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

PI-LQAGLPA----NTTAVVGSDVELLCKVYSDA----QP-HIQWLK-HVVINGSSFGA---------DGFPYVQVLKTTDINSSEVEV-----LYLRNV
.. ...  |.      |...| .|.| |.. .|     .. .|.| . .   ... . .         .| .|..  .   .  |         | ..|.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

SAEDAGEYTCLAGNS-IGLSYQSAWLTV
. .| | |.| . |. ..   .. .|||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set FGFR4.AA I-set 318-347 50 7.9e-05 18.9 Pfam 63-92 (92) Show / Hide 
Range on Protein: 318-347
Range on HMM: 63-92/92
Sequence Identity: 50% (15 aa)

RNVSAEDAGEYTCLAGNSIGLSYQSAWLTV
.|| ..|.|.||| | || | .  .| |||
SNVQPDDEGKYTCVATNSFGEAECTAELTV
IGv FGFR4.AA IGv 263-332 17 0.002894 3.65 SMART 1-76 (76) Show / Hide 
Range on Protein: 263-332
Range on HMM: 1-76/76
Sequence Identity: 17% (15 aa)

DVELLCKVYSDAQPHIQWLKH------------VVINGSSFGADGFPYVQVLKTTDIN----SSEVEVLYLRNVSAEDAGEYTCLA
.|.| ||.  .   .. |...            ...           |   .  .  |    |.    | ..|. .|| | |.|  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY---------SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
I-set FGFR4.AA I-set 253-282 26 0.085587 8.6 Pfam 7-36 (92) Show / Hide 
Range on Protein: 253-282
Range on HMM: 7-36/92
Sequence Identity: 26% (8 aa)

PANTTAVVGSDVELLCKVYSDAQPHIQWLK
| . .. .|..... |.|  | .| ..|.|
PKDVEVQEGETARFECQVTGDPPPQVSWFK
Kinase FGFR4.AA FGFR 464-740 69 1.2e-232 779.16 In-house 1-293 (293) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-293/293
Sequence Identity: 69% (204 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
|.|||.|||||||||..|||.|.|..||....||||||||.|..||||.|||||||.||.||.|||||||||.||||||||||||....||||.||||||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PPGPDLSPDGP-------RSSEGP--------LSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRL
|||.| ..|..       |..|..        |... ||||||||||||.||.|||||||||||||||||.|.||||.||||||..|.||||.||.||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIP-VEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEAL
|.|||||||||||||||||||||.|.|||||.|.||.|||.|| ||||...|.||||||.|.||..|.| .|..|||..|.||||||||||.|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FGFR4.AA Pkinase_Tyr 464-740 45 1.5e-157 534.22 Pfam 1-270 (270) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-270/270
Sequence Identity: 45% (129 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKD--LADLVSEMEVMKLIGRHKNIINLLGVCT-QEGP--LYVIVECAAKGNLREF
...|| ||||.||.|......|   .  ... .|||||||..|....  ..|. .|...|| .|.|.||..|.|||| |..|  .|...| ...|.|...
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYY-KKTSNGRLPVKWMAPEA
||..|            ....||. . |.. ..|.|.||.||||..||||||||||.||||. |.||.|||||| ... ||| .|...|.||.||||||.
LRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LFDRVYTHQSDVWSFGILLWEIFTLGGSP-YPGIPVEELFSLL-REGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEAL
......|..|||||||.|.|||||.|..| |||.. ||.. .. ..|.||..|.||| |.| ||..|||. |..||||....| |
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGFR4.AA TyrKc 464-740 39 5.3e-151 508.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-280/280
Sequence Identity: 39% (121 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIG-RHKNIINLLGVCTQE-------GPLYVIVECAAKGNL
..||| ||||.||.|.....            .|||||||..|    ..|. .|...|. .| .|.||..|.|||||.       .||....| ...|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

REFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHI-------DYYKKTS--NG
...||..||                |. . |.| ..|.|.||.||.|..||||||||||.||.|. ..||.||||.| ...        |||.|..  .|
KDYLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R--LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG-----IPVEELFSLLREGHRMERPPN--------CPSELYGLMRECWHAAPSQRP
.  ||..|||||.......|..|||||||...|||||.|..||||     .. .|.. ....|.||..|||        ||.|.| .|..|||. |..||
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TFKQLVEAL
||....| .
TFSEIHECF
Kinase FGFR4.AA TK 464-740 27 8.4e-137 460.78 In-house 1-486 (486) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-486/486
Sequence Identity: 27% (136 aa)

LVLGKPLGEGCFG---QVVRAEAFGMDPSRPDQT------------------STVAVKMLK--DNASDKDLAD--------------LVSEMEVMKL-IG
..||| |||| ||   .| ..|..|..|.....                    .|||||||  |..|...  |              ...||..|.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHKNIINLLGVCTQE------------GPLYVIVECAAKGN----LREFLRARRPPGPDLSPDGP-----------------------------------
.|.||..|.|||||.            .|.....|....|.    ||..||..||.. . .. ..                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----RSSEGPLSFPALVS-------------------CAYQVARGMQYLESRKC------IHRDLAARNVLVTEDDV-----------MKIADFG----
     . .. ||..  |..                   ...|.|.||.||.|..|      .||||||||.||.|..|            ||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARGVHH------------------------IDYYKKTSNGRLPVKWMAPEALFDRV---------YTHQSDVWSFGILLWEIFTLG-GSPYPGIP
    ||| ...                         |||...|.|.||..|||||.|.|||         .|..|||||||.|.|||||.| . .|.|..
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

V---------EELFSLLREG--------------HRMERPPNCP--------------SELYGLMRECWHAAPSQRPTFKQLVEAL
          .|.. .||.|              .||..||.||               |.| ||..|||. |..||||.||.|.|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGFR4.AA Ret 464-742 46 5.8e-126 424.76 In-house 1-293 (293) Show / Hide 
Range on Protein: 464-742
Range on HMM: 1-293/293
Sequence Identity: 46% (140 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDN-ASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG--PLYVIVECAAKGNLREFLR
|.|.. |||| |||||.| || .   .|  | |||||||| | |.   . || ||... |..  | ..| |.| |.|..  |. .||| .  | ||||||
LQLDDTLGEGHFGQVVKAQAFHIR-GHPGYT-TVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

ARRPP--------------GPDLSPDGPRSSEGPLS-----FPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYK
  |                ..|. |||    . ..      .  ..| | |. .||.|| . | .||||||||||| |  ..|| |||| | |   | | 
LSRKIGPYYEYSIGNRNCSIVDH-PDG----KDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYV

KTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALD
| | .|.||||||.|.|.| ||| .|||||||.|.||| |.|..|||||| | |..||. |.||.|| ||  |.| .|| ||   |  || || .   . 
KRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFE

K
|
K
Kinase FGFR4.AA TK-Unique 464-740 44 4.2e-120 405.31 In-house 1-294 (294) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-294/294
Sequence Identity: 44% (132 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG-PLYVIVECAAKGNLREFLRAR
|..|. .||| |||| |.|..| .    |... ||||||||||.| | .|. .| ..|| .|.|.||...||.||  . | . | | ...|||. .|| .
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RPP--GP--------DLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLES--RKCIHRDLAARNVLVTEDDVMKIADFGLARGVHH-IDYYKKTSNGRLP
||.  ..        |.  . .. .. |.|   |.. |.|.|.||.||.|  .|..||||.|||||.||| | ||.|||.|| |..  .| ...| ||.|
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VKWMAPEALF--DRVY-THQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNC-PSELYGLMRECWHAAPSQRPTFKQLVEAL
..|||||.|   ...| | .|||||||.|.|||||||. ||||.| ...  ..|.|.||..|..| . |.| ||..||.  |..||.| |..  |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FGFR4.AA UTK 464-740 36 1.1e-107 364.08 In-house 1-296 (296) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-296/296
Sequence Identity: 36% (112 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLK-DNASDKDLA---DLVSEME---VMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLR
. ||..||.| ||.| .|..   ..| . ... |||| .. . .. .. .   |.  |     .||    | |...|.||||||.|.....|....|.||
VQLGRQLGQGAFGEVHKARF--TQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

EFLRARRPPGPDLSPDGPRSSEGPLSFP--ALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTED-------DVMKIADFG---LARGVH---------
 .||  ||  |          . |...    ....|...|||||||.|....||||||||.||...        | ||||||   ..|.|.         
SYLRRHRPTPP----------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYW

HIDYYKKTSNGRLPVKWMAPEALFDR-VYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG--HRMERPPNCPSELYGLMRECWHAAPSQRPT
  .||......|.|..||||||| ..  .|..|||||||...|||.| |  ||||.  ....  ...|  .||..|. || ..| ||..|||. |. ||.
ESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPD

FKQLVEAL
|..||...
FEDLVQQM
Kinase FGFR4.AA Src 464-740 41 5.1e-103 348.54 In-house 1-255 (255) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-255/255
Sequence Identity: 41% (117 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
. | . ||.|.|| |  .          ...  |||| ||      . ...  | ..||   ||.....|. ||.|| | | . |  ..|.| ..|..  
IKLCRKLGQGQFGEVWMG--------YWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PPGPDLSPDGPRSSEGP-LSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHI-DYYKKTSNGRLPVKWMAPEALFDR
            ..||  |..| |.. | |||.||.||||.. |||||||||||| |. | |.||||||| . .  | |   .  ..|.||.||||.  .
------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYG

VYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYG-LMRECWHAAPSQRPTFKQLVEAL
..|  ||||||||||.||.| |  ||||   .| .  .  | || .|.||| |||  .|..|||. | |||||. | . |
RFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGFR4.AA InsR 464-742 37 1.4e-96 324.91 In-house 1-278 (278) Show / Hide 
Range on Protein: 464-742
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
.||....|.| || |    | |. |  ..    .|.| ...|||...  .  .| .||| .  ......|||||..  | ||. |  ..|.|. .||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

PPGPDLSPDGPRS-SEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRV
|   .   ....     . .   ... | ... || ||...| .|||||.|| .| .|   ||.|||..| .   |||.|   | ||| ||||| | | |
PEEEF--NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL-REGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDK
.| .|||||||..|||. |||  || |   |.      ..|  ...| |||  .. ||. ||.  |. ||||..... |  
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase FGFR4.AA RTKB 464-740 40 2.2e-96 325.45 In-house 1-264 (264) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-264/264
Sequence Identity: 40% (112 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
. ||. ||.| ||.| .|    .  .  ...  .|.| ||  ||  .  |  ||| ||| .| | |.| ..| | |. |. . || .  ||||..||..|
VWLGEKLGNGAFGEVFQAW---VRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR

PPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVY
         ....  ..|..  ||. . |.|.|| .|.... |||||.||||||. .   ||.|||.|| . | .|  .|   |||.|||||| . .| |
---------ASQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECY--ETTCTRLPIKWMAPESWAHRIY

THQS-DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEAL
| .| ||||||.  ||||.||| ||.  .. ..|..|. |||.. |   |.. ...|. || . ...||.|. ||.|.
TTKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FGFR4.AA VEGFR 586-740 57 2.5e-95 323.01 In-house 175-332 (332) Show / Hide 
Range on Protein: 586-740
Range on HMM: 175-332/332
Sequence Identity: 57% (91 aa)

LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARG-VHHI-DYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLG
|.. ..|||||| .|.|||||||||||||.|..|..| || ||||||       || .|.. |||| ||||||..||.||| .|||||.|..|||||.||
LICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLG

GSPYPGIP-VEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEAL
||||||.   ||... |..| ||..|  |. |.|  | .|||  | .||.|  ||| |
GSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FGFR4.AA PDGFR 580-740 55 6.1e-89 285.67 In-house 197-358 (358) Show / Hide 
Range on Protein: 580-740
Range on HMM: 197-358/358
Sequence Identity: 55% (90 aa)

PLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEI
.|..  |.. .||||.|| .|.|  |.||||||||||...  | || |||||| . .   |    | |||||||||| .|| ||| ||||||.|||||||
VLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEI

FTLGGSPYPGIPVEELF-SLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEAL
|.|||.||||.||.. |  . .|| ||..|   |.| |  |..|| . | .||||.||.. |
FSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FGFR4.AA S_TKc 464-744 23 2.2e-50 174.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 464-744
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK--GNLREFLRA
  .....|.| ||.| ..   .           ||.|..|         .. .|....|   .|.||..|..|.   . ||.. |..    |.|..... 
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

RRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDR
|...|..           |..     . .||......|. |.. |||||   |.|..|  . ||.|||||| .         .       .|||| |   
RGRHGLR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

VYTH-QSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVE-----ALDKVL
 |..  .|.||.|..|.| .. |  |.|   ....| ...           ..|.  ..| |..  |..|||  .. .     ...  .
GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGFR4.AA Pkinase 464-740 21 4e-48 171.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 464-740
Range on HMM: 1-293/293
Sequence Identity: 21% (69 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKML-KDNASDKDLADLVS--EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG----NLR
...|...|.| ||.| ..    .. . ..   .|||| . |...... .  ..   | ..|| . .|.||. |..... .. .|.. |.. .|     | 
YHIGRKIGSGSFGCVYKC----HHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

EFLRARRPPGPDLSPDGPRSSEGPL--SFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVM----KIADFGLARGV-HHIDYYKKTSNGRLP
.....              ...|..  |   . ...||..||..|. |...|||||   |.|. ....     ||.|||||. . .  .   .|  | ..
DYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

VKWMAPEALF-DRVYTHQSDVWSFGILLWEIFTLGGSPYPGI----PVEELFSLLREGHRMERPPNCP-----------------------SELYGLMRE
  .|||| .  .. |.. .|.||.|..|.| .. |  |.||     .  .   ....  . . . ..|                       .|.  ... 
--YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CWHAAPSQRPTFKQLVEA--L
|..  |..|||..|...   .
CLCKDPKKRPTAEQILQHPWF
Kinase FGFR4.AA VEGFR 464-563 48 1.5e-38 134.41 In-house 1-101 (332) Show / Hide 
Range on Protein: 464-563
Range on HMM: 1-101/332
Sequence Identity: 48% (50 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCT---QEGPLYVIVECAAKGNLREFLR
| |||.||.| ||||. |.||| . ...  . |||||||| .|     . |.||..... || | |  |.|| ||   | ||| ||||   .|||  .||
LKLGKMLGRGAFGQVHEASAFGIRKMET--CTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

ARR
. |
TKR
Kinase FGFR4.AA PDGFR 464-563 45 1.8e-32 101.25 In-house 1-98 (358) Show / Hide 
Range on Protein: 464-563
Range on HMM: 1-98/358
Sequence Identity: 45% (45 aa)

LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
|..|| || | ||.|| | |.|.  |. . . .|||||||  |       | ||  .|   | | ||.|||| ||  || |.| |    | | ..|. .|
LQFGKTLGSGAFGKVVEATAYGL--SKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR