Gene CDC2 (Mouse)

CDC2

Species: Mouse
Alias: CDC2, Cdc2a
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
CDC2.AA Protein Sugen 297 None Fasta, JSON
CDC2.NA RNA Sugen 2860 None Fasta, JSON
CDC2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CDC2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2.AA CDC2 4-287 68 1.2e-234 729.47 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-301/301
Sequence Identity: 68% (206 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEG--VPSTAIREISLLKELR-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQF
| |||||||||||||||.... |.||||.||||||.|.||  ||||||||||.||||. |||||.|.||..| ..||..||.|.||||||.| |||... 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT--HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL
|...|||||..|||||. |||.||..||||||||.|||.||.||.||||||||||||||.||  |||||||||.||.|||. |||||||.|||| ||||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKN---------LDENGLDLLSKMLVYDPAKRISGKMALKHP
   .||||||||||||||||.||| |||||.. ||.|..|.|||||||.|||  | ....|         ||..|.|||..||.|||.|||| |.||.||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase CDC2.AA CDK 4-287 52 3e-189 610.82 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-284/284
Sequence Identity: 52% (168 aa)

YIKIEKIGEGTYGVVYKGRHRVTG-----QIVAMKKIRLES-----EEEGVPSTAIREISLLKELRHPNIVSLQDVLMQD-----------SRLYLIFEF
| |.|||||||||||||.|.. ||     ||||.||||.|.     |.||.|.|||||||||||| |||||.| || ...           ..||..||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT-----IKLADFGLARAFGI------PIRVYTHEVVTLWYRS
. .|||||.|            .|.|..|.|.|. .|||....||||||||.||...|.     .|.|||||||||||      |.|.|||||||||||.
MDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRA

PEVLLGSARYS--TPVDIWSIGTIFAELAT---KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSK
||.|||| .||  ||.|.||.| ||||..|   .||||.|||||||||.||| .|||. ..||.|..|.||                        |||.|
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNK

MLVYDPAKRISGKMALKHPYF
||.|||.|||| . ||.||||
MLCYDPKKRISAEQALQHPYF
Kinase CDC2.AA CDK5 4-287 57 6.30000000001e-179 570.49 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 57% (167 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSS
| |.|||||||||.|||.| . |. |||.|..||.|| |||||||||||.|||||.|.||| | ||.  . .| |.|||.  |||||.||.     ||  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG--EMDMH

LVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELA-TKKP
..||.. | |.|. |||...|||||||||||||  .|. ||||||||||||||.| |.||||||||| | ||.||  |||..|.||.| ||||.| . .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK---NTFPKWKPGS-LASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYF
|| | .. |||.|||. .|||. . || .  | |||   . .|.. .   ....|..|||.|.|||.|||...|..||| | ||.||||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDC2.AA CMGC 4-287 27 6.00000000001e-153 506.57 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-513/513
Sequence Identity: 27% (144 aa)

YIKIEKIGEGTYGVVYKGRH--------------RVTGQIVAMKKIRLES---------EEEGVPSTAIREISLLKELR-----------------HPNI
| .|.||||||||||||.|.              . |..|||.|||...          |..|.|..|.|||..||.|.                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VSLQDVLMQDS-----------------RLYLIFEFLSMDLKKYLDSIPP-------------------------GQFMDSSLVKSYLHQILQGIV--FC
|.|.|... .                   |||.||.. .||..|... ..                          ...   ... | .|||.|.   .|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

HSRR--VLHRDLKPQNLLIDDK--------------------GTIKLADFGLARAFGIP---------------------IRVYTHEVVTLWYRSPEVLL
||..  ..||||||.|.||...                    |..|..||||||.....                      | |||.|||.|||.||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GSARYS---------TPVDIWSIGTIFAELATK--------KPLFHGDSE-----------IDQLFRIFRALGTPN---------------NEVWPEVES
|. .|.         ||.|.||.| ||||. |.        ||||.|.||           |||||.||. ||||.                | ||.. .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LQDYKN--------------T------------FPKWKPGSLASHVKN-----------------------------------LDENGLDLLSKMLVYDP
|..|..              .            ||.|.| .. . ...                                   .|. ..|||.|||.|||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

AKRISGKMALKHPYF
.|||. . ||.||||
DKRITAEQALQHPYF
Kinase CDC2.AA CDK7 4-287 44 1.6e-147 396.14 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-288/288
Sequence Identity: 44% (131 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIR-LESEEE---GVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYL--DSIPPG
| ||..||||....|||..  .|||||| |||. | . .|   |.  |||||| .|.|..|.|.. | |..|. | ..|.|.|.  ||       ||   
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSI---

QFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL
  .  . .|.|  ..|||. .||   .||||||| |||..  | .|.|||||||..| | |.||| ||| |||.|| | |   | | ||.||.| |||||
-ILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL

ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYF
    | . |||.|||| |||..||||. | ||.. ...|| ..| .. .     |        .  |||...|.  .| ||..   .||.|||
MLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY-IKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC2.AA PCTAIRE 4-287 50 2.9e-139 468.98 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-291/291
Sequence Identity: 50% (148 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSS
|||..| |||||  |||.| . |. .||.| ||||  ||| | |||||.||||.|.| |||.| |.. ..  | |.||.. ||||.|.|    |. |.. 
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDC--GNIMNMH

LVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPL
 || .| |.| |  .|| |..||||||||||||. .|  ||||||||||  .| ..| |||||||||.|.||.||  |||..|.| .| ||.|..| .||
NVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPL

FHGDS------EIDQLFRIFRALGTPNNEVWPEVESLQDYKN-TFPKWKPGSLASHVKNLD---ENGLDLLSKMLVYDPAKRISGKMALKHPYF
| |          |||  ||| |||| .. ||.|.|......  ||.... .| .|   ||   ... |||...| | . .|.|   |.|||||
FPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase CDC2.AA PITSLRE 4-287 43 7.6e-128 431.02 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-295/295
Sequence Identity: 43% (128 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLE--SEEEGVPSTAIREIS-LLKELRHPNIVSLQDVLM--QDSRLYLIFEFLSMDLKKYLDSIP-PG
. .. .|.||||||||... . |. |||.|.. .|   | || | |..|||. .|..|.|||||..  ..|       |...|..  |||  .. .    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL
|    . .|. . | | |. . |.  ..|||||  |||.  ||  |..|||||| .| ||. ||  |||||||.||.|||.  ||||||.||.| ||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN-T-FPKWKPGSLASHVK---NLDENGLDLLSKMLVYDPAKRISGKMALKHPYF
 |.|||| |.|||||. .|| ..|||.   || . .|   |. . ||. ... | ....    . ..|.||| .|| |.|..||.   |||||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDC2.AA PFTAIRE 4-287 48 2.7e-123 415.89 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 48% (142 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSS
| |.|| |||.|  ||||. ....|.||.| |||. .|||.| ||||| ||||.|.| ||| | |.   .  | ..||..  ||..|.|. | |  |.  
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGG--MHPN

LVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPL
 |. .| | | |  .|| ||||||||||||||| ..|  ||||||||||  .| . | ||||||||| | |||||  ||| .|.| .| || |. . .|.
NVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPA

FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK---WKPGSLASHVKNLD--ENGLDLLSKMLVYDPAKRISGKMALKHPYF
| |     ||| .||. ||||. . || | .|  ||    .    || .|   .  ..   .. ||..||| . | .|.| . |..||||
FPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDC2.AA Pkinase 4-287 34 8e-112 382.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-293/293
Sequence Identity: 34% (105 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIR--EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-----DLKKYLDSIPP
| ...|||.|..|.|||..|. ||.|||.|.|....|..... |..|  ||...|.|.||||| | |. . ....|...|.. .     ||. |.     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

GQFM--DSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI----KLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWS
.  .  .   .|.|. |||.|. .|||....||||||.|.|||..|.|    |..|||||. |   . . .|. ..|.||..|||..|.  |...||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGTIFAELATKKPLFHGD----SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHP
.| |..|.....|.| |.    . .||...|.| .|.|. . ||.  |  ... ... | .  .    .|..|...|.....| .||.||.. . .|.||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase CDC2.AA CDK4 4-287 46 4.90000000001e-108 365.23 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-290/290
Sequence Identity: 46% (137 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEE--GVPSTAIREISLLKELR---HPNIVSLQDV--LMQDSR----LYLIFEFLSMDLKKYLD
| ..  |||| || ||. |   ||..|| |..|  ..||  |.|   |||||... |    |||||.| ||   |   |    . ..||    ||. |||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SIPP-GQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIG
 .|| |  |    .|   ||.| |. | || |. ||||||||.|.   |..||||||||| ..      |  |||||||.||||| |  | ||||.||.|
KCPPPG--MPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMAL-TPVVVTLWYRAPEVLLQSY-YNTPVDMWSVG

TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYF
 ||||.   .||| | || ||| .||   |.|  . ||   ||      ||  .| .. . .  ... |.||| ||| |...||.|   .|.||||
CIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDC2.AA S_TKc 4-287 30 4.8e-106 359.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM---DLKKYLDSIPPGQF-
| ...|||.|..|.|||.||. ||.|||.|.|.          ...|||..||. .||||| | ||    ..||...|...    ||..|... ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST-PVDIWSIGTIFAE
  ..   ...|..||.... .|||....||||||.|.|.|.  .||..|||||| .       |. ..|.||..||||     |.. ..|.||.| |..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALK-------HPYF
... .|.|.      |....|. .|                                   .. ..|...|.|..||.||..   ||.       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2.AA CRK7 4-287 35 3.7e-104 352.34 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-343/343
Sequence Identity: 35% (123 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESE---EEGVPSTAIREISLLKELRHPNIVSLQDVLMQ--------DSR--LYLIFEFLSMDLKKY
| .|. ||||||| ||| .   ||..|| ||.|.. |   .|| | |||||| .|..| |.||| | ..           . .   |..||    ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDSIPPG--QFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI--RVYTHEVVTLWYRSPEVLLGSARY-----
|.|   .  .    . .|... |.| |.  || . .||||.|  |.|.. .| .|.||||||| .      | ||  |.||||| || |||  ||     
LES---KEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKW--KP
                                  . .|.|| | |..||.||||.| |  |..||  |..  |.|| ..||||  |. ..   ||   . 
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNR

GSLASHV---K--NLDENGLDLLSKMLVYDPAKRISGKMALKHPYF
 ..   .   |  ....  |||| |||..|| ||.. . .| |..|
RLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDC2.AA Pkinase_Tyr 4-152 30 6e-26 88.51 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-152
Range on HMM: 1-160/270
Sequence Identity: 30% (51 aa)

YIKIEKIGEGTYGVVYKGRHR----VTGQIVAMKKIRLESEEEGVPSTA------IREISLLKEL-RHPNIVSLQDVLM-QDSR--LYLIFEFLSM-DLK
 ....|.||| .|.||||. .     |.. || |...     ||  . .      .||....|.| .|||||.|  | . |.    .|...|.    ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYLDSI-PPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARA
.|| .  ...|  . .   .. .|| .|  . .|..  ||||   | |.......| .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDC2.AA TyrKc 4-234 23 1.1e-14 14.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-234
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKEL--RHPNIVSLQDVLMQD-------SRLYLIFEFLSM-DLKKYL-D
  ...|.||| .|.||||. .   . || |... ..         .||......|  .||||| |  | .|.         |....|. .  |||.|| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--------VYT-----HEV--VTLWYRSPEVLLG
. |       .   |. .|| .|  . ||... ||||   | |.....|.| .||||.|.  |           .|.     ..   . .   .||..  
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

SARYSTPVDIWSIGT----IFAELATKKPL----FHGDSEIDQLFRIFRALGTPNN------------------EVWPE-----------VESL
  ...|  |.|| |     ||   ..  |     .  ..|. .. .  . .  | |                  . | |           .| .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF