Gene sgg (Fruit Fly)

sgg

Species: Fruit Fly
Alias: zeste white 3, sgg/zw3, EG:BACR7C10.8, ZW-3, zeste-white3, l(1)zw3, DMSGG3, Zeste white-3, sgg46, Zw3, sgg, zw3/sgg, Zw-3, GSK3beta, EG:155E2.3, CG2621, Zw3[sgg], zeste-white 3, zw3(sgg), Zw3-sh, zw3, GSK3, zeste white-3, GSK-3, zw-3, sgg10, SGG/GSK3b, l(1)3Ba, sgg39, zw[3], sgg-zw3, zest-white 3, SFO060, shaggy-zeste white 3, zw3[sgg], Zw3 kinase, Sgg, Zw3/GSK3, ZW3, DMZ3K25Z, Zeste-white 3
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 3A9--B1,

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
sgg.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
sgg.AA Protein Various 1008 None Fasta, JSON

Protein domain

Protein domains of sgg.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase sgg.AA GSK 548-832 59 4.2e-230 710.93 In-house 1-328 (328) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-328/328
Sequence Identity: 59% (195 aa)

YTDTKVIGNGSFGVVFQAKLC----DTGEL----VAIKKVLQDRRFK-NRELQIMRKL---EHCNIVKLLYFFYSSGEKRDE--VFLN-LVLEYIPETVY
|...||||.||||||.||...    .|.|     ||||||.||.|.| |||||||..|    |.|||.|.||||...||.||  |..| ||.||.|.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

KVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLH--GEPNVSYICSRYYRAPELIFGAINYTTKI
.|.|.|.| ||..||..|.|||||.||.|||.||.|||||||||||.|.||.|.|||.||||||||| .  .|||.||||||||||||||||. |||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFP-----QIKSHPWQK-------------------VFRI-RTPTE-
||||.|||.||.|.|||.|||||.||||||.||.|||||.|||..|||.|.|||||     |||.|||||                   .|.. .|. . 
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

AINLVSLLLEYTPSARITPLKACAHPFF
.| |.| .|.|.|..|..||.|||||||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase sgg.AA CMGC 548-832 22 1.7e-128 424.74 In-house 1-513 (513) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-513/513
Sequence Identity: 22% (118 aa)

YTDTKVIGNGSFGVVFQAKL--------------CDTGELVAIKKVLQDRRFKN----------------RELQIMRKLE-----------------HCN
|.  |.|| |..|||....               ..|.|.|||||. ..  ...                ||..|...|                  | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLLYFFYSSGEKRDE-----------VFLNLVLEYIPETVYKVARQYAK------------------------TKQTIPINFIRLYMYQLFRSLA--Y
||||...||.......|           . |.|| ||.. . |.. ... .                        ... ..|  || ||||..|.|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHSLG--ICHRDIKPQNLLLDPETAV-------------------LKLCDFGSAKQLLHG----------------------EPNVSYICSRYYRAPELI
.|| .  |.|||.||.|.|..... .                   ||.||||.|... .                       .|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGAINYT---------TKIDVWSAGCVLAELLLG--------QPIFPGDSG-----------VDQLVEVIKVLGTPT---------------REQIREMN
.|. .||         |.||.||.||..||...|        .|.|||.|.           .||| . .|||||||                |.. .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PNYTEFK---------------------------FPQIKSHPWQKVFRI----------------------------------RTPTEAINLVSLLLEYT
.... .|                           ||... .||...|                                    . . .||.|.. .|.| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PSARITPLKACAHPFF
|. |||.  |..||.|
PDKRITAEQALQHPYF
Kinase sgg.AA Pkinase 548-832 30 1.2e-97 335.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

YTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNR--------ELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQY-
|.  ..|| ||||.|....  .||..||.|..  ... ..         |.|||..| |.|||.|...|..      .  . .|.|| . ..| |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLY-VMDLFD

---AKTKQTI--PINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAV---LKLCDFGSAKQ--LLHGEPNVSYICSRYYRAPELIFGAINYTT
   .. . ..  . . .. ||||..| |.|.|| ||.|||.||.|.|.| .  .   .|.||||.|||  . ... . .. ....|.|||.| |.  |..
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KIDVWSAGCVLAELLLGQPIFPGD----SGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPL
|.|.||.||.|.|.|.|.|.|||.    . .||.. . ...|.|..... . ......| |.. . |.  ..| .... |.. ... .|.. |. |.|. 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

KACAHPFF
 .. ||.|
QILQHPWF
Kinase sgg.AA S_TKc 548-832 29 5.5e-88 299.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPE---TVYKVARQYAK--TK
|.  ..|| |.||.|....  .||..||||..    .   ||.||..|  | |||||...|..        .| .|.||..    ..... ... .  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTT-KIDVWSAGCVLAE
. .|   .| ||||... |.|.||.||.|||.||.|.|||    ..|.||||.|.||       ... ...|.|||..     |.. |.|.|| ||.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACA-------HPFF
.| |.| ||      |. ...|..|                                   . ||..... .|.. |. |.|  .| .       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase sgg.AA RCK 548-832 31 5.1e-86 272.9 In-house 1-298 (298) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-298/298
Sequence Identity: 31% (96 aa)

YTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKN-------RELQIMRKLE-HCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYA
|. .| .| |..|.|. |.  .|||.|||||    ..|..       ||.. .|||  | ||.||.  ..     .|.  | .|.||  . .|.  . ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR----DNDTYQLYFVFEYMDMNLYQMMKDFK

KTKQT-IPINF--IRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPE--------TAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTT
. ... .| |   |. .|||.. .||..|. |. |||.|| |... ..        . ..|..|||...      |.  |. .|.|||||..  . .|..
E-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNS

KIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMN--PNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKA
..|.|. ||. .||   .| ||| | .||. . .||.|||. .   .     . ..|.||| |. | ....    . ..|.|.  .| . |. |||. .|
PMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQA

CAHPFF
. ||.|
LQHPYF
Kinase sgg.AA CDK 548-832 29 1.3e-73 234.88 In-house 1-284 (284) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-284/284
Sequence Identity: 29% (97 aa)

YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDR--------RFKN---RELQIMRKLEHCNIVKLLYFFYSS---GEKRDEVF---LNLVLE
|   . || |..|||. |.  .||     ..||.||.  .          |     ||  ....| | |||||.  ....    . .|  .   | .| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDK-HENKLYMVFE

YIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETA----VLKLCDFGSAKQLL-------HGEPNVSYICSRYY
|..   .|. .             |. ||.|| | |.|.|| .| |||.||||.|..        .||. ||| |.             .  . .  . |
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELIFGAINYT--TKIDVWSAGCVLAELLL---GQPIFPGDSGVDQLVEVIKVLGTPTREQ---IREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAI
||||| .|. .|.  | ||.||.||..||...   ..|.|||||  |||  .....|||| ..   . .. |.|                          
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKL-PDY--------------------------

NLVSLLLEYTPSARITPLKACAHPFF
.| . .| | |. ||.   |  ||.|
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase sgg.AA CDC2 548-832 30 1.7e-73 225.06 In-house 1-301 (301) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-301/301
Sequence Identity: 30% (95 aa)

YTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKN--------RELQIMRKLE-HCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQY
|.  . || |..|||...|  .|...||.||.  ..            ||. .. .|  | |||||   ...         | .| ||.     |  ...
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-------NKLYMVFEYLDMDLKKYMDMS

AKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICS-----RYYRAPELIFGAINYTTKIDVW
 .... .| .... ||||. . ... |. .| |||.||||.|.| .....|. ||| |.    | |   |        . |||||. .|.  |.| .|.|
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

SAGCVLAEL---LLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFK--FPQIKSHPWQKVFRI--------RTPTEAINLVSLLLEYTPSAR
| ||..||.       |.|.|||  |||  . ..||||. .   ..  .....|  ||. |    .|..           .. |.| | . .| | |. |
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVT-QLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

ITPLKACAHPFF
|.  .| .||.|
ISAKEALQHPYF
Kinase sgg.AA CDKL 548-832 34 5.6e-60 203.75 In-house 1-286 (286) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-286/286
Sequence Identity: 34% (103 aa)

YTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQ---DRRFK---NRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKT
|    ..| || |||.  .  .||..||||| .    |.  |    ||. . . | | ||| |.  |   ..      | || ||.  ||  .  .    
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRK------LHLVFEYCDHTVLHELEE---Y

KQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLL-HGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLA
 . .. . .| ||.|. ..... |.  . |||||| |.|. |   ..|||||| |..|   ||    |   | ||||||  |   | . .|.|..|||.|
PNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMA

ELLLGQPIFPGDSGVDQLVEVIKVLG--TPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPT--EAINLVSLLLEYTPSARITPLKACAHPFF
|.. |||..||.| .|||   .|.||  .|  ..|  .|| .   |||.|. |.     | ..    .|....  .|.  |. |.|  ..  ||.|
EMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIE-HMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase sgg.AA CDK-Unclassified 548-832 28 6.6e-59 192.36 In-house 1-324 (324) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-324/324
Sequence Identity: 28% (95 aa)

YTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDR-------------RFK---NRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVF-----------L
|   ...| | || |. |   .|   |||||.                 ..|   .||. ... ..| || |..  .|    ..|              .
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHY----DHDRCSKNPYYDNLHPSF

NLVLEYIPETVYKVARQYAKTKQTIPIN--FIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPET----AVLKLCDFGSAKQLL----------HGEP
 .|.||.| | | .          ..     || .| |.. ..||.|. .| ||||||||....  .     .||. |||.|                .|
YMVMEYMPYTWYNQLHN-----NRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADP

NVSY---ICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQ---IREMNPNYTEFKFPQIKSHPWQKVFR
. .|   .  | |||||| ||   |.| .|.||.||..||.. | |||.| . ..|.  ..|.||||. ..   .| | | |    |..     |   | 
MQQYSTQVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYM-PDYCKIFFKYKQKFHWWNRFP

IRTPTEAINLVSLLLEYTPSARITPLKACAHPFF
  .    .|...... | |  | .  ..  || |
KCKHASENNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase sgg.AA MAPK 654-832 34 5.6e-55 188.53 In-house 121-328 (328) Show / Hide 
Range on Protein: 654-832
Range on HMM: 121-328/328
Sequence Identity: 34% (73 aa)

MYQLFRS--LAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHG--EPNV-------------SYICSRYYRAPELIFG--AINYTTKIDVWS
|||. |   | |||| .. |||.|| |.|.. |   ||.|||| | ..     ...               |.  |.|||||....  . .||...|.||
MYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWS

AGCVLAELLL-GQPIFPGDSGVDQLVEVIKVLGTPTREQIREMN-P----NYTE-FK-FPQIKSHPWQKVFRI---RTPTEAINLVSLLLEYTPSARITP
.|| .||.|  ..|.|||.. .||.  ...|||||..| |. .  .    || . .. .|. . .||.|.|     ..  .||.|.. .|.  |. ||| 
VGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITV

LKACAHPFF
  | .||.|
EEALQHPYF
Kinase sgg.AA ERK 654-832 33 1.1e-47 164.74 In-house 114-307 (307) Show / Hide 
Range on Protein: 654-832
Range on HMM: 114-307/307
Sequence Identity: 33% (66 aa)

MYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLL-HGEPNV--------SYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLL
|||. . | |||| .. |||.|| |.|.  .  .|| |||| |  .  . ..|.         |. .|.|||||..  . .||...|.||.|| .||.| 
MYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLG

GQPIFPGDSGVDQLVEVIKVLGTP-TREQIREM-NPNYTEF--KFPQ--IKSHPWQKVFRIRTP--TEAINLVSLLLEYTPSARITPLKACAHPFF
..|.||| . |.|. ......||| . |....  ..|. ..  ..|   ..  ||...|  ...   .||.| . .|.  |. |||   . .||.|
RKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFP-NANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase sgg.AA MAPK-Unclassified 708-832 23 5.8e-29 101.58 In-house 408-575 (575) Show / Hide 
Range on Protein: 708-832
Range on HMM: 408-575/575
Sequence Identity: 23% (40 aa)

YICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLG-----------QPIFPGDS--------------------GVDQLVEVIKVLGTPTREQIREM
|.  |.|||||...   .|.|..| ||.||..||...            .|.|||..                     .||.   . .||.|  | ... 
YVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFI

-NPNYTEF--KFPQIKSHPWQKVFRIRTP---------TEAINLVSLLLEYTPSARITPLKACAHPFF
 ...  ..   | . .. ..   .   .|          |.|..|. .| . |. |||   |  ||.|
TCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase sgg.AA MAPK-Unclassified 548-694 32 1.1e-24 85.81 In-house 1-154 (575) Show / Hide 
Range on Protein: 548-694
Range on HMM: 1-154/575
Sequence Identity: 32% (51 aa)

YTDTKVIGNGSFGVVFQAKLCDT-GELVAIKKVL------QDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKR---DEVFLNLVLEYIPETVYKVARQ
|. .|.|| |..|.|  |.   . .  ||||||       .| .   ||. | | | | ||...   ||  . .    | ..  .| .| .  ..    .
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIY--IVMDYMQTSLFDLHQI

YAKTKQ-TIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFG
. |  | .     |.  .||. | |.|.|| .| ||| || |||.. .   .. ||||
I-KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLIN-QDCSVRICDFG
Kinase sgg.AA TyrKc 548-832 23 3.4e-13 -9.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 548-832
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

YTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKN---RELQIMRKL--EHCNIVKLLYFFYSSGEKRDEVF-----LNLVLEYIPETVYKVARQ
 |  |..|.| ||.|.....    . ||.|..  |   .    ||..||.||  .| |||.|.    ..|..    |     | .|.|| |    |   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKDYLR

YAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHG----EPNVSYI-----CSR-----YYRAPELIFGA
. . |  ..      ...|  .  .|.|| .. |||.   | |.. .  . | .||| .. . ..    |    |      ...        ||| |.  
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

INYTTKIDVWSAGCVLAELL-LGQPIFPG---DSGVDQLVEVIKVLGTPTREQIREM----NPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEY
. .||| |||| | .. |.. .||.  ||      .    |||. . .  |  . .                         |  . |.|  .. .   ..
K-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F-VCCPDEMYQIMKQCWHE

TPSARITPLKACAHPFF
 |. | |      | .|
DPEDRPTFSEI--HECF
Kinase sgg.AA MAPK 548-605 35 1.4e-09 29.03 In-house 1-71 (328) Show / Hide 
Range on Protein: 548-605
Range on HMM: 1-71/328
Sequence Identity: 35% (25 aa)

YTDTKVIGNGSFGVVFQAKLCD------TGELVAIKKV---LQDRRFKN---RELQIMRKL-EHCNIVKLL
|.. | || |..|||. |.         .|. |||||.    |.  .     ||. ..| . .| ||.|||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLL
Kinase sgg.AA Pkinase_Tyr 548-605 30 2e-09 32.56 Pfam 1-70 (270) Show / Hide 
Range on Protein: 548-605
Range on HMM: 1-70/270
Sequence Identity: 30% (21 aa)

YTDTKVIGNGSFGVVFQAKLC----DTGELVAIKKVLQDRRFKN-------RELQIMRKL-EHCNIVKLL
 |  |..| |.||.|.....     .|.  ||.|.. ..   ..       ||..||..|  | |||.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase sgg.AA ERK 548-605 32 1.8e-08 27.84 In-house 1-70 (307) Show / Hide 
Range on Protein: 548-605
Range on HMM: 1-70/307
Sequence Identity: 32% (23 aa)

YTDTKVIGNGSFGVVFQAKLCD-----TGELVAIKKV---LQDRRFKN---RELQIMRKL-EHCNIVKLL
| ..| || |..|||. |.        ||. |||||.     .... .   ||. ..| . .| ||..|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLF
Kinase sgg.AA Pkinase_Tyr 716-743 46 2.476234 1.75 Pfam 182-208 (270) Show / Hide 
Range on Protein: 716-743
Range on HMM: 182-208/270
Sequence Identity: 46% (13 aa)

APELIFGAINYTTKIDVWSAGCVLAELL
||| |.  . .||| |||| | .. |..
APECINYGK-FTTKSDVWSFGVLMWEIF