Gene ALK2 (Mouse)

ALK2

Species: Mouse
Alias: D330013D15Rik, ALK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
ALK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON
ALK2.AA Protein Sugen 509 None Fasta, JSON
ALK2.NA RNA Sugen 1664 None Fasta, JSON

Protein domain

Protein domains of ALK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ALK2.AA Activin_recp 33-107 24 1.9e-26 89.42 Pfam 1-121 (121) Show / Hide 
Range on Protein: 33-107
Range on HMM: 1-121/121
Sequence Identity: 24% (30 aa)

YMCV-CEGLS------CG-NE-------DHCE-----------GQQCFSSLSINDG---FHVYQK----GCFQVYEQGK----MTCKT----PPSP---G
..|. |.| .      |. ||       ..||           ..||. |...||.    ...|.    ||....|...    ..||.    ...|   |
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

QAVEC-CQ-GDWCNRNITAQL
. .|| |. .|.||||.| ..
HNHECWCCETDYCNRNLTPPP
Kinase ALK2.AA Type1 208-495 74 3.8e-277 760.63 In-house 1-290 (290) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-290/290
Sequence Identity: 74% (216 aa)

ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR
|...||.|||||||||||.|.|||||||||.||||.|||||||.|.|||.||||||||||.||....|.|||||||.|||.|||||||. .|||| ..||
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

IVLSIASGLAHLHIEIFGTQ--GKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIW
...|.|.||||||.||||||  || ||||||.|||||.||||||||||||||||.|.|.|.|.|.|.||||||||||||||||||....||.|||..||.
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

AFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL
.||||.||.|||....||||||..|.||.||||||||||||||||...|||||||| |.|.....||||||||||||.||.|||||||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase ALK2.AA STKR 208-495 59 1.4e-219 715.94 In-house 1-312 (312) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-312/312
Sequence Identity: 59% (185 aa)

ITLLECVGKGRYGEVWRGSWQG----ENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSR-HSSTQLWLITHYHEMGSLYDYLQLTTLDT
|.|.||.|||||||||.|.|.|    |.||||||.||||.|||||||.|.|.|.||||||.|||.||... .| ||.||||.|||.|||.|||. .|.|.
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

VSCLRIVLSIASGLAHLHIEIF--GTQ--GKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVG-------NNPRVGTKRYMAPEVLDETI
 ...|. .|.|.|||||| ||.  |||  .| ||||||.||||||||..|.|||||.|||..|...|||.|..       .|..|||||||||||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

QVDCFDS-YKRVDIWAFGLVLWEVARRMVSNG------IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWF-SDPTLTSLAKLMKECWYQNPS
...||.| .||.|..|.|||.||.|||. ..|      ||..|..||||.|||.||||||.||||...|||||||||  ..| ..|..|.|.|||...|.
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLTALRIKKTL
||||||..|||.
ARLTALCVKKTM
Kinase ALK2.AA Type2 208-495 39 2.6e-111 368.83 In-house 1-315 (315) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-315/315
Sequence Identity: 39% (125 aa)

ITLLECVGKGRYGEVWRGSWQGE-----NVAVKIFSSRDEKSWFRETELYNT-VMLRHENILGFIASDM---TSRHSSTQLWLITHYHEMGSLYDYLQLT
|.|.| .||||.|.||...|...      ||||||. .|  ||  | ..| . ....||||| ||...           ..||.| .|. |||.|||   
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TLDTVSCLRIVLSIASGLAHLHIEIF-GTQ---GKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQ--------LDVGNNPRVGTKRYMAPEV
|.| ..|.|. .|.| |||||| ||  ..|    | .|||||.||||.||| .. |||||.|||.  . ....         |  |   |||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDETIQVD-CFDSYKRVDIWAFGLVLWEVARRMVSNG---IVEDYKPPFYDVVPND-PSFEDMRKVVCVDQQRPNIPNRWFSDPTLT-SLAKLMKECWYQ
|. ...   | |. |..|. |.||||||.. |    .    | .|..||   | .  ||||||. .|  . .||..|. |   |... .|  .. .|| .
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NPSARLTALRIKKTL
 . |||||. ..  .
DAEARLTAQCVQERM
Kinase ALK2.AA TKL 214-495 29 3.4e-111 375.71 In-house 1-364 (364) Show / Hide 
Range on Protein: 214-495
Range on HMM: 1-364/364
Sequence Identity: 29% (110 aa)

VGKGRYGEVWRGSWQG----------ENVAVKIFSSRD-------------------------EKSWFRETELYNTVM---LRHENILGFIASDMTSRH-
.|.|..|||..| |.|          . ||||.|.|..                         | ||||..| . ..|   |||.||. |..... ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF--GTQGKSAIAHRDLKSKNILVKKNGQ--------------C
        ...||.... |.. |||..||.         .|..|.||.|...|| ...  .|  | .|.|||||||||||..|..              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CIADLGLAVMHSQSTNQLDVG---------------NNPRVGTKRYMAPEVLDETIQVDC----------FDSYKRVDIWAFGLVLWEVARRMVSNGIVE
.|.|.||. ..|||.|. | .               .....||.|.||||||..... ..          |.  ...|...||.||||.. | .      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

DYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFS-------DPTLTSLAKLMKECWYQNPSARLTALRIKKTL
 |..|.......|| ||.| ..||....|| ||..| .       .....|..|||..|| ..|..|.....|.|.|
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ALK2.AA Pkinase 208-495 22 4.1e-77 267.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-293/293
Sequence Identity: 22% (75 aa)

ITLLECVGKGRYGEVWRGSWQGEN--VAVKIFSSRDEKSWFRET-----ELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMG----SLYDYLQ
.......|.| .|.|... ..|..  |||||.. |.||||...|     |..   .|.|.||. .. . ..    .. ..... |.|.|    .|.||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---LTTL--DTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQC----CIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVL
    ...  .   | .... |..||...| .         | |||||. |||...||..    .|.| |||  ..   .  .. .. ..|| .||||||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTL-----------------TSL
      .. .  ..||.|..|..|.|.. .           |||.. . ....  |.....| . ..|.  ... ...                    ..
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

AKLMKECWYQNPSARLTALRIKKT--L
 ...| |. ..|. |.||  |..   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ALK2.AA MLK 208-414 26 1.3e-36 124.59 In-house 1-229 (291) Show / Hide 
Range on Protein: 208-414
Range on HMM: 1-229/291
Sequence Identity: 26% (65 aa)

ITLLECVGKGRYGEVWRGSWQGEN-----VAVKIFS-------SRDEKSWFRETELYNTVMLRHEN----ILGFIASDMTSRHSSTQ-LWLITHYHEMGS
|...| .|.| .|.||.| |....     ||||..        . .. .|  |.| .   .|.|.|    |  | .      ..... . ....| | ||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV----CLQPPCHFCIVMEYCEGGS

LYDYLQLTT---------------LDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVK------KNGQCCIADLGLAVMHSQS-TNQL
||..|   .                |  . ... | .|.|.. || .      . .| ||||||.|||.       ..|.. |.| |.. . .|. ||  
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM-----APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM

DVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV
.     . || ..|||||.   .. . ..  . .|.| .|.||||.
S-----NAGTYAWMAPEVIQQ-FRCEKYS--EKCDVWSWGVVLWEM
Kinase ALK2.AA TKL-Unique 210-495 26 1.3e-36 126.64 In-house 1-290 (290) Show / Hide 
Range on Protein: 210-495
Range on HMM: 1-290/290
Sequence Identity: 26% (85 aa)

LLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETE-LYNTV----MLR-HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQ-------
 .. .| | ||.| .| | |. ||.|.|.   |.| ..... ..| |    .|. |.||. ...  |    .  .. ... | ..|||||.|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----LTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKN-----GQCCIADLGLAVMHSQSTNQLDVGNN-----PRVGTKRYM
     ..|.    ..... ||.|. .||     ....  |.||||||.|.||  |      .  |.| ||.   |....    ...      |.|. |.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLH----HCEPP--IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV--DQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
|||||        ..  . .|...|| ||||    .... |   || |. ..     ..|  ...| .  . .|| |||..       .. .|...|| .
APEVLRMNF----CQYSEKSDVYSFGIVLWE----IATRKITKTYKKPYQGM-----DQEQWCEMVHYMEENYRPPIPNHC-----PKEYRDLIQQCWHH

NPSARLTALRIKKTL
.|| | .   | . |
DPSQRPSFDEIIHRL
Kinase ALK2.AA S_TKc 208-502 20 1.6e-31 111.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 208-502
Range on HMM: 1-231/231
Sequence Identity: 20% (64 aa)

ITLLECVGKGRYGEVWRGSWQG--ENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEM--GSLYDYLQLTT----
 ..|. .||| .|.|... . .  . ||.|| .    ..  || ..      .|.||  .. .  .     . |.... | .   |.|.||..       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF
   ..   . ...  |...|...|        .  | |||||  |||. .  .  |.| |||              .  .||  |||||||         
RFPFPE-HARFYMYQICCALEYCH--------SHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

DSYK--RVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK-
 .|   ..|.|..| .|.| . .          .|||.         . | |...                   ..  ... |.  .|. |.||  . . 
-GYGKCKCDWWSCGCILYEMLCG----------YPPFP-------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

-TLTKIDNSL
  . |..  .
EWDIKCHPWF
Kinase ALK2.AA TK 208-414 16 2.9e-25 80.98 In-house 1-387 (486) Show / Hide 
Range on Protein: 208-414
Range on HMM: 1-387/486
Sequence Identity: 16% (65 aa)

ITLLECVGKGRYG---EVWRGSWQGEN---------------------------VAVKIFS---SRDEKSWFR-----------------ETELYNTVML
|||..  |.| .|   ||..| |.|.|                           ||||.     . ...  |                  | .. .  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILGFIA----SDMTSRHS----STQLWLITHYHEMGS----LYDYLQ-------------------------------------------------
.|.||. ...    ..  .. .    .  ..... | . |.    | |||.                                                 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LTTLDTVSCLR----------------IVLSIASGLAHLHIEIF-GTQGKSAI---AHRDLKSKNILVKKNGQ-----------CCIAD
           ||| | ... .                . . ||.|...||   . .      |    ||||   |.|| .|..           | |||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEF------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIAD

LGLAV-------MHSQSTNQLDVGNNPRVGT-----------------------KRYMAPEVLDETIQVDC---FDSYKRVDIWAFGLVLWEV
 ||.           .|     . .....|.                        |.||||.|.. .   .          |.|.|| ..||.
FGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase ALK2.AA STE 208-488 18 5.4e-20 67.37 In-house 1-348 (359) Show / Hide 
Range on Protein: 208-488
Range on HMM: 1-348/359
Sequence Identity: 18% (70 aa)

ITLLECVGKGRYGEVWRGSWQ--------GEN---------VAVKIFSSRDEKS---------------WFRE---TELYNTVMLR--HENILGFIASDM
 ...|..||| .|.| ..           ||.         .|.|. . .....                 ..    |.     ..  |.||  .. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TSR--HSS-TQLWLITHYHEMGSLYDYLQL--TTLDT-------------VSCLRIVLSIASG-LAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCC
     |.. ..||..  | . ||| | ..    ....                 .|. .|  | |..||           | |||.|. |||.     . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----VK

IADLGLAVMHSQSTN------------QLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPND
..| |..   ..|                .  .|  |||  .|||||..   |    . |  ..||| .|....| |          . |||. |  |  
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA----------TGKPPWHDMHPMR

PSFEDMRKVVCVD---------QQRPNIPN------------------RWFSDPTLTSLAKLMKECWYQNPSARLTA
  |. ... ....         .. | .|.                  . .|..    .   .. |   .|. | ||
AMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE----FKDFINKCLQKDPNKRPTA
Kinase ALK2.AA Ciliate-E2-Unclassified 208-411 17 3.1e-19 63.38 In-house 1-260 (352) Show / Hide 
Range on Protein: 208-411
Range on HMM: 1-260/352
Sequence Identity: 17% (50 aa)

ITLLECVGKGRYGEVWRGSWQGEN-------------VAVKIFSSRDEKSWFRETELYNT----------------VMLRHENILGFIASDMTSRHSSTQ
 ..... |.| .|.|..     ..             ...|.  . |   .. ..|. |                 ... |..|. ..  .     .   
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF----QDKQN

LWLITHYHEMGSLYDYLQLTT------------------LDTVSCL-----RIVLSIASGLAHLHIEIFGTQGKSA-IAHRDLKSKNILVKKNG---QCC
. ... | | |.| .|..                     ..   ..     ..   | .|| .||        ..  | |||.|  |||...||   ...
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH--------HKNNIIHRDIKPENILFDNNGKNYYIK

IADLGLAVMHSQSTNQLDVG-------------NNPRVGTKRYM----APEVLDE-TIQVDCFDSYKRVDIWAFGLVL
|.|.|.. ...|. |. | .              . ..|| .||    |||||..       .   . .|||..| .|
IIDFGIS-KKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVIL
GS ALK2.AA GS 178-208 67 3.4e-18 67.71 SMART 1-31 (31) Show / Hide 
Range on Protein: 178-208
Range on HMM: 1-31/31
Sequence Identity: 67% (21 aa)

STLAELLDHSCTSGSGSGLPFLVQRTVARQI
.|........||||||||||.||||||||||
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
TGF_beta_GS ALK2.AA TGF_beta_GS 178-206 62 1.6e-17 60.67 Pfam 1-29 (29) Show / Hide 
Range on Protein: 178-206
Range on HMM: 1-29/29
Sequence Identity: 62% (18 aa)

STLAELLDHSCTSGSGSGLPFLVQRTVAR
.|........||||||||||.|||||.||
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase ALK2.AA TyrKc 208-495 23 1.1e-16 46.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVML--RHENILGFIASDMTSR---HSSTQLWLITHYHEMGSLYDYLQLTT--L
|||..  | | .|||..| |  ..||||   .  ..   || ..    .|  .|.||. ...  ...     .. .|.... | . |.| |||. .   |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMC--KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

DTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQS------TNQLDVGN--NPR-VGTKRYMAPEVLDETI
 .   | . . ||.| ..||           . ||||   |.||..|... |.| ||.  .         .   ..    . . .   | ||||..    
CMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

QVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDP-----TLTSLAKLMKECWYQNPSARL
.  .| .    |.|.|| ..||    . ..|     ..| .... .. | ..... |     .|  ||     |       . . ..||.||  .|. | 
NYGKFTTK--SDVWSFGVCMWE----IFTYG-----QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDRP

TALRIKKTL
|   |.. .
TFSEIHECF
Kinase ALK2.AA Pkinase_Tyr 208-320 25 3.4e-11 38.54 Pfam 1-128 (270) Show / Hide 
Range on Protein: 208-320
Range on HMM: 1-128/270
Sequence Identity: 25% (33 aa)

ITLLECVGKGRYGEVWRGSWQ------GENVAVKIF--SSRDE---KSWFRETELYNTVML-RHENILGFIASDM-TSRHSSTQLWLITHYHEMGSLYDY
||...  |.| .|||..| |       .  ||||.   .. .|   .  | . |.     | .|.||. ...  .  ....  |..... | . |.|.||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDY

LQLT-----TLDTVSCLRIVLSIASGLAHLH
|.        |..   | . . ||.|...|.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase ALK2.AA Dicty4 306-387 32 1.1e-09 28.66 In-house 112-189 (277) Show / Hide 
Range on Protein: 306-387
Range on HMM: 112-189/277
Sequence Identity: 32% (29 aa)

LR---IVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAV----MHSQSTNQLDVGNNPRVGTKRYMAPEVL
.|   . ...| |...||  .      . | |||||| |.|| || .  ..|.||.       ....||  .     .||  .|||||.
KRAMRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-----CGTPCWMAPEVM
Kinase ALK2.AA Dicty4 208-244 37 1.2e-09 28.57 In-house 1-37 (277) Show / Hide 
Range on Protein: 208-244
Range on HMM: 1-37/277
Sequence Identity: 37% (14 aa)

ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKS
|.  .  ||| .||| .|.| |  ||||.. .. ...
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNF
Kinase ALK2.AA Pkinase_Tyr 334-414 29 2.7e-08 28.72 Pfam 134-207 (270) Show / Hide 
Range on Protein: 334-414
Range on HMM: 134-207/270
Sequence Identity: 29% (24 aa)

HRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL-DVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV
||||  .|.||..|... |.| |||  . ... .   .. . .    . ||||.. . .    | .    |.|.|| ..||.
HRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK-LPIKWMAPECINYGK----FTTK--SDVWSFGVLMWEI
Kinase ALK2.AA TK 473-495 34 0.000106 10.84 In-house 464-486 (486) Show / Hide 
Range on Protein: 473-495
Range on HMM: 464-486/486
Sequence Identity: 34% (8 aa)

LMKECWYQNPSARLTALRIKKTL
||..||  .|. | |   ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase ALK2.AA Dicty4 448-485 34 0.000161 11.18 In-house 231-263 (277) Show / Hide 
Range on Protein: 448-485
Range on HMM: 231-263/277
Sequence Identity: 34% (13 aa)

VCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR
||  . || ||     | ...|...|...||  .|. |
VCNKKLRPPIP-----DWCPPSWKHLIQWCWDHDPQHR
Kinase ALK2.AA Pkinase_Tyr 470-495 38 0.004567 11.01 Pfam 245-270 (270) Show / Hide 
Range on Protein: 470-495
Range on HMM: 245-270/270
Sequence Identity: 38% (10 aa)

LAKLMKECWYQNPSARLTALRIKKTL
. .|||.|| ..|. | |   |   |
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ALK2.AA MLK 469-485 52 0.00745 5.89 In-house 265-281 (291) Show / Hide 
Range on Protein: 469-485
Range on HMM: 265-281/291
Sequence Identity: 52% (9 aa)

SLAKLMKECWYQNPSAR
...||||.|| |.|. |
HWKKLMKQCWNQDPHKR