Gene aur (Fruit Fly)

aur

Species: Fruit Fly
Alias: SFO044, auroraA, 87A7-9/1, CG3068, early-A, ck10, aur, fruhe2, aurA, l(3)ck10, l(3)87Ac, ck[10]
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 87A3,

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
aur.AA Protein Various 411 None Fasta, JSON
aur.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of aur.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase aur.AA Aur 154-406 61 8.99999999999e-235 627.42 In-house 1-257 (257) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-257/257
Sequence Identity: 61% (158 aa)

FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDE
|.||..||.||||||||||.|...| .||||.|| || ....|||.||||.|||||.||.||..| ||||| ||||||||||.|.|.. || ||.|||||
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

RQSATYIQALCSALLYLHERDIIHRDIKPENLLLG-HKGVLKIADFGWSVHEP-NSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAP
 ..|.|.. .|.|| |.|...||||||||||.||. ..|..||.||||||| | |..|||.|||.||.|||||.|..| ..||.|.|||||.||..|..|
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FYS-KNYDETYKKIL-KVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPWI
|.| .|.||||..|. |||.. | |||| | .||||.|. .|..|..|||.| ||||
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase aur.AA AGC 154-406 24 1.6e-110 286.49 In-house 1-395 (395) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-395/395
Sequence Identity: 24% (99 aa)

FDIGRLLGRGKFGNVYLAREK------ESQFVVALKVLFKRQ-IGESN--VEHQVRRE------------IEIQSHLR----------HPHILR-LYAYF
|.. ...|.| || |||.|.|       .. . |.||| |.  | . .   .... .|             .| ....          || | . |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HDDVR--IYLILEYAP---------QG-TLFNALQAQ-PMKRFDERQSATYIQA-------LCSALLYLHE-RDIIHRD-IKPENLLLGHKGVLKIADFG
.|. .  .|...||.|          |  ||  || .   .|||| ..  |.         ...|| |||. ..||||| .||||.|| ..| .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WSVHEPNSM----------------------------------------------------RMTLCG--TVDYLPPEMVQGKPHTKNVDLWS--LGVLCF
 .   .|..                                                      |.||  | .|..||..    ..| .| ||  ||.| .
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLVGHAPFYSKN----------YDETYKKIL------KVDYKLP----------EHISKAASHLISKLLVLNPQHRLP----------LDQVMVHPWI
|.|.|. |||..|           .|...||.      . . |.|          ...|. | .||.|||. .| .||            .... ||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase aur.AA CAMK 159-406 22 6.7e-102 329.18 In-house 1-425 (425) Show / Hide 
Range on Protein: 159-406
Range on HMM: 1-425/425
Sequence Identity: 22% (96 aa)

LLGRGKFGNVYLAREKESQ------------FVVALKVLFKRQIGESN-------------------------VEHQVRREIEIQSH-------LRHPHI
 |||| || |.|...|...              || |.. |... ...                          ...||||||| ..       |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLYAYFHD-------------------DVRIYLIL---EYAPQG----TLFNALQAQPM-------------KRFDERQSATYIQALCSALLYLHERDI
..|| .. |                   | ..|...   ||.. |     ||. .....              .||.||. ..|.. .|||. |.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENLLLGHK-----------------GVLKIADFGWS--VHE-----------------------PNSMRMTLCGTVDYLP-PEMVQG------
.|||.||||.|| ..                 . .||.||| .  . .                       .. .  | |||  | . ||...|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KPHTKNVDLWSLGVLCFELLVGHAPFYSK-------------NYDETYKKILKVDYK-LPEH---------------ISKA--------ASH
        ..... .| ||.||... .|.|. |||..             |. |...||.| .|   |..               ||.         . .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISKLLVLNPQHRLPLDQVMVHPWI
||.|.|. .|..|. ..|.. |||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase aur.AA S_TKc 154-406 31 1.1e-98 335.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQ--GTLFNALQAQPMKR-
..|.|..|.| || ||..|.|... .||.|..            ..||||.| .. .||.| .|| .|.|  ..|...||...  |.||  .. .. .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTK-NVDLWSLGVLCFELL
   |.| . . |.. .|.|| |.|.. |||||.||||.|| .  ..||.||| . .      .|.||| .|..||..   ...|  .| ||.|.. .|.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

VGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMV-------HPWI
.|  ||.  ......|||.          |. | ..|.|.|. .|..|.   ...        |||.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase aur.AA CAMKL 154-406 33 3.5e-91 291.24 In-house 1-297 (297) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-297/297
Sequence Identity: 33% (99 aa)

FDIGRLLGRGKFGNVYLARE-KESQFVVALKVLFKRQIG-ESNVEHQ-----------VRREIEIQSHLR---HPHILRLYAYFHDDVR------IYLIL
..||. ||.| || | ||.  .  .  || |.. |. |  . ...             .||||.|...|.   ||.| .||  . ..        |||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAPQGT--LFNALQAQPMKR--FDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKG--VLKIADFGWSVH-EP-----NSMRMTLCGTVDYL
||.. |   ||. ..... .|  ..|..   | . ..||. |.|...|.||||||||.|| ..|  ..||.||| | . .|     . . .| ||.  | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEMVQG--KPHT-KNVDLWSLGVLCFELLVGHAPFYSK--------NYDETYKKILKVDYKLP--EHISKAASHLISKLLVLNPQHRLPLDQVMVHPWI
.||..||  ||.  . || ||.||. . ...|. ||           |. . |.|| .  |. |   |.|  . .||.|.|. || .|  ..|.| ||| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase aur.AA Pkinase 154-406 29 2.4e-87 301.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVR-REIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQG----TLFNALQAQPM
. ||| .|.| || ||....| .. .||.|.. || . ..  .. .| .||.|  .|.||.|.||| .|.|. .||...||.. |     ||  ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRF--DERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVL----KIADFGWSV---HEPNSMRMTLCGTVDYLPPEMVQ-GKPHTKNVDLWSL
..|  .|..   |.  ....| |.|.. |||||.||||.|. ..|..    ||.||| .    . .||  .|.||| .|..|| .. |..... || ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLCFELLVGHAPFYSK------NYDETYKKILKVDYKLPEHIS---------------------KAASHLISKLLVLNPQHRLPLDQVMVHPWI
|....|.| |. ||...      . .. ...|.. ... ..  .                     ... ..|...| ..|. |.  .|.. |||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase aur.AA MARK 154-406 37 4.1e-84 274.86 In-house 1-262 (262) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-262/262
Sequence Identity: 37% (98 aa)

FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFH--DDVR-IYLILEYAPQGTLFNALQAQPMKR
. ... .| | .. |.||. | ..  ||.|.. | .. . .    |.||||| ..| ||.| .|. ..   .  . ||||.|||. | |.. ..|.|  |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKG--VLKIADFGWSVHE-PNSMRMTLCGTVDYLPPEMVQGKPHT-KNVDLWSLGVLCFELL
  |.   .. . ..||. |.|...|.||||||||.|. ..|    ||.|||.|..  |...  | |||  | .||....|| . . || |||||. . ..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

VGHAPFYSKN--YDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPWI
.|. ||  ..  | | |||||. .|. | |.|| . .||..||..||  |  ....| |||.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase aur.AA Ciliate-E2 154-406 24 6.2e-77 261.91 In-house 1-365 (365) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-365/365
Sequence Identity: 24% (91 aa)

FDIGRLLGRGKFGNVYLARE-----------------------KESQFVVALKVLFKRQIGESNVEHQVRREIE----------IQSHLRHPHILRLYAY
... ...|.| || ||...                        |  .. .|.|.. |.|| . . | .. |||.          |...| ||.|...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--DDVRIYLILEYAPQGTLFNALQAQPMKR---------FDERQSATYIQALCS---------------ALLYLHERD-IIHRDIKPENLLLGHKGVL
|   ||  |||..||. .|.||  .. .. ||         |.|.. ..... ...               || |||..  ||||||||||.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGWSVHEPNSMRMTL---------------------------------CGTVDYLPPEMVQGKP---------HTKNVDLWSLGVLCFELLVGHAP
||.||| |    ... ...                                 |||  |..||...||.         ... .|.|||||. .|.| |  |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYSKNYDETYKKILKVDYKLP------------------EHISKAASHLISK----LLVLNPQHRLP-LDQVMVHPWI
|        ...|.. ....|                  ...|. . .||.|    .|. .|. |.   .|.. |||.
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase aur.AA Ciliate-E2-Unclassified 154-406 25 1e-72 247.91 In-house 1-352 (352) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQV----RREIEIQSH------------------LRHPHILRLYAYFHDDVRIYLIL
. |.. .|.| || ||....|. ... |.| . | ||  ..   ..    . ..|....                  . ||.|.... .| |.  ||...
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYAPQGTLFNALQAQPM---------------KRFDERQSA-----TYIQALCSALLYLHERD-IIHRDIKPENLLLGHKG---VLKIADFGWSV-----
||...|.|.. .. ..                |.|.|.|..     .|.  ....| |||.   ||||||||||.|.  .|    .||.||| |      
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------HEPNSMRMTLCGTVDYL----PPEMVQGKPHT----KNVDLWSLGVLCFELLVGHAPFYSKNYDE----------------TYKKILK
              .. |  | |||  |.    .||. ||. .     . .| |||||...|.| |  |||..|...                 |..|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

VDYKLPE--------HISKAASHLIS----KLLVLNPQHRLPLDQVMVHPWI
 ... |.        |.|. | ..|.    |.|. ||  |. ..|.. |||.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase aur.AA PKA 154-395 38 2.1e-72 246.82 In-house 1-247 (263) Show / Hide 
Range on Protein: 154-395
Range on HMM: 1-247/263
Sequence Identity: 38% (95 aa)

FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILR-LYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFD
|.| ..||.| || |.|.|.|.|   .|.|.| |..|   . .. |  |. | . ..|| | . .|. |.||  .|...||.| | .|  |..   .||.
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKS--GRFS

ERQSATYIQ-ALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGK-PHTKNVDLWSLGVLCFELLVGHA
. ..  |.    ..|| |||  .||.|| ||||.|.  .| .||.||| .    .   .||||| .||.||..|.| .| | || |.||.| .|.|.|. 
NPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYSK--NYDETYKKILKVDYKLPEHISKAA---SHLISKLLVLNPQHRL
||| .  .  ..|.||.. ..| |.|....|    .||.|||. ..  |.
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRY
Kinase aur.AA AktR 154-406 36 3.5e-72 246.1 In-house 1-268 (268) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-268/268
Sequence Identity: 36% (98 aa)

FDIGRLLGRGKFGNVYLAREK-ESQFVVALKVLFKRQIGESNVEHQVRREIEIQS-HLRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRF
|.. ..||.|.||.|||...| ..| ..|.|.. |  | | | .|....|  |   . .|| | .|.  | ..  ...|.|| | | ||. |. .  |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKK--KKF

DERQSATYIQALCSALLYLHER-DIIHRDIKPENLLLGHKGVLKIADFGWSV----HEPNSMRMTLCGTVDYLPPEMVQG-KPHTKNVDLWSLGVLCFEL
.| |.  |.   . || |||.. .|| ||.||||.||.  | .||.||| |      . . .  ..|||. |..|||..  |.|.|.||.|..|.. .|.
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LVGHAPFYSKNYDETYKKILKVD-YKLPEH--ISKAASHLIS-KLLVLNPQHRLP-----LDQVMVHPWI
..|. |||.||  . ..||.. .  | |..  .|...  ||  |||  ||..||       ...  ||| 
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase aur.AA RSK 157-406 33 5.9e-72 245.36 In-house 1-278 (278) Show / Hide 
Range on Protein: 157-406
Range on HMM: 1-278/278
Sequence Identity: 33% (92 aa)

GRLLGRGKFGNVYLAREK---ESQFVVALKVLFKRQIGESNV-EHQVRREIEIQSHLR-HPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMK-R
 ..||.| .| |.| |..    .. . | ||| |. |  ...    ...|..| .. . || | .|.  |...  .|||.|| . | ||  || . ..  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGH---KGVLKIADFGWSVH---EPNSMRMTLCGTVDYLPPEMVQ---GKP-HTKNVDLWSLGV
|.|.  . |.  . .|. .||...|||||.|||| |. .    | .|. ||| .     . |.. || |.|..|..|||.    ..  |.|..|.|||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LCFELLVGHAPFYS---KNYDETYKKILKVD--YKLP--EHISKAASHLISKLLVLNPQHRLP-----LDQVMVHPWI
| .|.|.|. ||..   .| .|. |.|.| .   ..|  . .|..| .||.|.|  .|. ||      ....  |||.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase aur.AA Pkinase_Tyr 154-299 29 2.6e-23 79.58 Pfam 1-156 (270) Show / Hide 
Range on Protein: 154-299
Range on HMM: 1-156/270
Sequence Identity: 29% (46 aa)

FDIGRLLGRGKFGNVYLAREK----ESQFVVALKVLFKRQIGESN-VEHQVRREIEIQSHL-RHPHILRLYAYFH-DDVR--IYLILEYAPQGTLFNALQ
  .|. ||.| ||.||... |    . .  || |.| | .  ...       ||..| ..| .||.|.|||.    ..    ||...||.| | | . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AQ--PMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFG
..  . ....  .   . .  .... ||... .||||.   | |.....| ||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase aur.AA TyrKc 154-406 21 3.6e-16 38.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 154-406
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHL--RHPHILRLYAYFHDD-------VRIYLILEYAPQGTLFNALQ
   |. ||.| || ||... |     || |.| .        .   .||..| ..|  .||.|.|||..  ..         .....||.| | | . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

AQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNS---------MRMT---LC---GTVDYLPPEMVQGKPH
.   | .  ..   .    ..   |||.. .||||.   | |.|.... ||.||| |    .           |..    .     .  ..||  . .  
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TKNVDLWSLGVLCFELL-VGHAPFYS-----KNYDETYKKILKVDYKLPEHI---------SKAASHLISKLLVLNPQHRLPLDQVMVHPWI
|   | || ||...|..  |  | .      .. .| .... . ..  . .          ...   ....    .|  |    ..  |  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF